The emerging role of ferroptosis in inflammation

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029

Cynaroside improved depressive-like behavior in CUMS mice by suppressing microglial inflammation and ferroptosis

Zhou, Y., Huang, Y., Ye, W., Chen, Z., & Yuan, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116425 · Cited by 66

Role of PKM2-Mediated Immunometabolic Reprogramming on Development of Cytokine Storm

Liu, Z., Le, Y., Chen, H., Zhu, J., & Lu, D. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.748573 · Cited by 66

Nitrogen-doped graphene quantum dots induce ferroptosis through disrupting calcium homeostasis in microglia

Wu, T., Wang, X., Cheng, J., Xue, L., Li, Y., Chen, M., Kong, L., & Tang, M. (2022) · Particle and Fibre Toxicology · doi:10.1186/s12989-022-00464-z · Cited by 64

Understanding the mechanistic roles of environmental heavy metal stressors in regulating ferroptosis: adding new paradigms to the links with diseases

Sahoo, K., & Sharma, A. (2023) · APOPTOSIS · doi:10.1007/s10495-022-01806-0 · Cited by 68

Circulating cell-free DNA, peripheral lymphocyte subsets alterations and neutrophil lymphocyte ratio in assessment of COVID-19 severity

Hammad, R., Eldosoky, M. A. E. R., Fouad, S. H., Elgendy, A.-E. A.-E., Tawfeik, A. M., Alboraie, M. A. A., & Abdelmaksoud, M. F. (2021) · Innate Immunity · doi:10.1177/1753425921995577 · Cited by 63

NVP-AUY922 alleviates radiation-induced lung injury via inhibition of autophagy-dependent ferroptosis

Li, L., Wu, D., Deng, S., Li, J., Zhang, F., Zou, Y., Zhang, T., & Xu, Y. X. (2022) · Cell Death Discovery · doi:10.1038/s41420-022-00887-9 · Cited by 64

Ferroptosis-related gene signature predicts the prognosis of papillary thyroid carcinoma

Shi, J., Wu, P., Sheng, L., Sun, W., & Zhang, H. (2021) · Cancer Cell International · doi:10.1186/s12935-021-02389-7 · Cited by 62

Association between iron status and the risk of adverse outcomes in COVID-19

Lv, Y., Chen, L., Liang, X., Liu, X., Gao, M., Wang, Q., Wei, Q., & Liu, L. (2020) · Clinical Nutrition · doi:10.1016/j.clnu.2020.11.033 · Cited by 61

Ferroptosis as a mechanism of oligodendrocyte loss and demyelination in experimental autoimmune encephalomyelitis

Li, X., Chu, Y., Ma, R., Dou, M., Li, S., Song, Y., Lv, Y., & Zhu, L. D. (2022) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2022.577995 · Cited by 62

lncRNA ZFAS1 Positively Facilitates Endothelial Ferroptosis via miR‐7‐5p/ACSL4 Axis in Diabetic Retinopathy

Liu, Y., Zhang, Z., Yang, J., Wang, J., Wu, Y., Zhu, R., Liu, Q., & Xie, P. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9004738 · Cited by 59

Vitexin Improves Cerebral ischemia‑reperfusion Injury by Attenuating Oxidative Injury and Ferroptosis via Keap1/Nrf2/HO-1signaling

Guo, L., & Shi, L. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03829-0 · Cited by 60

Moderate Intensity of Treadmill Exercise Rescues TBI-Induced Ferroptosis, Neurodegeneration, and Cognitive Impairments via Suppressing STING Pathway

Chen, J., Zhu, T., Yu, D., Yan, B., Zhang, Y., Jin, J., Yang, Z., Zhang, B., Hao, X., Chen, Z., et al. (2023) · Molecular Neurobiology · doi:10.1007/s12035-023-03379-8 · Cited by 60

Fatal COVID-19 pulmonary disease involves ferroptosis

Qiu, B., Zandkarimi, F., Saqi, A., Castagna, C., Tan, H., Sekulic, M., Miorin, L., Hibshoosh, H. H., Toyokuni, S., Uchida, K., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-48055-0 · Cited by 62

Sevoflurane inhibits ferroptosis: A new mechanism to explain its protective role against lipopolysaccharide-induced acute lung injury

Liu, X., Wang, L., Xing, Q., Li, K., Si, J., Ma, X., & Mao, L. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119391 · Cited by 58

Research progress on ferroptosis in diabetic kidney disease

Wu, Y., & Chen, Y. (2022) · Frontiers in Endocrinology · doi:10.3389/fendo.2022.945976 · Cited by 58

The roles and mechanisms of SREBP1 in cancer development and drug response

He, Y., Qi, S., Chen, L., Zhu, J., Liang, L., Chen, X., Zhang, H., Zhuo, L., Zhao, S., Liu, S., et al. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.04.022 · Cited by 58

Injectable bioadhesive hydrogel as a local nanomedicine depot for targeted regulation of inflammation and ferroptosis in rheumatoid arthritis

Yang, R., Yan, L., Xu, T., Zhang, K., Lu, X., Xie, C., & Fu, W. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122706 · Cited by 58

CYLD regulates cell ferroptosis through Hippo/YAP signaling in prostate cancer progression

Gu, Y., Wu, S., Fan, J., Meng, Z., Gao, G., Liu, T., Wang, Q., Xia, H., Wang, X., & Wu, K. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-06464-5 · Cited by 57

Recent Advances in the Inhibition of Membrane Lipid Peroxidation by Food-Borne Plant Polyphenols via the Nrf2/GPx4 Pathway

Zhang, M., Liu, J., Yu, Y., Liu, X., Shang, X., Du, Z., Xu, M., & Zhang, T. (2024) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.4c00523 · Cited by 66

Fibroblast ferroptosis is involved in periodontitis-induced tissue damage and bone loss

Lü, X., Dong, W., Chen, Y., Dai, W., Xiao, X., Liu, Z., Zhang, X., Bai, D., & Xu, H. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.109607 · Cited by 56

Scutellarein alleviates chronic obstructive pulmonary disease through inhibition of ferroptosis by chelating iron and interacting with arachidonate 15‐lipoxygenase

Liu, L., Zhang, Y., Wang, L., Liu, Y., Chen, H., Hu, Q., Xie, C., Meng, X., & Shen, X. (2023) · Phytotherapy Research · doi:10.1002/ptr.7928 · Cited by 56

Bioinformatics analysis of ferroptosis in spinal cord injury

Li, J.-Z., Fan, B.-Y., Sun, T., Wang, X.-X., Li, J.-J., Zhang, J.-P., Gu, G.-J., Shen, W., Liu, D.-R., Wei, Z.-J., et al. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350209 · Cited by 55

TMEM43 Protects against Sepsis-Induced Cardiac Injury via Inhibiting Ferroptosis in Mice

Chen, Z., Cao, Z., Gui, F., Zhang, M., Wu, X. G., Peng, H., Yu, B., Li, W., Ai, F., & Zhang, J. (2022) · Cells · doi:10.3390/cells11192992 · Cited by 57

Nanotechnology-enabled M2 macrophage polarization and ferroptosis inhibition for targeted inflammatory bowel disease treatment

Zhao, Y., Yin, W., Yang, Z., Sun, J., Chang, J., Huang, L., Xue, L., Zhang, X., Zhi, H., Chen, S., et al. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.01.051 · Cited by 55

Mucin 1 Inhibits Ferroptosis and Sensitizes Vitamin E to Alleviate Sepsis‐Induced Acute Lung Injury through GSK3 β /Keap1‐Nrf2‐GPX4 Pathway

Wang, Y., Gong, F., Qi, X., Zheng, Y., Zheng, X.-T., Chen, Y., Yang, Z., Qing-Ye, Mao, E., & Chen, E. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2405943 · Cited by 54

Mesenchymal Stem Cell‐Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO‐1 Signaling Pathway

Liu, J., Huang, J., Zhang, Z., Zhang, R., Sun, Q., Zhang, Z., Liu, Y., & Ma, B. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/3593294 · Cited by 54

Targeting ferroptosis: a new therapeutic opportunity for kidney diseases

Long, Z., Luo, Y., Yu, M., Wang, X., Zeng, L., & Yang, K. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1435139 · Cited by 59

Simvastatin inhibits hepatic stellate cells activation by regulating the ferroptosis signaling pathway

Kitsugi, K., Noritake, H., Matsumoto, M., Hanaoka, T., Umemura, M., Yamashita, M., Takatori, S., Ito, J., Ohta, K., Chida, T., et al. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2023.166750 · Cited by 53

MafG/MYH9-LCN2 axis promotes liver fibrosis through inhibiting ferroptosis of hepatic stellate cells

Deng, Y., Lu, L., Zhu, D., Zhang, H., Fu, Y., Tan, Y., Tan, X., Guo, M., Zhang, Y., Yang, H., et al. (2024) · Cell Death and Differentiation · doi:10.1038/s41418-024-01322-5 · Cited by 53

Silica Nanoparticles Cause Activation of NLRP3 Inflammasome in-vitro Model-Using Microglia

Hou, S., Li, C., Wang, Y., Sun, J., Guo, Y., Ning, X., Ma, K., Li, X., Shao, H., Cui, G., et al. (2022) · International Journal of Nanomedicine · doi:10.2147/ijn.s372485 · Cited by 51

Airborne Fine Particulate Matter (Pm2.5) Damages the Inner Blood–Retinal Barrier by Inducing Inflammation and Ferroptosis in Retinal Vascular Endothelial Cells

Gu, Y., Hao, S., Liu, K., Gao, M., Lu, B., Sheng, F., Zhang, L., Xu, Y., Wu, D., Han, Y., et al. (2022) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2022.156563 · Cited by 50

SARS-CoV-2 ORF3a sensitizes cells to ferroptosis via Keap1-NRF2 axis

Liu, L., Du, J., Yang, S., Zheng, B., Shen, J., Huang, J., Cao, L., Huang, S., Liu, X., Guo, L., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102752 · Cited by 53

Ferroptosis-related signature and immune infiltration characterization in acute lung injury/acute respiratory distress syndrome

Ma, A., Feng, Z., Yang, L. J., Wu, Q., Xiong, H., Dong, M., Cheng, J., Wang, Z., Yang, J. Y., & Kang, Y. (2023) · Respiratory Research · doi:10.1186/s12931-023-02429-y · Cited by 50

Nrf2‐Mediated Ferroptosis Inhibition Exerts a Protective Effect on Acute‐on‐Chronic Liver Failure

Wu, J., Xue, R., Wu, M., Yin, X., Xie, B., & Meng, Q. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/4505513 · Cited by 50

Inhibition of the IRE1/JNK pathway in renal tubular epithelial cells attenuates ferroptosis in acute kidney injury

Liang, Y., Liu, Z., Qu, L., Wang, Y., Zhou, Y., Liang, L., Guo, Y., & Tang, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.927641 · Cited by 50

β-Caryophyllene Acts as a Ferroptosis Inhibitor to Ameliorate Experimental Colitis

Wu, Y., Zhong, L., Huang, C., Guo, Y., Jin, F., Hu, Y., Zhao, Z.-B., Ren, Z., & Wang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232416055 · Cited by 52

Salidroside postconditioning attenuates ferroptosis-mediated lung ischemia-reperfusion injury by activating the Nrf2/SLC7A11 signaling axis

Wang, Y., Chen, Z., Luo, J., Zhang, J., Sang, A., Cheng, Z.-S., & Li, X. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.109731 · Cited by 49

Ferroptosis contribute to neonicotinoid imidacloprid-evoked pyroptosis by activating the HMGB1-RAGE/TLR4-NF-κB signaling pathway

Zhang, D., Wu, C., Ba, D., Wang, N., Wang, Y., Li, X., Li, Q., & Zhao, G. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.114655 · Cited by 49

H1N1 influenza virus infection through NRF2-KEAP1-GCLC pathway induces ferroptosis in nasal mucosal epithelial cells

Liu, C., Wu, X., Bing, X., Qi, W., Zhu, F., Guo, N., Li, C., Gao, X., Cao, X., Zhao, M., et al. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.05.004 · Cited by 50

Beneficial effects of oxymatrine from Sophora flavescens on alleviating Ulcerative colitis by improving inflammation and ferroptosis

Gao, B. B., Wang, L., Li, L.-Z., Fei, Z., Wang, Y. Y., Zou, X., Huang, M. C., Lei, S. S., & Li, B. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.118385 · Cited by 48

Diosmetin alleviates S. aureus-induced mastitis by inhibiting SIRT1/GPX4 mediated ferroptosis

Zhao, L., Jin, L., & Yang, B. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.122060 · Cited by 48

The Role of Ferroptosis in Acute Respiratory Distress Syndrome

Qu, M., Zhang, H., Chen, Z., Sun, X., Zhu, S., Nan, K., Chen, W., & Miao, C. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.651552 · Cited by 49

Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation

Qu, X., Sun, Z., Wang, Y., & Ong, H. S. (2021) · PeerJ · doi:10.7717/peerj.12510 · Cited by 48

Cooperation effects of radiation and ferroptosis on tumor suppression and radiation injury

Su, J., Bian, C., Zheng, Z., Wang, H., Meng, L., Xin, Y., & Jiang, X. M. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.951116 · Cited by 48

Interaction between ferroptosis and TNF ‐α: Impact in obesity‐related osteoporosis

Chen, X., Liu, C., Yu, R., Gan, Z., Zhang, Z., Chen, Z., Liu, Y., Wu, D., Yu, X., Liu, C., et al. (2023) · The FASEB Journal · doi:10.1096/fj.202201958r · Cited by 44

Triapine/Ce6-loaded and lactose-decorated nanomicelles provide an effective chemo-photodynamic therapy for hepatocellular carcinoma through a reactive oxygen species-boosting and ferroptosis-inducing mechanism

Zhang, P., Liu, C., Wu, W., Mao, Y., Qin, Y., Hu, J., Jing Hua, H. U., Fu, J., Hua, D., & Yin, J. (2021) · Chemical Engineering Journal · doi:10.1016/j.cej.2021.131543 · Cited by 45

Deciphering The Emerging Role of Programmed Cell Death in Diabetic Wound Healing

Song, J., Zhu, K., Wang, H., Wu, M., Wu, Y., & Zhang, Q. (2023) · International Journal of Biological Sciences · doi:10.7150/ijbs.88461 · Cited by 49

miRNA Involvement in Cerebral Ischemia-Reperfusion Injury

Neag, M. A., Mitre, A. O., Burlacu, C.-C., Inceu, A.-I., Mihu, C., Melincovici, C. S., Bichescu, M., & Buzoianu, A. D. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.901360 · Cited by 44

Discovery of decreased ferroptosis in male colorectal cancer patients with KRAS mutations

Yan, H. Y., Talty, R., Jain, A., Cai, Y. A., Zheng, J., Shen, X., Muca, E., Paty, P. B., Bosenberg, M., Khan, S. A., et al. (2023) · Redox Biology · doi:10.1016/j.redox.2023.102699 · Cited by 44

BRCC36 Deubiquitinates HMGCR to Regulate the Interplay Between Ferroptosis and Pyroptosis

Wang, H., Shu, L., Lv, C., Liu, N., Long, Y., Peng, X., Ling, H., Tao, T., Tang, J., Cheng, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202304263 · Cited by 48

The ERK-cPLA2-ACSL4 axis mediating M2 macrophages ferroptosis impedes mucosal healing in ulcerative colitis

Ye, Y., Liu, L., Feng, Z., Liu, Y., Miao, J., Wei, X., Li, H., Yang, J., Cao, X., & Zhao, J. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.02.016 · Cited by 47

PRDX6-mediated pulmonary artery endothelial cell ferroptosis contributes to monocrotaline-induced pulmonary hypertension

Liao, J., Xie, S., Deng, Y., Wu, D., Meng, H., Lan, W., & Dai, P. (2022) · Microvascular Research · doi:10.1016/j.mvr.2022.104471 · Cited by 42

Inhibition of ferroptosis underlies EGCG mediated protection against Parkinson’s disease in a Drosophila model

Xia, Y., Wang, H., Xie, Z., Liu, Z., & Wang, H.-L. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.12.005 · Cited by 45

Iron homeostasis and neurodegeneration in the ageing brain: Insight into ferroptosis pathways

Alrouji, M., Anwar, S., Venkatesan, K., Shahwan, M. J., Hassan, M. I., Islam, A., & Shamsi, A. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102575 · Cited by 45

SENP1 inhibition suppresses the growth of lung cancer cells through activation of A20-mediated ferroptosis

Gao, C., Xiao, F., Zhang, L., Sun, Y., Wang, L., Liu, X., Sun, H., Xie, Z., Liang, Y., Xu, Q., et al. (2022) · Annals of Translational Medicine · doi:10.21037/atm-21-6909 · Cited by 43

S100A8 regulates autophagy-dependent ferroptosis in microglia after experimental subarachnoid hemorrhage

Tao, Q., Qiu, X., Li, C., Zhou, J., Gu, L., Zhang, L., Pang, J., Zhang, L., Yin, S., Jiang, Y. Q., et al. (2022) · Experimental Neurology · doi:10.1016/j.expneurol.2022.114171 · Cited by 42

Molecular Mechanisms of the Anti-Inflammatory Effects of Epigallocatechin 3-Gallate (EGCG) in LPS-Activated BV-2 Microglia Cells

Payne, A., Taka, E., Adinew, G. M., & Soliman, K. F. A. (2023) · Brain Sciences · doi:10.3390/brainsci13040632 · Cited by 40

Circular RNA circACAP2 Suppresses Ferroptosis of Cervical Cancer during Malignant Progression by miR-193a-5p/GPX4

Liu, Y., Li, L., Yang, Z., Wen, D., & Hu, Z. (2022) · Journal of Oncology · doi:10.1155/2022/5228874 · Cited by 41

Novel druggable mechanism of Parkinson's disease: Potential therapeutics and underlying pathogenesis based on ferroptosis

Jiang, X., Wu, K., Ye, X., Xie, T., Zhang, P., Blass, B. E., & Bai, R. (2023) · Medicinal Research Reviews · doi:10.1002/med.21939 · Cited by 40

GPX4 restricts ferroptosis of NKp46+ILC3s to control intestinal inflammation

Li, X., He, J., Gao, X., Zheng, G., Chen, C., Chen, Y., Xing, Z., Wang, T., Tang, J., Guo, Y., et al. (2024) · Cell Death and Disease · doi:10.1038/s41419-024-07060-3 · Cited by 40

Ferroptosis meets inflammation: A new frontier in cancer therapy

Liu, H., Xue, H., Guo, Q., Xue, X., Yang, L., Zhao, K., & Liu, Y. (2025) · Cancer Letters · doi:10.1016/j.canlet.2025.217696 · Cited by 44

Ferroptosis plays an important role in promoting ionizing radiation-induced intestinal injuries

Wang, L., Wang, A., Fu, Q., Shi, Z., Chen, X., Wang, Y., Xu, W., Wang, T., Zhang, S., & Hu, S. (2022) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2022.01.068 · Cited by 42

Atorvastatin attenuates ferroptosis-dependent myocardial injury and inflammation following coronary microembolization via the Hif1a/Ptgs2 pathway

Liu, T., Shu, J., Liu, Y., Xie, J. W., Li, T., Li, H., & Li, L. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1057583 · Cited by 39

Exploration and breakthrough in the mode of chondrocyte death - A potential new mechanism for osteoarthritis

Chen, B., Wang, L., Xie, D., & Wang, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115990 · Cited by 39

Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells

Zhou, D., Mei, Y., Song, C., Cheng, K., Cai, W., Guo, D., Gao, S., Lv, J., Liu, T., Zhou, Y., et al. (2024) · European Journal of Clinical Investigation · doi:10.1111/eci.14226 · Cited by 39

Mini-Review: GSDME-Mediated Pyroptosis in Diabetic Nephropathy

Li, W., Sun, J., Zhou, X., Lu, Y., Cui, W., & Miao, L. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.780790 · Cited by 40

CNS Redox Homeostasis and Dysfunction in Neurodegenerative Diseases

Goldsteins, G., Hakosalo, V., Jaronen, M., Keuters, M. H., Lehtonen, Š., & Koıstınaho, J. (2022) · Antioxidants · doi:10.3390/antiox11020405 · Cited by 42

Lipocalin-2 in neutrophils induces ferroptosis in septic cardiac dysfunction via increasing labile iron pool of cardiomyocytes

Huang, Y., Zhang, N., Xie, C., You, Y., Guo, L., Ye, F., Xie, X., & Wang, J. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.922534 · Cited by 38

Jing-Fang n-butanol extract and its isolated JFNE-C inhibit ferroptosis and inflammation in LPS induced RAW264.7 macrophages via STAT3/p53/SLC7A11 signaling pathway

Li, X., Qi, H., Zhang, X., Liang, H., & Zeng, N. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116689 · Cited by 38

Peroxiredoxin 6 suppresses ferroptosis in lung endothelial cells

Torres-Velarde, J. M., Allen, K. N., Salvador‐Pascual, A., Leija, R. G., Luong, D., Moreno-Santillán, D. D., Ensminger, D. C., & Vázquez‐Medina, J. P. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.208 · Cited by 44

The Potential Role of Ferroptosis in Systemic Lupus Erythematosus

Chen, Q., Wang, J., Xiang, M., Wang, Y., Zhang, Z., Liang, J. F., & Xu, J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.855622 · Cited by 38

The role of ferroptosis in fish inflammation

Gao, F., Shi, X., Pei, C., Zhao, X., Zhu, L., Zhang, J., Li, L., Li, C., & Kong, X. (2022) · Reviews in Aquaculture · doi:10.1111/raq.12719 · Cited by 38

Gualou-Xiebai herb pair ameliorate atherosclerosis in HFD-induced ApoE−/− mice and inhibit the ox-LDL-induced injury of HUVECs by regulating the Nrf2-mediated ferroptosis

Zhu, L., Bao, Y., Liu, Z., Liu, J., Li, Z., Sun, X., Zhou, A., & Wu, H. (2024) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2024.117892 · Cited by 37

Ferroptosis in organ ischemia–reperfusion injuries: recent advancements and strategies

Luan, X., Chen, P., Miao, L., Yuan, X., Yu, C., & Di, G.-H. (2024) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-024-04978-2 · Cited by 36

RNA N4‐acetylcytidine modification and its role in health and diseases

Wang, Q., Yuan, Y., Zhou, Q., Jia, Y., Liu, J. L., Xiao, G., Li, C., & Jiang, X. (2025) · MedComm · doi:10.1002/mco2.70015 · Cited by 40

Ferroptosis in Cancer and Inflammatory Diseases: Mechanisms and Therapeutic Implications

Shen, G., Liu, J., Wang, Y., Deng, Z., & Deng, F. (2025) · MedComm · doi:10.1002/mco2.70349 · Cited by 47

Farrerol alleviates collagenase‐induced tendinopathy by inhibiting ferroptosis in rats

Wu, Y., Qian, J., Li, K., Li, W., Yin, W., & Jiang, H. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17388 · Cited by 36

Narrative review of ferroptosis in obesity

He, L., Zhou, Z., & Li, C. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17701 · Cited by 36

Effects of Chronic Heat Stress on Growth, Apoptosis, Antioxidant Enzymes, Transcriptomic Profiles, and Immune-Related Genes of Hong Kong Catfish (Clarias fuscus)

Liu, Y., Tian, C., Yang, Z., Huang, C., Jiao, K.-Z., Yang, L., Duan, C., Zhang, Z., & Li, G. (2024) · Animals · doi:10.3390/ani14071006 · Cited by 36

Peroxisomal homeostasis in metabolic diseases and its implication in ferroptosis

Han, J., Zheng, D., Liu, P.-S., Wang, S., & Xie, X. (2024) · Cell Communication and Signaling · doi:10.1186/s12964-024-01862-w · Cited by 37

Old and New Players of Inflammation and Their Relationship With Cancer Development

Chavez-Dominguez, R., Perez-Medina, M., Aguilar‐Cázares, D., Galicia-Velasco, M., Meneses-Flores, M., Islas-Vázquez, L., Camarena, Á., & López-González, J. S. (2021) · Frontiers in Oncology · doi:10.3389/fonc.2021.722999 · Cited by 40

Ferroptosis Inhibitors as Potential New Therapeutic Targets for Cardiovascular Disease

Farzipour, S., Shaghaghi, Z., Motieian, S., Alvandi, M., Yazdi, A., Asadzadeh, B., & Abbasi, S. (2022) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557522666220218123404 · Cited by 37

Ferroptosis Involvement in Glioblastoma Treatment

Mitre, A. O., Florian, I. A., Buruiană, A., Boer, A., Moldovan, I. M., Şoriţău, O., Florian, I. Ş., & Șușman, S. (2022) · Medicina · doi:10.3390/medicina58020319 · Cited by 39

SARS-CoV-2 Infection Dysregulates Host Iron (Fe)-Redox Homeostasis (Fe-R-H): Role of Fe-Redox Regulators, Ferroptosis Inhibitors, Anticoagulants, and Iron-Chelators in COVID-19 Control

Naidu, S. A. G., Clemens, R., & Naidu, A. S. (2022) · Journal of Dietary Supplements · doi:10.1080/19390211.2022.2075072 · Cited by 40

GCH1 reduces LPS-induced alveolar macrophage polarization and inflammation by inhibition of ferroptosis

Xiao, Y., Yuan, Y., Yang, Y., Liu, B., Ding, Z., Luo, J., Chen, S., & Yu, L. (2023) · Inflammation Research · doi:10.1007/s00011-023-01785-1 · Cited by 35

Curcumin-loaded biomimetic nanosponges for osteoarthritis alleviation by synergistically suppressing inflammation and ferroptosis

Xu, H., Liu, S., Wei, Y., Cao, S., Deng, J., Li, G., Sheng, W., Qi, T., Zhang, P., Lin, J., et al. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.152132 · Cited by 35

Ru single-atom nanozymes targeting ROS-ferroptosis pathways for enhanced endometrial regeneration in intrauterine adhesion therapy

Liang, Y., Meng, J., Yu, Z., Guo, Y., Zhang, X., Yan, Y., Du, S., Jin, S., Li, J., Yang, H., et al. (2024) · Biomaterials · doi:10.1016/j.biomaterials.2024.122923 · Cited by 37

Ferroptosis in Intracerebral Hemorrhage: A Panoramic Perspective of the Metabolism, Mechanism and Theranostics

Lu, C., Tan, C., Ouyang, H., Chen, Z., Yan, Z., & Zhang, M. (2022) · Aging and Disease · doi:10.14336/ad.2022.01302 · Cited by 37

Unraveling the interplay between iron homeostasis, ferroptosis and extramedullary hematopoiesis

Fernández-García, V., González-Ramos, S., Martín‐Sanz, P., Castrillo, A., & Boscá, L. (2022) · Pharmacological Research · doi:10.1016/j.phrs.2022.106386 · Cited by 35

Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis

Zhang, K., Wu, Y., Chen, G., Wang, H., Liu, Y., & Zhou, Y. (2023) · Cancer Cell International · doi:10.1186/s12935-023-02848-3 · Cited by 33

Inhibition of ferroptosis ameliorates hypertensive nephropathy through p53/Nrf2/p21 pathway by Taohongsiwu decoction: Based on network pharmacology and experimental validation

Xie, T., Bai, Z., Chen, Z., Liang, H., Liu, T., Lam, L. K., Xu, P., Xie, P., Chen, L., & Xiao, Y. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116506 · Cited by 33

The dance of macrophage death: the interplay between the inevitable and the microenvironment

Makuch, M., Stepanechko, M., & Bzowska, M. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1330461 · Cited by 35

PRMT5 K240lac confers ferroptosis resistance via ALKBH5/SLC7A11 axis in colorectal cancer

Qu, S., Feng, B., Xing, M., Qiu, Y.-Y., Ma, L., Yang, Z., Ji, Y., Huang, F., Wang, Y., Zhou, J., et al. (2025) · Oncogene · doi:10.1038/s41388-025-03457-2 · Cited by 35

An arylthiazyne derivative is a potent inhibitor of lipid peroxidation and ferroptosis providing neuroprotection in vitro and in vivo

Keuters, M. H., Keksa-Goldsteine, V., Dhungana, H., Huuskonen, M. T., Pomeshchik, Y., Savchenko, E., Korhonen, P., Singh, Y., Wojciechowski, S., Lehtonen, Š., et al. (2021) · Scientific Reports · doi:10.1038/s41598-021-81741-3 · Cited by 33

Inhibition of YAP by lenvatinib in endothelial cells increases blood pressure through ferroptosis

Chen, L., Zhu, D., Xia, W., Hong, Z., Wang, Q., Sun, Y., Yang, Y., Han, S.-Q., Tang, L., Lou, J., et al. (2022) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2022.166586 · Cited by 33

Next Generation, Modifiable Cardiometabolic Biomarkers: Mitochondrial Adaptation and Metabolic Resilience: A Scientific Statement From the American Heart Association

Mietus‐Snyder, M., Perak, A. M., Cheng, S. C., Hayman, L. L., Haynes, N., Meikle, P. J., Shah, S. H., & Suglia, S. F. (2023) · Circulation · doi:10.1161/cir.0000000000001185 · Cited by 32

Carboxymethylated pachyman induces ferroptosis in ovarian cancer by suppressing NRF1/HO‑1 signaling

Jing, T., Guo, Y., & Wei, Y. (2022) · Oncology Letters · doi:10.3892/ol.2022.13281 · Cited by 32

CircEXOC5 promotes ferroptosis by enhancing ACSL4 mRNA stability via binding to PTBP1 in sepsis-induced acute lung injury

Wang, W. J., Xu, R., Zhao, H., Xiong, Y., & He, P. (2022) · Immunobiology · doi:10.1016/j.imbio.2022.152219 · Cited by 32

Catechin Mediates Ferroptosis to Exert an Anti-Inflammatory Effect on RAW 264.7 Cells

Kuang, W., Yang, J., Liu, Z., Zeng, J., Xia, X., Chen, X., Zhong, S., & Huang, R. (2022) · Foods · doi:10.3390/foods11111572 · Cited by 31

Molecular mechanisms of ferroptosis and their role in inflammation

Wang, F., He, J., Xing, R., Sha, T., & Sun, B. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.2016739 · Cited by 50

Editorial: Ferroptosis as a novel therapeutic target for inflammation-related diseases

Liang, Y., Su, Z., Mao, X., Wan, S., & Luo, L. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1152326 · Cited by 2

Molecular mechanisms of ferroptosis and relevance to inflammation

Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 273

Inflammation in a ferroptotic environment

Wickert, A., Schwantes, A., Fuhrmann, D. C., & Brüne, B. (2024) · Frontiers in Pharmacology · doi:10.3389/fphar.2024.1474285 · Cited by 27

Ferroptosis in infection, inflammation, and immunity

Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 836