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The emerging role of ferroptosis in inflammation
Open accessAbstract
Ferroptosis is a newly discovered type of cell death triggered by intracellular phospholipid peroxidation that is morphologically, biologically and genetically distinct from other types of cell death. Ferroptosis is classified as regulated necrosis and is more immunogenic than apoptosis. To date, compelling evidence indicates that ferroptosis plays an important role in inflammation, and several antioxidants functioning as ferroptosis inhibitors have been shown to exert anti-inflammatory effects in experimental models of certain diseases. Our review provides an overview of the link between ferroptosis and inflammation; a better understanding of the mechanisms underlying ferroptosis and inflammation may hasten the development of promising therapeutic strategies involving ferroptosis inhibitors to address inflammation.
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“In an oxalate-induced mouse model of AKI, evidence of inflammation was observed, and the ferroptosis inhibitor Ferrostatin-1 successfully inhibited neutrophil infiltration and the expression of pro-inflammatory cytokines such as CXCL-2 and IL-6.255,256”
From Inflammation and aging: signaling pathways and intervention therapies (2023) · cites this paper as [256]
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“Ferroptosis represents an iron-dependent RCD pathway characterized by lipid peroxidation and downregulation of the antioxidant defense of cells [39,40,41].”
From Role of Regulated Cell Death Pathways in Snakebite Envenomation: Mechanisms, Crosstalk, and Therapeutic Opportunities (2026) · cites this paper as [41]
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“This theory is supported by previous data demonstrating that inflammation induces iron-dependant peroxidation processes resulting in cellular apoptosis, a process which is referred to as ferroptosis [29, 30].”
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“Notably, iron dysmetabolism and ferroptosis have also been linked to typical COVID-19 associated symptoms, such as cognitive impairment and anosmia [15, 29].”
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Mechanisms of Ferroptosis and Emerging Links to the Pathology of Metabolic Disorders
Singh, B., Srivastava, N., & Sharma, A. (2025) · Current Indian Science · doi:10.2174/012210299x394730250912071440
Pantothenic acid alleviates endometrial injury induced by vagotomy in mice
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Metadata
- Authors
- Sun, Y., Chen, P., Zhai, B., Zhang, M., Xiang, Y., Fang, J., Xu, S., Gao, Y., Chen, X., Sui, X., & Li, G.
- Affiliations
- Hangzhou Normal University (CN)
- Affiliated Hospital of Hangzhou Normal University (CN)
- Corresponding author
- Sui, Xinbing
- Li, Guoxiong
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2020-07
- Volume
- 127
- Pages
- 110108
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3013314180
- Cited by
- 739
- References
- 154
- Citations by year
- 2026: 62 · 2025: 137 · 2024: 187 · 2023: 142 · 2022: 148 · 2021: 50 · 2020: 12
- FWCI
- 12.65
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Natural Science Foundation of China (81730108, 81874380, 81672932, 81973635)
- Science and Technology Program of Zhejiang Province (2019ZZ016)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Ferroptosis and cancer prognosis
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Cell death mechanisms and regulation
- Keywords
- ferroptosis, inflammation, regulated necrosis, phospholipid peroxidation, ferroptosis inhibitors, antioxidants, anti-inflammatory activity, immunogenic cell death, treatment options
- MeSH terms
- Ferroptosis, Animals, Antioxidants, Humans, Inflammation, Necrosis
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