The DOI matches its Crossref record; 402 of the 407 references it cites were found in a registry or an index.
Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine
Open accessAbstract
Extracellular matrix is rich in biomolecules including structural proteins, glycosaminoglycans, and small molecules that are important for the maintenance and repair of tissue. Decellularized extracellular matrix (dECM) is expected to retain these key biomolecules and makes it a promising biomaterial candidate for regenerative medicine applications. To date, dECM-particle based biomaterials have been developed to engineer over 15 tissue types or organs, with the ultimate goal of mimicking specific biological and physical properties of the native tissue. The most common scaffold types are injectable hydrogels, electrospun scaffolds and bioprinted scaffolds. The purpose of this review paper is to highlight key challenges, fabrication methods and progress made for each tissue type, along with the discussion of other elements that are integral to push dECM biomaterials towards effective and specialized tissue repair.
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“Decellularized extracellular matrix (dECM) contains an abundance of tissue‐specific growth factors and signaling molecules, which play a pivotal role in the development of the cellular microenvironment niche”
From Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations (2025) · cites this paper as [10]
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Cited by
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Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
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Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications
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Metadata
- Authors
- Brown, M., Li, J., Moraes, C., Tabrizian, M., & Li-Jessen, N. Y. K.
- Affiliations
- McGill University (CA)
- Corresponding author
- Tabrizian, Maryam
- Venue
- Biomaterials
- Publisher
- Elsevier BV
- Published
- 2022-10
- Volume
- 289
- Pages
- 121786
- ISSN
- 0142-9612 (ISSN-L)
- OpenAlex
- W4294408764
- Cited by
- 282
- References
- 407
- Citations by year
- 2026: 65 · 2025: 90 · 2024: 74 · 2023: 48 · 2022: 5
- FWCI
- 12.89
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (am, 715 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Biomaterials (acceptedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Natural Sciences and Engineering Research Council of Canada (ALLRP 548623-19, RGPIN-2018–03843)
- Canada Research Chairs
- Topics
- Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
- Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
- Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
- Keywords
- decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, injectable hydrogel, electrospun scaffolds, biomimetic scaffolds, tissue repair, scaffold fabrication techniques
- MeSH terms
- Decellularized Extracellular Matrix, Biocompatible Materials, Extracellular Matrix, Glycosaminoglycans, Hydrogels, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds
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