Cited by 378Curcumin's Biomedical ApplicationsGenetics, Aging, and Longevity in Model OrganismsPhytochemicals and Antioxidant Activities

The Role of Curcumin in Aging and Senescence: Molecular Mechanisms

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Zia, Aliabbas, Farkhondeh, Tahereh, Pourbagher-Shahri, Ali Mohammad, Samarghandian, Saeed·2021·Biomedicine & Pharmacotherapy

Abstract

Healthy aging and human longevity are intricate phenotypes affected by environmental factors such as physical exercise, diet, health habits, and psychosocial situations as well as genetic factors. Diet and caloric restriction have a crucial role in healthy aging. Curcumin, a polyphenolic compound isolated from the Curcuma longa, has been shown to exert anti-aging characteristics. Recently, investigations on curcumin with regard to aging and age-associated disease in model organisms has described that curcumin and its metabolites, prolong the mean lifespan of some aging model organisms such as C. elegans, D. melanogaster, yeast, and mouse. It has been proposed to have several biological activities, such as antioxidative, anti-inflammatory, anticancer, chemopreventive, and anti-neurodegenerative characteristics. In several studies on various model organisms it has been shown that the lifespan extension via curcumin treatment was connected with enhanced superoxide dismutase (SOD) activity, and also declined malondialdehyde (MDA) and lipofuscin levels. As well as the pivotal role of curcumin on the modulating of major signaling pathways that influence longevity of organisms like IIS, mTOR, PKA, and FOXO signaling pathways. This review defines the use of curcumin in traditional and modern medicine, its biochemistry and biological functions, such as curcumin's anti-aging, anti-cancer, anti-microbial, anti-inflammatory, and anti-oxidant characteristics. Also, the review further describes the role of curcumin in a pharmacological context and new insights on its therapeutic capacity and restrictions. Particularly, the review emphasizes in-depth on the efficiency of curcumin and its mechanism of action as an anti-aging compound and also treating age-related disease.

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Crossref · 10.1016/j.biopha.2020.111119

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  • CUR possesses antioxidant properties, through which it can prevent lipid peroxidation, stabilize Nrf2 with consequent expression of HO-1, and increase levels of antioxidant enzymes such as SOD, GST, GSH and GPx.

    “Further, CUR possesses antioxidant properties, through which it can prevent lipid peroxidation, stabilize Nrf2, with the consequent expression of HO-1, and increase the levels of antioxidant enzymes, such as SOD, GST, GSH and GPx [395].”

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Research works printed but not linked: 4

  1. V.P. Menon, A.R. Sudheer, Antioxidant and Anti-inflammatory Properties of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer, 2007, pp. 105-125.
  2. S.C. Johnson, Nutrient Sensing, Signaling and Ageing: the Role of IGF-1 and mTOR in Ageing and Age-related Disease. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, Springer, 2018, pp. 49-97.
  3. M.S. Hayden, S. Ghosh, Signaling to NF-κB. Genes Development, 2004, pp. 2195-2224, 18(18).
  4. B.B. Aggarwal, Y.-J. Surh, S. Shishodia, The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease: Springer Science & Business Media, 2007.

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Authors
Zia, A., Farkhondeh, T., Pourbagher-Shahri, A. M., & Samarghandian, S.
Affiliations
  • University of Tehran (IR)
  • Birjand University of Medical Sciences (IR)
  • University of Neyshabur (IR)
Corresponding author
Samarghandian, Saeed
Venue
Biomedicine & Pharmacotherapy
Publisher
Elsevier BV
Published
2021-02
Volume
134
Pages
111119
ISSN
0753-3322 (ISSN-L)
OpenAlex
W3114209299
Cited by
378
References
154
Citations by year
2026: 46 · 2025: 93 · 2024: 92 · 2023: 78 · 2022: 49 · 2021: 20
FWCI
2.61
Type
journal article
Language
en
Open access
Locations
  • Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
  • Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
Keywords
curcumin, healthy aging, senescence, lifespan extension, age-related diseases, caloric restriction, dietary polyphenols, turmeric, oxidative stress, anti-inflammatory activity, anticancer activity, antimicrobial activity, mTOR signaling, FoxO signaling, PKA signaling, superoxide dismutase, lipofuscin, model organisms
MeSH terms
Healthy Aging, Age Factors, Animals, Anti-Inflammatory Agents, Antioxidants, Curcumin, Humans, Signal Transduction, Cellular Senescence, Oxidative Stress, Inflammation Mediators

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