Cited by 283Tissue Engineering and Regenerative MedicineHydrogels: synthesis, properties, applications3D Printing in Biomedical Research

The DOI matches its Crossref record; 402 of the 407 references it cites were found in a registry or an index.

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Open access

Brown, Mika, Li, Jianyu, Moraes, Christopher, Tabrizian, Maryam, Li-Jessen, Nicole Y.K.·2022·Biomaterials

DOI 10.1016/j.biomaterials.2022.121786

Open this paper in CoChat — free account

Abstract

Extracellular matrix is rich in biomolecules including structural proteins, glycosaminoglycans, and small molecules that are important for the maintenance and repair of tissue. Decellularized extracellular matrix (dECM) is expected to retain these key biomolecules and makes it a promising biomaterial candidate for regenerative medicine applications. To date, dECM-particle based biomaterials have been developed to engineer over 15 tissue types or organs, with the ultimate goal of mimicking specific biological and physical properties of the native tissue. The most common scaffold types are injectable hydrogels, electrospun scaffolds and bioprinted scaffolds. The purpose of this review paper is to highlight key challenges, fabrication methods and progress made for each tissue type, along with the discussion of other elements that are integral to push dECM biomaterials towards effective and specialized tissue repair.

Integrity signals

Registry

Crossref · 10.1016/j.biomaterials.2022.121786

Cites

402 of 402 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Heart disease and stroke statistics-2018 update: a report from the american heart association
Benjamin, E. J., Virani, S. S., Callaway, C. W., Chamberlain, A. M., Chang, A. R., Cheng, S., Chiuve, S. E., Cushman, M., Delling, F. N., Deo, R., et al. (2018) · Circulation · doi:10.1161/cir.0000000000000558 · Cited by 7,146
Mechanical properties and the hierarchical structure of bone
Rho, J. Y., Kuhn, L. T., & Zioupos, P. (1998) · Medical Engineering & Physics · doi:10.1016/s1350-4533(98)00007-1 · Cited by 2,596
Global burden of COPD: risk factors, prevalence, and future trends
Mannino, D. M., & Buist, A. S. (2007) · The Lancet · doi:10.1016/s0140-6736(07)61380-4 · Cited by 2,120
Printing three-dimensional tissue analogues with decellularized extracellular matrix bioink
Pati, F., Jang, J., Ha, D.-H., Won Kim, S., Rhie, J.-W., Shim, J.-H., Kim, D.-H., & Cho, D.-W. (2014) · Nature Communications · doi:10.1038/ncomms4935 · Cited by 1,904
Polymeric Scaffolds in Tissue Engineering Application: A Review
Dhandayuthapani, B., Yoshida, Y., Maekawa, T., & Kumar, D. S. (2011) · International Journal of Polymer Science · doi:10.1155/2011/290602 · Cited by 1,773
Tough adhesives for diverse wet surfaces
Li, J., Celiz, A. D., Yang, J., Yang, Q., Wamala, I., Whyte, W., Seo, B. R., Vasilyev, N. V., Vlassak, J. J., Suo, Z., et al. (2017) · Science · doi:10.1126/science.aah6362 · Cited by 1,607
Self-citation
Skin immune sentinels in health and disease
Nestle, F. O., Meglio, P. D., Qin, J., & Nickoloff, B. J. (2009) · Nature reviews. Immunology · doi:10.1038/nri2622 · Cited by 1,529
Physical approaches to biomaterial design
Mitragotri, S., & Lahann, J. (2009) · Nature Materials · doi:10.1038/nmat2344 · Cited by 1,445
Extracellular matrix: A dynamic microenvironment for stem cell niche
Gattazzo, F., Urciuolo, A., & Bonaldo, P. (2014) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2014.01.010 · Cited by 1,365
Unlike Bone, Cartilage Regeneration Remains Elusive
Huey, D. J., Hu, J. C. Y., & Athanasiou, K. A. (2012) · Science · doi:10.1126/science.1222454 · Cited by 1,209

Show all 407 references

Research works printed but not linked: 7

Mohiuddin, 2019, Human adipose-derived hydrogel characterization based on in vitro ASC biocompatibility and differentiation, Stem Cells Int., 2019
Mohiuddin, 2020, Characterization and proteomic analysis of decellularized adipose tissue hydrogels derived from lean and overweight/obese, Hum. Donors, 4
Nguyen, 2020, Devices, fabrication of an injectable acellular adipose matrix for soft tissue regeneration, J. Sci.: Adv. Mater. Devices, 6, 1
Zhang, 2021, 3D bioprinting of biomimetic bilayered scaffold consisting of decellularized extracellular matrix and silk fibroin for osteochondral repair, Int. J. Bioprint., 7, 401, 10.18063/ijb.v7i4.401 · DOI
Moztarzadeh, 2019, Chapter 13 - nanoengineered biomaterials for lung regeneration, 305
López-Martínez, 2021, Biotechnology, A natural xenogeneic endometrial extracellular matrix hydrogel toward improving current human in vitro models and future in vivo applications, Front. Bioeng., 9, 156
Pan, 2016, Technology, 3D bioplotting of gelatin/alginate scaffolds for tissue engineering: influence of crosslinking degree and pore architecture on physicochemical properties, J. Mater. Sci., 32, 889

Sorted by citations

Extracellular vesicle-loaded hydrogels for tissue repair and regeneration
Ju, Y., Hu, Y., Pu, Y., Xie, X., & Fang, B. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100522 · Cited by 471
Bioactive scaffolds for tissue engineering: A review of decellularized extracellular matrix applications and innovations
Liu, J., Song, Q., Yin, W., Li, C., An, N., Le, Y., Wang, Q., Feng, Y., Hu, Y., & Wang, Y. (2025) · Exploration · doi:10.1002/exp.20230078 · Cited by 140
Injectable smart stimuli-responsive hydrogels: pioneering advancements in biomedical applications
Liu, J., Du, C., Huang, W., & Lei, Y. (2023) · Biomaterials Science · doi:10.1039/d3bm01352a · Cited by 133
Progress in biomaterials inspired by the extracellular matrix
Chen, Z., Du, C., Liu, S., Liu, J., Yang, Y., Dong, L., Zhao, W., Huang, W., & Lei, Y. (2024) · Giant · doi:10.1016/j.giant.2024.100323 · Cited by 140
Decellularized extracellular matrix-based composite scaffolds for tissue engineering and regenerative medicine
Xu, P., Kankala, R. K., Wang, S., & Chen, A. (2024) · Regenerative Biomaterials · doi:10.1093/rb/rbad107 · Cited by 129
Functional acellular matrix for tissue repair
Wang, B., Qinglai, T., Yang, Q., Li, M., Zeng, S., Yang, X., Xiao, Z., Tong, X., Lei, L., & Li, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100530 · Cited by 111
Harnessing developmental dynamics of spinal cord extracellular matrix improves regenerative potential of spinal cord organoids
Sun, Z., Chen, Z., Yin, M., Wu, X., Guo, B., Cheng, X., Quan, R., Sun, Y., Zhang, Q., Fan, Y., et al. (2024) · Cell stem cell · doi:10.1016/j.stem.2024.03.007 · Cited by 102
Biomaterial-based regenerative therapeutic strategies for spinal cord injury
Chen, K., Yu, W., Zheng, G., Zeng, X., Yang, C., Wang, Y., Yue, Z., Yuan, W., Hu, B., & Chen, H. (2024) · NPG Asia Materials · doi:10.1038/s41427-023-00526-4 · Cited by 90
Extracellular matrix: the critical contributor to skeletal muscle regeneration—a comprehensive review
Ahmad, K., Shaikh, S., Chun, H. J., Ali, S. M., Lim, J. H., Ahmad, S. S., Lee, E. J., & Choi, I. (2023) · Inflammation and Regeneration · doi:10.1186/s41232-023-00308-z · Cited by 89
Development of Matrix Metalloproteinases-Mediated Extracellular Matrix Remodeling in Regenerative Medicine: A Mini Review
Chen, K., Xu, M., Lu, F., & He, Y. (2023) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-023-00536-x · Cited by 77
The Role of Hydrogel in Cardiac Repair and Regeneration for Myocardial Infarction: Recent Advances and Future Perspectives
Li, P., Hu, J., Wang, J., Zhang, J., Wang, L., & Zhang, C. (2023) · Bioengineering · doi:10.3390/bioengineering10020165 · Cited by 69
3D bioprinting advanced biomaterials for craniofacial and dental tissue engineering – A review
Xu, H., Zhang, Y., Zhang, Y., Zhao, Z., Xue, T., Wang, J., Li, M., Zhao, S., Zhang, H., & Ding, Y. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.112886 · Cited by 67
Self-healing hydrogels based on biological macromolecules in wound healing: A review
Pu, Y., Li, Z., Fang, B., & Liu, L. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127612 · Cited by 67
Extracellular matrix-inspired biomaterials for wound healing
Hosty, L., Heatherington, T., Quondamatteo, F., & Browne, S. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09750-9 · Cited by 63
Biological Materials for Tissue-Engineered Vascular Grafts: Overview of Recent Advancements
Francesco, D. D., Pigliafreddo, A., Casarella, S., Nunno, L. D., Mantovani, D., & Boccafoschi, F. (2023) · Biomolecules · doi:10.3390/biom13091389 · Cited by 60
Adipose-derived stem cell-based optimization strategies for musculoskeletal regeneration: recent advances and perspectives
Yuan, C., Song, W. D., Jiang, X., Wang, Y., Li, C., Yu, W., & He, Y. (2024) · Stem Cell Research & Therapy · doi:10.1186/s13287-024-03703-6 · Cited by 53
Injectable, Electroconductive, Free Radical Scavenging Silk Fibroin/Black Phosphorus/Glycyrrhizic Acid Nanocomposite Hydrogel for Enhancing Spinal Cord Repair
Zhang, B., Wang, W., Gao, P. D., Li, X., Chen, L., Lin, Z., Chen, H., Liang, W., Kong, Z., Lin, D., et al. (2024) · Advanced Healthcare Materials · doi:10.1002/adhm.202304300 · Cited by 53
Biomaterials for Corneal Regeneration
Li, Y., & Wang, Z. (2024) · Advanced Science · doi:10.1002/advs.202408021 · Cited by 52
Decoding bone-inspired and cell-instructive cues of scaffolds for bone tissue engineering
Hussain, Z., Mehmood, S., Liu, X., Liu, Y., Wang, G., & Pei, R. (2023) · Engineered Regeneration · doi:10.1016/j.engreg.2023.10.003 · Cited by 51
Organoids in the oral and maxillofacial region: present and future
Wu, Y., Li, X., Liu, H., Yang, X. Y., Li, R., Zhao, H., & Shang, Z. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00324-w · Cited by 49
Mimicked Spinal Cord Fibers Trigger Axonal Regeneration and Remyelination after Injury
Chen, Z., Sun, Z., Fan, Y., Yin, M., Jin, C., Guo, B., Yin, Y., Quan, R., Zhao, S., Han, S., et al. (2023) · ACS Nano · doi:10.1021/acsnano.3c09892 · Cited by 48
Construction of vascular grafts based on tissue-engineered scaffolds
Lang, Z., Chen, T., Zhu, S., Wu, X., Wu, Y., Miao, X., Wang, Q., Zhao, L., Zhu, Z., & Xu, R. X. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101336 · Cited by 48
Decellularized extracellular matrix materials for treatment of ischemic cardiomyopathy
Liu, W., Zhang, X., Jiang, X., Dai, B., Zhang, L., & Zhu, Y. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.10.015 · Cited by 47
Flourishing tumor organoids: History, emerging technology, and application
Yang, Q., Li, M., Yang, X., Xiao, Z., Tong, X., Tuerdi, A., Li, S., & Lei, L. (2023) · Bioengineering & Translational Medicine · doi:10.1002/btm2.10559 · Cited by 46
Decellularized extracellular matrix and silk fibroin-based hybrid biomaterials: A comprehensive review on fabrication techniques and tissue-specific applications
Ghosh, S., & Pati, F. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.127410 · Cited by 42
Animal tissue-derived biomaterials for promoting wound healing
Cao, X., Lin, X., Li, N., Zhao, X., Zhou, M., & Zhao, Y. (2023) · Materials Horizons · doi:10.1039/d3mh00411b · Cited by 41
Exploiting the Potential of Decellularized Extracellular Matrix (ECM) in Tissue Engineering: A Review Study
Milan, P. B., Masoumi, F., Biazar, E., Jalise, S. Z., & Mehrabi, A. (2024) · Macromolecular Bioscience · doi:10.1002/mabi.202400322 · Cited by 43
Low-Intensity Pulsed Ultrasound Responsive Scaffold Promotes Intramembranous and Endochondral Ossification via Ultrasonic, Thermal, and Electrical Stimulation
Jia, W., Wang, T., Chen, F., Liu, Z., Hou, X., Cao, W., Zhao, X., Lu, B., Hu, Y., Dong, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c13357 · Cited by 42
Investigation on repairing diabetic foot ulcer based on 3D bio-printing Gel/dECM/Qcs composite scaffolds
Zhong, Y., Ma, H., Lu, Y., Cao, L., Cheng, Y. Y., Tang, X., Sun, H., & Song, K. (2023) · Tissue and Cell · doi:10.1016/j.tice.2023.102213 · Cited by 40
Revolutionizing pressure ulcer regeneration: Unleashing the potential of extracellular matrix-derived temperature-sensitive injectable antioxidant hydrogel for superior stem cell therapy
Tang, J., Zhang, P., Liu, Y., Hou, D., Chen, Y., Cheng, L., Xue, Y., & Liu, J. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122880 · Cited by 40
Towards Safety and Regulation Criteria for Clinical Applications of Decellularized Organ-Derived Matrices
van Hengel, E. V. A., van der Laan, L. J. W., de Jonge, J., & Verstegen, M. M. A. (2025) · Bioengineering · doi:10.3390/bioengineering12020136 · Cited by 43
Crosslinking strategies of decellularized extracellular matrix in tissue regeneration
Qiao, S., Peijie, T., & Jiang, N. (2023) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.37650 · Cited by 40
Ameliorating impaired cardiac function in myocardial infarction using exosome-loaded gallic-acid-containing polyurethane scaffolds
Das, A., Nikhil, A., Shiekh, P. A., Yadav, B., Jagavelu, K., & Kumar, A. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.11.009 · Cited by 38
Photo‐Responsive Decellularized Small Intestine Submucosa Hydrogels
Duong, V. T., Nguyen, H. D., Luong, N. H., Chang, C., & Lin, C. (2024) · Advanced Functional Materials · doi:10.1002/adfm.202401952 · Cited by 37
Understanding the multi-functionality and tissue-specificity of decellularized dental pulp matrix hydrogels for endodontic regeneration
Liang, Z., Li, J., Lin, H., Zhang, S., Liu, F., Rao, Z., Chen, J., Feng, Y., Zhang, K., Quan, D., et al. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.04.040 · Cited by 36
Self-citation
Research progress in decellularized extracellular matrix hydrogels for intervertebral disc degeneration
Peng, B., Du, L., Zhang, T., Chen, J., & Xu, B. (2023) · Biomaterials Science · doi:10.1039/d2bm01862d · Cited by 34
Injectable Xenogeneic Dental Pulp Decellularized Extracellular Matrix Hydrogel Promotes Functional Dental Pulp Regeneration
Yuan, S., Yang, X., Wang, X., Chen, J., Tian, W., & Yang, B. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms242417483 · Cited by 37
Nano-biomaterials and advanced fabrication techniques for engineering skeletal muscle tissue constructs in regenerative medicine
Han, S., Cruz, S. H., Park, S., & Shin, S. R. (2023) · Nano Convergence · doi:10.1186/s40580-023-00398-y · Cited by 32
Liver click dECM hydrogels for engineering hepatic microenvironments
Milton, L. A., Davern, J. W., Hipwood, L., Chaves, J. C. S., McGovern, J., Broszczak, D., Hutmacher, D. W., Meinert, C., & Toh, Y.-C. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.06.037 · Cited by 31
A multifunctional decellularized gut suture platform
Lee, J. S., Kim, H., Carroll, G., Liu, G. W., Kirtane, A. R., Hayward, A. M., Wentworth, A. J., Lopes, A., Collins, J. E., Tamang, S., et al. (2023) · Matter · doi:10.1016/j.matt.2023.04.015 · Cited by 32
Self-citation
Hydrogel-mediated delivery of platelet-derived exosomes: Innovations in tissue engineering
Saberian, M., & Abak, N. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e24584 · Cited by 29
Extracellular‐Matrix‐Based Materials from Decellularized Tissue: Opportunities, Challenges, and Future Directions in Regenerative Medicine
Laude, M., Kolliopoulos, V., Mikos, A. G., White, L. J., & Cosgriff‐Hernandez, E. (2025) · Advanced Healthcare Materials · doi:10.1002/adhm.202502107 · Cited by 30
Antimicrobial peptides as antimicrobials for wound care management: A comprehensive review
Kanaujia, K. A., Mishra, N., Rajinikanth, P. S., & Saraf, S. A. (2024) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2024.105570 · Cited by 29
Biomimetic fabrication bioprinting strategies based on decellularized extracellular matrix for musculoskeletal tissue regeneration: Current status and future perspectives
Liu, H., Xing, F., Yu, P., Lu, R., Ma, S., Shakya, S., Xiang, Z., Peng, K., Zhang, D., & Liu, M. (2024) · Materials & Design · doi:10.1016/j.matdes.2024.113072 · Cited by 31
Restoring tendon microenvironment in tendinopathy: Macrophage modulation and tendon regeneration with injectable tendon hydrogel and tendon-derived stem cells exosomes
Li, D., Li, S., He, S., He, H., Yuan, G., Ma, B., Zhang, Y., Yuan, C., Liu, Z., Deng, Z., et al. (2025) · Bioactive Materials · doi:10.1016/j.bioactmat.2025.01.016 · Cited by 28
Mechanisms underlying the cell-matrixed nerve grafts repairing peripheral nerve defects
Wang, S., Wang, H., Lu, P., Gong, L., Gu, X., & Li, M. (2023) · Bioactive Materials · doi:10.1016/j.bioactmat.2023.09.002 · Cited by 28
Advances in 3D bioprinting for medical application: opportunities and challenges
Kazemi, M., & Maralbashi, S. (2025) · BioMedical Engineering OnLine · doi:10.1186/s12938-025-01498-y · Cited by 29
Treated Dentin Matrix in Tissue Regeneration: Recent Advances
Bi, F., Zhang, Z., & Guo, W. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics15010091 · Cited by 28
MSCs-derived ECM functionalized hydrogel regulates macrophage reprogramming for osteoarthritis treatment by improving mitochondrial function and energy metabolism
Chen, Z., Pang, Q.-M., Zhan, J., Liu, J., Zhao, W., Dong, L., & Huang, W. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101340 · Cited by 26
A review of 3D bioprinting for organoids
Li, Z., Chen, L., Wu, J., Chen, Y., Zhu, Y. Z., Li, G., Xie, G., Tang, G., & Xie, M. (2025) · Medical Review · doi:10.1515/mr-2024-0089 · Cited by 27
Extracellular matrix dysregulation in PCOS: pathogenesis, therapeutic strategies, and innovative technologies
Liu, Y., Zhu, J., Yang, Y., Chen, Z., Zhou, Y. F., Fei, W., Zhang, X., & Zheng, Y. (2025) · Journal of Biological Engineering · doi:10.1186/s13036-025-00533-9 · Cited by 26
Decellularized matrix for repairing intervertebral disc degeneration: Fabrication methods, applications and animal models
Hu, Q., Li, H., Ye, Z., Wei, Z., & Ao, J. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100523 · Cited by 26
Engineering Cell–ECM–Material Interactions for Musculoskeletal Regeneration
Jones, C. L., Penney, B. T., & Theodossiou, S. K. (2023) · Bioengineering · doi:10.3390/bioengineering10040453 · Cited by 26
Extracellular matrix-based biomaterials in burn wound repair: A promising therapeutic strategy
Song, Y., Liu, P., Zhou, X., Chen, Y., Wu, W., Zhang, J.-Y., Li‐Ling, J., & Xie, H. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.137633 · Cited by 25
The Prospect of Hepatic Decellularized Extracellular Matrix as a Bioink for Liver 3D Bioprinting
Shi, W. T., Zhang, Z., & Wang, X. (2024) · Biomolecules · doi:10.3390/biom14081019 · Cited by 26
Extracellular matrix hydrogels with fibroblast growth factor 2 containing exosomes for reconstructing skin microstructures
Zhou, Z., Bu, Z., Wang, S., Yu, J., Liu, W., Huang, J., Hu, J., Xu, S., & Wu, P. (2024) · Journal of Nanobiotechnology · doi:10.1186/s12951-024-02718-8 · Cited by 24
Creating a Microenvironment to Give Wings to Dental Pulp Regeneration—Bioactive Scaffolds
Hu, N., Li, W., Jiang, W., Wen, J., & Gu, S. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010158 · Cited by 23
Acellular embryoid body and hydroxybutyl chitosan composite hydrogels promote M2 macrophage polarization and accelerate diabetic cutaneous wound healing
Zhang, Y., Chen, Z.-H., Zhao, K., Mu, Y., Li, K.-L., Yuan, Z.-M., Liu, Z.-G., Han, L., & Lü, W. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.100975 · Cited by 22
3D Printing of Thick Myocardial Tissue Constructs with Anisotropic Myofibers and Perfusable Vascular Channels
Cui, H., Yu, Z., Huang, Y., Hann, S.-Y., Esworthy, T. J., Shen, Y.-L., & Zhang, L. G. (2023) · Biomaterials Advances · doi:10.1016/j.bioadv.2023.213579 · Cited by 21
Two Decades of Advances and Limitations in Organ Recellularization
Stoian, A., Adil, A., Biniazan, F., & Haykal, S. (2024) · Current Issues in Molecular Biology · doi:10.3390/cimb46080543 · Cited by 21
Organoids/organs-on-chips towards biomimetic human artificial skin
Huang, Y., Wu, X., Xu, Y., Yang, N., Xi, P., Wang, Y., Zhu, Y., & Chen, X. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf029 · Cited by 26
Three-Dimensional Bioprinting of Naturally Derived Hydrogels for the Production of Biomimetic Living Tissues: Benefits and Challenges
Merotto, E., Pavan, P. G., & Piccoli, M. (2023) · Biomedicines · doi:10.3390/biomedicines11061742 · Cited by 20
Designing Regenerative Bioadhesives for Tissue Repair and Regeneration
Li, X., Liu, Y., Liu, S., Li‐Jessen, N. Y. K., Haglund, L., Huang, B., & Li, J. (2023) · Advanced Therapeutics · doi:10.1002/adtp.202300139 · Cited by 20
Self-citation
Histological evaluation of the regenerative potential of a novel photocrosslinkable gelatin-treated dentin matrix hydrogel in direct pulp capping: an animal study
Sedek, E. M., Abdelkader, S., Fahmy, A. E., Kamoun, E. A., Nouh, S. R., & Khalil, N. (2024) · BMC Oral Health · doi:10.1186/s12903-024-03868-9 · Cited by 20
Injectable decellularized extracellular matrix hydrogel with cell-adaptable supramolecular network enhances cartilage regeneration by regulating inflammation and facilitating chondrogenesis
Dai, W., Gong, X., Wang, C., Liu, P., Shi, W., Cheng, J., Cao, C., Hu, X., Wang, J., & Ao, Y. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.155138 · Cited by 20
Recent advances in self-healing hydrogel design for enhanced wound care: A comprehensive study on polysaccharides and proteins in comparison with synthetic polymers
Matini, A., & Naghib, S. M. (2025) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2025.147075 · Cited by 20
Decellularized extracellular matrix: Advanced bioplatforms for functional tissue restoration via innovative decellularization techniques
Wang, Z., Lin, X. Q., Shi, Y., Yan, H., Shang, Y., & Ren, H. (2026) · Biomedical Technology · doi:10.1016/j.bmt.2025.100131 · Cited by 19
Local Management for Diabetic Foot Ulcers
Hu, Q., Jian, Y., Chu, X., Wang, Y., Liu, Z., Zhang, N., Deng, C., Shi, X., & Wei, Z. (2024) · Annals of Surgery · doi:10.1097/sla.0000000000006398 · Cited by 19
A Decellularized Uterine Endometrial Scaffold Enhances Regeneration of the Endometrium in Rats
Yoshimasa, Y., Takao, T., Katakura, S., Tomisato, S., Masuda, H., Tanaka, M., & Maruyama, T. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087605 · Cited by 18
Mimicking Molecular Pathways in the Design of Smart Hydrogels for the Design of Vascularized Engineered Tissues
Nicosia, A., Salamone, M., Costa, S., Ragusa, M. A., & Ghersi, G. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512314 · Cited by 19
Control of the growth and development of murine preantral follicles in a biomimetic ovary using a decellularized porcine scaffold
Park, E. Y., Park, J. H., Mai, N. T. Q., Moon, B.-S., & Choi, J. K. (2023) · Materials Today Bio · doi:10.1016/j.mtbio.2023.100824 · Cited by 18
Adipose-derived stem cells derived decellularized extracellular matrix enabled skin regeneration and remodeling
Zhang, J., Yang, X. D., Yang, Q., Chen, J., Liu, L., Jin, J., & Zhu, S. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1347995 · Cited by 17
A coaxial 3D bioprinted hybrid vascular scaffold based on decellularized extracellular matrix/nano clay/sodium alginate bioink
Zhu, J., Ma, H., Du, J., Fang, H., Cheng, Y. Y., Xu, J., Pan, B., & Song, K. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.139056 · Cited by 16
Bioinspired smart dentin ECM-chitosan hydrogels for dentin-pulp complex regeneration
Osman, M., Sharmin, Z., Suchy, S., Gao, F., Kaminski, A., Mitchell, J. C., Sigar, I. M., & Carrilho, M. (2025) · Journal of Dentistry · doi:10.1016/j.jdent.2025.105811 · Cited by 16
Self‐Assembled Bifunctional Exosomes Simplify Chondrocyte‐Targeted Sustained‐Release Systems in Decellularized Cartilage Microgels for Synergistic Osteoarthritis Therapy
Deng, S., Chen, X., Cao, H., Chen, M., Shi, W., Li, N., Liang, J., Fan, Y., Wang, Q., & Zhang, X. (2025) · Small · doi:10.1002/smll.202503492 · Cited by 18
Hydroxybutyl chitosan-based thermosensitive hydrogel enhanced osteoporotic bone regeneration through sustained release of alendronate and BMP-2
Lei, M., Liu, H., Zhong, Q., Zhao, L., Liu, J., Mai, H., Zhang, Y., Wang, H., Chen, Y., Chen, R., et al. (2025) · Carbohydrate Polymers · doi:10.1016/j.carbpol.2025.124609 · Cited by 16
Injectable Decellularized Extracellular Matrix-Based Bio-Ink with Excellent Biocompatibility for Scarless Urethra Repair
Fang, W., Yang, M., Jin, Y., Zhang, K., Wang, Y., Liu, M., Wang, Y., Yang, R., & Fu, Q. (2023) · Gels · doi:10.3390/gels9110913 · Cited by 16
The Ogden model for hydrogels in tissue engineering: Modulus determination with compression to failure
Nedrelow, D. S., Townsend, J. M., & Detamore, M. S. (2023) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2023.111592 · Cited by 15
Insulin modified Decellularized Adipose Tissue/Tremella Polysaccharide hydrogel loaded with ADSCs for skin wound healing
Dong, J., Kong, L., Jiang, W., Wang, Q., Chen, Y., & Liu, H. (2023) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.03.027 · Cited by 15
Biotechnological advances and applications of human pluripotent stem cell-derived heart models
Muniyandi, P., O’Hern, C., Popa, M. A., & Aguirre, A. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1214431 · Cited by 14
Composite bioink incorporating cell-laden liver decellularized extracellular matrix for bioprinting of scaffolds for bone tissue engineering
You, P., Sun, H., Chen, H., Li, C., Mao, Y., Zhang, T., Yang, H., & Dong, H. (2024) · Biomaterials Advances · doi:10.1016/j.bioadv.2024.214017 · Cited by 14
Advances in mesenchymal stem cells and their derivatives for promoting peripheral nerve regeneration
Wei, S., Dong, J., Hu, Q., Bai, J., Gao, X., Shan, H., Sheng, L., Dai, J., Tao, L., Yan, B., et al. (2025) · Burns & Trauma · doi:10.1093/burnst/tkaf027 · Cited by 14
Unraveling the Relevance of Tissue‐Specific Decellularized Extracellular Matrix Hydrogels for Vocal Fold Regenerative Biomaterials: A Comprehensive Proteomic and In Vitro Study
Brown, M., Zhu, S., Taylor, L., Tabrizian, M., & Li‐Jessen, N. Y. K. (2023) · Advanced NanoBiomed Research · doi:10.1002/anbr.202200095 · Cited by 14
Self-citation
Decellularized matrix bioink with gelatin methacrylate for simultaneous improvements in printability and biofunctionality
Seok, J. M., Ahn, M., Kim, D., Lee, J., Lee, D., Choi, M.-J., Yeo, S. J., Lee, J. H., Lee, K., Kim, B. S., et al. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.130194 · Cited by 14
Cartilage Decellularized Extracellular Matrix-Based Hydrogel with Enhanced Tissue Adhesion and Promoted Chondrogenesis for Cartilage Tissue Engineering
Li, J., Jiang, B., Zhang, P., Wu, J., Fan, N., Zhu, C., Yang, Y., Zhang, E., Wang, F., & Yang, L. (2024) · ACS Applied Polymer Materials · doi:10.1021/acsapm.3c01733 · Cited by 14
Self-citation
Characterization of a decellularized pericardium extracellular matrix hydrogel for regenerative medicine: insights on animal-to-animal variability
Francesco, D. D., Marcello, E., Casarella, S., Copes, F., Chevallier, P., Carmagnola, I., Mantovani, D., & Boccafoschi, F. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1452965 · Cited by 15
Tumor organoids in cancer medicine: from model systems to natural compound screening
Cong, R., Lu, C., Li, X., Xu, Z., Wang, Y., & Sun, S. (2025) · Pharmaceutical Biology · doi:10.1080/13880209.2025.2458149 · Cited by 16
Collagen-based biomaterials in organoid technology for reproductive medicine: composition, characteristics, and applications
Feng, B., Yang, H., Zhu, M., Li, J., Chang, H., Leung, P. C. K., Guo, J., & Zhang, Y. (2023) · Collagen and Leather · doi:10.1186/s42825-023-00142-6 · Cited by 13
Self-citation
Advances in ex vivo expansion of hematopoietic stem and progenitor cells for clinical applications
Branco, A., Rayabaram, J., Miranda, C. C., Fernandes‐Platzgummer, A., Fernandes, T. G., Sajja, S., da Silva, C. L., & Vemuri, M. C. (2024) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2024.1380950 · Cited by 13
High-precision bioactive scaffold with dECM and extracellular vesicles targeting 4E-BP inhibition for cartilage injury repair
Han, Y., Dong, Y., Jia, B., Shi, X., Zhao, H., Li, S., Wang, H., Sun, B., Yin, L., & Dai, K. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101114 · Cited by 13
The considerations on selecting the appropriate decellularized ECM for specific regeneration demands
Zhang, S., Guo, Y., Lu, Y., Liu, F., Heng, B. C., & Deng, X. (2024) · Materials Today Bio · doi:10.1016/j.mtbio.2024.101301 · Cited by 13
Heterogeneous focal adhesion cytoskeleton nanoarchitectures from microengineered interfacial curvature to oversee nuclear remodeling and mechanotransduction of mesenchymal stem cells
Fan, H., Zhao, H. F., Hou, Y., Meng, D., Jiang, J., Lee, E., Fu, Y., Zhang, X., Chen, R., & Wang, Y.-T. (2025) · Cellular & Molecular Biology Letters · doi:10.1186/s11658-025-00692-z · Cited by 13
Merging Natural Biopolymers with Supramolecular Chemistry: Emulating the Native Extracellular Matrix’s Complexity
Sousa, V., Ladeira, B., Garanger, É., Lecommandoux, S., Meijer, E. W., Dankers, P. Y. W., Mano, J. F., & Borges, J. (2025) · ACS Nano · doi:10.1021/acsnano.5c10088 · Cited by 12
Advanced hydrogel therapeutics for intervertebral disc degeneration: Engineering structural–functional properties in natural and synthetic biomaterials
Chen, T., Lu, D., Wang, S., Yang, H., Fan, W., Xiao, Z., Wang, Z., Makvandi, P., Zhu, R., & Cheng, L. (2025) · Bioengineering & Translational Medicine · doi:10.1002/btm2.70059 · Cited by 12
Developing Bovine Brain-Derived Extracellular Matrix Hydrogels: a Screen of Decellularization Methods for Their Impact on Biochemical and Mechanical Properties
Sorhun, D. T., Kuşoğlu, A., & Öztürk, E. (2023) · ACS Omega · doi:10.1021/acsomega.3c04064 · Cited by 12
Characterisation of Matrix-Bound Nanovesicles (MBVs) Isolated from Decellularised Bovine Pericardium: New Frontiers in Regenerative Medicine
Francesco, D. D., Varsavia, C. D., Casarella, S., Donetti, E., Manfredi, M., Mantovani, D., & Boccafoschi, F. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25020740 · Cited by 12
Generation of Tailored Extracellular Matrix Hydrogels for the Study of In Vitro Folliculogenesis in Response to Matrisome-Dependent Biochemical Cues
McDowell, H. B., McElhinney, K. L., Tsui, E. L., & Laronda, M. M. (2024) · Bioengineering · doi:10.3390/bioengineering11060543 · Cited by 12
Cell‐Derived Matrix: Production, Decellularization, and Application of Wound Repair
Xu, Y., Yao, Y., & Gao, J. (2024) · Stem Cells International · doi:10.1155/2024/7398473 · Cited by 12
EVs from cells at the early stages of chondrogenesis delivered by injectable SIS dECM promote cartilage regeneration
Zhu, W., Shi, J., Weng, B., Zhou, Z., Mao, X., Pan, S., Peng, J., Zhang, C., Mao, H., Li, M., et al. (2024) · Journal of Tissue Engineering · doi:10.1177/20417314241268189 · Cited by 12
ECM-mimetic glucomannan hydrogel promotes pressure ulcer healing by scavenging ROS, promoting angiogenesis and regulating macrophages
Sun, M., Wang, Q., Li, T., Wang, W., Li, Z., Ji, Y., Zhang, S., Li, Y., Liu, W., & Yu, Y. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.135776 · Cited by 12

Authors: Brown, M., Li, J., Moraes, C., Tabrizian, M., & Li-Jessen, N. Y. K.
Affiliations: McGill University (CA)
Corresponding author: Tabrizian, Maryam
ORCID: Brown, Mika
Li, Jianyu
Moraes, Christopher
Tabrizian, Maryam
Venue: Biomaterials
Publisher: Elsevier BV
Published: 2022-10
Volume: 289
Pages: 121786
ISSN: 0142-9612 (ISSN-L)
DOI: 10.1016/j.biomaterials.2022.121786
OpenAlex: W4294408764
Cited by: 282
References: 407
Citations by year: 2026: 65 · 2025: 90 · 2024: 74 · 2023: 48 · 2022: 5
FWCI: 12.89
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (am, 715 d)
doi.org/10.15223/policy-017 (stm-asf)
doi.org/10.15223/policy-037 (stm-asf)
doi.org/10.15223/policy-012 (stm-asf)
doi.org/10.15223/policy-029 (stm-asf)
doi.org/10.15223/policy-004 (stm-asf)
Locations: Biomaterials (acceptedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health
Natural Sciences and Engineering Research Council of Canada (ALLRP 548623-19, RGPIN-2018–03843)
Canada Research Chairs
Topics: Health Sciences › Medicine › Surgery › Tissue Engineering and Regenerative Medicine
Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Engineering › Biomedical Engineering › 3D Printing in Biomedical Research
Keywords: decellularized extracellular matrix, tissue engineering scaffolds, regenerative medicine, injectable hydrogel, electrospun scaffolds, biomimetic scaffolds, tissue repair, scaffold fabrication techniques
MeSH terms: Decellularized Extracellular Matrix, Biocompatible Materials, Extracellular Matrix, Glycosaminoglycans, Hydrogels, Tissue Engineering, Regenerative Medicine, Tissue Scaffolds

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Decellularized extracellular matrix: New promising and challenging biomaterials for regenerative medicine

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks