Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

Thiol–Ene Click Chemistry

Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201

Glutathione Metabolism and Its Implications for Health

Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

Functional Nanomaterials for Phototherapies of Cancer

Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,438

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,207

Glutathione synthesis

Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192

Peptide supplementation relieves stress and enhances glycolytic flux in filamentous fungi during organic acid bioproduction

Zhang, J., Wu, N., Ou, W., Li, Y., Liang, Y., Peng, C., Li, Y., Xu, Q. C., & Tong, Y. (2022) · Biotechnology and Bioengineering · doi:10.1002/bit.28152 · Cited by 13

Tumor cell-intrinsic BIN1 deficiency promotes the immunosuppression and impedes ferroptosis of non-small cell lung cancer via G3BP1-mediated degradation of STAT1

Wang, J., Jia, Y., Liu, T., Liu, X., Yin, S., Chen, J., Xu, X., Zhang, Y., & Liu, L. (2025) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-025-03404-9 · Cited by 12

A Multifunctional Polyester Nanoplatform for the Synergistic Anticancer: Enhanced Photodynamic Therapy and Targeted Gene Silencing

Zhang, X., Xu, D.-Z., Zhao, W., Han, X.-Y., Lu, Z., & Liu, R. (2025) · Angewandte Chemie International Edition · doi:10.1002/anie.202505041 · Cited by 14

A biodegradable self-cascading copper-based nanozyme for augmented cancer catalytic therapy and cuproptosis

Liu, S., Wang, C., Wang, C., Deng, Y., Tang, Y., Tian, B., Xia, H., Chen, Y., Jin, L., Guo, Z., et al. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.138692 · Cited by 15

pH-responsive sparfloxacin/Fe3+ nanoparticles eradicate intratumoral bacteria and activate ferroptosis for enhanced antitumor immunotherapy in breast cancer

Sun, Z., Xu, M., Nie, L., Wang, C., Wu, J., Wang, W., Shi, S., & Song, H. (2025) · Biomaterials · doi:10.1016/j.biomaterials.2025.123804 · Cited by 12

Plasma Membrane-Targeted Photooxidant for Chemotherapy-Enhanced Lipid Peroxidation

Deng, F., Yan, M.-Y., Liu, Y., Yu, B.-X., Huang, J., Wang, C., Cheng, H. B., & Li, S. (2022) · ACS Applied Bio Materials · doi:10.1021/acsabm.2c00597 · Cited by 12

Quercetin Inhibits Intrahepatic Cholangiocarcinoma by Inducing Ferroptosis and Inhibiting Invasion via the NF-κB Pathway

Song, Y., Zhang, Z., Chai, Q., He, Z., Qi, Y., Xia, G., Yu, Z., Yang, R., Huang, J., Li, Y., et al. (2023) · The American Journal of Chinese Medicine · doi:10.1142/s0192415x23500337 · Cited by 14

NQO-1 activatable NIR photosensitizer for visualization and selective killing of breast cancer cells

Li, Z., Feng, Q., Hou, J., & Shen, J. (2023) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2023.107021 · Cited by 12

Platelet membrane biomimetic nanomedicine induces dual glutathione consumption for enhancing cancer radioimmunotherapy

Li, X., Yang, Z., Qi, P., Zhu, D., Sun, C., Wei, N., Zhang, Y., & Wang, Z. (2024) · Journal of Pharmaceutical Analysis · doi:10.1016/j.jpha.2024.01.003 · Cited by 13

A pH-responsive injectable hydrogel for enhanced chemo-chemodynamic synergistic therapy

Zhang, Y., Zhang, X., Zhang, L., Yao, J., Wang, S., Zhao, J., Sun, H.-X., & Li, Z. (2024) · Colloids and Surfaces A Physicochemical and Engineering Aspects · doi:10.1016/j.colsurfa.2024.133748 · Cited by 12

Sulfasalazine-loaded nanoframes: A new frontier in bladder cancer therapy through ferroptosis induction

Yan, X., Li, Q., Xiao, S., Chen, J., & Song, W. (2024) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2024.114394 · Cited by 12

Mitochondria-targeted H2O2 homeostatic disruptors: Harnessing glutathione autoxidation and reversing GSDME “silencing” for ferroptotic and dual-pathway pyroptotic oncotherapy

Wang, J., Xie, Y., Zhu, G., Wang, M., Qian, Y., Sun, Q., & Li, C. (2025) · Nano Today · doi:10.1016/j.nantod.2025.102640 · Cited by 12

A Integrated Molecule Based on Ferritin Nanoplatforms for Inducing Tumor Ferroptosis with the Synergistic Photo/Chemodynamic Treatment

Tang, Y., Zhang, Q., Chen, H., Chen, G., Li, Z., Chen, G., Lin, L., Yu, Z., Su, M., & Zhang, B. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c18072 · Cited by 12

Biodegradable Vanadium-Based Nanomaterials for Photothermal-Enhanced Tumor Ferroptosis and Pyroptosis

Zhang, J., Shi, M., Sun, J., Xu, L., Xu, Y., Jiang, W., Zhao, W., Zhou, M., Mao, C., & Zhang, S. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c16568 · Cited by 12

Metal-organic coordinated self-assembled nanomedicine for enhanced cuproptosis-mediated chemo-photo-chemodynamic synergistic therapy of non-small cell lung cancer

Liu, R.-G., Zhao, R., Yu, Z.-W., Liu, C., Liu, C., & Wu, X. W. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.161305 · Cited by 12

Integrative investigation on the mechanisms of modified Zuojin pill (SQQT) in ameliorating gastric metaplasia

Yang, X., Zhang, J., Ma, J., Huang, J., Wang, P., Wang, F., & Tang, X. (2025) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2025.119643 · Cited by 12

Oxygen metabolism abnormalities and high-altitude cerebral edema

Li, Z., Zhang, J., Zhang, X., Jin, Q., Zheng, X., Mo, L., & Da, Z. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1555910 · Cited by 14

Enhanced Sonodynamic Cancer Therapy through Boosting Reactive Oxygen Species and Depleting Glutathione

Zheng, N., Li, D., Hu, X., Yan, L., Ding, L., Feng, J., Ji, T., He, S., Huang, Y., & Hu, J. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c00946 · Cited by 13

Investigation of Cytotoxicity and Oxidative Stress Induced by the Pyrethroid Bioallethrin in Human Glioblastoma Cells: The Protective Effect of Vitamin E (VE) and Its Underlying Mechanism

Lin, Y., Chen, W., & Liang, W. (2022) · Chemical Research in Toxicology · doi:10.1021/acs.chemrestox.2c00033 · Cited by 12

Bioresponsive cisplatin crosslinked albumin hydrogel served for efficient cancer combination therapy

Yan, A., Zhang, Z., Gu, J., Ding, X., Chen, Y., Du, J., Wei, S., Sun, H., Xu, J., Yu, S., et al. (2022) · Nano Research · doi:10.1007/s12274-022-4925-y · Cited by 12

A metal-organic framework-based redox homeostasis disruptor selectively potentiate the cytotoxicity of dihydroartemisinin for cancer therapy

Fan, J., Liu, X., Wang, Q., Wang, H., Liu, H., Han, D., & Ren, J. (2023) · Nano Research · doi:10.1007/s12274-023-5385-8 · Cited by 12

Self‐Regenerating Photothermal Agents for Tandem Photothermal and Thermodynamic Tumor Therapy

Li, X., Jiang, Y., Tang, W., Yue, S., Wang, W., Yao, H., Xu, J., Chen, Z., & Zhu, J. (2024) · Small Methods · doi:10.1002/smtd.202400697 · Cited by 12

Nanozyme-enabled cancer theranostics: bridging enzyme mimicry and material intelligence

Wang, Y., Sun, X., Wang, S., Zhang, Z., Sun, J., Luo, C., He, Z., & Zhang, S. (2025) · Materials Horizons · doi:10.1039/d5mh01000d · Cited by 12

Dual-Function Biomaterials for Postoperative Osteosarcoma: Tumor Suppression and Bone Regeneration

Dong, H. F., Zhang, Q., Feng, Z.-Y., Huang, K., Nie, R., Li, L., Duan, H., & Xie, H.-Q. (2025) · Research · doi:10.34133/research.0978 · Cited by 12

Integrating machine learning algorithms to systematically assess reactive oxygen species levels to aid prognosis and novel treatments for triple -negative breast cancer patients

Li, J., Yu, L., Zhao, X., & Wu, C. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1196054 · Cited by 11

Regulation of Redox Homeostasis Through DNA/RNA Methylation and Post-Translational Modifications in Cancer Progression

Qi, Q., Yang, S., Li, J., Li, P., & Du, L. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2023.0371 · Cited by 12

Photothermal theranostics with glutathione depletion and enhanced reactive oxygen species generation for efficient antibacterial treatment

Wu, Y., Liu, X., Zhang, X., Zhang, S., Niu, P., & Gao, H. (2023) · RSC Advances · doi:10.1039/d3ra03246a · Cited by 11

Role of thermal and reactive oxygen species-responsive synthetic hydrogels in localized cancer treatment (bibliometric analysis and review)

Ahmed, Y. W., Tsai, H., Wu, T.-Y., Darge, H. F., & Chen, Y.-S. (2023) · Materials Advances · doi:10.1039/d3ma00341h · Cited by 11

Dual-responsive persistent luminescence nanoflowers for glutathione detection and imaging

Chen, X., Zhang, H., Liang, X., & Li, L. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.135200 · Cited by 11

A self-cascade terpolymer platform for amplified chemo-chemodynamic therapy with synergistic immunogenic cell death enhancement

Ma, W., Wang, B., Wang, D., Liu, Y., Jiang, M.-C., Zhang, J., Peng, D.-D., Li, Z., Yu, C., & Wei, H. (2024) · Supramolecular Materials · doi:10.1016/j.supmat.2024.100066 · Cited by 11

Design of Evodiamine–Glucose Conjugates with Improved In Vivo Antitumor Activity

Wu, Z., Chen, S., Chen, Z., Dong, G., Xu, D., & Sheng, C. (2024) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.4c00221 · Cited by 11

TCM targets ferroptosis: potential treatments for cancer

Qin, L., Zhong, Y., Li, Y., & Yang, Y. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1360030 · Cited by 11

Interleukin‐33 increases the sensitivity of multiple myeloma cells to the proteasome inhibitor bortezomib through reactive oxygen species‐mediated inhibition of nuclear factor kappa‐B signal and stemness properties

Shao, R., Liu, S., Liu, W., Song, C., Liu, L., Zhu, L., Peng, F., Lu, Y., & Tang, H. (2024) · MedComm · doi:10.1002/mco2.562 · Cited by 11

Phosphorylated FOXQ1, a novel substrate of JNK1, inhibits sorafenib-induced ferroptosis by activating ETHE1 in hepatocellular carcinoma

Liu, Y., Shao, K., Yang, W., Shen, Q., Lu, M., Shao, Z., Chu, S., Wang, Y., Wang, X., Chen, X., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06789-1 · Cited by 12

Reactive oxygen species driven prodrug-based nanoscale carriers for transformative therapies

Vasvani, S., Vasukutty, A., Bardhan, R., Park, I., & Uthaman, S. (2024) · Biomaterials Science · doi:10.1039/d4bm00647j · Cited by 11

Multimodal enhancement of ferroptosis for synergistic cascade colorectal cancer therapy

Wu, Z., Chen, K., Mo, W., Wang, Y., Lin, X., Lin, X., Mo, C., Wang, H., Li, X., Fan, X., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155048 · Cited by 11

Membrane-immobilized gemcitabine for cancer-targetable NK cell surface engineering

Noh, K. M., Jangid, A. K., Park, J., Kim, S. J., & Kim, K. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01639d · Cited by 12

Disulfide-Bridged Cationic Dinuclear Ir(III) Complex with Aggregation-Induced Emission and Glutathione-Consumption Properties for Elevating Photodynamic Therapy

Huang, M., Cui, J. W., Wu, Q., Liu, S.-N., Zhu, D., Li, G., Bryce, M. R., Wang, D., & Tang, B. Z. (2024) · Inorganic Chemistry · doi:10.1021/acs.inorgchem.4c04571 · Cited by 11

A novel cyanine photosensitizer for sequential dual-site GSH depletion and ROS-potentiated cancer photodynamic therapy

Chen, L., Yang, J. J., Su, F., Liu, Z., Huang, S., Zhang, J.-F., Li, J., & Mao, W. (2024) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2024.117165 · Cited by 11

Engineering of redox-triggered polymeric lipid hybrid nanocarriers for selective drug delivery to cancer cells

Lokesh, B. S., Ajmeera, S., Choudhary, R., Moharana, S. K., Purohit, C. S., & Konkimalla, V. B. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb01236d · Cited by 11

Recent Advances in Enzyme‐Activated Dual‐Locked Probes for Biological Applications

Li, Y., Jiang, G., Zhou, J., Shi, L., & Yuan, L. (2025) · Chemistry - An Asian Journal · doi:10.1002/asia.202401647 · Cited by 11

Emerging reactive oxygen and nitrogen species regulators for biomedical therapy: 2D MXenzymes

Si, J., Lan, H., An, J., Ge, S., Liu, W., Zhang, Y., Mao, X., & He, W. (2025) · Materials Today · doi:10.1016/j.mattod.2025.02.004 · Cited by 11

Chlorophyllin exerts synergistic anti-tumor effect with gemcitabine in pancreatic cancer by inducing cuproptosis

Ren, J., Su, T., Ding, J., Chen, F., Mo, J., Li, J., Wang, Z., Han, L., Wu, Z., & Wu, S. (2025) · Molecular Medicine · doi:10.1186/s10020-025-01180-y · Cited by 12

MnO 2 -based nanoparticles remodeling tumor micro-environment to augment sonodynamic immunotherapy against breast cancer

Liao, H., Chen, M., Liao, Z., Luo, Y., Chen, S., Wang, L., Wang, Z. G., & Niu, C. (2025) · Biomaterials Science · doi:10.1039/d5bm00189g · Cited by 11

Redox-Regulated Pathways in Glioblastoma Stem-like Cells: Mechanistic Insights and Therapeutic Implications

Esteban-Román, N. F., Taddei, E., Castro-Velázquez, E., Villafuentes-Vidal, L., Velez-Herrera, A., Rubio‐Osornio, M., & Rubio, C. (2025) · Brain Sciences · doi:10.3390/brainsci15080884 · Cited by 14

Cyclization-induced NIRF and functional specificity: NIR probe based on phenothiazine core for ultra-fast detecting mitochondrial HClO during cell ferroptosis

Lu, Z., Xu, X., Liu, Q., Zhao, B., Jiang, T., Liu, T., Jang, W. J., Yoon, J., & Fan, C. (2025) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2025.138800 · Cited by 11

1H HR-MAS NMR Based Metabolic Profiling of Lung Cancer Cells with Induced and De-Induced Cisplatin Resistance to Reveal Metabolic Resistance Adaptations

Vermathen, M., von Tengg‐Kobligk, H., Hungerbühler, M. N., Vermathen, P., & Ruprecht, N. O. (2021) · Molecules · doi:10.3390/molecules26226766 · Cited by 11

Glutathione-depleting polymer delivering chlorin e6 for enhancing photodynamic therapy

Wang, S.-Y., Chen, G., Chen, J., Wang, J., Deng, S., & Cheng, D. (2022) · RSC Advances · doi:10.1039/d2ra01877b · Cited by 11

Glutathione-responsive mesoporous silica nanocarriers for chemo–photothermal–photodynamic therapy of cancer

Zhang, X., Chen, M., Kan, Y., Dong, Y., Zhang, X., Wang, X., Su, H., Xu, S., & Yan, X. (2023) · Journal of Materials Science · doi:10.1007/s10853-023-08156-5 · Cited by 11

Core-shell cisplatin/SiO2 nanocapsules combined with PTC-209 overcome chemotherapy–Acquired and intrinsic resistance in hepatocellular carcinoma

Li, W., Solenne, T. O. S. B., Wang, H., Li, B., Liu, Y., Wang, F., & Tan, Y. (2023) · Acta Biomaterialia · doi:10.1016/j.actbio.2023.08.021 · Cited by 11

Quantitative analysis of sulfhydryl compounds in biological Samples: Advancements in chromatographic and mass spectrometric techniques

Yang, X., Chen, M., Liu, Y., Li, X., Luo, Y., Yang, S., Yang, S., Zheng, H., & Chen, D. (2024) · Microchemical Journal · doi:10.1016/j.microc.2024.110502 · Cited by 11

Managing GSH elevation and hypoxia to overcome resistance of cancer therapies using functionalized nanocarriers

Dabbour, N. M., Salama, A. M., Donia, T., Al-Deeb, R. T., Elghane, A. M. A., Badry, K. H., & Loutfy, S. A. (2021) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2021.103022 · Cited by 11

Tumor microenvironment/NIR-responsive oxygen-irrelevant radical nanogenerator for hypoxia-independent photothermal-thermodynamic osteosarcoma nanotherapy

Deng, X., Wang, Y., Zhao, R., Zhang, Z., Yuan, X., Ge, Z., Fang, Q., Wang, D., Liu, W., Lin, W. T., et al. (2022) · Materials & Design · doi:10.1016/j.matdes.2022.111282 · Cited by 11

Activation-Triggered Lysosome-Retaining Visible/NIR-II Integrated Fluorescent Probe Enables Tracking of Lysosomal Changes during Ferroptosis in Cells and In Vivo

Ge, H., Huang, H., He, S., Chen, K., Dai, M., Zhang, Z., Chen, X., Zhang, L., Mao, G., & Liu, H. (2025) · Analytical Chemistry · doi:10.1021/acs.analchem.5c02897 · Cited by 10

Targeting ferroptosis for neuroprotection: potential therapeutic avenues in neurodegenerative and neuropsychiatric diseases

Khan, M. S., Hu, Q., Okeibunor, K., Ma, L., & Bopassa, J. C. (2025) · Frontiers in Physiology · doi:10.3389/fphys.2025.1641323 · Cited by 12

Nanomaterial-mediated ferroptosis as a promising strategy for cancer therapy

Tang, Y., Zhou, Q., Fan, Y., Liu, T., Zhu, L., & Liu, M. (2025) · Nanoscale · doi:10.1039/d5nr03627e · Cited by 10

Stimuli-activatable protein degraders for targeted cancer therapy: from prodrug design to nanoplatform applications

Jiang, X., Chen, Y., Gao, Y., Rong, R., Lai, Y., Zhu, Z., & Xu, Z. (2026) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2026.115808 · Cited by 10

Nanozyme hydrogel for enhanced alkyl radical generation and potent antitumor therapy

Ning, S., Liu, Z., Chen, M., Zhu, D., & Huang, Q. (2022) · Nanoscale Advances · doi:10.1039/d2na00395c · Cited by 10

Design of a Structurally Novel Multipotent Drug Candidate by the Scaffold Architecture Technique for ACE-II, NSP15, and M pro Protein Inhibition: Identification and Isolation of a Natural Product to Prevent the Severity of Future Variants of Covid 19 and a Colorectal Anticancer Drug

Pakrashy, S., Mandal, P. K., Dey, S. K., Choudhury, S. M., Alasmary, F. A., Almalki, A. S., Islam, M. A., & Dolai, M. (2022) · ACS Omega · doi:10.1021/acsomega.2c04051 · Cited by 10

Nucleotide metabolism is linked to cysteine availability

Allen, A. E., Sun, Y., Wei, F., Reid, M. A., & Locasale, J. W. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.103039 · Cited by 10

Metabolomics profiling and chemoresistance mechanisms in ovarian cancer cell lines: Implications for targeting glutathione pathway

Alarcón, P., Pérez, A. J., Toledo, K., Contreras, H., Ormazábal, V., Nova‐Lamperti, E., Aguayo, C. R., Salomón, C., & Zuñiga, F. A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122166 · Cited by 10

Iron‐Confined CRISPR/Cas9‐Ribonucleoprotein Delivery System for Redox‐Responsive Gene Editing

Qiu, L., Sun, M., Chen, L., Jiang, J., Fu, Z., Wang, Y., Bi, Y., Guo, Q., Bai, H., Chen, S., et al. (2024) · Small · doi:10.1002/smll.202309431 · Cited by 10

IL-1α facilitates GSH synthesis to counteract oxidative stress in oral squamous cell carcinoma under glucose-deprivation

Ji, Y., Zhang, Z., Zhao, X. O., Li, Z., Hu, X., Zhang, M., Pan, X., Wang, X., & Chen, W. (2024) · Cancer Letters · doi:10.1016/j.canlet.2024.216833 · Cited by 11

Host cell CRISPR genomics and modelling reveal shared metabolic vulnerabilities in the intracellular development of Plasmodium falciparum and related hemoparasites

Maurizio, M., Masid, M., Woods, K. L., Caldelari, R., Doench, J. G., Naguleswaran, A., Joly, D. A. H. L., Fernández, M. G., Zemp, J., Borteele, M., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-50405-x · Cited by 10

Glutathione S‐transferase‐Pi 1 protects cells from irradiation‐induced death by inhibiting ferroptosis in pancreatic cancer

Zhu, Y., Chen, Y., Wang, Y., Zhu, Y., Wang, H., Zuo, M., Wang, J., Li, Y., & Chen, X.-L. (2024) · The FASEB Journal · doi:10.1096/fj.202400373rr · Cited by 12

The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities

Firouzjaei, A. A., & Mohammadi‐Yeganeh, S. (2024) · Frontiers in Oncology · doi:10.3389/fonc.2024.1424218 · Cited by 10

Human umbilical cord mesenchymal stem cells restore chemotherapy-induced premature ovarian failure by inhibiting ferroptosis in vitro ovarian culture system

Chen, J., He, Z., Xu, W., Kang, Y., Zhu, F., Tang, H., Wang, J., & Zhong, F. (2024) · Reproductive Biology and Endocrinology · doi:10.1186/s12958-024-01310-x · Cited by 10

Accurate regulation of carbon skeletons bonded to Fe-N4 single atom nanozymes for efficient generation of reactive oxygen species

Nan, F., Wei, Q., Kou, T., Zhao, Y., Shen, L., Li, D., Chang, T., Wang, L., Lang, F., & Yu, W. W. (2024) · Science China Chemistry · doi:10.1007/s11426-024-2268-7 · Cited by 10

Hijacking the hyaluronan assisted iron endocytosis to promote the ferroptosis in anticancer photodynamic therapy

Deng, H. X., Chen, J., Wang, H., Liu, R., Zhang, Y., Chang, H., Tung, C., & Zhang, W. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.123123 · Cited by 10

Decoding ferroptosis: transforming orthopedic disease management

Huo, G., Lin, Y., Liu, L., He, Y., Qu, Y., Liu, Y., Zhu, R., Wang, B., Gong, Q., Han, Z., et al. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1509172 · Cited by 10

Iron‐Based Nanomaterials for Modulating Tumor Microenvironment

Wang, L., Zhang, X., He, L., Wei, Y., Zhang, Y., Wu, A., & Li, J. (2025) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.70001 · Cited by 10

Plasma-activated saline hyperthermic perfusion-induced pyroptosis boosts peritoneal carcinomatosis immunotherapy

Qi, M., Zhao, X., Fan, R., Jiao, L., Li, Z., Liu, N., Sun, X., Xu, D., Zheng, J., Liu, D., et al. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.02.002 · Cited by 10

Ferroptosis in senescence and age-related diseases: pathogenic mechanisms and potential intervention targets

Liu, C., Pan, J., & Bao, Q. (2025) · Molecular Biology Reports · doi:10.1007/s11033-025-10338-0 · Cited by 13

New developments in the role of ferroptosis in sepsis‑induced cardiomyopathy (Review)

Wang, D., Qu, X., Zhang, Z.-H., & Zhou, G.-S. (2025) · Molecular Medicine Reports · doi:10.3892/mmr.2025.13483 · Cited by 12

Role of METTL16 in PPARγ methylation and osteogenic differentiation

Lu, L., Wang, L., Yang, M., & Wang, H. (2025) · Cell Death and Disease · doi:10.1038/s41419-025-07527-x · Cited by 11

Jahn–Teller-Driven Electronic Modulation of Bio-Heterojunction for Wound Regeneration after Postoperative Tumor Resection

He, M., Yang, X., Xiang, D., Chan, Y. K., Yin, G., Yang, W., & Deng, Y. (2025) · Nano Letters · doi:10.1021/acs.nanolett.5c01632 · Cited by 10

Single-cell analysis of diquat-induced oxidative stress and its impact on organ-specific toxicity

Chen, Z., Lin, G., Ye, K., Wang, J., Tang, M., Lai, K., Yuan, Y., Lin, S., Dai, X., Chen, H., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.118246 · Cited by 12

Enhancing Antioxidant and Cytotoxic Properties of CeO2 Through Silver Decoration: A Study on Ag@CeO2 Nanocomposites

Chen, Y., He, J., Chen, S., Li, Q., & Lin, X. (2025) · Nanomaterials · doi:10.3390/nano15100748 · Cited by 10

Lanthanide nanocrystals-based direct triple-state energy converters for mitophagy and ferroptosis-induced antitumor immunoreaction

Sun, Q., Qian, Y., Wang, J., Wang, M., Zhao, G., Wang, G., & Li, C. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113887 · Cited by 10

Lignin-Based Therapeutics: Targeting Mitochondrial Pathways in Osteosarcoma

Wang, Y., Zhou, S., Zhuang, Z., An, X., Wu, W., Jiang, B., Zhang, C., Manan, S., Wang, P., & Jin, Y. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5c01065 · Cited by 10

Copper metabolism and cuproptosis: broad perspectives in the treatment of hepatocellular carcinoma

Liang, J., Wang, R., Wu, H., Huang, Z. D., Zhang, R., & Jiang, F. (2025) · Frontiers in Oncology · doi:10.3389/fonc.2025.1555858 · Cited by 10

V o-AgFeO 2− x nanozymes treat infected wounds and promote wound healing

Chen, H., Wang, W., Li, Y., Shu, L., Fan, N., Mei, H., Wu, K., Yan, T., Shi, L., & Wang, X. (2025) · Nano Research · doi:10.26599/nr.2025.94907899 · Cited by 10

S-glutathionylation in cancer: from fundamental mechanisms to clinical applications

Dong, S., Linghu, L., Xiao, D., Liu, S., & Tao, Y. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107924 · Cited by 10

Natural Polyphenol–Metal Supramolecular Nanocomplex for Ferroptosis Activation in Chemoresistant Hepatocellular Carcinoma

Yan, Q., Fan, J., Zhang, Y., Yang, W., Cao, J., Liu, B., & He, Q. G. (2025) · Aggregate · doi:10.1002/agt2.70149 · Cited by 10

The Assessment of Anti-Melanoma Potential of Tigecycline—Cellular and Molecular Studies of Cell Proliferation, Apoptosis and Autophagy on Amelanotic and Melanotic Melanoma Cells

Rok, J., Kowalska, J., Rzepka, Z., Stencel, D., Skorek, A., Banach, K., & Wrześniok, D. M. (2023) · Cells · doi:10.3390/cells12121564 · Cited by 10

Facile synthesis of an acid-responsive cinnamaldehyde-pendant polycarbonate for enhancing the anticancer efficacy of etoposide via glutathione depletion

Wu, S., Liao, K., Chen, J., & Li, F. (2024) · RSC Advances · doi:10.1039/d4ra02468k · Cited by 10

Ultrasound-amplified polymetallic nanozyme-induced pyroptosis for lung cancer theranostics

Nie, K., Zhu, L., Chen, Y., Yu, L., Chang, M., Chen, Y., & Yu, H. (2023) · Nano Today · doi:10.1016/j.nantod.2023.102050 · Cited by 9

Multilevel Heterogeneity of Colorectal Cancer Liver Metastasis

Chen, H., Zhai, C., Xu, X., Wang, H., Han, W., & Shen, J. (2023) · Cancers · doi:10.3390/cancers16010059 · Cited by 10

Modulators of Candida albicans Membrane Drug Transporters: A Lucrative Portfolio for the Development of Effective Antifungals

Jaiswal, N., & Kumar, A. (2024) · Molecular Biotechnology · doi:10.1007/s12033-023-01017-1 · Cited by 9

AChE activity self-breathing control mechanisms regulated by H2Sn and GSH: Persulfidation and glutathionylation on sulfhydryl after disulfide bonds cleavage

Zhu, Y., Hu, Z., Liu, Y., Yan, T., Liu, L., Wang, Y., & Bai, B. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.129117 · Cited by 10

Tumor microenvironment-responsive self-assembling polymeric prodrug-based nanomaterials for cancer therapy

Rani, P., Rahim, J. U., Patra, S., Gupta, R., Gulati, M., & Kapoor, B. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105715 · Cited by 10

Inhibition of Human Colorectal Cancer by a Natural Product 7-Acetylhorminone and Interactions with BSA/HSA: Multispectral Analysis and In Silico and In Vitro Studies

Pakrashy, S., Chakraborty, S., Manna, S., Goswami, J. N., Bhattacharya, B., Emmerling, F., Mandal, J., Misra, S., Choudhury, S. M., Okla, M. K., et al. (2024) · ACS Applied Bio Materials · doi:10.1021/acsabm.4c00335 · Cited by 9

Biomimetic Cancer-Targeting Nanoplatform Boosting AIEgens-Based Photodynamic Therapy and Ferroptosis by Disrupting Redox-Homeostasis

Wan, Y., Cao, Y., Hu, D., Lai, Q., Liu, Y., Chen, Y., Wu, M., & Feng, S. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c00376 · Cited by 9

Targeting xCT with sulfasalazine suppresses triple-negative breast cancer growth via inducing autophagy and coordinating cell cycle and proliferation

Long, Y., Xu, Z., Yu, J., Hu, X., Xie, Y., Duan, X., Li, N., Yan, Y., Wang, Y., & Qin, J. (2024) · Anti-Cancer Drugs · doi:10.1097/cad.0000000000001630 · Cited by 9

Design of Cell-Specific Targeting Peptides for Cancer Therapy

Chen, X., Wang, D., Jiang, Y., & Jiang, T. (2024) · Targets · doi:10.3390/targets2030011 · Cited by 9

Sea Cucumber Viscera Processed by Protease Hydrolysis Combined with Cordyceps militaris Fermentation Protect Caco-2 Cells against Oxidative Damage via Enhancing Antioxidant Capacity, Activating Nrf2/HO-1 Pathway and Improving Cell Metabolism

Mi, R., Fu, Z., Jiang, J., Gao, S., Guan, X., Wang, X., & Zhou, Z. (2024) · Antioxidants · doi:10.3390/antiox13080988 · Cited by 9

ZMAT2 condensates regulate the alternative splicing of TRIM28 to reduce cellular ROS accumulation, thereby promoting the proliferation of HCC cells

Zhu, Y.-N., Li, J., Li, S., Yang, Z., Qiao, Z., Gu, X., He, Z., Wu, D., Ma, X., Yao, S., et al. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01790-9 · Cited by 9

ROS-Responsive and Self-Catalytic Nanocarriers for a Combination of Chemotherapy and Reinforced Ferroptosis against Breast Cancer.

Zhang, B., Liu, H., Wang, Y., & Zhang, Y. (2024) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.4c01233 · Cited by 10

The molecular mechanisms of chemotherapeutic resistance in tumors (Review)

Weng, X., Zeng, W.-H., Zhong, L., Xie, L., Ge, W.-J., Lai, Z., Qin, Q., Liu, P., Cao, D., & Zeng, X. (2024) · Oncology Reports · doi:10.3892/or.2024.8816 · Cited by 9

Demystifying the management of cancer through smart nano-biomedicine via regulation of reactive oxygen species

Mishra, A. P., Kumar, R., Harilal, S., Nigam, M., Datta, D., Singh, S. K., Waranuch, N., & Chittasupho, C. (2024) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-024-03469-x · Cited by 9

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer

Dangi, K., Kumar, V., Mittal, D., Yadav, P., Malik, M., & Verma, A. K. (2025) · Nanomedicine · doi:10.1080/17435889.2025.2489918 · Cited by 13

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Xiong, Y., Xiao, C., Li, Z., & Yang, X. (2021) · Chemical Society Reviews · doi:10.1039/d0cs00718h · Cited by 702

Glutathione Depletion and Stalwart Anticancer Activity of Metallotherapeutics Inducing Programmed Cell Death: Opening a New Window for Cancer Therapy

Roy, N., & Paira, P. (2024) · ACS Omega · doi:10.1021/acsomega.3c08890 · Cited by 60

Harnessing ROS Amplification and GSH Depletion Using a Carrier‐Free Nanodrug to Enhance Ferroptosis‐Based Cancer Therapy

Zhang, H., Shan, G., Liu, M., Sun, Q., Yang, T., Peng, R., Li, X., Mei, Y., He, X., & Qiao, L. (2024) · Small · doi:10.1002/smll.202409250 · Cited by 33

Novel strategies of glutathione depletion in photodynamic and chemodynamic therapy: A review

Wolny, D., Stojko, M., & Zajdel, A. (2024) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/191025 · Cited by 11