The Role of Curcumin in Aging and Senescence: Molecular Mechanisms
Open accessAbstract
Healthy aging and human longevity are intricate phenotypes affected by environmental factors such as physical exercise, diet, health habits, and psychosocial situations as well as genetic factors. Diet and caloric restriction have a crucial role in healthy aging. Curcumin, a polyphenolic compound isolated from the Curcuma longa, has been shown to exert anti-aging characteristics. Recently, investigations on curcumin with regard to aging and age-associated disease in model organisms has described that curcumin and its metabolites, prolong the mean lifespan of some aging model organisms such as C. elegans, D. melanogaster, yeast, and mouse. It has been proposed to have several biological activities, such as antioxidative, anti-inflammatory, anticancer, chemopreventive, and anti-neurodegenerative characteristics. In several studies on various model organisms it has been shown that the lifespan extension via curcumin treatment was connected with enhanced superoxide dismutase (SOD) activity, and also declined malondialdehyde (MDA) and lipofuscin levels. As well as the pivotal role of curcumin on the modulating of major signaling pathways that influence longevity of organisms like IIS, mTOR, PKA, and FOXO signaling pathways. This review defines the use of curcumin in traditional and modern medicine, its biochemistry and biological functions, such as curcumin's anti-aging, anti-cancer, anti-microbial, anti-inflammatory, and anti-oxidant characteristics. Also, the review further describes the role of curcumin in a pharmacological context and new insights on its therapeutic capacity and restrictions. Particularly, the review emphasizes in-depth on the efficiency of curcumin and its mechanism of action as an anti-aging compound and also treating age-related disease.
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CUR possesses antioxidant properties, through which it can prevent lipid peroxidation, stabilize Nrf2 with consequent expression of HO-1, and increase levels of antioxidant enzymes such as SOD, GST, GSH and GPx.
“Further, CUR possesses antioxidant properties, through which it can prevent lipid peroxidation, stabilize Nrf2, with the consequent expression of HO-1, and increase the levels of antioxidant enzymes, such as SOD, GST, GSH and GPx [395].”
From The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence (2022) · cites this paper as [395]
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Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567 · see citing works
The serial cultivation of human diploid cell strains
Hayflick, L., & Moorhead, P. S. (1961) · Experimental Cell Research · doi:10.1016/0014-4827(61)90192-6 · Cited by 8,508 · see citing works
THE NF-κB AND IκB PROTEINS: New Discoveries and Insights
Baldwin, A. S. (1996) · Annual Review of Immunology · doi:10.1146/annurev.immunol.14.1.649 · Cited by 5,882 · see citing works
Inflamm‐aging: An Evolutionary Perspective on Immunosenescence
FRANCESCHI, C., BONAFÈ, M., VALENSIN, S., OLIVIERI, F., DE LUCA, M., OTTAVIANI, E., & DE BENEDICTIS, G. (2000) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2000.tb06651.x · Cited by 5,358 · see citing works
NF-κB regulation in the immune system
Li, Q., & Verma, I. M. (2002) · Nature Reviews Immunology · doi:10.1038/nri910 · Cited by 4,007 · see citing works
Rapamycin fed late in life extends lifespan in genetically heterogeneous mice
Harrison, D. E., Strong, R., Sharp, Z. D., Nelson, J. F., Astle, C. M., Flurkey, K., Nadon, N. L., Wilkinson, J. E., Frenkel, K., Carter, C. S., et al. (2009) · Nature · doi:10.1038/nature08221 · Cited by 3,766 · see citing works
A C. elegans mutant that lives twice as long as wild type
Kenyon, C., Chang, J., Gensch, E., Rudner, A., & Tabtiang, R. (1993) · Nature · doi:10.1038/366461a0 · Cited by 3,387 · see citing works
Extending Healthy Life Span—From Yeast to Humans
Fontana, L., Partridge, L., & Longo, V. D. (2010) · Science · doi:10.1126/science.1172539 · Cited by 3,023 · see citing works
Cellular senescence in aging and age-related disease: from mechanisms to therapy
Childs, B. G., Durik, M., Baker, D. J., & van Deursen, J. M. (2015) · Nature Medicine · doi:10.1038/nm.4000 · Cited by 2,363 · see citing works
Integrating cell-signalling pathways with NF-κB and IKK function
Perkins, N. D. (2007) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm2083 · Cited by 2,350 · see citing works
Kimura, K. D., Tissenbaum, H. A., Liu, Y., & Ruvkun, G. (1997) · Science · doi:10.1126/science.277.5328.942 · Cited by 2,250 · see citing works
Curcumin as “Curecumin”: From kitchen to clinic
Goel, A., Kunnumakkara, A. B., & Aggarwal, B. B. (2007) · Biochemical Pharmacology · doi:10.1016/j.bcp.2007.08.016 · Cited by 2,220 · see citing works
A cytokine-responsive IκB kinase that activates the transcription factor NF-κB
DiDonato, J. A., Hayakawa, M., Rothwarf, D. M., Zandi, E., & Karin, M. (1997) · Nature · doi:10.1038/41493 · Cited by 2,125 · see citing works
IGF-1 receptor regulates lifespan and resistance to oxidative stress in mice
Holzenberger, M., Dupont, J., Ducos, B., Leneuve, P., Géloën, A., Even, P. C., Cervera, P., & Le Bouc, Y. (2003) · Nature · doi:10.1038/nature01298 · Cited by 2,109 · see citing works
IKK-1 and IKK-2: Cytokine-Activated IκB Kinases Essential for NF-κB Activation
Mercurio, F., Zhu, H., Murray, B. W., Shevchenko, A., Bennett, B. L., Li, J. W., Young, D. B., Barbosa, M. S., Mann, M., Manning, A. M., et al. (1997) · Science · doi:10.1126/science.278.5339.860 · Cited by 2,042 · see citing works
The essence of senescence: Figure 1.
Kuilman, T., Michaloglou, C., Mooi, W. J., & Peeper, D. S. (2010) · Genes & Development · doi:10.1101/gad.1971610 · Cited by 2,038 · see citing works
Curcumin: From ancient medicine to current clinical trials
Hatcher, H., Planalp, R. P., Cho, J., Torti, F. M., & Torti, S. V. (2008) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-008-7452-4 · Cited by 1,847 · see citing works
The p66shc adaptor protein controls oxidative stress response and life span in mammals
Migliaccio, E., Giorgio, M., Mele, S., Pelicci, G., Reboldi, P., Pandolfi, P. P., Lanfrancone, L., & Pelicci, P. G. (1999) · Nature · doi:10.1038/46311 · Cited by 1,712 · see citing works
Delves, P. J., & Roitt, I. M. (2000) · New England Journal of Medicine · doi:10.1056/nejm200007063430107 · Cited by 1,666 · see citing works
Tatar, M., Kopelman, A. H., Epstein, D., Tu, M., Yin, C. ‐., & Garofalo, R. S. (2001) · Science · doi:10.1126/science.1057987 · Cited by 1,630 · see citing works
Extension of Life-Span by Loss of CHICO, a Drosophila Insulin Receptor Substrate Protein
Clancy, D. J., Gems, D., Harshman, L. G., Oldham, S., Stocker, H., Hafen, E., Leevers, S. J., & Partridge, L. (2001) · Science · doi:10.1126/science.1057991 · Cited by 1,436 · see citing works
Regulation of lifespan in Drosophila by modulation of genes in the TOR signaling pathway
Kapahi, P., Zid, B. M., Harper, T., Koslover, D., Sapin, V., & Benzer, S. (2004) · Current Biology · doi:10.1016/j.cub.2004.03.059 · Cited by 1,293 · see citing works
Regulation of Yeast Replicative Life Span by TOR and Sch9 in Response to Nutrients
Kaeberlein, M., Powers, R. W., Steffen, K. K., Westman, E. A., Hu, D., Dang, N., Kerr, E. O., Kirkland, K. T., Fields, S., & Kennedy, B. K. (2005) · Science · doi:10.1126/science.1115535 · Cited by 1,293 · see citing works
Curcumin, an active component of turmeric ( Curcuma longa ), and its effects on health
Bozkurt, B. K., & Şanlıer, N. (2015) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2015.1077195 · Cited by 1,251 · see citing works
Ribosomal Protein S6 Kinase 1 Signaling Regulates Mammalian Life Span
Selman, C., Tullet, J. M. A., Wieser, D., Irvine, E., Lingard, S. J., Choudhury, A. I., Claret, M., Al-Qassab, H., Carmignac, D., Ramadani, F., et al. (2009) · Science · doi:10.1126/science.1177221 · Cited by 1,120 · see citing works
Influence of TOR kinase on lifespan in C. elegans
Vellai, T., Takacs-Vellai, K., Zhang, Y., Kovacs, A. L., Orosz, L., & Müller, F. (2003) · Nature · doi:10.1038/426620a · Cited by 1,057 · see citing works
Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila Melanogaster
Bjedov, I., Toivonen, J. M., Kerr, F., Slack, C., Jacobson, J., Foley, A., & Partridge, L. (2010) · Cell Metabolism · doi:10.1016/j.cmet.2009.11.010 · Cited by 1,057 · see citing works
Extension of Chronological Life Span in Yeast by Decreased TOR Pathway Signaling
Powers, R. W., Kaeberlein, M., Caldwell, S. D., Kennedy, B. K., & Fields, S. (2006) · Genes & Development · doi:10.1101/gad.1381406 · Cited by 982 · see citing works
Amalraj, A., Pius, A., Gopi, S., & Gopi, S. (2016) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2016.05.005 · Cited by 976 · see citing works
Cellular senescence as a tumor-suppressor mechanism
Campisi, J. (2001) · Trends in Cell Biology · doi:10.1016/s0962-8924(01)02151-1 · Cited by 936 · see citing works
Rapamycin, But Not Resveratrol or Simvastatin, Extends Life Span of Genetically Heterogeneous Mice
Miller, R. A., Harrison, D. E., Astle, C. M., Baur, J. A., Boyd, A. R., de Cabo, R., Fernandez, E., Flurkey, K., Javors, M. A., Nelson, J. F., et al. (2011) · The Journals of Gerontology: Series A · doi:10.1093/gerona/glq178 · Cited by 896 · see citing works
Regulation of Longevity and Stress Resistance by Sch9 in Yeast
Fabrizio, P., Pozza, F., Pletcher, S. D., Gendron, C. M., & Longo, V. D. (2001) · Science · doi:10.1126/science.1059497 · Cited by 874 · see citing works
Nutrition and the immune system: an introduction.
Chandra, R. (1997) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/66.2.460s · Cited by 866 · see citing works
Gruver, A., Hudson, L., & Sempowski, G. (2007) · The Journal of Pathology · doi:10.1002/path.2104 · Cited by 834 · see citing works
Flurkey, K., Papaconstantinou, J., Miller, R. A., & Harrison, D. E. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.111158898 · Cited by 826 · see citing works
Cellular senescence and tumor suppressor gene p16
Rayess, H., Wang, M. B., & Srivatsan, E. S. (2012) · International Journal of Cancer · doi:10.1002/ijc.27316 · Cited by 825 · see citing works
Madrid, L. V., Mayo, M. W., Reuther, J. Y., & Baldwin, A. S. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m101103200 · Cited by 777 · see citing works
Salminen, A., Kauppinen, A., & Kaarniranta, K. (2012) · Cellular Signalling · doi:10.1016/j.cellsig.2011.12.006 · Cited by 763 · see citing works
Redox regulation of FoxO transcription factors
Klotz, L.-O., Sánchez-Ramos, C., Prieto-Arroyo, I., Urbánek, P., Steinbrenner, H., & Monsalve, M. (2015) · Redox Biology · doi:10.1016/j.redox.2015.06.019 · Cited by 747 · see citing works
Long live FOXO : unraveling the role of FOXO proteins in aging and longevity
Martins, R., Lithgow, G. J., & Link, W. (2015) · Aging Cell · doi:10.1111/acel.12427 · Cited by 728 · see citing works
Toussaint, O., Medrano, E. E., & von Zglinicki, T. (2000) · Experimental Gerontology · doi:10.1016/s0531-5565(00)00180-7 · Cited by 713 · see citing works
Jia, K., Chen, D., & Riddle, D. L. (2004) · Development · doi:10.1242/dev.01255 · Cited by 705 · see citing works
TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO
Robida-Stubbs, S., Glover-Cutter, K., Lamming, D. W., Mizunuma, M., Narasimhan, S. D., Neumann-Haefelin, E., Sabatini, D. M., & Blackwell, T. K. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.04.007 · Cited by 648 · see citing works
IKKβ Suppression of TSC1 Links Inflammation and Tumor Angiogenesis via the mTOR Pathway
Lee, D., Kuo, H.-P., Chen, C., Hsu, J.-M., Chou, C., Wei, Y., Sun, H., Li, L., Ping, B., Huang, W., et al. (2007) · Cell · doi:10.1016/j.cell.2007.05.058 · Cited by 639 · see citing works
Akt-dependent regulation of NF-κB is controlled by mTOR and Raptor in association with IKKPreprint
Dan, H. C., Cooper, M. J., Cogswell, P. C., Duncan, J. A., Ting, J. P.-Y., & Baldwin, A. S. (2008) · Genes & Development · doi:10.1101/gad.1662308 · Cited by 638 · see citing works
Madrid, L. V., Wang, C.-Y., D, D. C. G., Schottelius, A. J. G., Baldwin, A. S., & Mayo, M. W. (2000) · Molecular and Cellular Biology · doi:10.1128/mcb.20.5.1626-1638.2000 · Cited by 634 · see citing works
The role of oxidative damage and stress in aging
Bokov, A. F., Chaudhuri, A. R., & Richardson, A. G. (2004) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2004.07.009 · Cited by 621 · see citing works
FOXO transcription factors: key regulators of cellular quality control
Webb, A. E., & Brunet, A. (2014) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2014.02.003 · Cited by 620 · see citing works
Tumor Suppressive Functions of p53Preprint
Zilfou, J. T., & Lowe, S. W. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a001883 · Cited by 572 · see citing works
The impact of oxidative DNA damage and stress on telomere homeostasis
Barnes, R. P., Fouquerel, E., & Opresko, P. L. (2018) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2018.03.013 · Cited by 558 · see citing works
Accumulation of single-strand breaks is the major cause of telomere shortening in human fibroblasts
von Zglinicki, T., Pilger, R., & Sitte, N. (2000) · Free Radical Biology and Medicine · doi:10.1016/s0891-5849(99)00207-5 · Cited by 546 · see citing works
The biology of replicative senescence
Campisi, J. (1997) · European Journal of Cancer · doi:10.1016/s0959-8049(96)00058-5 · Cited by 538 · see citing works
Mechanism of telomere shortening by oxidative stress
KAWANISHI, S., & OIKAWA, S. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1297.047 · Cited by 522 · see citing works
Motif module map reveals enforcement of aging by continual NF-κB activity
Adler, A. S., Sinha, S., Kawahara, T. L. A., Zhang, J. Y., Segal, E., & Chang, H. Y. (2007) · Genes & Development · doi:10.1101/gad.1588507 · Cited by 466 · see citing works
Mitsiades, C. S., Mitsiades, N., Poulaki, V., Schlossman, R. L., Akiyama, M., Chauhan, D., Hideshima, T., Treon, S. P., Munshi, N. C., Richardson, P. G. G., et al. (2002) · Oncogene · doi:10.1038/sj.onc.1205664 · Cited by 463 · see citing works
Telomeres, telomerase, and aging: Origin of the theory
Olovnikov, A. M. (1996) · Experimental Gerontology · doi:10.1016/0531-5565(96)00005-8 · Cited by 431 · see citing works
Regulation of NF-κB, Th Activation, and Autoinflammation by the Forkhead Transcription Factor Foxo3a
Lin, L., Hron, J. D., & Peng, S. L. (2004) · Immunity · doi:10.1016/j.immuni.2004.06.016 · Cited by 420 · see citing works
FOXO Transcription Factors: Their Clinical Significance and Regulation
Wang, Y., Zhou, Y., & Graves, D. T. (2014) · BioMed Research International · doi:10.1155/2014/925350 · Cited by 419 · see citing works
Curry Consumption and Cognitive Function in the Elderly
Ng, T. P., Chiam, P., Lee, T. M., Chua, H.-C., Lim, L. E. C., & Kua, E. H. (2006) · American Journal of Epidemiology · doi:10.1093/aje/kwj267 · Cited by 353 · see citing works
Rapamycin increases lifespan and inhibits spontaneous tumorigenesis in inbred female mice
Anisimov, V. N., Zabezhinski, M. A., Popovich, I. G., Piskunova, T. S., Semenchenko, A. V., Тындык, М. Л., Yurova, M. N., Rosenfeld, S. V., & Blagosklonny, M. V. (2011) · Cell Cycle · doi:10.4161/cc.10.24.18486 · Cited by 347 · see citing works
Stanfel, M. N., Shamieh, L. S., Kaeberlein, M. R., & Kennedy, B. K. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2009.06.007 · Cited by 339 · see citing works
Apolipoprotein E Polymorphism and Alzheimer Disease
Ganguli, M., Chandra, V., Kamboh, M. I., Johnston, J. M., Dodge, H. H., Thelma, B. K., Juyal, R. C., Pandav, R. S., Belle, S. H., & DeKosky, S. T. (2000) · Archives of Neurology · doi:10.1001/archneur.57.6.824 · Cited by 337 · see citing works
Medvedik, O., Lamming, D. W., Kim, K. D., & Sinclair, D. A. (2007) · PLoS Biology · doi:10.1371/journal.pbio.0050261 · Cited by 311 · see citing works
Marquardt, J. U., Gómez-Quiroz, L. E., Camacho, L. O. A., Pinna, F., Lee, Y., Kitade, M., Domínguez, M. P., Castven, D., Breuhahn, K., Conner, E. A., et al. (2015) · Journal of Hepatology · doi:10.1016/j.jhep.2015.04.018 · Cited by 309 · see citing works
Jennings, B. J., Ozanne, S. E., Dorling, M. W., & Hales, C. N. (1999) · FEBS Letters · doi:10.1016/s0014-5793(99)00336-1 · Cited by 303 · see citing works
Oxidative stress, inflamm-aging and immunosenescence
Cannizzo, E. S., Clement, C. C., Sahu, R. K., Follo, C., & Santambrogio, L. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.06.005 · Cited by 303 · see citing works
Özcan, S., Alessio, N., Acar, M. B., Mert, E., Omerli, F., Peluso, G., & Galderisi, U. (2016) · Aging · doi:10.18632/aging.100971 · Cited by 295 · see citing works
Cheng, K. K., Chan, P. S., Fan, S., Kwan, S. M., Yeung, K. L., Wáng, Y. X. J., Chow, A. H. L., Wu, E. X., & Baum, L. (2015) · Biomaterials · doi:10.1016/j.biomaterials.2014.12.005 · Cited by 293 · see citing works
Tilstra, J. S., Clauson, C. L., Niedernhofer, L. J., & Robbins, P. D. (2011) · Europe PMC (PubMed Central) · Cited by 290 · see citing works
Effect of dietary turmeric (curcuma longa) on iron-induced lipid peroxidation in the rat liver
Reddy, A. C. P., & Lokesh, B. R. (1994) · Food and Chemical Toxicology · doi:10.1016/0278-6915(94)90201-1 · Cited by 270 · see citing works
Telomeres—structure, function, and regulation
Lu, W., Zhang, Y., Liu, D., Songyang, Z., & Wan, M. (2012) · Experimental Cell Research · doi:10.1016/j.yexcr.2012.09.005 · Cited by 265 · see citing works
The aging process and potential interventions to extend life expectancy.
Tosato, M., Zamboni, V., Ferrini, A., & Cesari, M. (2007) · PubMed Central · Cited by 260 · see citing works
Curcumin-mediated lifespan extension in Caenorhabditis elegans
Liao, V. H., Yu, C., Chu, Y.-J., Li, W.-H., Hsieh, Y., & Wang, T.-T. (2011) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2011.07.008 · Cited by 259 · see citing works
Role of Curcumin in Disease Prevention and Treatment
Rahmani, A. H., Alsahli, M. A., Aly, S. M., et al. (2018) · Advanced Biomedical Research · doi:10.4103/abr.abr_147_16 · Cited by 255 · see citing works
Horizons in the evolution of aging
Flatt, T., & Partridge, L. (2018) · BMC Biology · doi:10.1186/s12915-018-0562-z · Cited by 255 · see citing works
Protective Role of Antioxidative Food Factors in Oxidative Stress Caused by Hyperglycemia
Osawa, T., & Kato, Y. (2005) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1333.050 · Cited by 250 · see citing works
Thayyullathil, F., Chathoth, S., Hago, A., et al. (2008) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2008.08.014 · Cited by 246 · see citing works
Oxidative Stress, Inflammaging, and Immunosenescence
Bauer, M. E., & la Fuente, M. D. (2013) · Elsevier eBooks · doi:10.1016/b978-0-12-397803-5.00004-6 · Cited by 229 · see citing works
Piper, M. D. W., & Bartke, A. (2008) · Cell Metabolism · doi:10.1016/j.cmet.2008.06.012 · Cited by 219 · see citing works
Lee, K., Lee, B.-S., Semnani, S., Avanesian, A., Um, C.-Y., Jeon, H., Seong, K.-M., Yu, K., Min, K., & Jafari, M. (2010) · Rejuvenation Research · doi:10.1089/rej.2010.1031 · Cited by 214 · see citing works
PKA isoforms, neural pathways, and behaviour: making the connection
Brandon, E. P., Idzerda, R. L., & McKnight, G. S. (1997) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(97)80069-4 · Cited by 206 · see citing works
Altıntaş, Ö., Park, S., & Lee, S. (2016) · BMB Reports · doi:10.5483/bmbrep.2016.49.2.261 · Cited by 205 · see citing works
Coluzzi, E., Colamartino, M., Cozzi, R., Leone, S., Meneghini, C., O’Callaghan, N., & Sgura, A. (2014) · PLoS ONE · doi:10.1371/journal.pone.0110963 · Cited by 197 · see citing works
Lifespan-regulating genes in C. elegans
Uno, M., & Nishida, E. (2016) · npj Aging and Mechanisms of Disease · doi:10.1038/npjamd.2016.10 · Cited by 192 · see citing works
Pawelec, G., & Solana, R. (1997) · Immunology Today · doi:10.1016/s0167-5699(97)01145-6 · Cited by 164 · see citing works
Pietsch, K., Saul, N., Menzel, R., Stürzenbaum, S. R., & Steinberg, C. E. W. (2008) · Biogerontology · doi:10.1007/s10522-008-9199-6 · Cited by 161 · see citing works
Curcumin, Hormesis and the Nervous System
Scuto, M. C., Mancuso, C., Tomasello, B., Ontario, M. L., Cavallaro, A. S., Frasca, F., Maiolino, L., Salinaro, A. T., Calabrese, E. J., & Calabrese, V. (2019) · Nutrients · doi:10.3390/nu11102417 · Cited by 155 · see citing works
Free radical scavenging ability and antioxidant efficiency of curcumin and its substituted analogue
Khopde, S. M., Priyadarsini, K. I., Venkatesan, P., et al. (1999) · Biophysical Chemistry · doi:10.1016/s0301-4622(99)00070-8 · Cited by 153 · see citing works
Melatonin and the Immune System in Aging
Cardinali, D. P., Esquifino, A. I., Srinivasan, V., & Pandi-Perumal, S. R. (2008) · NeuroImmunoModulation · doi:10.1159/000156470 · Cited by 152 · see citing works
Sun, L. Y., Spong, A., Swindell, W. R., Fang, Y., Hill, C. M., Huber, J. A., Boehm, J. D., Westbrook, R., Salvatori, R., & Bartke, A. (2013) · eLife · doi:10.7554/elife.01098 · Cited by 151 · see citing works
The Role of Curcumin in the Modulation of Ageing
Bielak-Żmijewska, A., Grabowska, W., Ciolko, A., Bojko, A., Mosieniak, G., Bijoch, Ł., & Sikora, E. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051239 · Cited by 143 · see citing works
Oxidative Stress Induces Telomere Dysfunction and Senescence by Replication Fork Arrest
Coluzzi, E., Leone, S., & Sgura, A. (2019) · Cells · doi:10.3390/cells8010019 · Cited by 138 · see citing works
Curcumin-supplemented diets increase superoxide dismutase activity and mean lifespan in Drosophila
Shen, L., Xiao, F., Yuan, P., et al. (2012) · AGE · doi:10.1007/s11357-012-9438-2 · Cited by 135 · see citing works
Cellular senescence, ageing and disease
Burton, D. G. A. (2008) · AGE · doi:10.1007/s11357-008-9075-y · Cited by 135 · see citing works
Jennings, B. J., Ozanne, S. E., & Hales, C. N. (2000) · Molecular Genetics and Metabolism · doi:10.1006/mgme.2000.3077 · Cited by 126 · see citing works
The effects of tetrahydrocurcumin and green tea polyphenol on the survival of male C57BL/6 mice
Kitani, K., Osawa, T., & Yokozawa, T. (2007) · Biogerontology · doi:10.1007/s10522-007-9100-z · Cited by 126 · see citing works
DNA damage by oxidative stress: Measurement strategies for two genomes
González-Hunt, C. P., Wadhwa, M., & Sanders, L. H. (2018) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.11.001 · Cited by 126 · see citing works
Floyd, S., Favre, C., Lasorsa, F. M., Leahy, M., Trigiante, G., Ströbel, P., Marx, A., Loughran, G., O’Callaghan, K., Marobbio, C. M. T., et al. (2007) · Molecular Biology of the Cell · doi:10.1091/mbc.e06-12-1109 · Cited by 124 · see citing works
Mammalian Target of Rapamycin: A Signaling Kinase for Every Aspect of Cellular Life
Weichhart, T. (2011) · Methods in molecular biology · doi:10.1007/978-1-61779-430-8_1 · Cited by 123 · see citing works
NF-κB Signaling in the Aging Process
Salminen, A., & Kaarniranta, K. (2009) · Journal of Clinical Immunology · doi:10.1007/s10875-009-9296-6 · Cited by 123 · see citing works
DNA repair after oxidative stress: Current challenges
Houten, B. V., Santa-González, G. A., & Camargo, M. (2017) · Current Opinion in Toxicology · doi:10.1016/j.cotox.2017.10.009 · Cited by 117 · see citing works
Suryanarayana, P., Satyanarayana, A., Balakrishna, N., Kumar, P. U., & Reddy, G. B. (2007) · PubMed · Cited by 114 · see citing works
The impact of curcumin and its modified formulations on Alzheimer's disease
Farkhondeh, T., Samarghandian, S., Pourbagher‐Shahri, A. M., & Sedaghat, M. (2019) · Journal of Cellular Physiology · doi:10.1002/jcp.28411 · Cited by 109 · see citing works
Self-citationProtective Effects of Chrysin Against Drugs and Toxic Agents
Samarghandian, S., Farkhondeh, T., & Azimi–Nezhad, M. (2017) · Dose-Response · doi:10.1177/1559325817711782 · Cited by 104 · see citing works
Self-citationMazucanti, C. H., Cabral‐Costa, J. V., Vasconcelos, A. R., Andreotti, D. Z., Scavone, C., & Kawamoto, E. M. (2015) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026615666150610125715 · Cited by 102 · see citing works
Mollazade, M., Nejati‐Koshki, K., Akbarzadeh, A., et al. (2013) · Asian Pacific Journal of Cancer Prevention · doi:10.7314/apjcp.2013.14.11.6925 · Cited by 101 · see citing works
Dierick, J.-F., Eliaers, F., Remacle, J., Raes, M., Fey, S. J., Larsen, P. M., & Toussaint, O. (2002) · Biochemical Pharmacology · doi:10.1016/s0006-2952(02)01171-1 · Cited by 95 · see citing works
N-Acetylcysteine slows down ageing and increases the life span of Drosophila melanogaster
Brack, C., Bechter-Thüring, E., & Labuhn, M. (1997) · Cellular and Molecular Life Sciences · doi:10.1007/pl00013199 · Cited by 92 · see citing works
Role of the Immune System in Aging and Longevity
Alonso‐Fernández, P., & la Fuente, M. D. (2011) · Current Aging Science · doi:10.2174/1874609811104020078 · Cited by 91 · see citing works
Siddique, Y. H., Naz, F., & Jyoti, S. (2014) · BioMed Research International · doi:10.1155/2014/606928 · Cited by 90 · see citing works
Samarghandian, S., Azimi–Nezhad, M., Borji, A., Samini, M., & Farkhondeh, T. (2017) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-017-1753-9 · Cited by 90 · see citing works
Self-citationCurcumin inhibits telomerase activity in human cancer cell lines
Cui, S., Qu, X., Xie, Y.-Y., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.2.227 · Cited by 86 · see citing works
Extending healthy ageing: nutrient sensitive pathway and centenarian population
Davinelli, S., Willcox, D. C., & Scapagnini, G. (2012) · Immunity & Ageing · doi:10.1186/1742-4933-9-9 · Cited by 83 · see citing works
Role of p53 isoforms and aggregations in cancer
Kim, S., & An, S. S. A. (2016) · Medicine · doi:10.1097/md.0000000000003993 · Cited by 81 · see citing works
DAF-16/Forkhead Box O Transcription Factor: Many Paths to a Single Fork(head) in the Road
Yen, K., Narasimhan, S. D., & Tissenbaum, H. A. (2010) · Antioxidants and Redox Signaling · doi:10.1089/ars.2010.3490 · Cited by 79 · see citing works
Tong, R., Wu, X., Liu, Y., Liu, Y., Zhou, J., Jiang, X., Zhang, L., He, X., & Ma, L. (2020) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2020/2543504 · Cited by 76 · see citing works
Lifespan Extension by the Antioxidant Curcumin in Drosophila Melanogaster
Suckow, M. A., & Suckow, B. K. (2006) · International Journal of Biomedical Science · doi:10.59566/ijbs.2006.2401 · Cited by 72 · see citing works
Xiang, L., Nakamura, Y., Lim, Y., Yamasaki, Y., Kurokawa-Nose, Y., Maruyama, W., Osawa, T., Matsuura, A., Motoyama, N., & Tsuda, L. (2011) · Aging · doi:10.18632/aging.100396 · Cited by 64 · see citing works
Lifespan extension by the antioxidant curcumin in Drosophila melanogaster.
Suckow, B. K., & Suckow, M. A. (2006) · Europe PMC (PubMed Central) · Cited by 63 · see citing works
Ren, L., Zhan, P., Wang, Q., Wang, C., Liu, Y., Yu, Z., & Zhang, S. (2019) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2019.05.010 · Cited by 63 · see citing works
The antioxidant curcumin postpones ovarian aging in young and middle-aged mice
Azami, S. H., Nazarian, H., Abdollahifar, M., Eini, F., Farsani, M. A., & Novin, M. G. (2019) · Reproduction Fertility and Development · doi:10.1071/rd18472 · Cited by 59 · see citing works
Variable effects of vitamin E on Drosophila longevity
Driver, C., & Georgeou, A. (2003) · Biogerontology · doi:10.1023/a:1023347803932 · Cited by 58 · see citing works
The anti-cancer efficacy of curcumin scrutinized through core signaling pathways in glioblastoma
Chiu, Y. (2010) · International Journal of Molecular Medicine · doi:10.3892/ijmm_00000455 · Cited by 58 · see citing works
Telomere and Telomerase as Targets for Cancer Therapy
Tian, X., Chen, B., & Liu, X. (2009) · Applied Biochemistry and Biotechnology · doi:10.1007/s12010-009-8633-9 · Cited by 52 · see citing works
Bertrand, F., Desbois‐Mouthon, C., Cadoret, A., Prunier, C., Robin, H., Capeau, J., Atfi, A., & Cherqui, G. (1999) · Journal of Biological Chemistry · doi:10.1074/jbc.274.43.30596 · Cited by 52 · see citing works
Nutrient sensing, growth and senescence
Carroll, B., & Korolchuk, V. I. (2018) · FEBS Journal · doi:10.1111/febs.14400 · Cited by 50 · see citing works
Receno, C. N., Chen, L., Korol, D. L., Atalay, M., Heffernan, K. S., Brutsaert, T. D., & DeRuisseau, K. C. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20051178 · Cited by 50 · see citing works
Phenome and genome based studies into human ageing and longevity: An overview
Slagboom, P. E., van den Berg, N., & Deelen, J. (2017) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2017.09.017 · Cited by 49 · see citing works
Impact of curcumin on replicative and chronological aging in the Saccharomyces cerevisiae yeast
Stępień, K., Wojdyła, D., Nowak, K., & Mołoń, M. (2019) · Biogerontology · doi:10.1007/s10522-019-09846-x · Cited by 47 · see citing works
Davis, T., & Kipling, D. (2005) · Biogerontology · doi:10.1007/s10522-005-4901-4 · Cited by 46 · see citing works
Parikh, A. R., Kathawala, K., Li, J.-T., Chen, C., Shan, Z., Cao, X., Zhou, X., & Garg, S. (2018) · Drug Delivery and Translational Research · doi:10.1007/s13346-018-0570-0 · Cited by 46 · see citing works
Niswender, C. M., Ishihara, R. W., Judge, L. M., et al. (2002) · Journal of Biological Chemistry · doi:10.1074/jbc.m203327200 · Cited by 45 · see citing works
Telomere uncapping and vascular aging
Morgan, R. G., Donato, A. J., & Walker, A. E. (2018) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00008.2018 · Cited by 45 · see citing works
Protective effects of curcumin on acrolein-induced neurotoxicity in HT22 mouse hippocampal cells
Shi, L.-Y., Zhang, L., Li, H., Liu, T., Lai, J., Wu, Z., & Qin, J. (2018) · Pharmacological Reports · doi:10.1016/j.pharep.2018.05.006 · Cited by 45 · see citing works
Curcumin Inhibits Age-Related Vascular Changes in Aged Mice Fed a High-Fat Diet
Takano, K., Tatebe, J., Washizawa, N., & Morita, T. (2018) · Nutrients · doi:10.3390/nu10101476 · Cited by 43 · see citing works
Immune regulation by Foxo transcription factors
Peng, S. L. (2007) · Autoimmunity · doi:10.1080/08916930701464913 · Cited by 42 · see citing works
Curcumin induces p53-independent inactivation of Nrf2 during oxidative stress–induced apoptosis
Méndez-García, L., Castillo, M. M., Villegas‐Sepúlveda, N., Orozco, L., & Córdova, E. J. (2019) · Human & Experimental Toxicology · doi:10.1177/0960327119845035 · Cited by 41 · see citing works
Saghir, S. A. M., Alharbi, S. A., Al-Garadi, M. A., Al-Gabri, N. A., Rady, H. Y., Olama, N. K., Abdulghani, M. A. M., Hroob, A. M. A., Almaiman, A. A., Bin-Jumah, M. N., et al. (2020) · Processes · doi:10.3390/pr8020127 · Cited by 41 · see citing works
Tavakol, S., Zare, S., Hoveizi, E., et al. (2019) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-019-00258-3 · Cited by 40 · see citing works
Lin, C.-C., Chiang, T.-H., Sun, Y., & Lin, M.-S. (2019) · Nutrients · doi:10.3390/nu11030700 · Cited by 37 · see citing works
Curcumin Mitigates Accelerated Aging after Irradiation inDrosophilaby Reducing Oxidative Stress
Seong, K. M., Yu, M. R., Lee, K., Park, S., Jin, Y. W., & Min, K. (2015) · BioMed Research International · doi:10.1155/2015/425380 · Cited by 36 · see citing works
Curcumin supplementation and motor-cognitive function in healthy middle-aged and older adults
Santos-Parker, J. R., Lubieniecki, K. L., Rossman, M. J., Ark, H. J. V., Bassett, C. J., Strahler, T. R., Chonchol, M., Justice, J., & Seals, D. (2018) · Nutrition and Healthy Aging · doi:10.3233/nha-170029 · Cited by 31 · see citing works
Kiss, H., Mihalik, Á., Nánási, T., Őry, B., Spiró, Z., Sőti, C., & Csermely, P. (2008) · Nature Precedings · doi:10.1038/npre.2008.2610.1 · Cited by 29 · see citing works
miR‐20a and miR‐290, multi‐faceted players with a role in tumourigenesis and senescence
Rizzo, M., Mariani, L., Pitto, L., Rainaldi, G., & Simili, M. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01173.x · Cited by 28 · see citing works
Curcumin supplementation increases survival and lifespan in Drosophila under heat stress conditions
Chen, Y., Liu, X., Jiang, C., Liu, L., Ordovás, J. M., Lai, C., & Shen, L. (2018) · BioFactors · doi:10.1002/biof.1454 · Cited by 28 · see citing works
AGING: A THEORY BASED ON FREE RADICAL AND RADIATION CHEMISTRY
Harraan, D. (1955) · eScholarship (California Digital Library) · Cited by 24 · see citing works
Differential expression of mRNAs for protein kinase inhibitor isoforms in mouse brain.
Seasholtz, A. F., Gamm, D. M., Ballestero, R. P., et al. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.5.1734 · Cited by 20 · see citing works
Oral curcumin supplementation improves fine motor function in the middle-aged rhesus monkey
Moore, T. L., Bowley, B. G. E., Shultz, P. L., Calderazzo, S. M., Shobin, E., Uprety, A. R., Rosene, D. L., & Moss, M. B. (2018) · Somatosensory & Motor Research · doi:10.1080/08990220.2018.1432481 · Cited by 14 · see citing works
Kulminski, A. M., Loika, Y., Huang, J. V., Arbeev, K. G., Bagley, O., Ukraintseva, S. V., Yashin, A. I., & Culminskaya, I. V. (2019) · Frontiers in Genetics · doi:10.3389/fgene.2019.00433 · Cited by 12 · see citing works
Tuohy, V. K., Thomas, D., Haqqi, T., et al. (1995) · Autoimmunity · doi:10.3109/08916939509008017 · Cited by 11 · see citing works
Nutritional imbalances linking cellular senescence and type 2 diabetes mellitus
Testa, R., Genovese, S., & Ceriello, A. (2014) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000066 · Cited by 6 · see citing works
Inhibition of telomerase activity and cell growth by curcumin in human brain tumour cells
Khaw, A. K., & Hande, M. P. (2007) · Cancer Research · Cited by 4 · see citing works
Correction: Disruption of Protein Kinase A in Mice Enhances Healthy Aging
Enns, L. C., Morton, J. F., Treuting, P. R., Emond, M. J., Wolf, N. S., Dai, D., McKnight, G. S., Rabinovitch, P. S., & Ladiges, W. (2010) · PLoS ONE · doi:10.1371/annotation/c7cad2dc-1eca-487e-89ae-151a22d8a0b4 · Cited by 2 · see citing works
Correction: Disruption of Protein Kinase A in Mice Enhances Healthy Aging
Enns, L. C., Morton, J., Treuting, P. R., Emond, M. J., Wolf, N. S., Dai, D., McKnight, G. S., Rabinovitch, P. S., & Ladiges, W. (2010) · PLoS ONE · doi:10.1371/annotation/d51a16b6-dc82-4cdb-8118-d7c982233d7c · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 4
- V.P. Menon, A.R. Sudheer, Antioxidant and Anti-inflammatory Properties of Curcumin. The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease, Springer, 2007, pp. 105-125.
- S.C. Johnson, Nutrient Sensing, Signaling and Ageing: the Role of IGF-1 and mTOR in Ageing and Age-related Disease. Biochemistry and Cell Biology of Ageing: Part I Biomedical Science, Springer, 2018, pp. 49-97.
- M.S. Hayden, S. Ghosh, Signaling to NF-κB. Genes Development, 2004, pp. 2195-2224, 18(18).
- B.B. Aggarwal, Y.-J. Surh, S. Shishodia, The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease: Springer Science & Business Media, 2007.
Cited by
Sorted by citations
Inflammation and aging: signaling pathways and intervention therapies
Li, X., Li, C., Zhang, W., Wang, Y., Qian, P., & Huang, H. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01502-8 · Cited by 1,443 · see citing works
The Role of Antioxidants in the Interplay between Oxidative Stress and Senescence
Varesi, A., Chirumbolo, S., Campagnoli, L. I. M., Pierella, E., Piccini, G. B., Carrara, A., Ricevuti, G., Scassellati, C., Bonvicini, C., & Pascale, A. (2022) · Antioxidants · doi:10.3390/antiox11071224 · Cited by 145 · see citing works
The significance of caloric restriction mimetics as anti-aging drugs
Nassar, K., El-mekawey, D., Elmasry, A. E., Refaey, M. S., El-Sayed Ghoneim, M., & Elshaier, Y. A. M. M. (2024) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2023.149354 · Cited by 16 · see citing works
- Authors
- Zia, A., Farkhondeh, T., Pourbagher-Shahri, A. M., & Samarghandian, S.
- Affiliations
- University of Tehran (IR)
- Birjand University of Medical Sciences (IR)
- University of Neyshabur (IR)
- Corresponding author
- Samarghandian, Saeed
- Venue
- Biomedicine & Pharmacotherapy
- Publisher
- Elsevier BV
- Published
- 2021-02
- Volume
- 134
- Pages
- 111119
- ISSN
- 0753-3322 (ISSN-L)
- OpenAlex
- W3114209299
- Cited by
- 378
- References
- 154
- Citations by year
- 2026: 46 · 2025: 93 · 2024: 92 · 2023: 78 · 2022: 49 · 2021: 20
- FWCI
- 2.61
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Biomedicine & Pharmacotherapy (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- curcumin, healthy aging, senescence, lifespan extension, age-related diseases, caloric restriction, dietary polyphenols, turmeric, oxidative stress, anti-inflammatory activity, anticancer activity, antimicrobial activity, mTOR signaling, FoxO signaling, PKA signaling, superoxide dismutase, lipofuscin, model organisms
- MeSH terms
- Healthy Aging, Age Factors, Animals, Anti-Inflammatory Agents, Antioxidants, Curcumin, Humans, Signal Transduction, Cellular Senescence, Oxidative Stress, Inflammation Mediators
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