Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

ROS function in redox signaling and oxidative stress

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Oxidative stress: oxidants and antioxidants

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Thiol–Ene Click Chemistry

Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201

Glutathione Metabolism and Its Implications for Health

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Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

Functional Nanomaterials for Phototherapies of Cancer

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Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,207

Glutathione synthesis

Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192

Dual-doped metalloporphyrin MOFs-based nanoagent increases low-dose radiotherapy efficacy by apoptosis-ferroptosis for hepatocellular carcinoma

Wang, X., Zhou, J., Zhu, Y., Yu, C., Sun, D., Yao, Y., Feng, L., Zhou, Y., & Zhou, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.157645 · Cited by 9

Preparation of Glutathione-Regulated Sorafenib Targeted Nanodrug Delivery System and Its Antihepatocellular Carcinoma Activity

Wu, Y., Wang, X., Li, L., Wang, M., Tian, S., Song, J., & Ma, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c11076 · Cited by 10

The impact of ferroptosis and ferroptosis-related non-coding RNAs on breast cancer progression

Liu, W., Jiang, C., Ma, Y., Wang, W., Peng, J., Ma, W., Xu, S., & Wu, D. (2024) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2024.1506492 · Cited by 9

Meta-analysis of endocrine-disrupting chemical effects on earthworm functional traits

Chen, G., Fan, J., Xu, Y., Su, P., Yao, M., He, X., Zhang, C., Zhang, C., Gao, P., & Zhu, L. (2025) · Environmental Research · doi:10.1016/j.envres.2025.121208 · Cited by 10

Glutathione peroxidase 4 (GPX4) and obesity interact to impact tumor progression and treatment response in triple negative breast cancer

Devericks, E. N., Brosnan, B. H., Ho, A. N., Glenny, E. M., Malian, H. M., Teegarden, D., Wendt, M. K., Coleman, M. F., & Hursting, S. D. (2025) · Cancer & Metabolism · doi:10.1186/s40170-025-00380-8 · Cited by 9

Advances in Sonodynamic Therapy: Focus on Ferroptosis

Su, W., Wang, H., Pan, J., & Zhou, Q. S. (2025) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c02603 · Cited by 9

Enhanced Tumor Ablation and Immune Activation Via Irreversible Electroporation and Functionalized Vermiculite Nanosheets

Li, R., Niu, G., She, Y., Li, R., Yuan, M., Pei, Z., Kang, Y., & Ji, X. (2025) · Small · doi:10.1002/smll.202411879 · Cited by 9

A hollow nanozyme-based multifunctional platform enhances sonodynamic–chemodynamic-induced ferroptosis for cancer therapy

Shen, Q., Zhu, X., Huo, M., Lin, Y., Zhang, B., Yang, M., Yang, Z., Zhang, L., & Gai, Y. (2025) · RSC Advances · doi:10.1039/d5ra00032g · Cited by 9

Synthesis and Structure of Naphthoyl Thiourea‐Based Binuclear Ruthenium(II) Arene Complexes: Studies on Anticancer Activity and Apoptotic Mechanism

Arunachalam, A., & Ramesh, R. (2025) · ChemBioChem · doi:10.1002/cbic.202500057 · Cited by 9

Ferroptosis-mediated immune responses in osteoporosis

Wang, X., Yike, W., Gongwen, L., & Xu, Y. (2025) · Journal of Orthopaedic Translation · doi:10.1016/j.jot.2025.03.011 · Cited by 11

Thymoquinone suppresses cell growth and induces ferroptosis in renal cell carcinoma by reducing SERPINH1 expression

Luo, R., Li, S., Wang, H., Zhang, Z., Li, L., & Shang, P. (2025) · Letters in Drug Design & Discovery · doi:10.1016/j.lddd.2025.100013 · Cited by 9

Hollow heterojunction nanocages of zeolitic imidazolate framework-8@zinc sulfide@copper sulfide for synergistic tumor therapy

Chen, Y., Sun, B., Yu, Z., Cheng, Z., Chen, S., & Chang, B. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.137811 · Cited by 9

Exogenous Maresin1 attenuates doxorubicin-induced cardiomyocyte ferroptosis and mitochondrial impairment via NRF2/GPX4 axis

Wang, F., Zhang, W., Yin, L., Huang, C., & Zhào, H. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.05.388 · Cited by 9

Betaine protects cerebral microvascular endothelium and ameliorates hypertension-induced cognitive dysfunction via upregulation of the endothelial nitric oxide synthase/nitric monoxide signaling pathway

Sun, J., Zhang, W., Wang, X., Zhao, X., & Gao, S. (2025) · Journal of Hypertension · doi:10.1097/hjh.0000000000004085 · Cited by 10

Mesoporous Nanoplatform That Efficiently Delivers DOX as an H2O2 Generator to Trigger Mutual Amplification of Cuproptosis and Chemodynamic Therapy

Du, H., Tong, W., Peng, B., Gao, W. M., Wang, Y., Wang, H., Liu, J., Liu, Y., Sun, B., Ma, J., et al. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500933 · Cited by 9

Revealing a close link between ferroptosis and drug-induced liver injury with dual-site NIR ratiometric fluorescent probe for mitochondrial peroxynitrite

Lü, Z., Xu, X., Zhao, B., Jiang, T., Liu, T., Jang, W. J., Yoon, J., Yan, M., & Fan, C. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138985 · Cited by 9

Plasmon-boosted titanium nitride-based nanoplatform for synergistic photothermal-chemodynamic cancer therapy with smart degradability

Yang, R., You, Z., 谢伯军, Liu, M., Santiago, E. Y., Besteiro, L. V., Wang, Y., Ma, B., Liu, H., & Ma, D. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123950 · Cited by 9

Nanomedical approaches to deplete intracellular glutathione in oncology

Bonet‐Aleta, J., Hueso, J. L., Mosseri, A., & Santamarı́a, J. (2026) · Chemical Science · doi:10.1039/d5sc09556e · Cited by 9

Binary prodrug nanoassemblies combining chemotherapy and ferroptosis activation for efficient triple-negative breast cancer therapy

Li, L., Sun, B., Sun, J., Chen, L., & He, Z. (2024) · Chinese Chemical Letters · doi:10.1016/j.cclet.2024.109538 · Cited by 9

Genistin modulates high-mobility group box protein 1 (HMGB1) and nuclear factor kappa-B (NF-κB) in Ehrlich-ascites-carcinoma-bearing mice

Saleh, M. A., Antar, S. A., Abdo, W., Ashour, A. A., & Zaki, A. A. (2022) · Environmental Science and Pollution Research · doi:10.1007/s11356-022-22268-6 · Cited by 9

Synthesis of a novel triphenylamine-based multifunctional fluorescent probe for continuous recognition application s

Tian, X., Zhang, K., Wang, N., Cheng, B., Xu, H., & Guang, S. (2023) · New Journal of Chemistry · doi:10.1039/d2nj05116h · Cited by 9

A tetrasulfide bond-bridged mesoporous organosilica-based nanoplatform for triple-enhanced chemodynamic therapy combined with chemotherapy and H 2 S therapy

Liu, M., Xu, H. X., Zhou, F., Gong, X., Tan, S., & He, Y. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb02147e · Cited by 9

Albumin tailoring molecular rotation and electrophilicity of a GSH-depleting radiosensitizer for potentiating ferroptosis-mediated radioimmunotherapy

Gao, M., Huang, X., Wu, Z., Xiao, W., Du, Z., Mo, B., Wu, C. F., Xing, H., Wang, W., Li, R., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153595 · Cited by 9

Revealing the exceptional antioxidant activity of phosphorylated polysaccharides from medicinal Abrus cantoniensis Hance

Lian, S., Su, J., Fatima, I., Zhang, Y., Kuang, T., Hu, H., Qu, D., Si, H., & Sun, W. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.134532 · Cited by 8

Self-Healing Photothermal Nanotherapeutics for Enhanced Tumor Therapy through Triple Ferroptosis Amplification and Cascade Inflammation Inhibition

Zheng, Y., Zheng, F., Xu, R., Sun, X., Yu, J., Chen, H., & Gao, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c09399 · Cited by 8

Dimethyl fumarate and extracorporeal photopheresis combination-therapy synergize in inducing specific cell death and long-term remission in cutaneous T cell lymphoma

Sener, Ö. C., Melchers, S., Tengler, L., Beltzig, P. L., Albrecht, J. D., Tümen, D., Gülow, K., Utikal, J. S., Goerdt, S., Hein, T., et al. (2024) · Leukemia · doi:10.1038/s41375-024-02479-1 · Cited by 8

Immunomodulatory Pd-FePorP nanozyme for inhibition of tumor invasion and metastasis by reinforced ferroptosis and specific epithelial-mesenchymal reversal

Zhai, X., Zhou, T., Chen, J., Su, P., Li, X., Su, H., Bao, B., Weng, L., & Wang, L. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.158682 · Cited by 8

Tailored biomimetic nanoreactor improves glioma chemodynamic treatment via triple glutathione depletion and prompt acidity elevation

Wen, Y., Qiu, Q., Feng, F., Zhu, Y., Zhang, J., Sun, Z., Zhang, T., Shi, W. M., & Shi, J. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101447 · Cited by 8

Cotargeting of thioredoxin 1 and glutamate-cysteine ligase in both imatinib-sensitive and imatinib-resistant CML cells

Sun, X., Zhang, C., Fan, B., Liu, Q., Shi, X., Wang, S., Chen, T., Cai, X., Hu, C., Sun, H., et al. (2025) · Biochemical Pharmacology · doi:10.1016/j.bcp.2025.116763 · Cited by 8

Glutathione reductase underlies the stability of mutant p53 by antagonizing protein glutathionylation

Wang, L., Zhong, S., Fan, X., Xu, Y., Wang, M., Xu, Y., Cai, Y., Cao, Z., Ye, Z., Wen, L., et al. (2025) · Redox Biology · doi:10.1016/j.redox.2025.103522 · Cited by 8

Enhanced anticancer effect of carfilzomib by codelivery of calcium peroxide nanoparticles targeting endoplasmic reticulum stress

Yin, D., Wu, X., Chen, X., Chen, J., Xia, X., Wang, J., Chen, X., & Zhu, X. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101649 · Cited by 8

Biomineralization of Copper‐Celastrol Nanohybrids for Synergistic Antitumor Therapy

Li, Y., Wang, N., Li, H., Zhang, X., Meng, L., Yu, Y., Wang, S., & Deng, L. (2025) · Small · doi:10.1002/smll.202412802 · Cited by 8

Regulation of SLC7A11 by LncRNA GPRC5D-AS1 mediates ferroptosis in skeletal muscle: Mechanistic exploration of sarcopenia

Gong, W., Wang, Y., Li, Q., Gao, Y., & Li, J. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1557218 · Cited by 8

KRAS and NRF2 drive metabolic reprogramming in pancreatic cancer cells: the influence of oxidative and nitrosative stress

Rapozzi, V., Comuzzi, C., Giorgio, E. D., & Xodo, L. E. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1547582 · Cited by 9

Multi-omics analysis reveals glutathione metabolism-related immune suppression and constructs a prognostic model in lung adenocarcinoma

Chi, Y., Ma, G., Liu, Q., Xiang, Y., Liu, D., & Du, J. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1608407 · Cited by 10

Harnessing the interaction between redox signaling and senescence to restrain tumor drug resistance

Wu, H., Yu, Y., He, X., Gong, Y., Huang, J., & Wu, P. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1639772 · Cited by 10

Nickel exposure induced endoplasmic reticulum stress by disturbing calcium homeostasis and triggered mitochondrial autophagy in domestic animal oocytes

Zhong, C., Hou, S.-K., Guo, J., Zhao, J., Wang, J., Fang, Y., Liu, H., Ding, H., Ma, X., & Lyu, W. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118668 · Cited by 8

SLC6A8-mediated creatine uptake suppresses ERK2-FSP1 signaling and induces ferroptosis in colorectal cancer

Zhou, X., Wang, G., Wu, Y., Wu, M., Zhai, X., Tian, C., Prochownik, E. V., Jiang, C., & Li, Y. (2025) · Cell Reports · doi:10.1016/j.celrep.2025.116139 · Cited by 8

Methionine induced placental angiogenesis through activating WNT3A/CTNNB1-PIGF-VEGFR1 pathway

Zou, Y., Tu, J., Wang, Z., Quan, S., Zhao, L., Yang, Y., Zeng, X., Qiao, S., Zeng, X., & Cai, S. (2025) · Cell Communication and Signaling · doi:10.1186/s12964-025-02488-2 · Cited by 8

GSH fluorescent probes for disease diagnosis and treatment

Zheng, R., Wan, G., Liu, J., Wang, L., & Liang, X. (2025) · Dyes and Pigments · doi:10.1016/j.dyepig.2025.113478 · Cited by 8

YTHDF2-mediated stabilization of SREBF1 promotes lipid metabolic reprogramming and ferroptosis-associated radioresistance in anaplastic thyroid carcinoma

Dai, B., Li, J., Xu, L., Chen, W., Chen, J., Song, M., Liu, Y., Wang, L., Zhang, L., Chen, J., et al. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.218232 · Cited by 8

Ferroptosis Induction Improves the Sensitivity of Docetaxel in Prostate Cancer

Chen, X., Yu, Y., Liang, S., Guan, Z., Shi, H., Zhu, Q., & Lin, J. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4930643 · Cited by 8

Nanoporous Silica Nanoparticles Coloaded with Cisplatin Prodrug and l -Buthionine Sulfoximine for Cancer Therapy

Xiao, F., Li, M., Ju, J., Wu, H., Geng, Y., Jia, S., Li, S., & Huang, S. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.2c04933 · Cited by 8

Copper-Based Metal–Organic Framework Enables ROS Amplification and Drug Potency Activation

Zuo, J., Hao, S., Li, W., Huang, H., Liu, M., & Guo, H. (2023) · Langmuir · doi:10.1021/acs.langmuir.2c03489 · Cited by 8

A new iron( iii ) complex-functionalized selenium nanowires (Fe@SeNWs) for potential phototherapeutic applications with red light

Bhowmik, R., Upadhyay, A., Pal, M., Bera, A., & Roy, M. (2024) · New Journal of Chemistry · doi:10.1039/d3nj05613a · Cited by 8

Exposure to Titanium Dioxide Nanoparticles Leads to Specific Disorders of Spermatid Elongation via Multiple Metabolic Pathways in Drosophila Testes

Cheng, X., Jiang, T., Huang, Q., Ji, L., Li, J., Kong, X., Zhu, X., He, X., Deng, X., Wu, T., et al. (2024) · ACS Omega · doi:10.1021/acsomega.4c01140 · Cited by 8

SLC25A19 is a novel prognostic biomarker related to immune invasion and ferroptosis in HCC

Liu, S., Zhang, P., Wu, Y., Zhou, H., Wu, H., Jin, Y., Wu, D., & Wu, G. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112367 · Cited by 8

Manganese (III) phthalocyanine complex nanoassembly: Oxygen-Independent generation of superoxide radicals and singlet oxygen for ultrasound-augmented chemodynamic therapy

Sun, Y. H., Li, C., Liu, Z., Tang, C., Cui, Z., Zhou, Z., Liu, Q., Yang, S., Yang, S., & Yang, H. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.153363 · Cited by 8

Tumor microenvironment modulation innovates combinative cancer therapy via a versatile graphene oxide nanosystem

Cai, C., Zhang, Q., Ye, J., Yao, S., Li, Q., Fan, Z., Ge, S., Wang, Y., Xu, D., Zhou, J., et al. (2025) · Biomaterials Science · doi:10.1039/d5bm00202h · Cited by 9

HXV2O5 Nanocatalysts Combined with Ultrasound for Triple Amplification of Oxidative Stress to Enhance Cancer Catalytic Therapy

Hou, L., Gong, F., Han, Z., Wang, Y., Yang, Y., Cheng, S., Yang, N., Liu, Z., & Cheng, L. (2022) · Angewandte Chemie · doi:10.1002/ange.202208849 · Cited by 8

Huntingtin-associated protein 1 is a potential tumor suppressor for gastric cancer

Qu, Y.-M., Chen, A., Zhao, X., Wang, Z., Guo, D., Shao, S.-L., Tao, Y.-Y., Li, Q.-J., Wang, M., & Ma, W. (2022) · Molecular Biology Reports · doi:10.1007/s11033-022-08090-w · Cited by 8

Single‐cell transcriptomics dissects epithelial heterogeneity in HPV+ cervical adenocarcinoma

Wang, C., Li, L., Wang, F., Li, X., Sun, J., Li, X., Lei, T., Huang, Q., Zhang, G., Wang, H., et al. (2023) · Journal of Medical Virology · doi:10.1002/jmv.28480 · Cited by 9

A versatile supramolecular nanoagent for three-pronged boosting chemodynamic therapy

Liu, X., Liu, J., Xu, Q., Tao, W., Xie, X., Meng, C., Zhou, Q., Zhang, Y., & Ling, Y. (2023) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2023.04.185 · Cited by 8

Advancements in Analyzing Tumor Metabolites through Chemical Derivatization-Based Chromatography

Lu, Y., Zhang, H., Zhou, B.-J., Tang, W., & Zhou, J.-L. (2023) · Journal of Chromatography A · doi:10.1016/j.chroma.2023.464236 · Cited by 8

Enhancing anticancer activity of Clerodendrum viscosum vent. extracts by solvent fractionation: An in vitro and in silico mechanistic study

Roy, A. C., Singh, K., Prasad, A., Kulshreshtha, D., Priya, K., Kumari, A. R., & Ghosh, I. (2024) · Process Biochemistry · doi:10.1016/j.procbio.2024.07.007 · Cited by 7

Contributions of Surface Oxidizing Species and Cu+ to the Antibacterial Activities of Cu2O with Different Crystalline Structures

Mu, Y., He, Q., Li, C., Sheng, D., Wu, S., Liu, Y., Ren, H., & Han, X. (2024) · Langmuir · doi:10.1021/acs.langmuir.4c00984 · Cited by 7

Pleiotropy of biomineralized bacterial outer membrane vesicles in modulating immune systems for liver cancer therapy

Luo, Y., Xu, Z., Du, Q., Xu, L., Wang, Y., Xu, J., Wang, J., Chen, S., Zhang, W., Liu, B., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155592 · Cited by 7

Deep-Sea-Derived Isobisvertinol Targets TLR4 to Exhibit Neuroprotective Activity via Anti-Inflammatory and Ferroptosis-Inhibitory Effects

Xu, Z., Xie, M., Xie, C., Yang, X., & Wang, J. (2025) · Marine Drugs · doi:10.3390/md23010049 · Cited by 7

Bidirectional regulation of reactive oxygen species for radiosensitization in nasopharyngeal carcinoma

Chen, J., Feng, C., Lan, Y., Chen, X., Peng, Z., Huang, Z., Wang, R., Zhang, W., Ye, Y., Mao, Z., et al. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03177-5 · Cited by 7

A magnetic nanoreactor with microenvironment regulation capability for targeted and enhanced tumor chemodynamic therapy

Li, X., Tang, Q.-Y., Tang, M.-C., Deng, H.-R., Hu, K., Pan, L.-F., Wang, S.-B., Li, B., & Kong, X. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161356 · Cited by 7

Investigation of the Molecular Mechanisms of Paraoxonase‐2 Mediated Radiotherapy and Chemotherapy Resistance in Oral Squamous Cell Carcinoma

Kamal, M. V., Prabhu, K., Sharan, K., Pai, A., Chakrabarty, S., Damerla, R. R., Shetty, P. S., Belle, V. S., Rao, M., & Kumar, N. A. N. (2025) · Clinical and Translational Science · doi:10.1111/cts.70201 · Cited by 7

Selenium supplementation protects cancer cells from the oxidative stress and cytotoxicity induced by the combination of ascorbate and menadione sodium bisulfite

Gencheva, R., Coppo, L., Arnér, E. S. J., & Ren, X. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.03.049 · Cited by 7

Antiproliferative and apoptotic effects of (1R*,12R*)-dolabella-4(16),7,10-triene-3,13-dione (CI-A) in oral cancer cells are mediated by oxidative stress and ERK activation

Chuang, Y.-T., Liu, W., Chien, T., Cheng, Y., Jeng, J., Chen, C., Tang, J., & Chang, H. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114615 · Cited by 7

Increased ZNF83 is a potential prognostic biomarker and regulates oxidative stress-induced ferroptosis in clear cell renal cell carcinoma

Lyu, Z., Wang, H., Dai, F., Lin, Y., Wen, H., Liu, X., Feng, X., Xu, Z., & Huang, L. (2025) · Journal of Molecular Medicine · doi:10.1007/s00109-025-02543-y · Cited by 7

The evaluation and molecular mechanisms of hepatotoxicity induced by trans-emodin dianthrones isolated from Polygonum multiflorum Thunb. in vitro

Li, J., Li, W., Wang, S., Zheng, H., Bao, J., Wang, Y., & Jin, H. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119916 · Cited by 7

Targeting amino acid in tumor therapy

Ge, M., Xu, Y., Cui, L., Huang, E., Liu, Z., & Yin, K. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1582116 · Cited by 8

X-ray stimulates NQO1-dependent cascade reactions to induce strong immunogenicity for MRI-guided cancer radio-chemodynamic-immunotherapy

Li, H., Ma, J., Wu, Y., Wang, C., Lan, T., Su, L., Zhu, L., Huang, S.-W., Deng, K., & Wei, Y. (2025) · Theranostics · doi:10.7150/thno.110573 · Cited by 7

A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer

Wu, T., Li, T., Zhang, C., Tian, Y., Li, H., He, Y., Xu, Y. L., Gong, T., Zhao, J., & Wang, Z. (2025) · Nature Communications · doi:10.1038/s41467-025-62880-x · Cited by 7

Structural Characterization and Anti-Tumor Activity of a Polysaccharide from Laetiporus sulphureus in A549 Cells

Qu, Y., Yang, X., Zhao, D., Zhang, P., Mi, Y., Xu, J. J., Zhao, B., & Shi, D. (2025) · Molecules · doi:10.3390/molecules30183706 · Cited by 7

Upconversion Nanoparticles‐Based Multimodal Tumor Therapy Integrating Photoclick‐Induced Aggregation of Gold Nanoparticles and Ceria‐Curcumin Redox Modulation With Inflammation Attenuation Post‐Treatment

Li, J., Lee, M. L., Chen, P., Hu, K., Li, T., Zou, Z., Song, Q., Wang, C., & Li, H. (2025) · Aggregate · doi:10.1002/agt2.70161 · Cited by 7

Metal–organic frameworks for natural medicines delivery: stimuli-responsive strategies and synergistic cancer therapy applications

Mu, R., Chen, Y., Chen, D., Zhang, X., Cheng, Z., Chen, X., Cheng, S., Zheng, W., & Zhao, L. (2025) · Chemical Communications · doi:10.1039/d5cc06724c · Cited by 8

Spatial molecular profiling of living single-cell by membrane-interfaced 3D SERS substrates

Yu, H., Yun, J., & Nam, W. (2026) · npj Biosensing · doi:10.1038/s44328-025-00076-5 · Cited by 7

CoQ10 oxidoreductases in ferroptosis and cancer: redox regulation and therapeutic opportunities

Lee, J., Yoo, I., Kim, M., Kim, H., & Lee, N. (2026) · Experimental & Molecular Medicine · doi:10.1038/s12276-026-01736-w · Cited by 7

Protein-coated cobalt oxide–hydroxide nanospheres deliver photosensitizer IR780 iodide for near-infrared light-triggered photodynamic/photothermal/chemodynamic therapy against colon cancer

Hu, H., Yao, S., Xu, Q., Cai, X., Mo, Z., Yang, Z., Chen, W. C., He, Q., Dai, X., & Xu, Z. (2023) · Journal of Materials Chemistry B · doi:10.1039/d3tb01657a · Cited by 7

Mechanisms of ferroptosis in nonalcoholic fatty liver disease and therapeutic effects of traditional Chinese medicine: a review

Wang, N., Que, H., Luo, Q., Zheng, W., Li, H., Wang, Q., & Gu, J. P. (2024) · Frontiers in Medicine · doi:10.3389/fmed.2024.1356225 · Cited by 7

A Big Prospect for Hydrogel Nano-System in Glioma

Zhang, L., Teng, F., Xin, H., Xu, W., Wu, W., Yao, C., & Wang, Z. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s470315 · Cited by 9

Simple ROS-responsive micelles loaded Shikonin for efficient ovarian cancer targeting therapy by disrupting intracellular redox homeostasis

Hu, K., Li, X., Zhaodan, T., & Shi, Y. (2024) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2024.114525 · Cited by 7

Oligoasthenozoospermia is alleviated in a mouse model by [Gly14]‐humanin‐mediated attenuation of oxidative stress and ferroptosis

Liu, Y., Feng, Q., Zou, L., Zhu, C., & Xia, W. (2024) · Andrology · doi:10.1111/andr.13786 · Cited by 7

Sulforaphane Wrapped in Self-Assembled Nanomicelle Enhances the Effect of Sonodynamic Therapy on Glioma

Li, Y., Yang, X., Wei, Z., Niu, H., Wu, L., Chen, C., Liu, H., Cai, T., & Fan, H. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics17010034 · Cited by 7

A Self‐Priming Pyroptosis‐Inducing Agent for Activating Anticancer Immunity

Li, Y., Feng, H., Huang, Y., Wang, Y., Ding, Y., Mao, Z., Du, Y., & Wang, W. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202500610 · Cited by 7

Bioengineering extracellular vesicles as novel nanocarriers towards brain disorders

Wu, J., Ma, L., Sun, D., Zhang, X., Cui, J., Du, Y., Guo, Y., Wang, X., Di, L., & Wang, R. (2022) · Nano Research · doi:10.1007/s12274-022-4913-2 · Cited by 8

Four-Photon Absorption Iron Complex for Magnetic Resonance/Photoacoustic Dual-Model Imaging and an Enhanced Ferroptosis Process

Zhang, L., Ma, S., Wang, T., Li, S., Wang, L., Li, D., Tian, Y., & Zhang, Q. (2022) · Analytical Chemistry · doi:10.1021/acs.analchem.2c04763 · Cited by 7

Nanomedicine-based modulation of redox status for cancer therapy

Jin, P., Li, L., Nice, E. C., & Huang, C. (2023) · Australian Journal of Chemistry · doi:10.1071/ch22246 · Cited by 7

Ferroptosis in liver diseases: Fundamental mechanism and clinical implications

Lai, M.-S., Yan, X.-P., Branch, D. R., Loriamini, M., & Chen, L.-M. (2024) · World Journal of Gastroenterology · doi:10.3748/wjg.v30.i32.3730 · Cited by 8

Ferroptosis-related gene signature for predicting prognosis and identifying potential therapeutic drug in EGFR wild-type lung adenocarcinoma

Zhang, C., Wu, Q., Yang, H., Zhang, H., Liu, C., Yang, B. H., & Hu, Q. (2024) · Communications Biology · doi:10.1038/s42003-024-07117-1 · Cited by 8

Ultrasound-assisted extraction of prenylated flavonoids from Sophora flavescens: Optimization, mechanistic characterization, antioxidant and anti-inflammatory activities

Kong, S., Liu, Y., Tang, R., Liao, Q., Bai, D., Lv, D., Xu, Z., Lin, L., & Li, H. (2025) · Industrial Crops and Products · doi:10.1016/j.indcrop.2025.120559 · Cited by 6

A 3D supramolecular network built by tetranuclear Ag(I) clusters: Insights from DFT applications and study of cytotoxicity, oxidative stress in HLCs, MCF-7 cells

Barman, S., Mahata, R., Choudhury, S. M., Brandão, P., Zangrando, E., Gassoumi, B., Ghalla, H., & Dalai, S. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.141633 · Cited by 6

Developmental Toxicity and Cardiotoxicity of N, N-Dimethylaniline in Zebrafish Embryos

Liu, B., Peng, B., Jin, Y., Tao, Y., Xu, W., Zhang, Y., & Li, Z. (2025) · Toxics · doi:10.3390/toxics13020125 · Cited by 6

Undulated 1D Polymeric Chains of Ag(I) Turning into a 3D Network by Carboxylate Ions and Water Molecules: Hirshfeld Surface Analysis, Insights from DFT Applications and Study of Cytotoxicity, Oxidative Stress in HLCs and MCF-7 Cells

Barman, S., Mahata, R., Choudhury, S. M., Brandão, P., Zangrando, E., Gassoumi, B., Ghalla, H., & Dalai, S. (2025) · Journal of Inorganic and Organometallic Polymers and Materials · doi:10.1007/s10904-025-03691-x · Cited by 6

Dual‐Mode Radiosensitization of Esophageal Squamous Cell Carcinoma via SOCS6‐Loaded Virus‐Inspired Manganese‐Bismuth Bimetallic Oxide Nanoparticles

Ma, R., Yang, Z., Miao, X., Hu, J. R., Zhang, T., Ma, L., Lin, J., & Zhao, L. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202404737 · Cited by 6

Photosensitizer Delivery and Improved Anticancer Photodynamic Application Using Redox‐Sensitive Nanocarriers

Mansurova, E. E., Shulaeva, M. M., Lyubina, A. P., Voloshina, A. D., Fazleeva, R. R., Yanilkin, V. V., Nizameev, I. R., Kadirov, M. K., Ziganshinа, A. Y., Semenov, V. E., et al. (2025) · ChemistrySelect · doi:10.1002/slct.202406168 · Cited by 6

Nanofabricated Bacterial Cell Walls with Intrinsic Peroxidase‐Mimicking and Sonodynamic Activities for Cancer Combination Treatment

Yang, M., Yang, M., Li, J., Bai, L., Cheng, Y., Liu, Y., Cao, M., Yang, X., Wang, Y., & Liu, Y. (2025) · Advanced Science · doi:10.1002/advs.202505310 · Cited by 6

Recent status and trends regarding oxidative stress in gliomas (2013 - 2025): a systematic review and bibliometric analysis

Zeng, Y., Lu, X., Wang, Y.-D., He, J., Cao, H., Zhang, L., & Cheng, L. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1586515 · Cited by 7

Synthesis, characterization and induction of ferroptosis of iridium( iii ) complexes against B16 melanoma cells

Sheng, Z., Liu, Y. F., Xu, L., Yao, X., Chen, J., Liu, Y., & Wang, X. (2025) · Dalton Transactions · doi:10.1039/d5dt00899a · Cited by 6

Cocklebur-Inspired PAMAM-F127 Core–Shell Nanoparticles for Multistimuli Responsive and Folate-Targeted Drug Delivery

Nguyen-Dinh, T.-D., Luu, C. H., Nguyen, C. K., Ly, H. Q., Nguyen, H. T., Nguyen, D. K. V., Huynh, T., Ching, Y. C., & Nguyen, D. H. (2025) · ACS Applied Polymer Materials · doi:10.1021/acsapm.5c00737 · Cited by 6

ATB0,+-targeted nanoparticles trigger STAT3-ferroptosis regulatory axis for enhanced gastric cancer therapy

Zheng, H., Mao, X., Chen, Z., Wang, L., Shangguan, F., Tao, Z., Ye, J., Yao, Q., Yao, Q., Yan, L., et al. (2025) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2025.114918 · Cited by 6

Application of metal–organic framework-based reactive oxygen species therapy in cancer

Liu, H., Wang, X., Wang, P., Liu, H., Wang, Q., Xu, C., & Tian, H. (2025) · Biomaterials Science · doi:10.1039/d5bm00791g · Cited by 6

Mechanisms and advantages of natural derived small molecule compounds in the prevention and treatment of colorectal cancer: a review

Liao, M., Dong, H., Chen, G., Li, W., & Li, G. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1658493 · Cited by 7

Nanoparticle-driven reactive oxygen species therapy: A new frontier in osteosarcoma treatment

He, L., Habibović, P., & van Rijt, S. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114289 · Cited by 6

Targeting polyamine metabolism induces oxidative/carbonyl stress to reinvigorate antitumor immunity in prostate cancer

Zhang, A., Zheng, J., Xu, Y., Fu, S., Du, Q., Zhao, C., Meng, Y., Li, M., Wang, L., Wang, S., et al. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.114283 · Cited by 7

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Dangi, K., Kumar, V., Mittal, D., Yadav, P., Malik, M., & Verma, A. K. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2489918 · Cited by 13

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Xiong, Y., Xiao, C., Li, Z., & Yang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00718h · Cited by 702

Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy

Roy, N., & Paira, P. (2024) · ACS Omega · doi:10.1021/acsomega.3c08890 · Cited by 60

Harnessing ROS Amplification and GSH Depletion Using a Carrier‐Free Nanodrug to Enhance Ferroptosis‐Based Cancer Therapy

Zhang, H., Shan, G., Liu, M., Sun, Q., Yang, T., Peng, R., Li, X., Mei, Y., He, X., & Qiao, L. (2024) · Small · doi:10.1002/smll.202409250 · Cited by 33

Novel strategies of glutathione depletion in photodynamic and chemodynamic therapy: A review

Wolny, D., Stojko, M., & Zajdel, A. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/191025 · Cited by 11