Cited by 752Ferroptosis and cancer prognosisIron Metabolism and DisordersCell death mechanisms and regulation

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The emerging role of ferroptosis in inflammation

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Sun, Yitian, Chen, Peng, Zhai, Bingtao, Zhang, Mingming, Xiang, Yu, Fang, Jiaheng, Xu, Sinan, Gao, Yufei, Chen, Xin, Sui, Xinbing, Li, Guoxiong·2020·Biomedicine & Pharmacotherapy

DOI 10.1016/j.biopha.2020.110108

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Abstract

Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.

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Authors: Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., Sui, X., & Li, G.
Affiliations: Hangzhou Normal University (CN)
Affiliated Hospital of Hangzhou Normal University (CN)
Corresponding author: Sui, Xinbing
Li, Guoxiong
ORCID: Chen, Peng
Zhai, Bingtao
Zhang, Mingming
Xu, Sinan
Gao, Yufei
Chen, Xin
Sui, Xinbing
Li, Guoxiong
Venue: Biomedicine & Pharmacotherapy
Publisher: Elsevier BV
Published: 2020-07
Volume: 127
Pages: 110108
ISSN: 0753-3322 (ISSN-L)
DOI: 10.1016/j.biopha.2020.110108
OpenAlex: W3013314180
Cited by: 739
References: 154
Citations by year: 2026: 62 · 2025: 137 · 2024: 187 · 2023: 142 · 2022: 148 · 2021: 50 · 2020: 12
FWCI: 12.65
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor)
Locations: Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: National Natural Science Foundation of China (81730108, 81874380, 81672932, 81973635)
Science and Technology Program of Zhejiang Province (2019ZZ016)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
Keywords: ferroptosis, inflammation, regulated necrosis, phospholipid peroxidation, ferroptosis inhibitors, antioxidants, anti-inflammatory activity, immunogenic cell death, treatment options
MeSH terms: Ferroptosis, Animals, Antioxidants, Humans, Inflammation, Necrosis

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