Cited by 1,168Nanoplatforms for cancer theranosticsSulfur Compounds in BiologyRedox biology and oxidative stress

The DOI matches its Crossref record; 251 of the 254 references it cites were found in a registry or an index.

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Niu, Boyi, Liao, Kaixin, Zhou, Yixian, Wen, Ting, Quan, Guilan, Pan, Xin, Wu, Chuanbin·2021·Biomaterials

DOI 10.1016/j.biomaterials.2021.121110

Open this paper in CoChat — free account

Abstract

Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2021.121110

Cites

251 of 251 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

1 retracted

RETRACTED: Monodispersed Copper(I)‐Based Nano Metal–Organic Framework as a Biodegradable Drug Carrier with Enhanced Photodynamic Therapy Efficacy
Cai, X., Xie, Z., Ding, B., Shao, S., Liang, S., Pang, M., & Lin, J. (2019) · Advanced Science · doi:10.1002/advs.201900848 · Cited by 209
Retracted
Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
ROS function in redox signaling and oxidative stress
Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931
Oxidative stress: oxidants and antioxidants
Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577
Thiol–Ene Click Chemistry
Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201
Glutathione Metabolism and Its Implications for Health
Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842
Association of reactive oxygen species levels and radioresistance in cancer stem cells
Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555
Functional Nanomaterials for Phototherapies of Cancer
Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,438
Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species
He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,207
Glutathione synthesis
Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192

Show all 254 references

Sorted by citations

Items 901–1,000 of 1,000

GSH‐Depleted Platinum(II) Metallacycles to Turn On the NIR Emission in Boosting Synergistic Cancer Therapy
Shen, Q., Gao, K. S., Zhang, P., Luo, X., Yang, J., Zhou, P., Xu, Y., Xu, C., Meng, L., Wang, H., et al. (2025) · Aggregate · doi:10.1002/agt2.70215 · Cited by 2
Macrophage-membrane-camouflaged Fe-TCPP MOF nanoplatform for biomimetic cisplatin delivery and ferroptosis-enhanced therapy in triple-negative breast cancer
Li, W., Meng, X., Xie, F., Jia, W., Yao, J., & Wang, P. (2025) · Cancer Nanotechnology · doi:10.1186/s12645-025-00357-8 · Cited by 2
One-pot self-assembled bimetallic cu/fe-doped ZIF-based nanocomposites for tumor-specific chemo/chemodynamic therapy-amplified ferroptosis
Pan, Y. H., Rao, C., Guo, M., Deng, Y., Chen, R., Ju, R., Peng, Y., Muyi, Z., Liu, J., & Huang, Y. (2026) · Materials Today Chemistry · doi:10.1016/j.mtchem.2026.103366 · Cited by 2
Towards safer deep eutectic solvents: Insights from an in vivo study of reline toxicity under different preparation methods
Kang, Y., Lee, S. C., Kang, S., Bae, B., Chen, J., Cha, H., Kang, Y., Kim, S., Shin, B. S., Kim, H. S., et al. (2026) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2026.141165 · Cited by 3
Hollow cerium oxide nanoparticles promote M2 polarization and modulate the SLC7A11/GSH/GPX4 axis to attenuate macrophage ferroptosis for inflammatory wound repair
Sun, S., Luo, D., Song, K., Cui, J., Liu, J., & Li, X. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.115505 · Cited by 2
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma
Sun, Y., Yan, Y., Zhou, Y., Chen, Y., Liu, C., Bao, Y., Zhang, Y., Han, H., & Chen, H. (2026) · Respiratory Research · doi:10.1186/s12931-026-03558-w · Cited by 2
Self-citation
Boosting Cuproptosis in Breast Cancer Therapy via Photodynamic Treatment With a New Liposome
Yu, J., Sun, N., You, L., Liu, J., Niu, M., Shi, J., Chen, W., Li, F., Wang, S., & Liu, J. (2026) · FASEB BioAdvances · doi:10.1096/fba.2025-00280 · Cited by 2
Proteolysis-targeting Chimeras induce ferroptosis in cancer: From Mechanism to clinical application
Nx, Z., Zhong, X.-Y., Zhang, S.-H., Liu, M.-C., Xia, Q. D., Yu, X., & Wang, S.-G. (2026) · Pharmacological Research · doi:10.1016/j.phrs.2026.108141 · Cited by 2
Mitochondria-targeting iridium(III) complex enhances anticancer activity via PDK inhibition and energy metabolism disruption
Xu, S., Xu, N., Fang, H., Zhu, Z., Su, Y., & Su, Z. (2026) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2026.113317 · Cited by 2
Redox-responsive nanoparticles for enhanced mRNA delivery: a comprehensive review
Wang, Z., Chen, B., (24124354), Y. G., Wu, C., Shuai, Q., & Yan, Y. (2026) · Journal of Materials Chemistry B · doi:10.1039/d6tb00186f · Cited by 2
Self-citation
A Cu-based metal-organic framework based on desloratadine and siHIF-1α for achievement of genes/drugs/CDT combination therapy in hepatocellular carcinoma
Ding, D., Huang, Z., Wang, L., Wang, Z., Qin, J., Ni, M., Yao, B., & Yang, Y. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04334-0 · Cited by 2
Metal-organic frameworks for Cuproptosis-based Cancer therapy
Li, Y., Niu, H., Kim, K., Kim, H., Liu, Y., Wen, M., Kang, H., Zhao, Y., Yoon, J., & Zhang, H. (2026) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2026.217975 · Cited by 2
Neuron-targeted selenoprotein-enriched exosomes attenuate ferroptosis in spinal cord injury by stabilizing lipid droplets
Wang, W., Tang, J., Jiang, X., Wu, J., Huang, Y., Guo, Q., Lin, Z., Wang, W., Meng, J., Xi, K., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.176852 · Cited by 2
Live-Cell Derivatization Enables High-Throughput Analysis of Thiols with CyESI-MS
Xu, K., Yang, J., Pan, S., Du, M., Cheng, R., Cao, J., Zhao, B., Zhang, S., & Zhang, X. (2026) · Analytical Chemistry · doi:10.1021/acs.analchem.5c07995 · Cited by 2
Breaking the “Whack‐a‐Mole” Dilemma in Cancer Therapy: Ultrasound‐Propelled ROS Storm Enables Triple‐Modal Cell Death
Luo, M., Zhao, L., Zhang, M., Fan, W., Liu, W., Yang, Y., Guo, Y., Zhang, Q., Cao, S., Zhang, M., et al. (2026) · Small · doi:10.1002/smll.202514512 · Cited by 2
Mn 3 O 4 Nanozymes Mitigate Salt Stress in Tomato ( Solanum lycopersicum ) by Scavenging Reactive Oxygen Species and Enhancing Photosynthesis
Liu, H., Wang, J., Wu, Y.-X., Hai-e, S., Zhang, X.-Y., Tian, H., Li, H.-J., Li, N., Liu, B.-R., & Song, X.-M. (2026) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c12852 · Cited by 2
Glutathione in Our Diet and Its Role in the Body: From Disease Prevention to Anti-Aging
Bradauskienė, V., Moščenkova, E., Šniepienė, G., Kubiliūtė, R., & Vaičiulytė, L. (2026) · Nutrients · doi:10.3390/nu18101640 · Cited by 2
Molecularly engineered BODIPY photosensitizers for combined cancer phototherapy and immunotherapy
Wang, H., Zhang, Y., & Zhou, M. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1849977 · Cited by 2
Sonosensitizer‐Functionalized Polymetallic Nanoenzymes for Photoacoustic Imaging‐Guided Cancer Sonodynamic Immunotherapy
Li, C., Pang, F., Ma, Y., Bin, Y., Huang, L., Zhao, J., Huang, M., Liang, J., Zhang, L., Zhao, S., et al. (2026) · SmartMat · doi:10.1002/smm2.70095 · Cited by 2
Precisely designed Fe x ( x = 1–2) cluster nanocatalysts for effective nanocatalytic tumor therapy
Meng, Y., Zhang, D., Song, Y., Yang, X., Gao, Y., Ma, J., Hu, Z., & Zheng, X. (2022) · Nanoscale · doi:10.1039/d2nr05869c · Cited by 2
A Fe( iii ) intercalated clay nanoplatform for combined chemo/chemodynamic therapy
Chen, Y. S., Zhai, J., Wei, S., Tang, A., & Yang, H. (2024) · Chemical Communications · doi:10.1039/d3cc06205h · Cited by 2
Theoretical insights into a turn-on fluorescence probe based on naphthalimide for peroxynitrite detection
Huang, H., Zou, Z., & Peng, Y. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e37298 · Cited by 2
Buthionine sulfoximine acts synergistically with doxorubicin as a sensitizer molecule on different tumor cell lines
Pereira, J. C., de Sousa, R. W. R., Conceição, M. L. P., do Nascimento, M. L. L. B., de Almeida, A. T. A., dos Reis, A. C., Cavalcante, M. L. D. S., Oliveira, C. D. R., Martins, I. R. R., Torres‐Leal, F. L., et al. (2025) · Journal of Toxicology and Environmental Health · doi:10.1080/15287394.2024.2448663 · Cited by 3
Knowledge map in biomaterials and related immune response: a scientometric analysis
Yu, C., Xu, C., Wang, T., & Xu, J. (2025) · Frontiers in Materials · doi:10.3389/fmats.2025.1534127 · Cited by 2
Rapid and Sensitive Glutathione Detection Using Water‐Soluble Fluorescent Bimetallic Nanoparticles
Mahanty, A., Akhuli, A., Patra, C., Ghosh, J., & Sarkar, M. (2025) · ChemNanoMat · doi:10.1002/cnma.202400642 · Cited by 2
Tick HRF-dependent ferroptosis pathway to promote tick acquisition of Babesia microti
Chen, S., Hu, S., Zhou, Y., Cao, J., Zhang, H., Wang, Y., & Zhou, J. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1560152 · Cited by 2
Self-citation
Transcription Factor YY2 Inhibits Tumor Cell Glutamine Catabolism by Regulating GLS1 RNA Splicing Isoform GAC
Liu, J., Li, J., Li, Y., Wei, M., Xiang, D., Zhao, H., Miyagishi, M., Kasim, V., & Wu, S. (2025) · American Journal Of Pathology · doi:10.1016/j.ajpath.2025.04.003 · Cited by 2
Role and mechanism of lncRNA ZEB1-AS1 endogenous competition for miR-365a-3p targeting NRF2 in ferroptosis in articular chondrocytes
Zhang, R., Liu, Y., Zang, H., He, A., Mao, Y., & Liu, W. (2025) · Journal of Molecular Histology · doi:10.1007/s10735-025-10450-2 · Cited by 2
Triaptosis and Cancer: Next Hope?
Li, Z., Zhou, K., Wu, J., Cao, L., Wang, G.-R., Luo, H.-Y., Liu, B., & Bu, L. (2025) · Research · doi:10.34133/research.0880 · Cited by 4
Intracellular co-self-assembly of 68Ga/Gd nanoparticles for enhanced PET/MRI hybrid imaging of orthotopic tumors
Cai, K., Zhang, X., Guo, X., Wang, C., Huang, Y., Zhang, G., Zheng, Y., Bi, Z., Qian, Y., Zhang, J., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.167568 · Cited by 2
Multifunctional Mn–Cu Bimetallic DNAsome for Photothermal-Assisted Chemodynamic Cancer Therapy
Raj, G., Prasad, J., Ghosh, T., Kumar, D. B., Beena, A. V., Perozhy, H., Kalita, J., Vasudev, D. S., Krishna, A., & Varghese, R. (2025) · ACS Applied Bio Materials · doi:10.1021/acsabm.5c00519 · Cited by 2
Development of durable MOF-based antimicrobial elastomeric sealant for effective microbial decontamination in building environments
Nam, J., Yeon, K., & Kim, J. (2025) · Progress in Organic Coatings · doi:10.1016/j.porgcoat.2025.109768 · Cited by 2
The cyclin-dependent kinase inhibitor p27 facilitates chemosensitivity by promoting ferroptosis in epithelial ovarian cancer
Zhu, M., Huang, L., Sun, S., Chen, M., Cai, J., Zhang, Y., Wang, L., Cai, L., & Peng, M. (2025) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2025.111011 · Cited by 2
Mn(III)-porphyrin/hyaluronic acid nanoparticles for enhanced sonodynamic/chemodynamic synergistic therapy via remodeling tumor reductive microenvironment
Sun, Y., Li, H., Xie, G., Miao, Y., Yang, Y., Shi, P., Wang, L., Yang, J., Zhang, J., He, J., et al. (2025) · European Polymer Journal · doi:10.1016/j.eurpolymj.2025.114295 · Cited by 2
Synergistic Effects of Anticancer Drug Delivered via Nanoporous Zeolitic Imidazolate Frameworks: Implications for Tumor Therapy
Liu, H., Qi, D., Luo, Y., Bao, H., Li, T., Sun, K., & Song, S. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c05355 · Cited by 2
Glutathione's antioxidant effects and its ability to shield mice's hepatocytes from damage caused by furan
Ibrahim, I., Saleh, H. M., & Hamouda, A. (2024) · Food Technology Research Journal · doi:10.21608/ftrj.2024.346574 · Cited by 2
[Manganese-based nanoparticles for chemodynamic therapy of gastrointestinal cancer].
Lin, X., Huang, M., Chen, J., Zhou, X., Zhong, Z., Lu, W., Huang, X., & Liu, T. (2023) · PubMed Central · doi:10.12122/j.issn.1673-4254.2023.08.22 · Cited by 1
Oxidative Stress Adverse Effects in Histological Changes Induced by Anticancer Drugs: A Review Article
Khudhair, D. A., Alkufaishi, Z. H. J., & Al-khafaji, T. M. J. (2024) · Journal of Medical and Health Studies · doi:10.32996/jmhs.2024.5.2.16 · Cited by 1
Advanced nanotherapeutics inspired by the abnormal microenvironment of leukemia
Zhang, H., Liu, T., Liu, M., Wang, S., Huang, Y., Ma, Y., Sun, B., He, Z., & Sun, J. (2024) · Nano Research · doi:10.1007/s12274-024-6838-4 · Cited by 1
[Ferroptosis suppressor genes are highly expressed in esophageal cancer to inhibit tumor cell ferroptosis].
Wang, Y., & Zhang, P. (2024) · PubMed Central · doi:10.12122/j.issn.1673-4254.2024.07.19 · Cited by 1
Phototherapy meets chemodynamic therapy: a win–win strategy rejuvenating cancer treatment
Chen, L., Cai, Y., Gao, F., & Dong, X. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13937-6.00023-8 · Cited by 1
An edible green algae polysaccharide from Caulerpa racemosa var. peltate induced apoptosis of liver cancer cells Hepa1-6 by regulating glutathione metabolism
Xia, X., Zhou, H., Zhang, R., Zhang, X., Xu, B., Wong, I. N., & Huang, R. (2024) · Food Science and Human Wellness · doi:10.26599/fshw.2024.9250300 · Cited by 1
Engineered Reactive Oxygen Species (ROS)‐Responsive Artificial H+/Cl− Ion Channels for Targeted Cancer Treatment
Jia, C., Luo, D., Zhou, J., Xie, X., Lam, H. Y. I., Li, P., Mu, Y., Zeng, Z., & Ren, C. (2024) · Angewandte Chemie · doi:10.1002/ange.202419800 · Cited by 1
CaCO3-based nanomedicine with multi-functions of ferroptosis-apoptosis and microenvironment regulation in cancer
Zhang, X., Feng, Y., Cao, W., Yu, F., Sun, L., Barth, S., & He, H. (2024) · Nano Today · doi:10.1016/j.nantod.2024.102594 · Cited by 1
Lysosomal-targeted near-infrared phototherapy agent with type-I photodynamic activity for high-performance synergistic therapy under hypoxia
Tang, X., Yang, X., Wang, Y., Chen, L., Chen, P., & Zhao, M. (2025) · Surfaces and Interfaces · doi:10.1016/j.surfin.2025.106075 · Cited by 1
9-Hexadecenoic acid inhibits the aggressiveness of gastric cancer via targeting PTPN1/FTH1 signaling
Wang, X., & Peng, H. (2025) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001724 · Cited by 1
Nanoemulsion-based nanoplatform as a new PEITC nano - delivery system to pancreatic cancer cells
Grzeszczak, A., Zaremba-Czogalla, M., Zagórska, A., Walczak, M., Gawlik, M. T., Żarnowski, R., Andes, D. R., Gubernator, J., & Jaromin, A. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106987 · Cited by 1
P16 hypermethylation is a potential cause of oxidative stress due to long-term exposure to hexavalent chromium
Dong, X., Yu, N., Li, Y., & Lou, J. (2025) · Environmental Toxicology and Chemistry · doi:10.1093/etojnl/vgaf126 · Cited by 1
Self‐assembly of verteporfin dimers into folate receptor‐targeted lipid nanoparticles for photodynamic therapy of ovarian cancer
del Valle, C. A., Srivastava, P., McNaughton, K. A., & Huang, H. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70031 · Cited by 1
Propofol is involved in neurotoxicity by mediating the occurrence of ferroptosis
Zuo, L., Wang, M., Tian, X., He, L., Wang, L., Li, Y., & Yao, X. (2025) · Medicine · doi:10.1097/md.0000000000043390 · Cited by 1
Clinical and biological impact of SNAT7 in lung adenocarcinoma: implications for prognosis and treatment
Hashinokuchi, A., Haratake, N., Ono, Y., Tomonaga, T., Bassi, G., Matsudo, K., Kinoshita, F., Matsubara, T., Kohno, M., Takenaka, T., et al. (2025) · International Journal of Clinical Oncology · doi:10.1007/s10147-025-02851-w · Cited by 1
Proficient photothermal-enhanced cascade catalytic nanoplatform for multi-responsive release and synergistic tumor therapy
Zhu, W., Li, F., Hou, T., Xu, T., Liu, J., Cai, D., Liu, C., Jiang, K., Wang, L., Tao, W., et al. (2025) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2025.137972 · Cited by 1
Exposure of dairy goat mammary epithelial cells to bis(2-ethylhexyl) phthalate induces oxidative stress and alters gene/protein expression, posing health risks
Xu, X., Luo, M., Hu, J., Wang, H., Wang, X., Bu, J., Li, J., Yan, H., & An, X. (2025) · Journal of Environmental Sciences · doi:10.1016/j.jes.2025.08.040 · Cited by 1
Liposome modification THP boosts glioma ferroptosis and immunogenic cell death through reinforcement of mitochondrial dysfunction and mitophagy
Huang, J., Chen, H., Xu, Y., Huang, C., Lin, R., Su, Z., & Wu, J. (2025) · Journal of Materials Science · doi:10.1007/s10853-025-11491-4 · Cited by 1
Effects of the Thai Herbal Wattana Formula and Its Ingredients in the Human Hepatocarcinoma HepG2 Cells: Safety and Efficacy Considerations
Booranasubkajorn, S., Lumlerdkij, N., Chaisri, S. M. A., Akarasereenont, P., & Prieto, J. M. (2025) · Natural Product Communications · doi:10.1177/1934578x251385040 · Cited by 1
A dynamic protein corona substitution strategy for activatable imaging-guided synergistic theranostics in triple-negative breast cancer
Mu, X., Li, Y., Wang, S., Fu, H., Gao, M., Lü, Y., & Zhou, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102390 · Cited by 1
A gold-doped Thionin carbon nanozyme induces ferroptosis to boost chemo/photo-dynamic therapy
Mao, J., Huang, X., Liu, Y., Wang, Y., Li, D., Xu, Z., Yan, X., Liu, T., & Wang, H. (2025) · Materials & Design · doi:10.1016/j.matdes.2025.114917 · Cited by 1
Harnessing big data for precision medicine: radiomics based application of nanomaterials in MRI enhancement and multimodal therapy of hepatocellular carcinoma
Shen, H., Ran, D., Zhu, J., Tao, A., Zheng, K., Zhu, Q., & Wang, H. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1659180 · Cited by 3
Behavioral and pharmacological effects of phytochemicals in Cinnamomum verum bark extract for prevention of experimental murine coccidiosis
Murshed, M., Alzaylaee, H., Ibrahim, K. E., Ammari, A. A., Ahmed, H., & Al-Quraishy, S. (2025) · Frontiers in Veterinary Science · doi:10.3389/fvets.2025.1715869 · Cited by 1
Light, Dyes, and Action: Photodynamic Inactivation of Leishmania amazonensis Using Methylene Blue, New Methylene Blue, and Novel Ruthenium-Based Derivatives
Vasco-dos-Santos, D. R., Vacani-Martins, N., Silva, F. C., Alves, L. A., da Rocha, Z. N., Henriques‐Pons, A., Torres-Santos, E. C., & Vannier-Santos, M. A. (2025) · Biology · doi:10.3390/biology14121710 · Cited by 1
Monometal-doped nanozymes ameliorate rheumatoid arthritis by regulating neutrophil ferroptosis via the MDM2–P53–SLC7A11 pathway
Gong, X., Wang, H., Yan, A., Zhang, Y., Xia, C., Huang, H., Li, J., Li, Q., Yuan, K., Huang, G., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.102613 · Cited by 1
A versatile bacterial cell wall-based nanomedicine for combination treatment of oral squamous cell carcinoma
Ma, A., Wang, C., Wang, Y., Zhang, G., Guo, Z., Wu, L., Li, X., Wang, Y., Wang, Y., & Yang, X. (2025) · Biomaterials Science · doi:10.1039/d5bm01457c · Cited by 1
Augmenting sonodynamic therapy with single-atom nanoenzyme via tumor microenvironment-mediated reactive oxygen species generation
Yang, H. J., Ji, Q., Zhu, W., Geng, Y., & Chen, B. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2599400 · Cited by 1
TPEDCC-PEG-based photodynamic therapy exhibits potent therapeutic efficacy against echinococcosis by inducing oxidative stress and mitochondria-mediated apoptosis
Ma, Z., Xie, L., Li, W., Wang, Z., Zhao, H., Qiu, L., Ma, Z., Tian, J., Shi, L., Yuan, M., et al. (2025) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0013793 · Cited by 1
Construction of self-sustaining dual regeneration system through co-immobilized multienzyme and cofactor for sustainable 13-hydroxyoctadecadienoic acid synthesis
Liu, X., Li, K., Wang, P., Wang, K., Dai, S., Xie, X., Yang, M., Xu, L., Yan, Y., & Yan, J. (2025) · Bioresource Technology · doi:10.1016/j.biortech.2025.133916 · Cited by 1
CaCO 3 -assisted engineering of NIR-II phototheranostics enables photothermally enhanced ferroptosis in cancer through synergistically depleting intracellular glutathione
Gao, J., Ding, H., Wu, Q., Hu, Y., Yan, Y., Chen, M., Wang, C., Liu, Z., & Feng, L. (2026) · Nanoscale Horizons · doi:10.1039/d5nh00664c · Cited by 1
Dual‐Pathway Defense: Ultramicro‐Pulverised Powder of Polygonum chinense L. and Atractylodes rhizome (PAUP) Rescues Broilers From E. coli ‐Triggered Liver Injury Through Modulation of Oxidative Stress and Inflammation
Cai, J., Guo, Y., Liang, S., Liu, Y., Huang, F., Lv, Q., Zhang, L., Qin, Y., Chen, X., Liang, Y., et al. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.71424 · Cited by 1
Induction of Ferroptosis by Dual-Targeting pH-Responsive Nanomicelles in the Treatment of Tamoxifen-Resistant Breast Cancer
Zeng, Y., Ji, Q., Wang, N., Guo, X., Wang, X., Zhang, J., & Wang, X. (2026) · ACS Applied Nano Materials · doi:10.1021/acsanm.5c05586 · Cited by 1
pH-triggered aggregation of enzyme-powered nanomotors for improved tumor accumulation and penetration in ferroptosis-enhanced anticancer therapy
Pan, Y., Xie, Q., Wang, H., Lin, T., Ma, X., Zhao, Z., Liu, Y.-Q., & Ji, Y. (2026) · Materials Today Chemistry · doi:10.1016/j.mtchem.2026.103349 · Cited by 1
Engineered virus-derived platform enables glutathione depletion and cuproptosis for enhanced cancer immunotherapy
Wu, P., Wu, X., Li, M., Yan, X., Zhou, M., Zhang, G., Yan, X., Liu, T., Zhu, X., & Han, X. (2026) · Journal of Controlled Release · doi:10.1016/j.jconrel.2026.114619 · Cited by 1
Integrated In Silico and In Vitro Study of Copper Nanocatalyzed Carbonyl‐Functionalized Triazoles—Inducing S Phase Cell Cycle Arrest and Apoptosis in MCF‐7
Mondal, J., Dasgupta, T., Kumar, C. K., Nandagopal, P. B., Mal, S., Paul, S., Aishwarya, S., Pandya, C., Emerson, I. A., Manickam, V., et al. (2026) · ChemistryOpen · doi:10.1002/open.202500543 · Cited by 1
PFKFB4-Mediated HSPB1 phosphorylation suppresses ferroptosis to Promote gastric cancer progression
Ma, M., Xu, X., Yu, K., Yang, X., Qiang, W., Dal, E., Zhang, Y., Zhu, J., Sun, R., 张尚鑫, et al. (2026) · Biochemical Pharmacology · doi:10.1016/j.bcp.2026.117714 · Cited by 1
Simultaneous Down-Regulation of Intracellular hTERT and GPX4 mRNA Using MnO2-Nanosheet Probes to Induce Cancer Cell Death
Miao, Y., Zhou, T., Ji, Q., & Hong, M. (2026) · Sensors · doi:10.3390/s26030836 · Cited by 1
NAA20-mediated ACF1 lactylation drives neuroblastoma progression through enhancing GCLM-dependent glutathione synthesis
Han, B., Xu, M., Wang, Q., Lin, J., 褚珺, 徐蕴岚, & Jiang, D. (2026) · Cell Biology and Toxicology · doi:10.1007/s10565-026-10154-7 · Cited by 2
KIF23 Overexpression Promotes Cell Viability, Migration, and Invasion via the Wnt/β‐Catenin Signaling Pathway in Anaplastic Thyroid Carcinoma
Wu, Y., Zheng, C., Chen, W., & Xu, T. (2026) · International Journal of Endocrinology · doi:10.1155/ije/7664607 · Cited by 1
Diterpenoids and triterpenoids from the roots of Tripterygium regelii and their inhibitory effects on colorectal cancer cells
Guo, P., Yu, J., Zhao, Q., Sun, J. P., Lin, R., Sui, L., Leng, A., Wang, C., Wang, S., & Li, D. (2026) · Frontiers in Chemistry · doi:10.3389/fchem.2026.1784072 · Cited by 1
A precise theranostic nanoplatform amplifies anti-tumor efficacy via copper ionophores and sonodynamic therapy
Luo, X., Wang, X., Li, S., Chen, Q., Song, J., & Chen, J. (2026) · Materials Today Bio · doi:10.1016/j.mtbio.2026.102957 · Cited by 1
Dendrobium officinale inhibits colorectal cancer progression by induction of glutathione peroxidase 4-mediated ferroptosis
Jiang, R., Tan, X., Zhang, G., Chen, H., Yu, H., Zheng, Y., Kong, M., Shan, K., Liu, J., Zhang, R., et al. (2026) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(26)61108-9 · Cited by 1
Nanodynamic Therapy in Colorectal Cancer: Engineering Precision Immunotherapy and Multimodal Synergy
Wang, F., Zhang, Z., Chen, J., Qian, L., Chen, B., Zhai, L., Zhao, J., Chen, T., Zhou, J., Gou, K., et al. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s598076 · Cited by 1
Scutellarin modulates Nrf2 to alleviate inflammation, pyroptosis, and ferroptosis in acetaminophen-induced hepatotoxicity
Pu, R., Cui, Q., Xing, Z., Liu, L., Xiao, W., & Xiao, Q. (2026) · Phytomedicine · doi:10.1016/j.phymed.2026.158107 · Cited by 1
Recent Progress on Polyphenols of Malaysian Honey and Their Molecular Mechanism Pathways in Cancer—A Comprehensive Review
Hatta, M. H. M., Amran, N., Kamisan, F. H., Daud, M. H., Manaf, M. F. A., Chelilah, K. K., & Karim, N. A. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27073074 · Cited by 2
One-pot synthesis of Mn/Fe bimetal-doped metal-organic framework as multifunctional nanocarriers for esophageal cancer targeted therapy
Ma, J., Zhang, X., Meng, X., Dai, Y., Wang, H., Ashrafizadeh, M., Conde, J., Li, Z., Yao, E., & He, W. (2026) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2026.101617 · Cited by 1
Self-assembled nanoparticles overcoming hypoxic and acidic microenvironment to synergistically potentiate ferroptosis in triple-negative breast cancer
Xu, S., Gao, W., Lin, S., Xu, S., Shi, X., Zheng, D., Liu, Z., Zeng, L., Huang, A., Song, H., et al. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126853 · Cited by 1
Diagnostic and therapeutic intelligent probe: Photoacoustic/ fluorescent dual-modality of thiols detection in tumor and ROS-potentiated cancer photodynamic therapy
Su, X., Zeng, R., Li, H., Lan, C., Jiang, N., Ding, Y., Lan, J., Zhang, T., & Yi, T. (2026) · Analytica Chimica Acta · doi:10.1016/j.aca.2026.345479 · Cited by 1
Dual organelle targeting type I/II photosensitizer triggers ferroptosis-like/apoptosis for photodynamic immunotherapy
Duan, Z., Deng, L., Li, Q., Li, L., Li, C., Zhao, Y., & Liu, R. (2026) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2026.109852 · Cited by 1
Piezoelectric-amplified sonodynamic efficiency and nanozyme activities of bismuth/cerium co-doped sodium niobate for destruction of tumors
Xie, S., Ye, Y., Li, W., Wang, X., Wei, J., Zhang, F., & Lin, G. (2026) · Nano Research · doi:10.26599/nr.2026.94908708 · Cited by 1
Targeting PTDSS1 to modulate GSH synthesis triggers mitophagy and induces ferroptosis in esophageal squamous cell carcinoma cells
Zhang, X., Cao, S., Zhou, C., Jiang, W., Wang, H., Hui, B., Deng, X., & Gu, Y. (2026) · Cell Death and Disease · doi:10.1038/s41419-026-08702-4 · Cited by 1
Engineering the Iron Center: Hemin Nanozymes for Programmable Cancer Catalysis
Alsharabasy, A. M., Isaac, G. T., & Pandit, A. S. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c00429 · Cited by 1
The application of the pillararene-based GSH depletion strategy in tumor therapy
Liu, Y., Liu, M., Xie, S., Ma, J., Han, W., Sun, T., & Lu, B. (2026) · Chemical Communications · doi:10.1039/d6cc02664h · Cited by 1
Autonomous Microrobots for Spatiotemporally Active Therapeutic Delivery and Controlled Release
Zhong, S., Wu, A., Bai, S., Huang, H., Fukuda, T., & Wang, H. (2026) · Cyborg and Bionic Systems · doi:10.34133/cbsystems.0617 · Cited by 2
Multiresponsive Glutathione-Functionalized Waterborne Polyurethane/PEDOT System for Electrically and Redox-Controlled Delivery of an Anticancer Peptide
Cancilla, F., Palumbo, F. S., Fiorica, C., Pitarresi, G., Pérez‐Madrigal, M. M., Alemán, C., & Resina, L. (2026) · ACS Applied Polymer Materials · doi:10.1021/acsapm.6c00875 · Cited by 1
In Situ Electroactive Bacteria-Activated Nanozyme for Amplifying Chemodynamic Therapy of Solid Tumors
Ren, Z., Peng, C., Liu, Y., Lin, B., Man, Y., Tan, Y., Liu, Z. H., & Chen, Q. (2026) · Nano Letters · doi:10.1021/acs.nanolett.6c00309 · Cited by 1
Sophopterocarpans A–B, two undescribed pterocarpan derivatives from Aspergillus sp.–fermented Sophora flavescens
Jin, Z.-D., Ye, H.-B., Bi, X.-S., Mou, G.-S., Wu, X.-R., Luo, X., Zhao, Y., & Zhao, L. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107303 · Cited by 1
Supramolecular Photosensitizers: From Engineering Principles to Functional Applications
Fan, L., & Song, Q. (2026) · Chemistry - A European Journal · doi:10.1002/chem.71305 · Cited by 1
Hypoxia-mediated chromatin accessibility reprogramming of CA9 induces treatment resistance in colorectal mucinous adenocarcinoma
Huang, A., Hong, H., Sun, Z., Gao, Z., Yang, Y., Chen, J. K., Sun, Y., Li, Z., Li, M., & Gu, J. (2026) · Journal of Gastroenterology · doi:10.1007/s00535-026-02461-x · Cited by 1
A multicomponent reaction-enabled discovery platform reveals a TXNRD1-targeted ferroptosis inducer
Fu, X., Wu, Q., Wu, S., Niu, G., Zhang, Z., Lin, Y., Cao, Y., Li, Y., Xiong, F., Qian, Y., et al. (2026) · The Innovation Drug Discovery · doi:10.59717/j.xinn-drugdisc.2026.100011 · Cited by 1
A highly sensitive Au@Pd NRs SERS microarray chip based on electrophoretic deposition for detection of GSH in the serum of colorectal cancer patients
Xie, C., Zhang, D., Wu, Y., He, Y., Ge, Y., & Deng, B. (2026) · RSC Advances · doi:10.1039/d6ra01029f · Cited by 1
Phase-regulated MOF-derived Co3O4/CoO@N-C heterojunctions for colorimetric glutathione detection
Jin, S., Wang, H., Liu, S., Tao, R., & Li, M.-T. (2026) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2026.146946 · Cited by 1
Mitochondrial Dysfunction and Diabetic Retinopathy: Research Progress from Pathogenic Mechanisms to Therapeutic Targets
Zhu, X., Jin, T., Zhang, Y., Lian, L., & Du, W. (2026) · Experimental Eye Research · doi:10.1016/j.exer.2026.111157 · Cited by 1
ROS as a powerful instrument for the advanced cancer prevention and management: Facts and outlook
Tang, Q., Cui, L., Du, W., Ruan, Y., Yang, L., Fu, C., Gui, J., Liu, Q., Chen, Y., Qiao, J., et al. (2026) · Journal of Advanced Research · doi:10.1016/j.jare.2026.07.002 · Cited by 1

Authors: Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C.
Affiliations: Sun Yat-sen University (CN)
Jinan University (CN)
Corresponding author: Pan, Xin
Wu, Chuanbin
ORCID: Wen, Ting
Quan, Guilan
Pan, Xin
Wu, Chuanbin
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2021-10
Volume: 277
Pages: 121110
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2021.121110
OpenAlex: W3198675921
Cited by: 1,168
References: 254
Citations by year: 2026: 168 · 2025: 353 · 2024: 330 · 2023: 201 · 2022: 110 · 2021: 6
FWCI: 13.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutathione depletion, cancer therapy, reactive oxygen species, ferroptosis, photodynamic therapy, sonodynamic therapy, chemodynamic therapy, oxidative stress, glutathione metabolism, glutathione synthesis, drug delivery systems, chemotherapy enhancement
MeSH terms: Ferroptosis, Antineoplastic Agents, Glutathione, Neoplasms, Photochemotherapy, Reactive Oxygen Species

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks