Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

ROS function in redox signaling and oxidative stress

Schieber, M., & Chandel, N. S. (2014) · Current Biology · doi:10.1016/j.cub.2014.03.034 · Cited by 6,931

Oxidative stress: oxidants and antioxidants

Sies, H. (1997) · Experimental Physiology · doi:10.1113/expphysiol.1997.sp004024 · Cited by 4,577

Thiol–Ene Click Chemistry

Hoyle, C. E., & Bowman, C. N. (2010) · Angewandte Chemie International Edition · doi:10.1002/anie.200903924 · Cited by 4,201

Glutathione Metabolism and Its Implications for Health

Wu, G., Lupton, J. R., Turner, N. D., Fang, Y.-Z., & Yang, S. (2004) · The Journal of Nutrition · doi:10.1093/jn/134.3.489 · Cited by 3,842

Association of reactive oxygen species levels and radioresistance in cancer stem cells

Diehn, M., Cho, R. W., Lobo, N. A., Kalisky, T., Dorie, M. J., Kulp, A. N., Qian, D., Lam, J. S., Ailles, L. E., Wong, M., et al. (2009) · Nature · doi:10.1038/nature07733 · Cited by 2,555

Functional Nanomaterials for Phototherapies of Cancer

Cheng, L., Wang, C., Feng, L., Yang, K., & Liu, Z. (2014) · Chemical Reviews · doi:10.1021/cr400532z · Cited by 2,438

Antioxidants Maintain Cellular Redox Homeostasis by Elimination of Reactive Oxygen Species

He, L., He, T., Farrar, S., Ji, L., Liu, T., & Ma, X. (2017) · Cellular Physiology and Biochemistry · doi:10.1159/000485089 · Cited by 2,207

Glutathione synthesis

Lu, S. C.-L. (2012) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2012.09.008 · Cited by 2,192

Oxidative complexity: The role of ROS in the tumor environment and therapeutic implications

Shen, T., Wang, Y., Cheng, L., Bode, A. M., Gao, Y., Zhang, S., Chen, X., & Luo, X. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118241 · Cited by 24

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

García-Peiro, J. I., Sancho‐Albero, M., de Miguel, S. B., Mosseri, A., Hornos, F., Contreras‐Montoya, R., Hueso, J. L., & Santamaria, J. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202502999 · Cited by 23

Ferroptosis Detection: From Approaches to Applications

Zeng, F., Nijiati, S., Tang, L., Ye, J., Zhou, Z., & Chen, X. S. (2023) · Angewandte Chemie · doi:10.1002/ange.202300379 · Cited by 25

Glutathione/Glucose-Depleting Nanoparticles with NO Generation for Ferroptosis/Starvation/NO-Induced Cancer Therapy

Fan, X., Chen, B., Xu, H. X., Pan, A., Liang, S., Tan, S., & He, Y. (2023) · Chemistry of Materials · doi:10.1021/acs.chemmater.2c03612 · Cited by 23

Targeted Delivery of Geraniol via Hyaluronic Acid-Conjugation Enhances Its Anti-Tumor Activity Against Prostate Cancer

Han, Y., Ning, N., He, F., Xu, J., Zhao, H., Duan, S., & Zhao, Y. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s444815 · Cited by 23

Bioactive compound schaftoside from Clinacanthus nutans attenuates acute liver injury by inhibiting ferroptosis through activation the Nrf2/GPX4 pathway

Yu, Y., Liang, J., Yuan, Z., Wang, A., Liu, X., Chen, Y., Zhang, M., Gao, Y., Zhang, H., & Liu, Y. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118135 · Cited by 23

Ultrasound-responsive Bi2MoO6-MXene heterojunction as ferroptosis inducers for stimulating immunogenic cell death against ovarian cancer

Cheng, S., Zhou, T., Luo, Y. Y., Zhang, J., Dong, K., Zhang, Q., Shu, W., Zhang, T., Zhang, Q., Shi, R., et al. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02658-3 · Cited by 23

A pH-Sensitive Nanoparticle as Reactive Oxygen Species Amplifier to Regulate Tumor Microenvironment and Potentiate Tumor Radiotherapy

Jiang, X., Jiang, X., Wu, D., Xie, W., Liu, X., & Zheng, J. (2024) · International Journal of Nanomedicine · doi:10.2147/ijn.s436160 · Cited by 25

A Coupling‐Induced Assembly Strategy for Constructing Artificial Shell on Mitochondria in Living Cells

Song, B., Wang, J., Zhang, G., Yi, N., Zhang, Y., Zhou, L., Guan, Y., Zhang, X., Zheng, W., Qiao, Z., et al. (2024) · Angewandte Chemie International Edition · doi:10.1002/anie.202411725 · Cited by 22

A hydrogen sulfide-activated Pd@Cu2O nanoprobe for NIR-II photoacoustic imaging of colon cancer and photothermal-enhanced ferroptosis therapy

Li, C., Luo, Y., Huang, L., Bin, Y., Liang, J., & Zhao, S. (2024) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2024.116906 · Cited by 22

Targeting novel regulated cell death: disulfidptosis in cancer immunotherapy with immune checkpoint inhibitors

Du, F., Wang, G., Dai, Q., Huang, J. H., Li, J., Liu, C., Du, K., Tian, H., Deng, Q., Xie, L., et al. (2025) · Biomarker Research · doi:10.1186/s40364-025-00748-4 · Cited by 25

Recent Progress in Radiosensitive Nanomaterials for Radiotherapy-Triggered Drug Release

Jiang, R., Fang, Q., Liu, W., Chen, L., & Yang, H. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c23023 · Cited by 22

Targeting ferroptosis in cancer: from mechanistic insights to therapeutic approaches

Wang, J., Guo, D., Jiang, S., Wu, W., & Gao, X. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00416-5 · Cited by 27

One-Step Fabrication of Multifunctional PLGA-HMME-DTX@MnO2 Nanoparticles for Enhanced Chemo-Sonodynamic Antitumor Treatment

Cao, J., Zheng, M., Sun, Z., Li, Z., Qi, X., & Shen, S. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s365570 · Cited by 22

C8orf76 Modulates Ferroptosis in Liver Cancer via Transcriptionally Up-Regulating SLC7A11

Li, D., Pan, J., Zhang, Y., Li, Y., Jin, S., Zhong, C., Chen, P., Ma, J., Hu, W., Fan, X., et al. (2022) · Cancers · doi:10.3390/cancers14143410 · Cited by 22

Nanoplatform-based cellular reactive oxygen species regulation for enhanced oncotherapy and tumor resistance alleviation

Wang, M., Ma, P., & Lin, J. (2023) · Chinese Chemical Letters · doi:10.1016/j.cclet.2023.108300 · Cited by 22

Resveratrol drives ferroptosis of acute myeloid leukemia cells through Hsa-miR-335-5p/NFS1/ GPX4 pathway in a ROS-dependent manner

Liu, J., Gao, W., Sheng, Y., Sun, J., & Wen, D. (2023) · Cellular and Molecular Biology · doi:10.14715/cmb/2023.69.7.21 · Cited by 22

Protecting against ferroptosis in hyperuricemic nephropathy: The potential of ferrostatin-1 and its inhibitory effect on URAT1

Li, Y., Zheng, F., Zhong, S., Zhao, K., Liao, H., Liang, J., Zheng, Q., Wu, H., Zhang, S., Cao, Y., et al. (2024) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2024.176528 · Cited by 23

Succinylated Type I Collagen Regulates Ferroptosis to Attenuate Skin Photoaging

Zhang, W., Zheng, Z., Wang, T., Yang, X., Zhao, J., Zhong, Y., Peng, X., & Zhou, Y. (2024) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.4c11952 · Cited by 23

Near infrared II excitation nanoplatform for photothermal/chemodynamic/antibiotic synergistic therapy combating bacterial biofilm infections

Wang, X., Zhang, C., He, L., Li, M., Chen, P., Yang, W., Sun, P., Li, D., & Zhang, Y. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-02212-7 · Cited by 21

Glioma stem cell membrane-camouflaged photothermal nanozyme for synergistic antitumor via dual-targeted drug delivery across blood-brain barrier

Lin, J., Sun, Z., Huang, Y., Liu, Q., Shen, M., Shao, C., Liao, W., Yang, Y., Song, Y., Wang, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.160181 · Cited by 21

Drug Delivery Systems Based on Metal–Organic Frameworks for Tumor Immunotherapy

Yang, N., He, Z., & Lang, T. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020225 · Cited by 23

Exosomes and ferroptosis: roles in tumour regulation and new cancer therapies

Shi, Y., Qiu, B., Huang, L., Lin, J., Li, Y., Ze, Y., Huang, C., & Yao, Y. (2022) · PeerJ · doi:10.7717/peerj.13238 · Cited by 23

Evaluation of the mycotoxin patulin on cytotoxicity and oxidative stress in human glioblastoma cells and investigation of protective effect of the antioxidant N-acetylcysteine (NAC)

Hsu, S.-S., Lin, Y., Chio, L., & Liang, W.-Z. (2022) · Toxicon · doi:10.1016/j.toxicon.2022.106957 · Cited by 21

A glutathione-activated NIR-II fluorescent probe for precise localization of micrometastases

Huang, Y. D., Tian, F., Sun, L., Ji, C., Grimes, C. A., & Cai, Q. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133457 · Cited by 22

Recent progress in cancer cell membrane-based nanoparticles for biomedical applications

Lin, Q., Peng, Y., Wen, Y., Li, X., Du, D., Dai, W., Tian, W., & Meng, Y. (2023) · Beilstein Journal of Nanotechnology · doi:10.3762/bjnano.14.24 · Cited by 21

Bioinformatics analysis of ferroptosis-related gene AKR1C3 as a potential biomarker of asthma and its identification in BEAS-2B cells

Wang, Y., Fan, J., Yu, T., Wang, L., Wang, L., Weng, C., Lai, C., Song, J., & Zhang, W. (2023) · Computers in Biology and Medicine · doi:10.1016/j.compbiomed.2023.106740 · Cited by 21

Mesoporous nanodrug delivery system: a powerful tool for a new paradigm of remodeling of the tumor microenvironment

Hang, Y., Liu, Y., Teng, Z., Cao, X., & Zhu, H. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01841-2 · Cited by 22

Alleviation of arsenic toxicity in pepper plants by aminolevulinic acid and heme through modulating its sequestration and distribution within cell organelles

Kaya, C., Ashraf, M., Alyemeni, M. N., Rinklebe, J., & Ahmad, P. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.121747 · Cited by 21

Emerging advances in fluorescence imaging and phototherapy of arthritis

Wang, X., Dai, J., Shao, C., Goto, T., & Dai, H. (2023) · Interdisciplinary materials · doi:10.1002/idm2.12130 · Cited by 21

Novel protective aspects of dietary polyphenols against pesticidal toxicity and its prospective application in rice-fish mode: A Review

Tahir, R., Samra, Afzal, F., Liang, J., & Yang, S. H. (2024) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2024.109418 · Cited by 21

Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer

Huang, J., Chen, J., & Li, J. (2024) · Journal of Molecular Histology · doi:10.1007/s10735-024-10186-5 · Cited by 24

Flower-Like MnO 2 Nanoparticle-Based Dual GSH-Depleting Nanosystems for Chemo-/Chemodynamic/Sonodynamic Cancer Therapy

Luo, Y., Fang, Z., Gao, Y., Chen, W., Xue, X., Xiao, C., & Wei, K. (2024) · ACS Applied Nano Materials · doi:10.1021/acsanm.4c00840 · Cited by 21

Endogenous and exogeneous stimuli-triggered reactive oxygen species evoke long-lived carbon monoxide to fight against lung cancer

Fang, Y., Yang, J., Liang, X., Wu, J., Xie, M., Zhang, K., & Su, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02688-x · Cited by 22

Versatile hydrogel-based drug delivery platform for multimodal cancer therapy from bench to bedside

Mei, Y., Hu, J., Cao, Y., Gao, X., Tang, L., & Wang, W. (2024) · Applied Materials Today · doi:10.1016/j.apmt.2024.102341 · Cited by 25

Bioconjugation and Reaction‐Induced Tumor Therapy via Alkynamide‐Based Thiol‐Yne Click Reaction

Wang, B., Li, C., He, D., Ding, K., Tian, Q., Feng, G., Qin, A., & Tang, B. Z. (2023) · Small · doi:10.1002/smll.202307309 · Cited by 20

Interference With Redox Homeostasis Through a G6PD-Targeting Self-Assembled Hydrogel for the Enhancement of Sonodynamic Therapy in Breast Cancer

Huang, C., Xu, Y. F., Wang, D., Chen, Z., Fang, W., Shi, C., Xiao, Z., & Luo, L. (2022) · Frontiers in Chemistry · doi:10.3389/fchem.2022.908892 · Cited by 20

Arsenic Prodrug-Mediated Tumor Microenvironment Modulation Platform for Synergetic Glioblastoma Therapy

Yan, J., Hanif, S., Zhang, D., Ismail, M., Wang, X., Li, Q., Shi, B., Muhammad, P., & Wu, H. (2022) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c12076 · Cited by 20

Investigations into ferroptosis in methylmercury‐induced acute kidney injury in mice

Ye, Y., Chen, Y., Wu, H., Fu, Y., Sun, Y., Wang, X., Li, P., Wu, Z., Wang, J., Yang, Z., et al. (2023) · Environmental Toxicology · doi:10.1002/tox.23770 · Cited by 20

Reactive Oxygen-Primed and Autophagy Inhibition-Sensitized Ferroptosis Combined with Photothermal Ablation for Tumor Therapy

Gu, D., Liu, M., Wu, H., Mao, J., Hu, J., Zhi, X., Wang, Z., Shang, X., Deng, X., & Wang, Y. (2023) · ACS Materials Letters · doi:10.1021/acsmaterialslett.3c00536 · Cited by 20

An injectable selenite-containing hydrogel for synergistic tumor therapy by triggering ROS/RNS generation and disrupting NADPH homeostasis

Tao, W., Wu, X., Li, J., Wu, F., Chen, C., Jiang, T. S., Xu, C., Jiang, S., Wang, J., Xiao, B., et al. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.147437 · Cited by 20

Biological Synthesis, Characterization, and Therapeutic Potential of S. commune-Mediated Gold Nanoparticles

Alqurashi, Y. E., Almalki, S. G., Ibrahim, I. M., Mohammed, A. O., Hady, A. E.-S. A. E., Kamal, M., Fatima, F., & Iqbal, D. (2023) · Biomolecules · doi:10.3390/biom13121785 · Cited by 20

Nanoplatform-based strategies for enhancing the lethality of current antitumor PDT

Lu, X., Xue, C., Dong, J., Zhang, Y., & Gao, F. (2024) · Journal of Materials Chemistry B · doi:10.1039/d4tb00008k · Cited by 22

Cascade Nanoreactor Employs Mitochondrial‐Directed Chemodynamic and δ‐ALA‐Mediated Photodynamic Synergy for Deep‐Seated Oral Cancer Therapy

Yin, Q., Zhang, J., Zhang, H., Gao, J., Weng, L., Liu, T., Sun, S., Yao, Y., & Chen, X. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304639 · Cited by 20

Self-assembled hyaluronic acid nanomicelle for enhanced cascade cancer chemotherapy via self-sensitized ferroptosis

Shi, J., Ma, W., Deng, J., Zheng, S., Xia, F., Liu, X., Kikkawa, A., Tanaka, K., Kamei, K., & Tian, C. (2024) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2024.122489 · Cited by 21

Bionic aggregation-induced emission photosensitizer for enhanced cancer immunotherapy

Chen, Z., Liu, Z., Zhou, Y., Rao, K., Lin, J., Zhu, D., Ning, S., & Wang, H. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101217 · Cited by 19

Nanozyme-mediated glutathione depletion for enhanced ROS-based cancer therapies: a comprehensive review

Wang, X., Wei, N., Zhang, Y., Yuan, F., Li, Y., Li, S., Wang, Z., & Sun, C. (2024) · Nanomedicine · doi:10.1080/17435889.2024.2446138 · Cited by 20

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition

Lei, L., Dai, W., Zhao, J., Jiang, A., Peng, H., Jin, Q., Li, X., & Tang, Z. (2025) · Advanced Science · doi:10.1002/advs.202504860 · Cited by 19

Albumin-assembled copper-bismuth bimetallic sulfide bioactive nanosphere as an amplifier of oxidative stress for enhanced radio-chemodynamic combination therapy

Tao, W., Tuo, Z., Wu, F., Mu, K., Xu, C., Shi, Y., Sun, Z., Wang, Y., Li, Y., Zhong, Z., et al. (2022) · Regenerative Biomaterials · doi:10.1093/rb/rbac045 · Cited by 19

A vinyl-decorated covalent organic framework for ferroptotic cancer therapy via visible-light-triggered cysteine depletion

Guan, Q., Zhou, L., Zhou, W. D., & Dong, Y. (2022) · Journal of Materials Chemistry B · doi:10.1039/d2tb01815b · Cited by 20

Design, synthesis and biological evaluation of liposome entrapped iridium(III) complexes toward SGC-7901 cells

Chen, Y.-C., Gu, Y., Hu, H., Liu, H., Li, W., Huang, C., Chen, J., Liang, L., & Liu, Y. (2023) · Journal of Inorganic Biochemistry · doi:10.1016/j.jinorgbio.2023.112134 · Cited by 19

Fluorescence Imaging-Incorporated Transcriptome Study of Glutathione Depletion-Enhanced Ferroptosis Therapy via Targeting Gold Nanoclusters

Zhao, D., Huang, X., Tian, Y., Zou, J., Wang, F., & Chen, X. S. (2023) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.2c18289 · Cited by 19

Metal selenide nanomaterials for biomedical applications

Li, X., Zhou, Y., Li, L., Wang, T., Wang, B., Che, R., Zhai, Y., Zhang, J., & Li, W. (2023) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2023.113220 · Cited by 19

Mesoporous silica-encapsulated Co-doped ceria nanodots with enhanced peroxidase-like activity enable intensive and long-lasting chemiluminescence for glutathione detection

Qian, S., Zhang, H., Sun, X., Tan, D., Tian, F., Zhang, T., Cui, Y. G., Chen, X., Liang, X., Cai, Z., et al. (2023) · Sensors and Actuators B Chemical · doi:10.1016/j.snb.2023.133609 · Cited by 19

pH-Activatable copper-axitinib coordinated multifunctional nanoparticles for synergistic chemo-chemodynamic therapy against aggressive cancers

Ji, M., Liu, H., Wang, H., Liang, X., Wei, M., Shi, D., Gou, J., Yin, T., He, H., Tang, X., et al. (2023) · Biomaterials Science · doi:10.1039/d3bm00861d · Cited by 20

High-performance pyrite nano-catalyst driven photothermal/chemodynamic synergistic therapy for Osteosarcoma

Li, M., Wang, M., Huang, J., Tang, S., Yang, J., Xu, Z., Xu, G., Chen, X., Liu, J., & Yang, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02419-2 · Cited by 21

Construction of glutathione-responsive paclitaxel prodrug nanoparticles for image-guided targeted delivery and breast cancer therapy

Ma, W., Zhao, Q., Zhu, S., Wang, X., Zhang, C., Ma, D., Li, N., & Yin, Y. (2024) · RSC Advances · doi:10.1039/d4ra00610k · Cited by 19

Self-assembled copper-based nanoparticles for enzyme catalysis-enhanced chemodynamic/photodynamic/antiangiogenic tritherapy against hepatocellular carcinoma

Wang, Y., Zhang, X., Ma, Y., Zhou, X., Xu, W., Qin, S., & Yang, C. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02626-x · Cited by 19

Single-atom catalysts: Enzyme-mimicking coordinations, platform designs, and biomedical applications

Le, X. T., & Youn, Y. S. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216642 · Cited by 19

Research progresses on mitochondrial-targeted biomaterials for bone defect repair

Wang, S., Liu, J., Zhou, L., Xu, H., Zhang, D., Zhang, X., Wang, Q., & Zhou, Q. H. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbae082 · Cited by 18

Dual Oxygen‐Supply Immunosuppression‐Inhibiting Nanomedicine to Avoid the Intratumoral Recruitment of Myeloid‐Derived Suppressor Cells

Yang, Z., Zuo, H., Hou, Y., Zhou, S., Zhang, Y., Yang, W., He, J., Shen, X., & Peng, Q. (2024) · Small · doi:10.1002/smll.202406860 · Cited by 19

An Endoplasmic Reticulum‐Targeting and Calcium Metabolism‐Disrupting Nanodrug Enhances Tumor Photodynamic Immunotherapy

Liang, S., Jiaerheng, G., Huang, C., Xie, Y., Zou, X., Liang, X., Li, C., & Liu, L. (2025) · Advanced Functional Materials · doi:10.1002/adfm.202424108 · Cited by 18

Mechanisms of radioresistance and radiosensitization strategies for Triple Negative Breast Cancer

Wang, Y., Liu, Z., Lv, Y., Long, J., Lü, Y., & Huang, P. (2025) · Translational Oncology · doi:10.1016/j.tranon.2025.102351 · Cited by 20

Mito-Nanozyme: Mitochondria-Targeted Nanozyme for Cancer Therapy

Li, Z., Song, J., Zhao, X., Wang, K., Liang, Y., Zhang, L., Guo, B., & Jiang, W. (2025) · Coordination Chemistry Reviews · doi:10.1016/j.ccr.2025.216899 · Cited by 18

Ferroptosis as a therapeutic target in glioblastoma: Mechanisms and emerging strategies

Mashayekhi, S., Majedi, H., Dehpour, A. R., Dehghan, S., Jafarian, M., Hadjighassem, M., & Hosseindoost, S. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102649 · Cited by 21

Anticancer therapeutic effect of ginsenosides through mediating reactive oxygen species

Li, X., Cao, D., Sun, S., & Wang, Y. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1215020 · Cited by 21

A Drosophila model of gestational antimony exposure uncovers growth and developmental disorders caused by disrupting oxidative stress homeostasis

Wang, X., Zhou, P., Zhang, Z., Huang, Q., Chen, X., Ji, L., Cheng, X., Shi, Y., Yu, S., Tang, J., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.09.002 · Cited by 18

A sequential dual-locked strategy with pH-responsive activation of photosensitizers and precise Cerenkov radiation delivery for cancer theranostics

Wu, Q., Zhang, Y., Jia, G., Hou, M., Jiang, Y., Wei, W., Liu, P., Huang, G., Zou, J., Zhang, J., et al. (2023) · Nano Today · doi:10.1016/j.nantod.2023.101984 · Cited by 18

Improvement of the effectiveness of sonodynamic therapy: by optimizing components and combination with other treatments

Wang, X., Xu, X., Yang, Z., Xu, X., Han, S., & Zhang, H. (2023) · Biomaterials Science · doi:10.1039/d3bm00738c · Cited by 18

“Triple-Hop” nano-bomb combining CDT, PDT and immunetherapy for NIR-triggered cancer therapy

Chen, H., Song, J., Wang, Y., Wang, T., Zhang, F., Lv, Y., Liu, Z., Fu, J., & Kong, X. (2023) · Chemical Engineering Journal · doi:10.1016/j.cej.2023.148268 · Cited by 18

Dye-augmented bandgap engineering of a degradable cascade nanoreactor for tumor immune microenvironment-enhanced dynamic phototherapy of breast cancer

He, Z., Du, J., Wang, Q., Chen, G., Li, X., Zhang, Z., Wang, S., Jing, W., Miao, Q., Li, Y., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.01.007 · Cited by 18

Defect engineering to tailor structure-activity relationship in biodegradable nanozymes for tumor therapy by dual-channel death strategies

Su, Y., Lv, M., Huang, Z., An, N., Chen, Y., Wang, H., Li, Z., Wu, S., Feng, Y., Shen, J., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.066 · Cited by 18

Serine synthesis controls mitochondrial biogenesis in macrophages

Wang, C., Zhao, M., Bin, P., Ye, Y., Chen, Q., Tang, Z., & Ren, W. (2024) · Science Advances · doi:10.1126/sciadv.adn2867 · Cited by 20

Bottle Nanomotors Amplify Tumor Oxidative Stress for Enhanced Calcium Overload/Chemodynamic Therapy

Jiang, Y., Xu, C., Li, Y., Wang, H., Liu, L., Ye, Y., Gao, J., Tian, H., Peng, F., Tu, Y., et al. (2024) · Small · doi:10.1002/smll.202404402 · Cited by 19

Glutathione-Depleted Photodynamic Nanoadjuvant for Triggering Nonferrous Ferroptosis to Amplify Radiotherapy of Breast Cancer

Shi, J., Cui, G., Jin, Y., Mi, B., Liu, K., Zhao, L., Bao, K., Lu, Z., Liu, J., Wang, Y., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202402474 · Cited by 18

Aryl Hydrocarbon Receptor Alleviates Hepatic Fibrosis by Inducing Hepatic Stellate Cell Ferroptosis

Liu, S. (2024) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.70278 · Cited by 17

Interlayer-engineered “six-in-one” nanozymes for cascade enzymatic/photothermal oncotherapy

Zhou, Z., Li, D., Yu, L., Zhu, Y., He, S., Wang, L., Wang, L., Zhang, W., Li, L., Ha, E., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.159189 · Cited by 18

Astaxanthin Prevents Glucocorticoid-Induced Femoral Head Osteonecrosis by Targeting Ferroptosis through the JAK2/STAT3 Signaling Pathway

Lin, Y., Chen, Z.-H., Yang, J., Han, L., Yu, Y., Zhan, J.-N., Tan, G.-C., Liu, L.-Y., Xie, C., Shan, P., et al. (2025) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c09284 · Cited by 17

Simultaneous Reversal of T Lymphocytes and Cancer Cells Metabolism Via a Biomimetic Heavy‐Atom‐Free Photosensitizers‐Based Combination Therapies to Boost Cancer Photoimmunotherapy

Zhang, Y., Wu, X., Wang, K., Tang, Y., Lu, X., Sun, F., Tang, H., Chen, X. S., & Ning, S. (2025) · Advanced Science · doi:10.1002/advs.202416143 · Cited by 18

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