Chlorogenic acid (CGA): A pharmacological review and call for further research

Flavonoids: an overview

Panche, A. N., Diwan, A. D., & Chandra, S. (2016) · Journal of Nutritional Science · doi:10.1017/jns.2016.41 · Cited by 5,953

Increased oxidative stress in obesity and its impact on metabolic syndrome

Furukawa, S., Fujita, T., Shimabukuro, M., Iwaki, M., Yamada, Y., Nakajima, Y., Nakayama, O., Makishima, M., Matsuda, M., & Shimomura, I. (2004) · Journal of Clinical Investigation · doi:10.1172/jci21625 · Cited by 5,508

Systems biology: a brief overview

Kitano, H. (2002) · Science · doi:10.1126/science.1069492 · Cited by 4,265

Chronic Inflammation in Obesity and the Metabolic Syndrome

Monteiro, R., & Azevedo, I. (2010) · Mediators of Inflammation · doi:10.1155/2010/289645 · Cited by 1,186

Antimicrobial properties of phenolic compounds from berries

Puupponen‐Pimiä, R., Nohynek, L. J., Meier, C., Kähkönen, M., Heinonen, M., Hopia, A., & Oksman‐Caldentey, K. (2001) · Journal of Applied Microbiology · doi:10.1046/j.1365-2672.2001.01271.x · Cited by 1,055

Chlorogenic acid exhibits anti-obesity property and improves lipid metabolism in high-fat diet-induced-obese mice

Cho, A.-S., Jeon, S.-M., Kim, M., Yeo, J., Seo, K., Choi, M., & Lee, M. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.01.003 · Cited by 787

The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature

Tajik, N., Tajik, M., Mack, I., & Enck, P. (2017) · European Journal of Nutrition · doi:10.1007/s00394-017-1379-1 · Cited by 730

Chlorogenic Acid: Recent Advances on Its Dual Role as a Food Additive and a Nutraceutical against Metabolic Syndrome

Santana‐Gálvez, J., Cisneros‐Zevallos, L., & Jacobo‐Velázquez, D. A. (2017) · Molecules · doi:10.3390/molecules22030358 · Cited by 725

Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

Meng, S., Cao, J., Feng, Q., Peng, J., & Hu, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/801457 · Cited by 619

Benzoic and Cinnamic Acid Derivatives as Antioxidants: Structure−Activity Relation

Natella, F., Nardini, M., Felice, M. D., & Scaccini, C. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980737w · Cited by 606

Cinnamic Acid Derivatives and Their Biological Efficacy

Ruwizhi, N., & Aderibigbe, B. A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21165712 · Cited by 484

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12620 · Cited by 476

Health Benefits and Chemical Composition of Matcha Green Tea: A Review

Kochman, J., Jakubczyk, K., Antoniewicz, J., Mruk, H., & Janda, K. (2020) · Molecules · doi:10.3390/molecules26010085 · Cited by 328

The Influence of Solvent Choice on the Extraction of Bioactive Compounds from Asteraceae: A Comparative Review

Lee, J.-E., Jayakody, J., Kim, J., Jeong, J.-W., Choi, K.-M., Kim, T., Seo, C., Azimi, I., Hyun, J., & Ryu, B. (2024) · Foods · doi:10.3390/foods13193151 · Cited by 327

The Odyssey of Bioactive Compounds in Avocado (Persea americana) and Their Health Benefits

Bhuyan, D. J., Alsherbiny, M. A., Perera, Low, M., Basu, A., Devi, O. A., Barooah, M. S., Li, C. G., & Papoutsis, K. (2019) · Antioxidants · doi:10.3390/antiox8100426 · Cited by 260

Neuroprotective Effects of Coffee Bioactive Compounds: A Review

Socała, K., Szopa, A., Serefko, A., Poleszak, E., & Właź, P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010107 · Cited by 271

Natural sweeteners: Sources, extraction and current uses in foods and food industries

Castro‐Muñoz, R., Correa-Delgado, M., Córdova-Almeida, R., Lara-Nava, D., Chávez-Muñoz, M., Velásquez-Chávez, V. F., Hernández-Torres, C. E., Gontarek‐Castro, E., & Ahmad, M. Z. (2021) · Food Chemistry · doi:10.1016/j.foodchem.2021.130991 · Cited by 260

Antibacterial and antioxidant activities for natural and synthetic dual-active compounds

Martelli, G., & Giacomini, D. (2018) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2018.09.009 · Cited by 232

A review on the traditional uses, phytochemistry, and pharmacological activities of clove basil (Ocimum gratissimum L.)

Ugbogu, O. C., Emmanuel, O., Agi, G. O., Ibe, C., Ekweogu, C. N., Ude, V. C., Uche, M. E., Nnanna, R. O., & Ugbogu, E. A. (2021) · Heliyon · doi:10.1016/j.heliyon.2021.e08404 · Cited by 214

The Effect of Time, Roasting Temperature, and Grind Size on Caffeine and Chlorogenic Acid Concentrations in Cold Brew Coffee

Fuller, M., & Rao, N. Z. (2017) · Scientific Reports · doi:10.1038/s41598-017-18247-4 · Cited by 180

Plant‐Based Synthesis of Zinc Oxide Nanoparticles (ZnO‐NPs) Using Aqueous Leaf Extract of Aquilegia pubiflora : Their Antiproliferative Activity against HepG2 Cells Inducing Reactive Oxygen Species and Other In Vitro Properties

Jan, H., Shah, M., Andleeb, A., Faisal, S., Khattak, A., Rizwan, M., Drouet, S., Hano, C., & Abbasi, B. H. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/4786227 · Cited by 182

Consumption of Chlorogenic Acids through Coffee and Health Implications

Farah, A., & Lima, J. D. P. (2019) · Beverages · doi:10.3390/beverages5010011 · Cited by 177

Targeting oxidative stress as a preventive and therapeutic approach for cardiovascular disease

Yan, Q., Liu, S., Sun, Y., Chen, C., Yang, S., Lin, M., Long, J., Yao, J., Lin, Y.-T., Yi, F., et al. (2023) · Journal of Translational Medicine · doi:10.1186/s12967-023-04361-7 · Cited by 184

An Updated Review on the Multifaceted Therapeutic Potential of Calendula officinalis L.

Shahane, K., Kshirsagar, M. M., Tambe, S. M., Jain, D. D., Rout, S., Ferreira, M. K. M., Mali, S. N., Amin, P. D., Srivastav, P. P., Cruz, J. N., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16040611 · Cited by 169

Anti-Cancer Effects of Green Tea Epigallocatchin-3-Gallate and Coffee Chlorogenic Acid

Hayakawa, S., Ohishi, T., Miyoshi, N., Oishi, Y., Nakamura, Y., & Isemura, M. (2020) · Molecules · doi:10.3390/molecules25194553 · Cited by 172

Chlorogenic acid‐mediated chemical defence of plants against insect herbivores

Kundu, A., & Vadassery, J. (2018) · Plant Biology · doi:10.1111/plb.12947 · Cited by 163

Chlorogenic acid for cancer prevention and therapy: Current status on efficacy and mechanisms of action

Gupta, A., Atanasov, A. G., Li, Y., Kumar, N., & Bishayee, A. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106505 · Cited by 163

Chlorogenic acid attenuates high-carbohydrate, high-fat diet–induced cardiovascular, liver, and metabolic changes in rats

Bhandarkar, N. S., Brown, L., & Panchal, S. K. (2018) · Nutrition Research · doi:10.1016/j.nutres.2018.11.002 · Cited by 166

Coffee Chlorogenic Acids Incorporation for Bioactivity Enhancement of Foods: A Review

Rojas-González, A., Figueroa-Hernández, C. Y., González-Ríos, Ó., Suárez-Quiroz, M. L., González‐Amaro, R. M., Hernández‐Estrada, Z. J., & Rayas‐Duarte, P. (2022) · Molecules · doi:10.3390/molecules27113400 · Cited by 172

Nicotine in Inflammatory Diseases: Anti-Inflammatory and Pro-Inflammatory Effects

Zhang, W., Lin, H., Zou, M., Yuan, Q., Huang, Z., Pan, X., & Zhang, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.826889 · Cited by 148

Antioxidant activity and polyphenol composition of sugarcane molasses extract

Deseo, M. A., Elkins, A., Rochfort, S. J., & Kitchen, B. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.126180 · Cited by 146

Chlorogenic Acid-Induced Gut Microbiota Improves Metabolic Endotoxemia

Ye, X., Liu, Y., Hu, J., Gao, Y., Ma, Y., & Wen, D. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2021.762691 · Cited by 145

Acidity and Antioxidant Activity of Cold Brew Coffee

Rao, N. Z., & Fuller, M. (2018) · Scientific Reports · doi:10.1038/s41598-018-34392-w · Cited by 144

Strategies to improve bioactive and antibacterial properties of polyetheretherketone (PEEK) for use as orthopedic implants

Zheng, Z., Liu, P., Zhang, X., Xin, J., wang, Y., Zou, X., Mei, X., Zhang, S., & Zhang, S. (2022) · Materials Today Bio · doi:10.1016/j.mtbio.2022.100402 · Cited by 149

Current Advances in Naturally Occurring Caffeoylquinic Acids: Structure, Bioactivity, and Synthesis

Liu, W., Li, J., Zhang, X., Zu, Y., Yue, Y., Liu, W., Xu, Z., Gao, H., Sun, X., Jiang, X., et al. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c03804 · Cited by 140

Pharmacological values and therapeutic properties of black tea (Camellia sinensis): A comprehensive overview

Naveed, M., Bibi, J., Kamboh, A. A., Suheryani, I., Kakar, I., Fazlani, S. A., FangFang, X., Kalhoro, S. A., Liang, Y., Kakar, M. U., et al. (2018) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2018.02.048 · Cited by 136

Simultaneous CRISPR/Cas9 Editing of Three PPO Genes Reduces Fruit Flesh Browning in Solanum melongena L.

Maioli, A., Gianoglio, S., Moglia, A., Acquadro, A., Valentino, D., Milani, A. M., Prohens, J., Orzáez, D., Granell, A., Lanteri, S., et al. (2020) · Frontiers in Plant Science · doi:10.3389/fpls.2020.607161 · Cited by 141

Quantification of Caffeine and Chlorogenic Acid in Green and Roasted Coffee Samples Using HPLC-DAD and Evaluation of the Effect of Degree of Roasting on Their Levels

Awwad, S. H., Issa, R. A., Alnsour, L., Albals, D., & Al-Momani, I. F. (2021) · Molecules · doi:10.3390/molecules26247502 · Cited by 127

Biogenic Synthesis and Characterization of Antimicrobial and Antiparasitic Zinc Oxide (ZnO) Nanoparticles Using Aqueous Extracts of the Himalayan Columbine (Aquilegia pubiflora)

Jan, H., Shah, M., Usman, H., Khan, M. A., Zia, M., Hano, C., & Abbasi, B. H. (2020) · Frontiers in Materials · doi:10.3389/fmats.2020.00249 · Cited by 126

Chlorogenic Acids in Cardiovascular Disease: A Review of Dietary Consumption, Pharmacology, and Pharmacokinetics

Li, L., Su, C., Chen, X., Wang, Q., Jiao, W., Luo, H., Tang, J., Wang, W., Li, S., & Guo, S. (2020) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.0c01554 · Cited by 129

Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation

Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125

Chlorogenic Acid: A Dietary Phenolic Acid with Promising Pharmacotherapeutic Potential

Singh, A. K., Singla, R. K., & Pandey, A. K. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220816154634 · Cited by 118

Coffee By-Products and Their Suitability for Developing Active Food Packaging Materials

Oliveira, G., Passos, C. P., Ferreira, P., Coimbra, M. A., & Gonçalves, I. (2021) · Foods · doi:10.3390/foods10030683 · Cited by 129

Green Extraction Methods for Extraction of Polyphenolic Compounds from Blueberry Pomace

Lončarić, A., Celeiro, M., Jozinović, A., Jelinić, J., Kovač, T., Jokić, S., Babić, J., Moslavac, T., Zavadlav, S., & Lores, M. (2020) · Foods · doi:10.3390/foods9111521 · Cited by 115

Chlorogenic Acid Alleviates Aβ25-35-Induced Autophagy and Cognitive Impairment via the mTOR/TFEB Signaling Pathway

Gao, L., Li, X., Meng, S., Ma, T., Wan, L., & Xu, S. (2020) · Drug Design Development and Therapy · doi:10.2147/dddt.s235969 · Cited by 115

Medioresinol as a novel PGC-1α activator prevents pyroptosis of endothelial cells in ischemic stroke through PPARα-GOT1 axis

Wang, Y., Guan, X., Gao, C., Ruan, W., Zhao, S., Kai, G., Li, F., & Pang, T. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105640 · Cited by 109

Chlorogenic acid improves health in juvenile largemouth bass (Micropterus salmoides) fed high-fat diets: Involvement of lipid metabolism, antioxidant ability, inflammatory response, and intestinal integrity

Yin, P., Xie, S., Zhuang, Z., Fang, H., Tian, L., Liu, Y., & Niu, J. (2021) · Aquaculture · doi:10.1016/j.aquaculture.2021.737169 · Cited by 110

Chlorogenic and caffeic acids in 64 fruits consumed in Brazil

Meinhart, A. D., Damin, F. M., Caldeirão, L., Filho, M. D. J., da Silva, L. C., Constant, L. D. S., Filho, J. T., Wagner, R. C., & Godoy, H. T. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.02.004 · Cited by 109

Targeted delivery of chlorogenic acid by mannosylated liposomes to effectively promote the polarization of TAMs for the treatment of glioblastoma

Ye, J., Yang, Y., Jin, J., Ji, M., Gao, Y., Feng, Y., Wang, H., Chen, X., & Liu, Y. (2020) · Bioactive Materials · doi:10.1016/j.bioactmat.2020.05.001 · Cited by 109

Viburnum opulus L.—A Review of Phytochemistry and Biological Effects

Kajszczak, D., Zakłos‐Szyda, M., & Podsędek, A. (2020) · Nutrients · doi:10.3390/nu12113398 · Cited by 107

In vitro antioxidant and antihypertensive compounds from camu-camu (Myrciaria dubia McVaugh, Myrtaceae) seed coat: A multivariate structure-activity study

Fidelis, M., Santos, J. S., Escher, G. B., do Carmo, M. A. V., Azevedo, L. C., da Silva, M. C., Putnik, P., & Granato, D. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.07.043 · Cited by 107

Beetroot, A Remarkable Vegetable: Its Nitrate and Phytochemical Contents Can be Adjusted in Novel Formulations to Benefit Health and Support Cardiovascular Disease Therapies

dos S. Baião, D., da Silva, D. V. T., & Paschoalin, V. M. F. (2020) · Antioxidants · doi:10.3390/antiox9100960 · Cited by 102

Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo

Wang, L., Du, H., & Chen, P. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110673 · Cited by 101

Valorization of sunflower by-product using microwave-assisted extraction to obtain a rich protein flour: Recovery of chlorogenic acid, phenolic content and antioxidant capacity

Náthia-Neves, G., & Alonso, E. (2020) · Food and Bioproducts Processing · doi:10.1016/j.fbp.2020.10.008 · Cited by 101

Polyphenol-Rich Loquat Fruit Extract Prevents Fructose-Induced Nonalcoholic Fatty Liver Disease by Modulating Glycometabolism, Lipometabolism, Oxidative Stress, Inflammation, Intestinal Barrier, and Gut Microbiota in Mice

Li, W., Yang, H., Zhao, Q., Wang, X., Zhang, J., & Zhao, X. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02523 · Cited by 100

Lycium barbarum L. leaves ameliorate type 2 diabetes in rats by modulating metabolic profiles and gut microbiota composition

Zhao, X., Guo, S., Lu, Y., Hua, Y., Zhang, F., Yan, H., Shang, E., Wang, H., Zhang, W., & Duan, J. (2019) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2019.109559 · Cited by 99

Covalent conjugation with (−)-epigallo-catechin 3-gallate and chlorogenic acid changes allergenicity and functional properties of Ara h1 from peanut

He, W., Zhang, T., Veličković, T. Ć., Li, S., Lyu, Y., Wang, L., Yi, J., Liu, Z., He, Z., & Wu, X. (2020) · Food Chemistry · doi:10.1016/j.foodchem.2020.127355 · Cited by 98

Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities

Yan, L., Guo, M.-S., Zhang, Y., Yu, L., Wu, J.-M., Tang, Y., Ai, W., Zhu, F.-D., Law, B. Y.-K., Chen, Q., et al. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/5288698 · Cited by 97

Chemical and bioactive characterization of the aromatic plant Levisticum officinale W.D.J. Koch: a comprehensive study

Spréa, R. M., Fernandes, Â. S. F., Calhelha, R. C., Pereira, C., Pires, T. C. S. P., Alves, M. J., Canan, C., Barros, L., Amaral, J. S., & Ferreira, I. C. F. R. (2020) · Food & Function · doi:10.1039/c9fo02841b · Cited by 97

Profiling of phenolic acids and flavonoids in sweet potato (Ipomoea batatas L.) leaves and evaluation of their anti-oxidant and hypoglycemic activities

Luo, D., Mu, T., & Sun, H. (2020) · Food Bioscience · doi:10.1016/j.fbio.2020.100801 · Cited by 97

The Chemopreventive Effects of Chlorogenic Acids, Phenolic Compounds in Coffee, against Inflammation, Cancer, and Neurological Diseases

Murai, T., & Matsuda, S. (2023) · Molecules · doi:10.3390/molecules28052381 · Cited by 100

Current Evidence to Propose Different Food Supplements for Weight Loss: A Comprehensive Review

Watanabe, M., Risi, R., Masi, D., Caputi, A., Balena, A., Rossini, G., Tuccinardi, D., Mariani, S., Basciani, S., Manfrini, S., et al. (2020) · Nutrients · doi:10.3390/nu12092873 · Cited by 98

Toxicity of Natural Deep Eutectic Solvent Betaine:Glycerol in Rats

Benlebna, M., Ruesgas-Ramón, M., Bonafos, B., Fouret, G., Casas, F., Coudray, C., Durand, E., Cruz Figueroa-Espinoza, M., & Feillet-Coudray, C. (2018) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b01746 · Cited by 90

Chlorogenic Acid Suppresses miR‐155 and Ameliorates Ulcerative Colitis through the NF‐κB/NLRP3 Inflammasome Pathway

Zeng, J., Zhang, D., Wan, X., Bai, Y., Yuan, C., Wang, T., Yuan, D., Zhang, C., & Liu, C. (2020) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.202000452 · Cited by 90

A review of pears (Pyrus spp.), ancient functional food for modern times

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Green Alternatives as Antimicrobial Agents in Mitigating Periodontal Diseases: A Narrative Review

Mosaddad, S. A., Hussain, A., & Tebyanian, H. (2023) · Microorganisms · doi:10.3390/microorganisms11051269 · Cited by 101

Caffeic Acid Targets AMPK Signaling and Regulates Tricarboxylic Acid Cycle Anaplerosis while Metformin Downregulates HIF-1α-Induced Glycolytic Enzymes in Human Cervical Squamous Cell Carcinoma Lines

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Extraction of lignin and therapeutic applications of lignin-derived compounds. A review

Spiridon, I. (2020) · Environmental Chemistry Letters · doi:10.1007/s10311-020-00981-3 · Cited by 88

Contents of chlorogenic acids and caffeine in various coffee-related products

Jeon, J., Kim, H.-T., Jeong, I., Hong, S., Oh, M.-S., Yoon, M., Shim, J., Jeong, J. H., & El‐Aty, A. M. A. (2019) · Journal of Advanced Research · doi:10.1016/j.jare.2019.01.002 · Cited by 91

Chlorogenic acid ameliorates experimental colitis in mice by suppressing signaling pathways involved in inflammatory response and apoptosis

Vukelić, I., Detel, D., Batičić, L., Potočnjak, I., Buljević, S., & Domitrović, R. (2018) · Food and Chemical Toxicology · doi:10.1016/j.fct.2018.08.061 · Cited by 86

The effect of artichoke on lipid profile: A review of possible mechanisms of action

Santos, H. O., Bueno, A. A., & Mota, J. F. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.10.007 · Cited by 90

Identification and Recovery of Valuable Bioactive Compounds from Potato Peels: A Comprehensive Review

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Hydroxycinnamic Acids and Derivatives Formulations for Skin Damages and Disorders: A Review

Contardi, M., Lenzuni, M., Fiorentini, F., Summa, M., Bertorelli, R., Suarato, G., & Athanassiou, A. (2021) · Pharmaceutics · doi:10.3390/pharmaceutics13070999 · Cited by 91

Dietary polyphenols in lipid metabolism: A role of gut microbiome

Ma, J., Zheng, Y., Tang, W., Yan, W., Nie, H., Fang, J. Q., & Liu, G. (2020) · Animal nutrition · doi:10.1016/j.aninu.2020.08.002 · Cited by 87

Ocimum Species: A Review on Chemical Constituents and Antibacterial Activity

Dharsono, H. D. A., Putri, S. A., Kurnia, D., Dudi, D., & Satari, M. H. (2022) · Molecules · doi:10.3390/molecules27196350 · Cited by 96

Development of natural deep eutectic solvent (NADES) based on choline chloride as a green solvent to extract phenolic compound from coffee husk waste

Maimulyanti, A., Nurhidayati, I., Mellisani, B., Putri, F. A. R., Puspita, F., & Prihadi, A. R. (2023) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2023.104634 · Cited by 94

Therapeutic Promises of Chlorogenic Acid with Special Emphasis on its Anti-Obesity Property

Kumar, R., Sharma, A., Iqbal, M. S., & Srivastava, J. K. (2019) · Current Molecular Pharmacology · doi:10.2174/1874467212666190716145210 · Cited by 81

Chlorogenic Acid Alleviates LPS-Induced Inflammation and Oxidative Stress by Modulating CD36/AMPK/PGC-1α in RAW264.7 Macrophages

Gu, T., Zhang, Z., Liu, J., Chen, L., Tian, Y., Xu, W., Zeng, T., Wu, W., & Lu, L. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713516 · Cited by 93

Chlorogenic Acid Prevents UVA-Induced Skin Photoaging through Regulating Collagen Metabolism and Apoptosis in Human Dermal Fibroblasts

Xue, N., Liu, Y., Jin, J., Ji, M. H., & Chen, X. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23136941 · Cited by 82

Antioxidant potential and phenolic composition of extracts from Stachys tmolea: An endemic plant from Turkey

Elfalleh, W., Kırkan, B., & Sarıkürkçü, C. (2018) · Industrial Crops and Products · doi:10.1016/j.indcrop.2018.10.078 · Cited by 80

Adsorption and desorption of chlorogenic acid by macroporous adsorbent resins during extraction of Eucommia ulmoides leaves

Jiang, H., Li, J., Chen, L., & Wang, Z. (2020) · Industrial Crops and Products · doi:10.1016/j.indcrop.2020.112336 · Cited by 80

Recent advances and trends in extraction techniques to recover polyphenols compounds from apple by-products

da Silva, L. C., Viganó, J., de Souza Mesquita, L. M., Dias, A. L. B., de Souza, M. C., Sanches, V. L., Chaves, J. O., Pizani, R. S., Contieri, L. S., & Rostagno, M. A. (2021) · Food Chemistry: X · doi:10.1016/j.fochx.2021.100133 · Cited by 78

Chemical Constituents and Biologic Activities of Sage Species: A Comparison between Salvia officinalis L., S. glutinosa L. and S. transsylvanica (Schur ex Griseb. & Schenk) Schur

Mocan, A., Babotă, M., Pop, A., Fizeșan, I., Diuzheva, A., Locatelli, M., Carradori, S., Campestre, C., Menghini, L., Sisea, C. R., et al. (2020) · Antioxidants · doi:10.3390/antiox9060480 · Cited by 84

Zn(II) Complex of Plant Phenolic Chlorogenic Acid: Antioxidant, Antimicrobial and Structural Studies

Kalinowska, M., Sienkiewicz-Gromiuk, J., Świderski, G., Pietryczuk, A., Cudowski, A., & Lewandowski, W. (2020) · Materials · doi:10.3390/ma13173745 · Cited by 79

Polyphenols as potential metabolism mechanisms regulators in liver protection and liver cancer prevention

Li, S., Yin, S., Ding, H., Shao, Y., Zhou, S., Pu, W., Han, L., Wang, T., & Yu, H. (2022) · Cell Proliferation · doi:10.1111/cpr.13346 · Cited by 85

Polyphenols from Stevia rebaudiana (Bertoni) leaves and their functional properties

Myint, K. Z., Wu, K., Xia, Y., Ye, F., Shen, J., Zhang, P., & Gu, J. (2020) · Journal of Food Science · doi:10.1111/1750-3841.15017 · Cited by 106

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Rodríguez, G. R. V., Quero, J., Osada, J., Martín‐Belloso, O., & Rodriguez‐Yoldi, M. J. (2021) · Biomolecules · doi:10.3390/biom11070977 · Cited by 77

Comparison between polyphenol profile and bioactive response in blackthorn (Prunus spinosa L.) genotypes from north Serbia-from raw data to PCA analysis

Popović, B. M., Blagojević, B., Pavlović, R. Ž., Mićić, N., Bijelić, S., Bogdanovic, B., Mišan, A. Č., Duarte, C. M. M., & Serra, T. (2019) · Food Chemistry · doi:10.1016/j.foodchem.2019.125373 · Cited by 77

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Dkhil, M. A., Moneim, A. E. A., Bauomy, A. A., Khalil, M., Al‐Shaebi, E. M., & Al‐Quraishy, S. (2019) · Molecular Biology Reports · doi:10.1007/s11033-019-05217-4 · Cited by 76

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Cai, Z., Wang, C., Zou, L., Liu, X., Chen, J., Tan, M., Mei, Y., & Wei, L. (2019) · Molecules · doi:10.3390/molecules24101936 · Cited by 75

Untargeted Mass Spectrometry-Based Metabolomics Tracks Molecular Changes in Raw and Processed Foods and Beverages

Gauglitz, J. M., Aceves, C. M., Aksenov, A. A., Aleti, G., Almaliti, J., Bouslimani, A., Brown, E. A. R., Campeau, A., Caraballo‐Rodríguez, A. M., Chaar, R., et al. (2018) · Food Chemistry · doi:10.1016/j.foodchem.2019.125290 · Cited by 78

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Gaudino, E. C., Colletti, A., Grillo, G., Tabasso, S., & Cravotto, G. (2020) · Foods · doi:10.3390/foods9111598 · Cited by 84

Physiological Effects and Human Health Benefits of Hibiscus sabdariffa: A Review of Clinical Trials

Montalvo‐González, E., Villagrán, Z., González-Torres, S., Iñiguez-Muñoz, L. E., Isiordia‐Espinoza, M. A., Ruvalcaba-Gómez, J. M., Arteaga-Garibay, R. I., Acosta, J., González‐Silva, N., & Esparza, L. M. A. (2022) · Pharmaceuticals · doi:10.3390/ph15040464 · Cited by 74

Fruit waste management by pigment production and utilization of residual as bioadsorbent

Gupta, N., Poddar, K., Sarkar, D., Kumari, N., Padhan, B., & Sarkar, A. (2019) · Journal of Environmental Management · doi:10.1016/j.jenvman.2019.05.055 · Cited by 73

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Sun, Z., Zhang, X., Wu, H., Wang, H., Bian, H., Zhu, Y., Xu, W., Liu, F., Wang, D., & Fu, L. (2020) · World Journal of Microbiology and Biotechnology · doi:10.1007/s11274-020-2799-2 · Cited by 72

Polyphenols in foods: Classification, methods of identification, and nutritional aspects in human health

Zhang, L., Han, Z., & Granato, D. (2021) · Advances in food and nutrition research · doi:10.1016/bs.afnr.2021.02.004 · Cited by 71

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Xie, M., Fei, Y. Q., Wang, Y., Wang, W. Y., & Wang, Z. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/3456542 · Cited by 67

Chemical composition, antioxidant, antimicrobial and antiproliferative activities of the extracts isolated from the pomace of rowanberry (Sorbus aucuparia L.)

Bobinaitė, R., Grootaert, C., Camp, J. V., Šarkinas, A., Liaudanskas, M., Žvikas, V., Viškelis, P., & Venskutonis, P. R. (2020) · Food Research International · doi:10.1016/j.foodres.2020.109310 · Cited by 66

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Ruan, J., Yan, J., Zheng, D., Sun, F., Wang, J., Han, L., Zhang, Y., & Wang, T. (2019) · Molecules · doi:10.3390/molecules24152784 · Cited by 65

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Sotto, A. D., Giacomo, S. D., Amatore, D., Locatelli, M., Vitalone, A., Toniolo, C., Rotino, G. L., Scalzo, R. L., Palamara, A. T., Marcocci, M. E., et al. (2018) · Molecules · doi:10.3390/molecules23082066 · Cited by 64

Recent progress in the study of Artemisiae Scopariae Herba (Yin Chen), a promising medicinal herb for liver diseases

Cai, Y., Zheng, Q., Sun, R., Wu, J., Li, X., & Liu, R. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110513 · Cited by 63

Potential nutraceutical and food additive properties and risks of coffee: a comprehensive overview

Saeed, M., Naveed, M., Bibi, J., Kamboh, A. A., Phil, L., & Sun, C. (2019) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2018.1489368 · Cited by 68

Natural products for the prevention and treatment of cholestasis: A review

Ma, X., Jiang, Y., Zhang, W., Wang, J., Wang, R., Wang, L., Wei, S., Wen, J., Li, H., & Zhao, Y. (2020) · Phytotherapy Research · doi:10.1002/ptr.6621 · Cited by 62

Chlorogenic Acid Metabolism: The Evolution and Roles in Plant Response to Abiotic Stress

Soviguidi, D. R. J., Pan, R., Liu, Y., Rao, L.-P., Zhang, W., & Yang, X. (2021) · Phyton · doi:10.32604/phyton.2022.018284 · Cited by 62

Antioxidant and Anti-Inflammatory Activity of Coffee Brew Evaluated after Simulated Gastrointestinal Digestion

Castaldo, L., Toriello, M., Sessa, R., Izzo, L., Lombardi, S., Narváez, A., Ritieni, A., & Grosso, M. (2021) · Nutrients · doi:10.3390/nu13124368 · Cited by 68

Effects of chlorogenic acid on growth, metabolism, antioxidation, immunity, and intestinal flora of crucian carp (Carassius auratus)

Jin, X., Su, M., Liang, Y., & Li, Y. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2022.1084500 · Cited by 62

CHLOROGENIC ACID: A PHARMACOLOGICALLY POTENT MOLECULE.

Maalik, A., Bukhari, S. M., Zaidi, A., Shah, K. H., & Khan, F. A. (2016) · PubMed · Cited by 41

A deeper insight into the pharmacological and biochemical effects of chlorogenic acid: a review article

Alenazi, A., Elkhoely, A. A., Kabel, A., & Eissa, A. A. (2026) · Journal of Advanced Pharmacy Research · doi:10.21608/aprh.2025.446825.1348

Roles of Chlorogenic Acid on Regulating Glucose and Lipids Metabolism: A Review

Meng, S., Cao, J., Feng, Q., Peng, J., & Hu, Y. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/801457 · Cited by 619

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Singh, A. K., Singla, R. K., & Pandey, A. K. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220816154634 · Cited by 118

Chlorogenic acid: A comprehensive review of the dietary sources, processing effects, bioavailability, beneficial properties, mechanisms of action, and future directions

Lu, H., Tian, Z., Cui, Y., Liu, Z., & Ma, X. (2020) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12620 · Cited by 476