Cited by 283Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications3D Printing in Biomedical Research

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Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

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Brown, Mika, Li, Jianyu, Moraes, Christopher, Tabrizian, Maryam, Li-Jessen, Nicole Y.K.·2022·Biomaterials

DOI 10.1016/j.biomaterials.2022.121786

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Abstract

Extracellular matrix is rich in biomolecules including structural proteins, glycosaminoglycans, and small molecules that are important for the maintenance and repair of tissue. Decellularized extracellular matrix (dECM) is expected to retain these key biomolecules and makes it a promising biomaterial candidate for regenerative medicine applications. To date, dECM-particle based biomaterials have been developed to engineer over 15 tissue types or organs, with the ultimate goal of mimicking specific biological and physical properties of the native tissue. The most common scaffold types are injectable hydrogels, electrospun scaffolds and bioprinted scaffolds. The purpose of this review paper is to highlight key challenges, fabrication methods and progress made for each tissue type, along with the discussion of other elements that are integral to push dECM biomaterials towards effective and specialized tissue repair.

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Authors: Brown, M., Li, J., Moraes, C., Tabrizian, M., & Li-Jessen, N. Y. K.
Affiliations: McGill University (CA)
Corresponding author: Tabrizian, Maryam
ORCID: Brown, Mika
Li, Jianyu
Moraes, Christopher
Tabrizian, Maryam
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2022-10
Volume: 289
Pages: 121786
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2022.121786
OpenAlex: W4294408764
Cited by: 282
References: 407
Citations by year: 2026: 65 · 2025: 90 · 2024: 74 · 2023: 48 · 2022: 5
FWCI: 12.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 715 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (acceptedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Natural Sciences and Engineering Research Council of Canada (ALLRP 548623-19, RGPIN-2018–03843)
Canada Research Chairs
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, injectable hydrogel, electrospun scaffolds, biomimetic scaffolds, tissue repair, scaffold fabrication techniques
MeSH terms: Decellularized Extracellular Matrix, Biocompatible Materials, Extracellular Matrix, Glycosaminoglycans, Hydrogels, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds

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Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

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