The emerging role of ferroptosis in inflammation

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

Dixon, S. J., Lemberg, K. M., Lamprecht, M. R., Skouta, R., Zaitsev, E. M., Gleason, C. E., Patel, D. N., Bauer, A. J., Cantley, A. M., Yang, W. S., et al. (2012) · Cell · doi:10.1016/j.cell.2012.03.042 · Cited by 18,691

Regulation of Ferroptotic Cancer Cell Death by GPX4

Yang, W. S., SriRamaratnam, R., Welsch, M. E., Shimada, K., Skouta, R., Viswanathan, V. S., Cheah, J. H., Clemons, P. A., Shamji, A. F., Clish, C. B., et al. (2014) · Cell · doi:10.1016/j.cell.2013.12.010 · Cited by 7,713

Ferroptosis: A Regulated Cell Death Nexus Linking Metabolism, Redox Biology, and Disease

Stockwell, B. R., Friedmann Angeli, J. P., Bayir, H., Bush, A. I., Conrad, M., Dixon, S. J., Fulda, S., Gascón, S., Hatzios, S. K., Kagan, V. E., et al. (2017) · Cell · doi:10.1016/j.cell.2017.09.021 · Cited by 7,695

ACSL4 dictates ferroptosis sensitivity by shaping cellular lipid composition

Doll, S., Proneth, B., Tyurina, Y. Y., Panzilius, E., Kobayashi, S., Ingold, I., Irmler, M., Beckers, J., Aichler, M., Walch, A., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2239 · Cited by 4,293

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

Friedmann Angeli, J. P., Schneider, M., Proneth, B., Tyurina, Y. Y., Tyurin, V. A., Hammond, V. J., Herbach, N., Aichler, M., Walch, A., Eggenhofer, E., et al. (2014) · Nature Cell Biology · doi:10.1038/ncb3064 · Cited by 3,732

The CoQ oxidoreductase FSP1 acts parallel to GPX4 to inhibit ferroptosis

Bersuker, K., Hendricks, J. M., Li, Z., Magtanong, L., Ford, B., Tang, P. H., Roberts, M. A., Tong, B., Maimone, T. J., Zoncu, R., et al. (2019) · Nature · doi:10.1038/s41586-019-1705-2 · Cited by 3,703

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

Kayagaki, N., Stowe, I. B., Lee, B. L., O’Rourke, K., Anderson, K., Warming, S., Cuellar, T., Haley, B., Roose-Girma, M., Phung, Q. T., et al. (2015) · Nature · doi:10.1038/nature15541 · Cited by 3,686

FSP1 is a glutathione-independent ferroptosis suppressor

Doll, S., Freitas, F. P., Shah, R., Aldrovandi, M., da Silva, M. C., Ingold, I., Goya Grocin, A., Xavier da Silva, T. N., Panzilius, E., Scheel, C. H., et al. (2019) · Nature · doi:10.1038/s41586-019-1707-0 · Cited by 3,341

Chemotherapy drugs induce pyroptosis through caspase-3 cleavage of a gasdermin

Wang, Y., Gao, W., Shi, X., Ding, J., Liu, W., He, H., Wang, K., & Shao, F. (2017) · Nature · doi:10.1038/nature22393 · Cited by 3,199

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

Kagan, V. E., Mao, G., Qu, F., Angeli, J. P. F., Doll, S., Croix, C. S., Dar, H. H., Liu, B., Tyurin, V. A., Ritov, V. B., et al. (2017) · Nature Chemical Biology · doi:10.1038/nchembio.2238 · Cited by 3,029

Transcriptome Analysis Unveils That Exosomes Derived from M1-Polarized Microglia Induce Ferroptosis of Neuronal Cells

Gao, S., Jia, S., Bai, L., Li, D., & Meng, C. (2022) · Cells · doi:10.3390/cells11243956 · Cited by 32

n-3 PUFA Promotes Ferroptosis in PCOS GCs by Inhibiting YAP1 through Activation of the Hippo Pathway

Zhang, P., Pan, Y., Wu, S., He, Y., Wang, J., Chen, L., Zhang, S., Zhang, H., Zhao, Y., Niu, L., et al. (2023) · Nutrients · doi:10.3390/nu15081927 · Cited by 31

Role and mechanism of ferroptosis in acute lung injury

Yu, T., & Sun, S. (2023) · Cell Cycle · doi:10.1080/15384101.2023.2278328 · Cited by 31

HMOX1 Promotes Ferroptosis in Mammary Epithelial Cells via FTH1 and Is Involved in the Development of Clinical Mastitis in Dairy Cows

Zhang, Q., Bai, X., Lin, T., Wang, X., Zhang, B., Dai, L., Shi, J., Zhang, Y., & Zhao, X. (2022) · Antioxidants · doi:10.3390/antiox11112221 · Cited by 31

Mitochondrial regulatory mechanisms in spinal cord injury: A narrative review

Chengjiang, L., Liu, Y., Ma, B., Zhou, M., Zhao, X., Fu, X., Kan, S.-L., Hu, W., & Zhu, R. (2022) · Medicine · doi:10.1097/md.0000000000031930 · Cited by 31

Exosomes from hypoxia‐pretreated adipose‐derived stem cells attenuate ultraviolet light‐induced skin injury via delivery of circ‐Ash1l

Zha, J., Pan, Y., Liu, X., Zhu, H. M., Liu, Y., & Zeng, W. (2022) · Photodermatology Photoimmunology & Photomedicine · doi:10.1111/phpp.12857 · Cited by 31

Ferroptosis in calcium oxalate kidney stone formation and the possible regulatory mechanism of ANKRD1

Zhao, J., Wu, Y., Zhou, K., Huang, M., Sun, Y., Kang, J., Su, Q., Zhao, Y., Liu, Q., & Li, C. (2023) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2023.119452 · Cited by 31

The role of ferroptosis in virus infections

Wang, J., Zhu, J., Ren, S., Zhang, Z., Niu, K., Li, H., Wu, W., & Chen, P. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1279655 · Cited by 33

Inflammatory cell death induced by cytotoxic lymphocytes: a dangerous but necessary liaison

de Miguel, D., Ramírez-Labrada, A., Uranga-Murillo, I., Hidalgo, S., Santiago, L., Gálvez, E. M., Arias, M. A., & Pardo, J. (2021) · FEBS Journal · doi:10.1111/febs.16093 · Cited by 33

Pyridoxal Isonicotinoyl Hydrazone Improves Neurological Recovery by Attenuating Ferroptosis and Inflammation in Cerebral Hemorrhagic Mice

Zhang, H., Wen, M., Chen, J., Yao, C., Lin, X., Lin, Z., Ru, J., Zhuge, Q., & Yang, S. (2021) · BioMed Research International · doi:10.1155/2021/9916328 · Cited by 30

The Spike Protein of SARS-CoV-2 Impairs Lipid Metabolism and Increases Susceptibility to Lipotoxicity: Implication for a Role of Nrf2

Nguyen, V., Zhang, Y., Gao, C., Cao, X., Tian, Y., Carver, W. E., Kiaris, H., Cui, T., & Tan, W. (2022) · Cells · doi:10.3390/cells11121916 · Cited by 31

Puerarin Induces Molecular Details of Ferroptosis-Associated Anti-Inflammatory on RAW264.7 Macrophages

Zeng, J., Zhao, N., Yang, J., Kuang, W., Xia, X., Chen, X., Liu, Z., & Huang, R. (2022) · Metabolites · doi:10.3390/metabo12070653 · Cited by 33

Integrative Analysis Links Ferroptosis to Necrotizing Enterocolitis and Reveals the Role of ACSL4 in Immune Disorders

Dang, D., Zhang, C., Meng, Z., Lv, X., Li, Z., Wei, J., & Wu, H. M. (2021) · iScience · doi:10.1016/j.isci.2022.105406 · Cited by 34

Broadening horizons: The role of ferroptosis in myocardial ischemia–reperfusion injury

Zhao, K., Chen, X., Bian, Y.-J., Zhou, Z., Wei, X., & Zhang, J. (2023) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-023-02506-5 · Cited by 31

Protective effects and mechanism of chemical- and plant-based selenocystine against cadmium-induced liver damage

Zhang, L., Shi, W., Xu, J., Liu, Y., Wang, S., Zheng, J.-Y., Li, Y.-H., Yuan, L., & Qin, L. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.133812 · Cited by 30

Particulate Matter Induces Oxidative Stress and Ferroptosis in Human Lung Epithelial Cells

Ahn, Y., Yim, Y., & Yoo, H. M. (2024) · Toxics · doi:10.3390/toxics12020161 · Cited by 30

A multi-platform analysis of human gingival crevicular fluid reveals ferroptosis as a relevant regulated cell death mechanism during the clinical progression of periodontitis

Torres, A., Michea, M. A., Végvári, Á., Arce, M., Pérez, V., Alcota, M., Morales, A., Vernal, R., Budini, M., Zubarev, R. A., et al. (2024) · International Journal of Oral Science · doi:10.1038/s41368-024-00306-y · Cited by 38

Role of ferroptosis in radiation-induced soft tissue injury

Berry, C. E., Kendig, C. B., An, N., Fazilat, A. Z., Churukian, A. A., Griffin, M., Pan, P. M., Longaker, M. T., Dixon, S. J., & Wan, D. C. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02003-5 · Cited by 33

Broadening horizons: the role of ferroptosis in polycystic ovary syndrome

Wang, M., Zhang, B.-Q., Ma, S., Xu, Y. J., Zhao, D.-H., Zhang, J., Li, C.-J., Zhou, X., & Zheng, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1390013 · Cited by 29

Mechanisms of doxorubicin-induced cardiac inflammation and fibrosis; therapeutic targets and approaches

Song, L., Qiu, Q., Ju, F., & Zheng, C. (2024) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2024.110140 · Cited by 35

IFP35 aggravates Staphylococcus aureus infection by promoting Nrf2-regulated ferroptosis

Dai, M., Ouyang, W., Yu, Y., Wang, T., Wang, Y., Cen, M., Yang, L., Yu, H., Yao, Y., & Xu, F. (2023) · Journal of Advanced Research · doi:10.1016/j.jare.2023.09.042 · Cited by 28

Propofol Mitigates Sepsis-Induced Brain Injury by Inhibiting Ferroptosis Via Activation of the Nrf2/HO-1axis

Zhou, Y., Yang, Y., Liang, Y., Pan, M., Tang, W., & Duan, H. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04163-3 · Cited by 30

Ginsenoside Rb1 targets to HO-1 to improve sepsis by inhibiting ferroptosis

He, S., Ye, H., Wang, Q., He, Y., Liu, X., Song, J., Zhao, C., Hu, Y., Luo, L., Guo, Y., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.11.007 · Cited by 28

Sesamin attenuates PM 2.5 -induced cardiovascular injury by inhibiting ferroptosis in rats

Ren, J., Yin, B., Li, X., Zhu, S., Deng, J.-L., Sun, Y., Zhang, Z.-A., Guo, Z., Pei, H., Zhang, F., et al. (2021) · Food & Function · doi:10.1039/d1fo02913d · Cited by 28

Endothelial progenitor cells-derived exosomes transfer microRNA-30e-5p to regulate Erastin-induced ferroptosis in human umbilical vein endothelial cells via the specificity protein 1/adenosine monophosphate-activated protein kinase axis

Xia, J., Song, X., Meng, J., & Lou, D. (2022) · Bioengineered · doi:10.1080/21655979.2022.2025519 · Cited by 28

Ferrostatin-1 alleviates ventilator-induced lung injury by inhibiting ferroptosis

Ling, M., Liu, Y., Qi, Z., Zhao, L., he, S. T., Lin, J., Mo, J., & Pan, L. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110356 · Cited by 28

The mechanism underlying correlation of particulate matter-induced ferroptosis with inflammasome activation and iron accumulation in macrophages

Park, M., Park, S., Choi, Y., Cho, Y., Kim, M. J., Park, Y., Chung, S. W., Lee, H., & Lee, S. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-01874-y · Cited by 27

Endoplasmic reticulum stress-mediated ferroptosis in granulosa cells contributes to follicular dysfunction of polycystic ovary syndrome driven by hyperandrogenism

Ding, H.-M., Xiang, Y., Zhu, Q., Wu, H., Xu, T., Huang, Z., & Ge, H. (2024) · Reproductive BioMedicine Online · doi:10.1016/j.rbmo.2024.104078 · Cited by 28

Ferroptosis: New Dawn for Overcoming the Cardio-Cerebrovascular Diseases

Luo, M.-Y., Su, J.-H., Gong, S.-X., Liang, N., Huang, W., Chen, W., Wang, A., & Tian, Y. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.733908 · Cited by 27

COVID-19-Related Brain Injury: The Potential Role of Ferroptosis

Zhang, R., Sun, C., Chen, X., Han, Y., Zang, W., Jiang, C., Wang, J., & Wang, J. (2022) · Journal of Inflammation Research · doi:10.2147/jir.s353467 · Cited by 27

Ferroptosis-related gene expression in the pathogenesis of preeclampsia

Ding, Y., Yang, X., Han, X., Shi, M., Sun, L., Liu, M., Zhang, P., Huang, Z., Yang, X., & Li, R. (2022) · Frontiers in Genetics · doi:10.3389/fgene.2022.927869 · Cited by 27

Precision nutrition to reset virus-induced human metabolic reprogramming and dysregulation (HMRD) in long-COVID

Naidu, A. S., Wang, C., Rao, P., Mancini, F., Clemens, R., Wirakartakusumah, A., Chiu, H., Yen, C., Porretta, S., Mathai, I., et al. (2024) · npj Science of Food · doi:10.1038/s41538-024-00261-2 · Cited by 32

A Ferroptosis-Related lncRNAs Signature Predicts Prognosis and Therapeutic Response of Gastric Cancer

Xiao, S., Liu, X., Yuan, L., & Wang, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.736682 · Cited by 26

Ferroptosis Related Immunomodulatory Effect of a Novel Extracellular Polysaccharides from Marine Fungus Aureobasidium melanogenum

Lin, Y., Yang, J., Luo, L., Zhang, X., Deng, S., Chen, X., Li, Y., Bekhit, A. E. A., Xu, B., & Huang, R. (2022) · Marine Drugs · doi:10.3390/md20050332 · Cited by 26

NOD2 ‐mediated HDAC6 / NF ‐κb signalling pathway regulates ferroptosis induced by extracellular histone H3 in acute liver failure

Chen, Q., Zhang, Q., Cao, P., Shi, C., Zhang, L., Wang, L., & Gong, Z. (2022) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17582 · Cited by 25

SP2509 functions as a novel ferroptosis inhibitor by reducing intracellular iron level in vascular smooth muscle cells

He, Y., Wang, X., Chen, S., Luo, H., Huo, B., Guo, X., Li, R., Chen, Y., Yi, X., Wei, X., et al. (2024) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2024.04.220 · Cited by 26

Caffeic acid alleviates skeletal muscle atrophy in 5/6 nephrectomy rats through the TLR4/MYD88/NF-kB pathway

He, J., He, Z., Wang, H., Zhang, C., Pei, T., Yan, S., Yan, Y., Wang, F., Chen, Y., Yuan, N., et al. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116556 · Cited by 25

Isochlorogenic acid A ameliorated lead-induced anxiety-like behaviors in mice by inhibiting ferroptosis-mediated neuroinflammation via the BDNF/Nrf2/GPX4 pathways

Guo, J., Li, H., Cheng, C., Shi, J.-X., Ruan, H.-N., Li, J., & Liu, C. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114814 · Cited by 24

New Insight into Neuropathic Pain: The Relationship between α7nAChR, Ferroptosis, and Neuroinflammation

Luo, F., & Huang, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25126716 · Cited by 26

SENP3 sensitizes macrophages to ferroptosis via de-SUMOylation of FSP1

Chen, X., Wang, J., Yang, P., Liu, H.-Y., Zhong, S., Lu, C., Gao, M., Liu, D., Zhang, J., Wang, J., et al. (2024) · Redox Biology · doi:10.1016/j.redox.2024.103267 · Cited by 25

EGCG Alleviates DSS-Induced Colitis by Inhibiting Ferroptosis Through the Activation of the Nrf2-GPX4 Pathway and Enhancing Iron Metabolism

Chen, J., Yin, C., Zhang, Y., Lai, X., Liu, C., Luo, Y., Luo, J., He, J., Yu, B., Wang, Q., et al. (2025) · Nutrients · doi:10.3390/nu17030547 · Cited by 25

Identification of Ferroptosis-Related Hub Genes and Their Association with Immune Infiltration in Chronic Obstructive Pulmonary Disease by Bioinformatics Analysis

Yang, Y.-C., Zhang, M., Liu, J., Jiang, Y., Ji, X.-L., & Qu, Y.-Q. (2022) · International Journal of COPD · doi:10.2147/copd.s348569 · Cited by 25

Endometrial Regenerative Cell-Derived Exosomes Attenuate Experimental Colitis through Downregulation of Intestine Ferroptosis

Zhu, Y., Qin, H., Sun, C., Shao, B., Li, G., Qin, Y., Kong, D., Ren, S., Wang, H., Wang, Z., et al. (2022) · Stem Cells International · doi:10.1155/2022/3014123 · Cited by 26

L-Citrulline Supplementation Restrains Ferritinophagy-Mediated Ferroptosis to Alleviate Iron Overload-Induced Thymus Oxidative Damage and Immune Dysfunction

Ba, T., Zhao, D., Chen, Y., Zeng, C., Zhang, C., Niu, S., & Dai, H. (2022) · Nutrients · doi:10.3390/nu14214549 · Cited by 27

Genetic analysis of potential biomarkers and therapeutic targets in ferroptosis from psoriasis

Wu, M.-N., Zhou, D., Jiang, C., Chen, W.-W., Chen, J.-C., Zou, Y.-M., Han, T., & Zhou, L.-J.-M. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1104462 · Cited by 25

Inhibition of STEAP1 ameliorates inflammation and ferroptosis of acute lung injury caused by sepsis in LPS-induced human pulmonary microvascular endothelial cells

Zou, X., Liu, C., Huang, Z., Xiang, S., Li, K., Yuan, Y., Hao, Y., & Zhou, F. (2023) · Molecular Biology Reports · doi:10.1007/s11033-023-08403-7 · Cited by 27

Role of ferroptosis in periodontitis: An animal study in rats

Fu, E., Kuo, C., Hsia, Y., Huang, Y., Tseng, H., Fu, M., & Shih, K. (2023) · Journal of Periodontal Research · doi:10.1111/jre.13165 · Cited by 25

Glyphosate drives autophagy-dependent ferroptosis to inhibit testosterone synthesis in mouse Leydig cells

Lu, L., Lian, C.-Y., Lv, Y.-T., Zhang, S., Wang, L., & Wang, L. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.169927 · Cited by 24

Physical Exercise-Induced Activation of NRF2 and BDNF as a Promising Strategy for Ferroptosis Regulation in Parkinson’s Disease

Thirupathi, A., Marqueze, L. F., Outeiro, T. F., Radak, Z. O., & Pinho, R. A. (2024) · Neurochemical Research · doi:10.1007/s11064-024-04152-6 · Cited by 25

The Metabolic Syndrome: An Overview and Proposed Mechanisms

Thomaz, F. S., John, O. D., Sinha, P., Shafie, S. R., & Worrall, S. (2024) · Obesities · doi:10.3390/obesities4030020 · Cited by 29

The role of microglia in neurodegenerative diseases: from the perspective of ferroptosis

Liu, Y., Jia, G.-R., Zhang, S.-H., Guo, Y., Ma, X., Xu, H., & Xie, J. (2025) · Acta Pharmacologica Sinica · doi:10.1038/s41401-025-01560-4 · Cited by 27

Targeting Autophagy, Ferroptosis, and Neuroinflammation: Polyphenol-Mediated Modulation of Emerging Signaling Pathways in Neurodegeneration

Jindal, A., & Nand, S. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05760-9 · Cited by 27

The Influence of Viral Infections on Iron Homeostasis and the Potential for Lactoferrin as a Therapeutic in the Age of the SARS-CoV-2 Pandemic

Ward, J. L., Torres‐Gonzalez, M., & Ammons, M. C. B. (2022) · Nutrients · doi:10.3390/nu14153090 · Cited by 24

Proteomics analysis of lung reveals inflammation and cell death induced by atmospheric H2S exposure in pig

Liu, Z., Fu, Q., Tang, S., Xie, Y., Meng, Q., Tang, X., Zhang, S., Zhang, H., & Schroyen, M. (2020) · Environmental Research · doi:10.1016/j.envres.2020.110204 · Cited by 24

Co-exposure of decabromodiphenyl ethane and polystyrene nanoplastics damages grass carp (Ctenopharyngodon idella) hepatocytes: Focus on the role of oxidative stress, ferroptosis, and inflammatory reaction

Shi, B., Xu, T., Chen, T., Xu, S., & Yao, Y. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.173575 · Cited by 24

Ferroptosis as an emerging target in sickle cell disease

Fortuna, V., Lima, J. C., Oliveira, G. F., de Oliveira, Y. S. C., Getachew, B., Nekhai, S. A., Aschner, M., & Tizabi, Y. (2024) · Current Research in Toxicology · doi:10.1016/j.crtox.2024.100181 · Cited by 25

Saikosaponin A attenuates osteoclastogenesis and bone loss by inducing ferroptosis

Li, T.-Q., Liu, Y., Feng, C., Bai, J., Wang, Z.-R., Zhang, X.-Y., & Wang, X. (2024) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2024.1390257 · Cited by 23

Advancements in programmed cell death research in antitumor therapy: a comprehensive overview

Wei, S., Han, C., Mo, S., Huang, H., & Luo, X. (2024) · APOPTOSIS · doi:10.1007/s10495-024-02038-0 · Cited by 29

Bioactivity Screening of Antarctic Sponges Reveals Anticancer Activity and Potential Cell Death via Ferroptosis by Mycalols

Riccio, G., Nuzzo, G., Zazo, G., Coppola, D., Senese, G., Romano, L., Costantini, M., Ruocco, N., Bertolino, M., Fontana, A., et al. (2021) · Marine Drugs · doi:10.3390/md19080459 · Cited by 23

Iron metabolism and chronic inflammation in IgA nephropathy

Tian, Z.-Y., Li, Z., Chu, L., Liu, Y., He, J., Yu, X., Li, A., & Zhang, H. (2023) · Renal Failure · doi:10.1080/0886022x.2023.2195012 · Cited by 24

The putative role of ferroptosis in gastric cancer: a review

Wang, L., & Wang, H. (2023) · European Journal of Cancer Prevention · doi:10.1097/cej.0000000000000817 · Cited by 25

Maresin1 Inhibits Ferroptosis via the Nrf2/SLC7A11/GPX4 Pathway to Protect Against Sepsis-Induced Acute Liver Injury

Guo, Y., Chen, H., Sun, J. W., Zhang, J., & Yin, Y. (2024) · Journal of Inflammation Research · doi:10.2147/jir.s498775 · Cited by 25

Circular RNAs modulate cell death in cardiovascular diseases

Pan, R., Koo, C., Su, W., You, Q., Guo, H.-D., & Liu, B. (2025) · Cell Death Discovery · doi:10.1038/s41420-025-02504-x · Cited by 24

Bioinformatics Identification of Ferroptosis-Associated Biomarkers and Therapeutic Compounds in Psoriasis

Mao, J., & Ma, X. (2022) · Journal of Oncology · doi:10.1155/2022/3818216 · Cited by 22

Targeting of non-apoptotic cancer cell death mechanisms by quercetin: Implications in cancer therapy

Yang, H., Xu, S., Tang, L., Gong, J., Fang, H., Wei, J., & Su, D. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1043056 · Cited by 24

Nature-Inspired Bioactive Compounds: A Promising Approach for Ferroptosis-Linked Human Diseases?

Hajj, S. E., Canabady‐Rochelle, L., & Gaucher, C. (2023) · Molecules · doi:10.3390/molecules28062636 · Cited by 24

COVID-19 induced liver injury from a new perspective: Mitochondria

Akbari, H., & Taghizadeh‐Hesary, F. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.04.001 · Cited by 24

Inflammation in Metal-Induced Neurological Disorders and Neurodegenerative Diseases

Wei, R., Wei, P., Yuan, H., Yi, X., Aschner, M., Jiang, Y., & Li, S. (2024) · Biological Trace Element Research · doi:10.1007/s12011-023-04041-z · Cited by 24

NOX4 regulates gastric cancer cell invasion and proliferation by increasing ferroptosis sensitivity through regulating ROS

Wang, L., & Gong, W. (2024) · International Immunopharmacology · doi:10.1016/j.intimp.2024.112052 · Cited by 22

Exosomal let-7a-5p derived from human umbilical cord mesenchymal stem cells alleviates coxsackievirus B3-induced cardiomyocyte ferroptosis via the SMAD2/ZFP36 signal axis

Li, X., Hu, Y., Wu, Y., Yang, Z., Liu, Y., & Liu, H. (2024) · Journal of Zhejiang University SCIENCE B · doi:10.1631/jzus.b2300077 · Cited by 22

Ferroptosis and Lipid Metabolism in Acute Myocardial Infarction

Wu, X., Li, J., Cheng, H., & Wang, L. (2024) · Reviews in Cardiovascular Medicine · doi:10.31083/j.rcm2505149 · Cited by 21

The recent advancements of ferroptosis of gynecological cancer

Tang, S., & Chen, L. (2024) · Cancer Cell International · doi:10.1186/s12935-024-03537-5 · Cited by 25

Bovine milk-derived extracellular vesicles reduce oxidative stress and ferroptosis induced by Klebsiella pneumoniae in bovine mammary epithelial cells

Liang, B., Xiong, Y., Cobo, E. R., Kastelic, J. P., Tong, X., Han, B., & Gao, J. (2025) · Journal of Animal Science and Biotechnology/Journal of animal science and biotechnology · doi:10.1186/s40104-025-01151-7 · Cited by 21

Plaque‐Targeted Delivery of Fluoride‐Free MXene Nanozyme for Alleviating Atherosclerosis via Sonocatalytic Therapy

Bai, Q., Lao, X., Pang, S., Zhao, Y., Liu, Y., Tian, X. Y., & Hao, J. (2025) · Advanced Materials · doi:10.1002/adma.202420189 · Cited by 21

RXRγ attenuates cerebral ischemia–reperfusion induced ferroptosis in neurons in mice through transcriptionally promoting the expression of GPX4

Yang, L., Du, B., Zhang, S., & Wang, M. (2022) · Metabolic Brain Disease · doi:10.1007/s11011-022-00988-5 · Cited by 21

Proteomic analysis reveals that ACSL4 activation during reflux esophagitis contributes to ferroptosis-mediated esophageal mucosal damage

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The opposite role of lactate dehydrogenase a (LDHA) in cervical cancer under energy stress conditions

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Quercetin promotes ATG5-mediating autophagy-dependent ferroptosis in gastric cancer

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Dabrafenib mitigates the neuroinflammation caused by ferroptosis in experimental autoimmune encephalomyelitis by up regulating Axl receptor

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The m6A eraser FTO suppresses ferroptosis via mediating ACSL4 in LPS-induced macrophage inflammation

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Targeting ferroptosis in the treatment of ulcerative colitis by traditional Chinese medicine: A novel therapeutic strategies

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Expression of Ferroptosis-Related Genes Shapes Tumor Microenvironment and Pharmacological Profile in Gastric Cancer

Xiao, S., Liu, X., Yuan, L., Chen, X., & Wang, F. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.694003 · Cited by 20

Bioinformatics Prediction and Experimental Validation of the Role of Macrophage Polarization and Ferroptosis in Gestational Diabetes Mellitus

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Hsp90α and cell death in cancers: a review

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Infection of Helicobacter pylori contributes to the progression of gastric cancer through ferroptosis

Liu, Y., Miao, R., Xia, J., Zhou, Y. C., Yao, J., & Shao, S. (2024) · Cell Death Discovery · doi:10.1038/s41420-024-02253-3 · Cited by 24

Ferroptosis in Cardiovascular Diseases and Ferroptosis-Related Intervention Approaches

Zhou, X., Wang, H., Yan, B., Nie, X., Chen, Q., Yang, X., Lei, M., Guo, X., Ouyang, C., & Ren, Z. (2024) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-024-07642-5 · Cited by 22

Inhibition of ferroptosis alleviates atherosclerosis and foam cell formation by regulating lipid metabolism via AMPK activation

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The role of ferroptosis in Alzheimer's disease: Mechanisms and therapeutic potential (Review)

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Regulated necrosis in COVID-19: A double-edged sword

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Novel Insights on Ferroptosis Modulation as Potential Strategy for Cancer Treatment: When Nature Kills

Consoli, V., Fallica, A. N., Sorrenti, V., Pittalà, V., & Vanella, L. (2023) · Antioxidants and Redox Signaling · doi:10.1089/ars.2022.0179 · Cited by 21

Exploring the relationship between anastasis and mitochondrial ROS-mediated ferroptosis in metastatic chemoresistant cancers: a call for investigation

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Molecular and therapeutic landscape of ferroptosis in skin diseases

Le, J., Meng, Y., Wang, Y., Li, D., Zeng, F., Xiong, Y., Chen, X., & Deng, G. (2024) · Chinese Medical Journal · doi:10.1097/cm9.0000000000003164 · Cited by 20

Yi-Qi-Jian-Pi-Xiao-Yu formula inhibits cisplatin-induced acute kidney injury through suppressing ferroptosis via STING-NCOA4-mediated ferritinophagy

Zhu, J., Yuan, A., Le, Y., Chen, X., Guo, J., Liu, J. L., Chen, H., Wang, C. Y., Lu, D., & Lu, K. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.156189 · Cited by 18

DAMP signaling networks: from receptors to diverse pathophysiological functions

Chen, R., Zou, J., Zhong, X. Y., Liu, J., Kang, R., & Tang, D. (2025) · Journal of Advanced Research · doi:10.1016/j.jare.2025.07.047 · Cited by 26

Ferroptosis participated in hippocampal neuroinflammation damage of in offspring rats after maternal sleep deprivation

Lv, J., Xu, S., Meng, C., Wang, Y., Ji, L., Li, X., Wang, X., & Li, Q. (2023) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2023.578021 · Cited by 18

Enriched Environment Attenuates Ferroptosis after Cerebral Ischemia/Reperfusion Injury via the HIF-1α-ACSL4 Pathway

Liu, J., Luo, Q., Ke, J., Zhang, D., Xu, Y., Liao, W., Chen, X., & Zhang, X. (2023) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2023/5157417 · Cited by 18

Temporal correlations of ferroptosis, inflammation and oxidative stress under acute ammonia exposure in brain tissue of yellow catfish (Pelteobagrus fulvidraco)

Long, X., He, K., Zhang, M., Li, M., Wang, Z., Wang, C., Dong, X., Shao, J., Gan, L., Hu, X., et al. (2023) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2023.109693 · Cited by 18

Iron-overload-induced ferroptosis in mouse cerebral toxoplasmosis promotes brain injury and could be inhibited by Deferiprone

Wang, C., Xie, L., Xing, Y., Liu, M., Yang, J., Gao, N., & Cai, Y. (2023) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0011607 · Cited by 19

Molecular mechanisms of ferroptosis and their role in inflammation

Wang, F., He, J., Xing, R., Sha, T., & Sun, B. (2021) · International Reviews of Immunology · doi:10.1080/08830185.2021.2016739 · Cited by 50

Editorial: Ferroptosis as a novel therapeutic target for inflammation-related diseases

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Molecular mechanisms of ferroptosis and relevance to inflammation

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Inflammation in a ferroptotic environment

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Ferroptosis in infection, inflammation, and immunity

Chen, X., Kang, R., Kroemer, G., & Tang, D. (2021) · The Journal of Experimental Medicine · doi:10.1084/jem.20210518 · Cited by 836