Cited by 1,168Nanoplatforms for cancer theranosticsSulfur Compounds in BiologyRedox biology and oxidative stress

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Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

Niu, Boyi, Liao, Kaixin, Zhou, Yixian, Wen, Ting, Quan, Guilan, Pan, Xin, Wu, Chuanbin·2021·Biomaterials

DOI 10.1016/j.biomaterials.2021.121110

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Abstract

Glutathione (GSH) is an important member of cellular antioxidative system. In cancer cells, a high level of GSH is indispensable to scavenge excessive reactive oxygen species (ROS) and detoxify xenobiotics, which make it a potential target for cancer therapy. Plenty of studies have shown that loss of intracellular GSH makes cancer cells more susceptible to oxidative stress and chemotherapeutic agents. GSH depletion has been proved to improve the therapeutic efficacy of ROS-based therapy (photodynamic therapy, sonodynamic therapy, and chemodynamic therapy), ferroptosis, and chemotherapy. In this review, various strategies for GSH depletion used in cancer therapy are comprehensively summarized and discussed. First, the functions of GSH in cancer cells are analyzed to elucidate the necessity of GSH depletion in cancer therapy. Then, the synthesis and metabolism of GSH are briefly introduced to bring up some crucial targets for GSH modulation. Finally, different approaches to GSH depletion in the literature are classified and discussed in detail according to their mechanisms. Particularly, functional materials with GSH-consuming ability based on nanotechnology are elaborated due to their unique advantages and potentials. This review presents the ingenious application of GSH-depleting strategy in cancer therapy for improving the outcomes of various therapeutic regimens, which may provide useful guidance for designing intelligent drug delivery system.

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Authors: Niu, B., Liao, K., Zhou, Y., Wen, T., Quan, G., Pan, X., & Wu, C.
Affiliations: Sun Yat-sen University (CN)
Jinan University (CN)
Corresponding author: Pan, Xin
Wu, Chuanbin
ORCID: Wen, Ting
Quan, Guilan
Pan, Xin
Wu, Chuanbin
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2021-10
Volume: 277
Pages: 121110
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2021.121110
OpenAlex: W3198675921
Cited by: 1,168
References: 254
Citations by year: 2026: 168 · 2025: 353 · 2024: 330 · 2023: 201 · 2022: 110 · 2021: 6
FWCI: 13.84
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (publishedVersion)
PubMed (publishedVersion)
Topics: Physical Sciences › Engineering › Biomedical Engineering › Nanoplatforms for cancer theranostics
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Sulfur Compounds in Biology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Redox biology and oxidative stress
Keywords: glutathione depletion, cancer therapy, reactive oxygen species, ferroptosis, photodynamic therapy, sonodynamic therapy, chemodynamic therapy, oxidative stress, glutathione metabolism, glutathione synthesis, drug delivery systems, chemotherapy enhancement
MeSH terms: Ferroptosis, Antineoplastic Agents, Glutathione, Neoplasms, Photochemotherapy, Reactive Oxygen Species

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Application of glutathione depletion in cancer therapy: Enhanced ROS-based therapy, ferroptosis, and chemotherapy

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