Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

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Tirzepatide protects against doxorubicin-induced cardiotoxicity by inhibiting oxidative stress and inflammation via PI3K/Akt signaling

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Effect of Theobroma cacao L. on the Efficacy and Toxicity of Doxorubicin in Mice Bearing Ehrlich Ascites Carcinoma

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Research progress on the molecular mechanisms of Saikosaponin D in various diseases (Review)

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Dimethyl Fumarate Ameliorates Doxorubicin-Induced Cardiotoxicity By Activating the Nrf2 Pathway

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Danhong injection attenuates doxorubicin-induced cardiotoxicity in rats via suppression of apoptosis: network pharmacology analysis and experimental validation

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The Formation of Self-Assembled Nanoparticles Loaded with Doxorubicin and d -Limonene for Cancer Therapy

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Potential role of endoplasmic reticulum stress in doxorubicin-induced cardiotoxicity-an update

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Metrnl as a secreted protein: Discovery and cardiovascular research

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Nano co-delivery of doxorubicin and plumbagin achieves synergistic chemotherapy of hepatocellular carcinoma

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Prophylactic Evidence of MSCs-Derived Exosomes in Doxorubicin/Trastuzumab-Induced Cardiotoxicity: Beyond Mechanistic Target of NRG-1/Erb Signaling Pathway

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Early Doxorubicin Myocardial Injury: Inflammatory, Oxidative Stress, and Apoptotic Role of Galectin-3

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Role and molecular mechanism of traditional Chinese medicine in preventing cardiotoxicity associated with chemoradiotherapy

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Elabela blunts doxorubicin-induced oxidative stress and ferroptosis in rat aortic adventitial fibroblasts by activating the KLF15/GPX4 signaling

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Fluorescent Alloyed CdZnSeS/ZnS Nanosensor for Doxorubicin Detection

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Chemical-induced phase transition and global conformational reorganization of chromatin

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Doxycycline Attenuates Doxorubicin-Induced Cardiotoxicity by Improving Myocardial Energy Metabolism in Rats

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RGS11-CaMKII complex mediated redox control attenuates chemotherapy-induced cardiac fibrosis

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α-Bisabolol, a Dietary Sesquiterpene, Attenuates Doxorubicin-Induced Acute Cardiotoxicity in Rats by Inhibiting Cellular Signaling Pathways, Nrf2/Keap-1/HO-1, Akt/mTOR/GSK-3β, NF-κB/p38/MAPK, and NLRP3 Inflammasomes Regulating Oxidative Stress and Inflammatory Cascades

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Qishen granule alleviates doxorubicin-induced cardiotoxicity by suppressing ferroptosis via nuclear erythroid factor 2-related factor 2 (Nrf2) pathway

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ST08 Altered NF-κB Pathway in Breast Cancer Cells In Vitro as Revealed by miRNA-mRNA Analysis and Enhanced the Effect of Cisplatin on Tumour Reduction in EAC Mouse Model

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Urolithin A attenuates Doxorubicin-induced cardiotoxicity by enhancing PINK1-regulated mitophagy via Ambra1

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Doxorubicin induced cardio toxicity through sirtuins mediated mitochondrial disruption

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Hydroethanolic extract of Cirsium setidens ameliorates doxorubicin-induced cardiotoxicity by AMPK-PGC-1α-SOD-mediated mitochondrial protection

Song, J., Kim, M., Lee, S., Hwang, J., Park, S., Park, S. W., Jeon, S., Lee, R.-R., Lee, J., & Choi, H. (2024) · Phytomedicine · doi:10.1016/j.phymed.2024.155633 · Cited by 20

Linggui Zhugan decoction ameliorating mitochondrial damage of doxorubicin-induced cardiotoxicity by modulating the AMPK-FOXO3a pathway targeting BTG2

Kong, L., Liu, Y., Wang, J., Lv, M.-J., Wang, Y.-Z., Sun, W., Cao, H., Guo, R., Zhang, L., Yu, Y., et al. (2025) · Phytomedicine · doi:10.1016/j.phymed.2025.156529 · Cited by 19

Fmoc-FF Nanogel-Mediated Delivery of Doxorubicin and Curcumin in Thyroid Cancer Cells

Gallo, E., Smaldone, G., Cimmino, L., Braile, M., Orlandella, F. M., Luciano, N., Accardo, A., & Salvatore, G. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020263 · Cited by 19

Methylene Blue Mitigates Doxorubicin-Induced Cardiotoxicity via KEAP1/NRF2/GPX-4/Caspase3 Modulation

Ibrahim, S. G., Abu‐Dief, A. M., Gad, A. M., Gad, E. S., Alzahrani, A. Y. A., Alraih, A. M., Barnawi, I. O., Mansour, M., Gadelmawla, M. H. A., & Khames, A. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26167680 · Cited by 19

Understanding the Protective Role of Exosomes in Doxorubicin‐Induced Cardiotoxicity

Zhang, G., Yang, X., Su, X., An, N., Yang, F., Li, X., Jiang, Y., & Xing, Y. (2022) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2022/2852251 · Cited by 19

Farnesol Protects against Cardiotoxicity Caused by Doxorubicin-Induced Stress, Inflammation, and Cell Death: An In Vivo Study in Wistar Rats

Alkhanjaf, A. A. M., Athar, M. T., Ullah, Z., Alsayhab, A. M. H., Umar, A., & Shaikh, I. A. (2022) · Molecules · doi:10.3390/molecules27238589 · Cited by 19

Niosomes Functionalized with a Synthetic Carbohydrate Binding Agent for Mannose-Targeted Doxorubicin Delivery

Burrini, N., D’Ambrosio, M., Gentili, M., Giaquinto, R., Settimelli, V., Luceri, C., Cirri, M., & Francesconi, O. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15010235 · Cited by 19

A bibliometric analysis of research progress on pharmacovigilance and cancer from 2002 to 2021

Sa, R., Xu, Y., Pan, X., Wang, Y., Lin, Z., Zhang, X., & Zhang, B. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1078254 · Cited by 21

Anthracycline in Medicinal Chemistry: Mechanism of Cardiotoxicity, Preventive and Treatment Strategies

Hussen, N. H., Hasan, A. H., Muhammed, G. O., Yassin, A. Y., Salih, R. R., Esmail, P. A., Alanazi, M. M., & Jamalis, J. (2023) · Current Organic Chemistry · doi:10.2174/1385272827666230423144150 · Cited by 19

Mechanistic insights into carvedilol's potential protection against doxorubicin-induced cardiotoxicity

Elmorsy, E. A., Saber, S., Hamad, R. S., Abdel‐Reheim, M. A., El-kott, A. F., AlShehri, M. A., Morsy, K., Negm, S., & Youssef, M. E. (2024) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2024.106849 · Cited by 19

Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress

Zhang, J., Zha, Y., Jiao, Y., Li, Y., & Zhang, S. (2023) · Toxicology · doi:10.1016/j.tox.2023.153426 · Cited by 19

In Vitro Potentiation of Doxorubicin Cytotoxicity Utilizing Clarithromycin Loaded-PEGylated Liposomes

Alfreahat, I., Nsairat, H., Al‐Deeb, I., Al-Samydai, A. M., & Alshaer, W. (2025) · Technology in Cancer Research & Treatment · doi:10.1177/15330338241312561 · Cited by 18

Galectin-3 and Myeloperoxidase May Monitor Cancer-Therapy-Related Cardiotoxicity? A Systematic Review and Meta-Analysis

Wu, Y., Gao, D., Xue, J., & Zuo, Z. (2022) · Biomolecules · doi:10.3390/biom12121788 · Cited by 18

Cardio-oncology: Shared Genetic, Metabolic, and Pharmacologic Mechanism

Zhao, Y., Jia, H., Hua, X., An, T., & Song, J. (2023) · Current Cardiology Reports · doi:10.1007/s11886-023-01906-6 · Cited by 19

Approaches for reducing chemo/radiation-induced cardiotoxicity by nanoparticles

Li, K., Chen, W., Ma, L., Yan, L., & Wang, B. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117264 · Cited by 18

Sheng-Mai-Yin inhibits doxorubicin-induced ferroptosis and cardiotoxicity through regulation of Hmox1

Meng, P.-N., Chen, Z., Sun, T., Wu, L., Wang, Y., Guo, T., Yang, J., & Zhu, J. (2023) · Aging · doi:10.18632/aging.205062 · Cited by 18

Deubiquitinase OTUB1 regulates doxorubicin-induced cardiotoxicity via deubiquitinating c-MYC

Xu, F., Zang, T., Chen, H., Zhou, C., Wang, R., Yu, Y., Shen, L., Qian, J., & Ge, J. (2023) · Cellular Signalling · doi:10.1016/j.cellsig.2023.110937 · Cited by 18

Self-assembly of maltose-albumin nanoparticles for efficient targeting delivery and therapy in liver cancer

Wang, L., Wu, Y., Yang, N., Yin, W., Huang, Y., Li, C., Zhuang, Y., Song, Z., Cheng, X., Shi, S., et al. (2023) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2023.128691 · Cited by 18

Cardioprotective Effect of Hydroalcohol Extract of Andaliman (Zanthoxylum acanthopodium DC.) Fruits on Doxorubicin-Induced Rats

Dalimunthe, A., Satria, D., Sitorus, P., Harahap, U., Angela, I. F. D., & Waruwu, S. B. (2024) · Pharmaceuticals · doi:10.3390/ph17030359 · Cited by 20

Thermosensitive polymer prodrug nanoparticles prepared by an all-aqueous nanoprecipitation process and application to combination therapy

Guerassimoff, L., Ferrere, M., Herck, S. V., Dehissi, S., Nicolas, V., Geest, B. G. D., & Nicolas, J. (2024) · Journal of Controlled Release · doi:10.1016/j.jconrel.2024.03.049 · Cited by 18

Novel PLGA-based nanoformulation decreases doxorubicin-induced cardiotoxicity

Drinković, N., Beus, M., Barbir, R., Debeljak, Ž., Lovaković, B. T., Kalčec, N., Ćurlin, M., Bekavac, A., Gorup, D., Mamić, I., et al. (2024) · Nanoscale · doi:10.1039/d3nr06269d · Cited by 18

Therapeutic Effects of Melatonin in the Regulation of Ferroptosis: A Review of Current Evidence

Pourhanifeh, M. H., Hosseinzadeh, A., Koosha, F., Reiter, R. J., & Mehrzadi, S. (2024) · Current Drug Targets · doi:10.2174/0113894501284110240426074746 · Cited by 18

An overview of different methods to establish a murine premature ovarian failure model

Pouladvand, N., Azarnia, M., Zeinali, H., Fathi, R., & Tavana, S. (2024) · Animal Models and Experimental Medicine · doi:10.1002/ame2.12477 · Cited by 18

Mitigating doxorubicin-induced hepatotoxicity in male rats: The role of aerobic interval training and curcumin supplementation in reducing oxidative stress, endoplasmic reticulum stress and apoptosis

Zobeydi, A. M., Namavar, S. N. M., Shahdani, M. S., Choobineh, S., Kordi, M. R., & Rakhshan, K. (2025) · Scientific Reports · doi:10.1038/s41598-025-91133-6 · Cited by 18

Unveiling the Multifaceted Pharmacological Actions of Indole-3-Carbinol and Diindolylmethane: A Comprehensive Review

Srikanth, Y., Dontiboina, H. R., Anusha, V. L., Dumala, N., Viswanadh, M. K., Chakravarthi, G., Nalluri, B. N., Yadagiri, G., & Ramakrishna, K. (2025) · Plants · doi:10.3390/plants14050827 · Cited by 17

Unlocking pH-responsive dual payload release through hydrazone linkage chemistry

Abd-Ellah, H. S., Zhao, D., Zhou, Y., & Baell, J. B. (2025) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2025.118172 · Cited by 17

Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart

Tiwari, V., Salgar, S., Jorvekar, S. B., Kumbhar, B. M., Arava, S. K., Borkar, R. M., & Banerjee, S. K. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167692 · Cited by 5

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, A., Cunha‐Oliveira, T., Simões, R. F., Carvalho, F. S., Burgeiro, A., Nordgren, K. K. S., Wallace, K. B., & Oliveira, P. J. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.011 · Cited by 78

Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature

Chen, Y., Huang, T., Shi, W., Fang, J., Deng, H., & Cui, G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.150 · Cited by 31

Pathophysiology of Doxorubicin-Mediated Cardiotoxicity

Arrigoni, R., Jirillo, E., & Caiati, C. (2025) · Toxics · doi:10.3390/toxics13040277 · Cited by 37

Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress and apoptosis.

Saleh, M. F., El‐Sayad, M. E., & Goda, A. E. (2021) · PubMed · doi:10.26355/eurrev_202111_27100 · Cited by 6