Cited by 752Ferroptosis and cancer prognosisIron Metabolism and DisordersCell death mechanisms and regulation

The DOI matches its Crossref record; 151 of the 154 references it cites were found in a registry or an index.

The emerging role of ferroptosis in inflammation

Open access

Sun, Yitian, Chen, Peng, Zhai, Bingtao, Zhang, Mingming, Xiang, Yu, Fang, Jiaheng, Xu, Sinan, Gao, Yufei, Chen, Xin, Sui, Xinbing, Li, Guoxiong·2020·Biomedicine & Pharmacotherapy

DOI 10.1016/j.biopha.2020.110108

Open this paper in CoChat — free account Open PDF

Abstract

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Integrity signals

Registry

Crossref · 10.1016/j.biopha.2020.110108

Cites

151 of 151 references verified0 citation errors · 0 not checkable

Statistics

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death
Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691
Regulation of Ferroptotic Cancer Cell Death by GPX4
Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713
Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease
Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695
ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition
Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293
Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice
Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732
The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis
Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703
Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling
Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686
FSP1 is a glutathione-independent ferroptosis suppressor
Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341
Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin
Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199
Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis
Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029

Show all 154 references

Sorted by citations

Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443
“In addition, it triggers the elevated production of the pro-inflammatory cytokine IL-6.”
BackgroundInfluential
Lipid Peroxidation and Iron Metabolism: Two Corner Stones in the Homeostasis Control of Ferroptosis
Rochette, L., Dogon, G., Rigal, E., Zeller, M., Cottin, Y., & Vergely, C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms24010449 · Cited by 966
Reactive oxygen species (ROS) scavenging biomaterials for anti-inflammatory diseases: from mechanism to therapy
Liu, J., Han, X., Zhang, T., Tian, K., Li, Z., & Luo, F. (2023) · Journal of Hematology & Oncology · doi:10.1186/s13045-023-01512-7 · Cited by 742
The interaction between ferroptosis and inflammatory signaling pathways
Chen, Y., Fang, Z., Yi, X., Wei, X., & Jiang, D. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05716-0 · Cited by 626
GPX4: The hub of lipid oxidation, ferroptosis, disease and treatment
Liu, Y., Wan, Y., Jiang, Y., Zhang, L., & Cheng, W. (2023) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2023.188890 · Cited by 546
Inflammation-related pyroptosis, a novel programmed cell death pathway, and its crosstalk with immune therapy in cancer treatment
Hsu, S., Li, C., Lin, I., Syue, W.-J., Chen, Y., Cheng, K., Teng, Y., Lin, Y., Yen, C., & Chiu, C. (2021) · Theranostics · doi:10.7150/thno.62521 · Cited by 502
GPX4, ferroptosis, and diseases
Zhang, W., Liu, Y., Yan, L., Zhu, C., & Zou, Z. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116512 · Cited by 474
Ferroptosis Mechanisms Involved in Neurodegenerative Diseases
Reichert, C. O., de Freitas, F. A., Sampaio‐Silva, J., Rokita-Rosa, L., Barros, P. D. L., Levy, D., & Bydlowski, S. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21228765 · Cited by 431
Pyroptosis in health and disease: mechanisms, regulation and clinical perspective
Liu, Y., Pan, R., Ouyang, Y., Gu, W., Xiao, T., Yang, H., Tang, L. Y., Wang, H., Xiang, B., & Chen, P. (2024) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-01958-2 · Cited by 391
Self-citation
Carbon Quantum Dots-Based Nanozyme from Coffee Induces Cancer Cell Ferroptosis to Activate Antitumor Immunity
Lu, Y., Zhao, M., Luo, Q.-W., Zhang, Y., Liu, T.-T., Yang, Z., Liao, M., Tu, P., & Zeng, K. (2022) · ACS Nano · doi:10.1021/acsnano.2c01619 · Cited by 296
Cell Death Mechanisms in Cerebral Ischemia–Reperfusion Injury
Zhang, Q., Jia, M., Wang, Y., Wang, Q., & Wu, J. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03697-8 · Cited by 332
Molecular mechanisms of ferroptosis and relevance to inflammation
Deng, L., He, S., Guo, N., Tian, W., Zhang, W., & Luo, L. (2022) · Inflammation Research · doi:10.1007/s00011-022-01672-1 · Cited by 273
Ferroptosis and its emerging roles in cardiovascular diseases
Li, N., Jiang, W., Wang, W., Xiong, R., Wu, X., & Geng, Q. (2021) · Pharmacological Research · doi:10.1016/j.phrs.2021.105466 · Cited by 256
The role of iron in the pathogenesis of COVID-19 and possible treatment with lactoferrin and other iron chelators
Habib, H. M., Ibrahim, S., Zaim, A., & Ibrahim, W. H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111228 · Cited by 259
Oxidative stress in intervertebral disc degeneration: Molecular mechanisms, pathogenesis and treatment
Wang, Y., Cheng, H., Wang, T., Zhang, K., Zhang, Y., & Kang, X. (2023) · Cell Proliferation · doi:10.1111/cpr.13448 · Cited by 243
Programmed cell death in atherosclerosis and vascular calcification
Li, M., Wang, Z., Fang, L., Cheng, S.-Q., Wang, X., & Liu, N. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04923-5 · Cited by 243
Inhibition of keratinocyte ferroptosis suppresses psoriatic inflammation
Shou, Y., Yang, L., Yang, Y., & Xu, J. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04284-5 · Cited by 226
Heme Oxgenase-1, a Cardinal Modulator of Regulated Cell Death and Inflammation
Ryter, S. W. (2021) · Cells · doi:10.3390/cells10030515 · Cited by 228
Liproxstatin-1 attenuates unilateral ureteral obstruction-induced renal fibrosis by inhibiting renal tubular epithelial cells ferroptosis
Zhang, B., Chen, X., Ru, F., Gan, Y., Li, B., Xia, W., Dai, G., He, Y., & Chen, Z. (2021) · Cell Death and Disease · doi:10.1038/s41419-021-04137-1 · Cited by 221
Self-citation
Targeting ferroptosis in acute kidney injury
Ni, L., Cheng, Y., & Wu, X. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04628-9 · Cited by 228
Microglia and macrophage exhibit attenuated inflammatory response and ferroptosis resistance after RSL3 stimulation via increasing Nrf2 expression
Cui, Y., Zhang, Z., Zhou, X., Zhao, Z., Zhao, R., Xu, X., Kong, X., Ren, J., Yao, X., Wen, Q., et al. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02231-x · Cited by 208
Ferrostatin-1 alleviates lipopolysaccharide-induced cardiac dysfunction
Xiao, Z., Kong, B., Fang, J., Qin, T., Dai, C., Shuai, W., & Huang, H. (2021) · Bioengineered · doi:10.1080/21655979.2021.2001913 · Cited by 199
Self-citation
Iron: Innocent bystander or vicious culprit in COVID-19 pathogenesis?
Edeas, M., Saleh, J., & Peyssonnaux, C. (2020) · International Journal of Infectious Diseases · doi:10.1016/j.ijid.2020.05.110 · Cited by 194
Persisting alterations of iron homeostasis in COVID-19 are associated with non-resolving lung pathologies and poor patients’ performance: a prospective observational cohort study
Sonnweber, T., Boehm, A., Sahanic, S., Pizzini, A., Aichner, M., Sonnweber, B., Kurz, K., Koppelstätter, S., Haschka, D., Petzer, V., et al. (2020) · Respiratory Research · doi:10.1186/s12931-020-01546-2 · Cited by 177
Natural terpenoids with anti-inflammatory activities: Potential leads for anti-inflammatory drug discovery
Ge, J., Liu, Z., Zhong, Z., Wang, L., Zhuo, X., Li, J., Jiang, X., Ye, X., Xie, T., & Bai, R. (2022) · Bioorganic Chemistry · doi:10.1016/j.bioorg.2022.105817 · Cited by 183
Ferroptosis: Emerging mechanisms, biological function, and therapeutic potential in cancer and inflammation
Jin, X., Tang, J., Qiu, X., Nie, X., Ou, S., Wu, G., Zhang, R., & Zhu, J. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01825-7 · Cited by 188
Plasmalogens and Chronic Inflammatory Diseases
Bozelli, J. C., Azher, S., & Epand, R. M. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.730829 · Cited by 182
Anti-CHAC1 exosomes for nose-to-brain delivery of miR-760-3p in cerebral ischemia/reperfusion injury mice inhibiting neuron ferroptosis
Wang, Y., Niu, H., Li, L., Han, J., Liu, Z., Chu, M., Sha, X., & Zhao, J. (2023) · Journal of Nanobiotechnology · doi:10.1186/s12951-023-01862-x · Cited by 172
Keratinocyte death by ferroptosis initiates skin inflammation after UVB exposure
Vats, K., Kruglov, O., Mizes, A., Самович, С. Н., Amoscato, A. A., Tyurin, V. A., Tyurina, Y. Y., Kagan, V. E., & Bunimovich, Y. L. (2021) · Redox Biology · doi:10.1016/j.redox.2021.102143 · Cited by 161
Endothelial cell ferroptosis mediates monocrotaline-induced pulmonary hypertension in rats by modulating NLRP3 inflammasome activation
Xie, S., Deng, Y., Guo, S., Li, J., Zhou, Y.-C., Liao, J., Wu, D., & Lan, W. (2022) · Scientific Reports · doi:10.1038/s41598-022-06848-7 · Cited by 150
NINJ1 induces plasma membrane rupture and release of damage-associated molecular pattern molecules during ferroptosis
Ramos, S., Hartenian, E., Santos, J. C., Walch, P., & Brož, P. (2024) · The EMBO Journal · doi:10.1038/s44318-024-00055-y · Cited by 163
Ferritinophagy and ferroptosis in cardiovascular disease: Mechanisms and potential applications
Qin, Y., Qiao, Y., Wang, D., Tang, C., & Yan, G. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111872 · Cited by 150
Role of Ferroptosis in Stroke
Xu, Y., Li, K., Zhao, Y., Zhou, L., Liu, Y., & Zhao, J. (2022) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-022-01196-6 · Cited by 151
Connecting the “Dots”: From Free Radical Lipid Autoxidation to Cell Pathology and Disease
Foret, M. K., Lincoln, R., Carmo, S. D., Cuello, A. C., & Cosa, G. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00761 · Cited by 150
Recent advances in small-molecule fluorescent probes for studying ferroptosis
Qi, Y., Wang, H., Chen, L., Duan, Y., Yang, S., & Zhu, H. (2022) · Chemical Society Reviews · doi:10.1039/d1cs01167g · Cited by 138
Fisetin ameliorates fibrotic kidney disease in mice via inhibiting ACSL4-mediated tubular ferroptosis
Wang, B., Yang, L., Yang, L., Liang, Y., Guo, F., Fu, P., & Ma, L. (2023) · Acta Pharmacologica Sinica · doi:10.1038/s41401-023-01156-w · Cited by 143
Implication of ferroptosis in aging
Mazhar, M., Din, A. U., Ali, H., Yang, G., Ren, W., Wang, L., Fan, X., & Yang, S. (2021) · Cell Death Discovery · doi:10.1038/s41420-021-00553-6 · Cited by 138
Inhibition of ferroptosis promotes retina ganglion cell survival in experimental optic neuropathies
Guo, M., Zhu, Y., Shi, Y., Meng, X., Dong, X., Zhang, H., Wang, X., Du, M., & Yan, H. (2022) · Redox Biology · doi:10.1016/j.redox.2022.102541 · Cited by 137
Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective
Hu, X., Li, Z., Lin, R., Shan, J.-Q., Yu, Q., Wang, R., Liao, L., Yan, W., Zhen, W., Shang, L., et al. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.634690 · Cited by 135
Causes of and Molecular Targets for the Treatment of Intervertebral Disc Degeneration: A Review
Ohnishi, T., Iwasaki, N., & Sudo, H. (2022) · Cells · doi:10.3390/cells11030394 · Cited by 130
Astaxanthin attenuates osteoarthritis progression via inhibiting ferroptosis and regulating mitochondrial function in chondrocytes
Wang, X., Li, H., Peng, P., Gong, Z., Huang, J. X., & Peng, H. (2022) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2022.110148 · Cited by 129
Astaxanthin attenuates ferroptosis via Keap1-Nrf2/HO-1 signaling pathways in LPS-induced acute lung injury
Luo, L., Huang, F., Zhong, S., Ding, R., Su, J., & Li, X. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.121091 · Cited by 125
Exosome-Derived lncRNA NEAT1 Exacerbates Sepsis-Associated Encephalopathy by Promoting Ferroptosis Through Regulating miR-9-5p/TFRC and GOT1 Axis
Wei, X.-B., Jiang, W.-Q., Zeng, J.-H., Huang, L.-Q., Ding, H.-G., Jing, Y.-W., Han, Y.-L., Li, Y.-C., & Chen, S.-L. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-02738-1 · Cited by 123
STAT3-mediated ferroptosis is involved in ulcerative colitis
Huang, F., Zhang, S., Li, X., Huang, Y., He, S., & Luo, L. (2022) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2022.06.242 · Cited by 118
Paraptosis: a unique cell death mode for targeting cancer
Hanson, S., Dharan, A., Jinsha, P. V., Pal, S., Nair, B. G., Kar, R., & Mishra, N. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1159409 · Cited by 124
Unleashing the power of porphyrin photosensitizers: Illuminating breakthroughs in photodynamic therapy
Akbar, A., Khan, S., Chatterjee, T., & Ghosh, M. (2023) · Journal of Photochemistry and Photobiology B Biology · doi:10.1016/j.jphotobiol.2023.112796 · Cited by 121
Glycyrrhizin Attenuates Hypoxic‐Ischemic Brain Damage by Inhibiting Ferroptosis and Neuroinflammation in Neonatal Rats via the HMGB1/GPX4 Pathway
Zhu, K., Zhu, X. Q., Liu, S., Yu, J., Wu, S., & Hei, M. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/8438528 · Cited by 114
Curcumin Attenuates Ferroptosis-Induced Myocardial Injury in Diabetic Cardiomyopathy through the Nrf2 Pathway
Zhang, W., Shaohuan, Q., Pinfang, K., & Chao, S. (2022) · Cardiovascular Therapeutics · doi:10.1155/2022/3159717 · Cited by 113
Damage-associated molecular patterns (DAMPs) in diseases: implications for therapy
Lin, H., Xiong, W. G., Fu, L., Yi, J., & Yang, J. (2025) · Molecular Biomedicine · doi:10.1186/s43556-025-00305-3 · Cited by 137
Lipocalin-2 silencing suppresses inflammation and oxidative stress of acute respiratory distress syndrome by ferroptosis via inhibition of MAPK/ERK pathway in neonatal mice
Wang, X., Zhang, C., Zou, N., Chen, Q., Wang, C., Zhou, X., Luo, L., Qi, H., Li, J., Liu, Z., et al. (2021) · Bioengineered · doi:10.1080/21655979.2021.2009970 · Cited by 108
Retracted
The Biological Functions and Regulatory Mechanisms of Fatty Acid Binding Protein 5 in Various Diseases
Xu, B., Chen, L., Zhan, Y., Marquez, K. N. S., Zhuo, L., Qi, S., Zhu, J., He, Y., Chen, X., Zhang, H., et al. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2022.857919 · Cited by 104
Self-citation
AKR1C1 Protects Corneal Epithelial Cells Against Oxidative Stress-Mediated Ferroptosis in Dry Eye
Zuo, X., Zeng, H., Wang, B., Yang, X., He, D., Wang, L., Ouyang, H., & Yuan, J. (2022) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.63.10.3 · Cited by 112
Ferroptosis and EMT: key targets for combating cancer progression and therapy resistance
Ren, Y., Mao, X., Xu, H. J., Dang, Q., Weng, S., Zhang, Y., Chen, S., Liu, S., Ba, Y., Zhou, Z., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04907-4 · Cited by 117
The role of ferroptosis mediated by NRF2/ERK-regulated ferritinophagy in CdTe QDs-induced inflammation in macrophage
Liu, N., Liang, Y., Wei, T., Zou, L., Huang, X., Kong, L., Tang, M., & Zhang, T. (2022) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2022.129043 · Cited by 106
Ferroptosis and Autophagy-Related Genes in the Pathogenesis of Ischemic Cardiomyopathy
Zheng, Y., Gao, W., Zhang, Q., Cheng, X., Liu, Y., Qi, Z., & Li, T. (2022) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2022.906753 · Cited by 108
Microplastics induced inflammation and apoptosis via ferroptosis and the NF-κB pathway in carp
Xu, T., Cui, J., Xu, R., Cao, J., & Guo, M. (2023) · Aquatic Toxicology · doi:10.1016/j.aquatox.2023.106659 · Cited by 104
Icariin inhibits chondrocyte ferroptosis and alleviates osteoarthritis by enhancing the SLC7A11/GPX4 signaling
Xiao, J., Luo, C., Li, A., Cai, F.-L., Wang, Y., Pan, X., Liu, X., Wang, Z., Xing, Z., Yu, L., et al. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112010 · Cited by 108
Herpes Simplex Virus 1-Induced Ferroptosis Contributes to Viral Encephalitis
Xu, X.-Q., Xu, T., Ji, W., Wang, C., Ren, Y., Xiong, X., Zhou, X., Lin, S., Xu, Y., & Qiu, Y. (2022) · mBio · doi:10.1128/mbio.02370-22 · Cited by 102
SIRT1-autophagy axis inhibits excess iron-induced ferroptosis of foam cells and subsequently increases IL-1Β and IL-18
Su, G., Yang, W. P., Wang, S., Geng, C., & Guan, X. (2021) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2021.05.011 · Cited by 99
The Role of Microglia in Alzheimer’s Disease From the Perspective of Immune Inflammation and Iron Metabolism
Long, H., Zhou, Z.-W., Cheng, Y., Luo, H., Li, F., Xu, S., & Gao, L. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.888989 · Cited by 100
Self-citation
Role of Histone Post-Translational Modifications in Inflammatory Diseases
Lin, Y., Qiu, T., Wei, G., Que, Y., Wang, W., Kong, Y., Xie, T., & Chen, X. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.852272 · Cited by 96
Self-citation
The MARCHF6 E3 ubiquitin ligase acts as an NADPH sensor for the regulation of ferroptosis
Nguyen, K. T., Mun, S.-H., Yang, J., Lee, J., Seok, O.-H., Kim, E., Kim, D., An, S. Y., Seo, D.-Y., Suh, J.-Y., et al. (2022) · Nature Cell Biology · doi:10.1038/s41556-022-00973-1 · Cited by 92
Neutral polysaccharide from Gastrodia elata alleviates cerebral ischemia–reperfusion injury by inhibiting ferroptosis‐mediated neuroinflammation via the NRF2 / HO ‐1 signaling pathway
Zhang, Y., Ye, P., Zhu, H., Gu, L., Li, Y., Feng, S., Zeng, Z., Chen, Q., Zhou, B., & Xiong, X. (2023) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.14456 · Cited by 95
Inflammation Triggers Chondrocyte Ferroptosis in TMJOA via HIF-1α/TFRC
Chen, B., Pathak, J. L., Lin, H., Guo, W. Q., Chen, W. J., Luo, G., Wang, L. J., Sun, X., Ding, Y., Li, J., et al. (2024) · Journal of Dental Research · doi:10.1177/00220345241242389 · Cited by 93
Immunogenic Cell Death, DAMPs and Prothymosin α as a Putative Anticancer Immune Response Biomarker
Birmpilis, A. I., Paschalis, A., Mourkakis, A., Christodoulou, P., Kostopoulos, I. V., Antimissari, E., Terzoudi, G. I., Georgakilas, A. G., Armpilia, C., Papageorgis, P., et al. (2022) · Cells · doi:10.3390/cells11091415 · Cited by 91
HDM induce airway epithelial cell ferroptosis and promote inflammation by activating ferritinophagy in asthma
Zeng, Z., Huang, H., Zhang, J., Liu, Y., Zhong, W., Chen, W., Lu, Y., Qiao, Y., Zhao, H., Meng, X., et al. (2022) · The FASEB Journal · doi:10.1096/fj.202101977rr · Cited by 93
Resveratrol attenuates rotenone-induced inflammation and oxidative stress via STAT1 and Nrf2/Keap1/SLC7A11 pathway in a microglia cell line
Sun, W., Li, H., Shen, Y., & Xiao, H. (2021) · Pathology - Research and Practice · doi:10.1016/j.prp.2021.153576 · Cited by 90
Crosstalk between ferroptosis and the epithelial-mesenchymal transition: Implications for inflammation and cancer therapy
Ebrahimi, N., Adelian, S., Shakerian, S., Afshinpour, M., Chaleshtori, S. R., Ravari, N. R., Rezaei‐Tazangi, F., Beiranvand, S., Hamblin, M. R., & Aref, A. R. (2022) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2022.01.006 · Cited by 91
Ferroptosis-Mediated Inflammation Promotes Pulmonary Hypertension
Kazmirczak, F., Vogel, N. T., Prisco, S. Z., Patterson, M. T., Annis, J. S., Moon, R. T., Hartweck, L. M., Mendelson, J. B., Kim, M., Mancipe, N. C., et al. (2024) · Circulation Research · doi:10.1161/circresaha.123.324138 · Cited by 106
Hydrogen sulfide alleviates the anxiety-like and depressive-like behaviors of type 1 diabetic mice via inhibiting inflammation and ferroptosis
Wang, Y., Wang, S., Yu, X., Zhang, J., Wang, S., Yang, Z. R., & Liu, C. (2021) · Life Sciences · doi:10.1016/j.lfs.2021.119551 · Cited by 89
The Interplay between Ferroptosis and Neuroinflammation in Central Neurological Disorders
Xu, Y., Jia, B., Li, J., Li, Q., & Luo, C. (2024) · Antioxidants · doi:10.3390/antiox13040395 · Cited by 92
Resveratrol Alleviates Diabetic Periodontitis-Induced Alveolar Osteocyte Ferroptosis Possibly via Regulation of SLC7A11/GPX4
Li, Y., Huang, Z., Pan, S.-S., Feng, Y., He, H., Cheng, S.-G., Wang, L., Wang, L., & Pathak, J. (2023) · Nutrients · doi:10.3390/nu15092115 · Cited by 87
Quercetin ameliorates ferroptosis of rat cardiomyocytes via activation of the SIRT1/p53/SLC7A11 signaling pathway to alleviate sepsis‑induced cardiomyopathy
Lin, X., Xiaoxia, Z., Chen, Q., Wang, X., Wu, Y., & Zhao, H. (2023) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2023.5319 · Cited by 85
Swine influenza virus triggers ferroptosis in A549 cells to enhance virus replication
Cheng, J., Tao, J., Li, B., Shi, Y., & Liu, H. (2022) · Virology Journal · doi:10.1186/s12985-022-01825-y · Cited by 81
Apolipoprotein C1 promotes glioblastoma tumorigenesis by reducing KEAP1/NRF2 and CBS-regulated ferroptosis
Zheng, X., Chen, W., Yi, J., Wan, L., Liu, J.-Y., Fu, W.-Q., Ren, L., Li, S., Ge, B.-B., Yang, Y., et al. (2022) · Acta Pharmacologica Sinica · doi:10.1038/s41401-022-00917-3 · Cited by 80
A shear-thinning, ROS-scavenging hydrogel combined with dental pulp stem cells promotes spinal cord repair by inhibiting ferroptosis
Ying, Y., Huang, Z., Tu, Y., Wu, Q., Li, Z., Zhang, Y., Yu, H., Zeng, A., Huang, H., Ye, J., et al. (2022) · Bioactive Materials · doi:10.1016/j.bioactmat.2022.09.019 · Cited by 79
Cross Talk Between Ferroptosis and Cerebral Ischemia
She, X., Lan, B., Tian, H.-M., & Tang, B. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00776 · Cited by 79
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis
Liu, Y., Cui, H., Mei, C., Cui, M., He, Q., Wang, Q., Li, D., Song, Y., Li, J., Chen, S., et al. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-06216-x · Cited by 81
Ferroptosis: an important player in the inflammatory response in diabetic nephropathy
Li, J., Li, L., Zhang, Z., Chen, P., Shu, H., Yang, C., Chu, Y., & Liu, J. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1294317 · Cited by 82
Self-citation
Ferroptosis, pyroptosis and necroptosis in acute respiratory distress syndrome
Zheng, Y., Huang, Y., Xu, Y., Sang, L., Liu, X., & Li, Y. (2023) · Cell Death Discovery · doi:10.1038/s41420-023-01369-2 · Cited by 80
Ferroptosis of macrophages facilitates bone loss in apical periodontitis via NRF2/FSP1/ROS pathway
Yang, M., Shen, Z., Zhang, X., Song, Z., Zhang, Y., Lin, Z., & Chen, L. (2023) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2023.08.020 · Cited by 77
Photodynamic therapy, priming and optical imaging: Potential co-conspirators in treatment design and optimization — a Thomas Dougherty Award for Excellence in PDT paper
Silva, P. D., Saad, M. A., Thomsen, H., Bano, S., Ashraf, S., & Hasan, T. G. (2020) · Journal of Porphyrins and Phthalocyanines · doi:10.1142/s1088424620300098 · Cited by 73
Restoring neuronal iron homeostasis revitalizes neurogenesis after spinal cord injury
Geng, H., Li, Z., Li, Z., Zhang, Y., Gao, Z., Sun, L., Li, X., Cui, J., Ni, S., & Hao, J. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220300120 · Cited by 76
Histochrome Attenuates Myocardial Ischemia-Reperfusion Injury by Inhibiting Ferroptosis-Induced Cardiomyocyte Death
Hwang, J., Park, J.-H., Park, B., Kim, H., Kim, J.-J., Sim, W., Mishchenko, N. P., Fedoreyev, S. A., Васильева, Е. А., Ban, K., et al. (2021) · Antioxidants · doi:10.3390/antiox10101624 · Cited by 75
Emerging Roles of the Iron Chelators in Inflammation
Paola, A. D., Tortora, C., Argenziano, M., Marrapodi, M. M., & Rossi, F. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23147977 · Cited by 80
Modes of Brain Cell Death Following Intracerebral Hemorrhage
Zhang, Y., Khan, S., Liu, Y., Zhang, R., Li, H., Wu, G., Tang, Z., Xue, M., & Yong, V. W. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.799753 · Cited by 71
Postconditioning with Irisin Attenuates Lung Ischemia/Reperfusion Injury by Suppressing Ferroptosis via Induction of the Nrf2/HO‐1 Signal Axis
Wang, Y., Dong, Z., Zhang, Z., Wang, Y., Yang, K., & Li, X. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/9911167 · Cited by 75
The Impacts of Iron Overload and Ferroptosis on Intestinal Mucosal Homeostasis and Inflammation
Huo, C., Li, G., Hu, Y., & Sun, H. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232214195 · Cited by 76
Self-citation
Hypermethylation of the Nrf2 Promoter Induces Ferroptosis by Inhibiting the Nrf2-GPX4 Axis in COPD
Zhang, Z., Fu, C., Liu, J., Sai, X., Qin, C., Di, T., Yang, Y., Wu, Y., & Bian, T. (2021) · International Journal of COPD · doi:10.2147/copd.s340113 · Cited by 69
Interplay Between Iron Overload and Osteoarthritis: Clinical Significance and Cellular Mechanisms
Cai, C., Hu, W., & Chu, T. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.817104 · Cited by 69
Extracellular CIRP Promotes GPX4-Mediated Ferroptosis in Sepsis
Shimizu, J., Murao, A., Nofi, C. P., Wang, P., & Aziz, M. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.903859 · Cited by 70
The interplay between ferroptosis and inflammation: therapeutic implications for cerebral ischemia-reperfusion
He, Y., Wang, J., Ying, C., Xu, K. L., Luo, J., Wang, B., Gao, J., Yin, Z., & Zhang, Y. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1482386 · Cited by 75
Types of necroinflammation, the effect of cell death modalities on sterile inflammation
Mázló, A., Jenei, V., Sára, B., Molnár, T., Bácsi, A., & Koncz, G. (2022) · Cell Death and Disease · doi:10.1038/s41419-022-04883-w · Cited by 69
From immune dysregulation to organ dysfunction: understanding the enigma of Sepsis
Liu, Z., Ting, Y., Li, M., Li, Y., Tan, Y., & Long, Y. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1415274 · Cited by 81
Tackling Chronic Inflammation with Withanolide Phytochemicals—A Withaferin A Perspective
Logie, E., & Berghe, W. V. (2020) · Antioxidants · doi:10.3390/antiox9111107 · Cited by 67
SARS-CoV-2 infection: can ferroptosis be a potential treatment target for multiple organ involvement?
Yang, M., & Lai, C. (2020) · Cell Death Discovery · doi:10.1038/s41420-020-00369-w · Cited by 67
Mechanisms of sepsis-induced acute liver injury: a comprehensive review
Guo, Y., Guo, W., Chen, H., Sun, J., & Yin, Y. (2025) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2025.1504223 · Cited by 73
Nobiletin protects against ferroptosis to alleviate sepsis-associated acute liver injury by modulating the gut microbiota
Huang, W., Chen, H., He, Q. Z., Xie, W., peng, Z., Ma, Q., Huang, Q., Chen, Z., & Liu, Y. (2023) · Food & Function · doi:10.1039/d3fo01684f · Cited by 66
Extracellular Matrix and Oxidative Stress Following Traumatic Spinal Cord Injury: Physiological and Pathophysiological Roles and Opportunities for Therapeutic Intervention
Chio, J. C. T., Punjani, N., Hejrati, N., Zavvarian, M.-M., Hong, J., & Fehlings, M. G. (2021) · Antioxidants and Redox Signaling · doi:10.1089/ars.2021.0120 · Cited by 67
Ferroptosis as a therapeutic target for inflammation-related intestinal diseases
Zhang, X., Ma, Y., Lv, G., & Wang, H. (2023) · Frontiers in Pharmacology · doi:10.3389/fphar.2023.1095366 · Cited by 67

Authors: Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., Sui, X., & Li, G.
Affiliations: Hangzhou Normal University (CN)
Affiliated Hospital of Hangzhou Normal University (CN)
Corresponding author: Sui, Xinbing
Li, Guoxiong
ORCID: Chen, Peng
Zhai, Bingtao
Zhang, Mingming
Xu, Sinan
Gao, Yufei
Chen, Xin
Sui, Xinbing
Li, Guoxiong
Venue: Biomedicine & Pharmacotherapy
Publisher: Elsevier BV
Published: 2020-07
Volume: 127
Pages: 110108
ISSN: 0753-3322 (ISSN-L)
DOI: 10.1016/j.biopha.2020.110108
OpenAlex: W3013314180
Cited by: 739
References: 154
Citations by year: 2026: 62 · 2025: 137 · 2024: 187 · 2023: 142 · 2022: 148 · 2021: 50 · 2020: 12
FWCI: 12.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81730108, 81874380, 81672932, 81973635)
Science and Technology Program of Zhejiang Province (2019ZZ016)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: ferroptosis, inflammation, regulated necrosis, phospholipid peroxidation, ferroptosis inhibitors, antioxidants, anti-inflammatory activity, immunogenic cell death, treatment options
MeSH terms: Ferroptosis, Animals, Antioxidants, Humans, Inflammation, Necrosis

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

The emerging role of ferroptosis in inflammation

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Self-check

Citations

Cites

Cited by

Related

Metadata

Record

About these checks