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Translational Approach: Dual-Mode Therapy with Selenium and Irradiation Enhances Doxorubicin Effectiveness in Triple-Negative Breast Cancer

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The Effects and Mechanisms of Indole Derivatives in Improving Doxorubicin-Induced Cardiomyopathy

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Xinmailong injection ameliorates Doxorubicin‑induced cardiotoxicity via the MDH2/OAA pathway

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Inhibition, But Not Depletion, of Erk Signaling Ameliorates Anthracycline-Induced Cardiotoxicity in Zebrafish

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Ganoderma applanatum (Pers.) Pat. augments antitumor activity of doxorubicin and provides chemoprevention to murine tumor model

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Parthenolide alleviates doxorubicin-induced cardiotoxicity via regulation of Cyp1a1 and Nppa and suppression of NLRP3 inflammasome

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The Protective Effects of Carvacrol Against Doxorubicin-Induced Cardiotoxicity In Vitro and In Vivo

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Thiolutin Alleviates Cardiotoxic Effects of Doxorubicin by Suppressing NLRP3 Inflammasome in the Mouse Model

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Ubiquitin E3 Ligases and p53 in Doxorubicin-Induced Cardiotoxicity

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Hydroxyl Radical-Responsive Nanoprobe Enables Ratiometric Fluorescence Monitoring of Cancer Cell Treatment Response

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Fibroblast growth factor 13 deficiency attenuates doxorubicin-induced cardiotoxicity by regulating Parkin-mediated myocardial injury

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Memantine, an NMDA Receptor Antagonist, Attenuates Doxorubicin-Induced Cardiac Oxidative Stress and Inflammation in Mouse 4T1 Breast Cancer Model

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Involvement of LncRNA FAF in chemotherapy-induced cardiotoxicity by mediating pyroptosis through modulation of the NLRP3-Caspase-1 signaling pathway

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A modular strategy to develop HSA-based DOX prodrug nanoparticles for safe and effective tumor therapy

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Barbeya oleoides leaf extract mitigates doxorubicin-induced cardiotoxicity: insights from in-vivo biochemical and histopathological analyses

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Real-Time Detection of Cardiotoxic Anticancer Drug by Diamond Microsensors in the Skin and Combined Monitoring of Electrocardiogram in Live Rats

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Herbacetin alleviates acute doxorubicin cardiotoxicity via regulating the ERK1/2-FOXO3a signaling pathway

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GSK-3α activation mitigates Doxorubicin-induced cardiomyopathy through Keap1/Nrf2/HO-1 axis

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Cardiovascular Impacts of SGLT2 Inhibitors on the Mitigation of Anthracycline-Induced Cardiomyopathy: A Comprehensive Systematic Review and Meta-Analysis

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Yiqi Wenyang formula ameliorates mitochondrial damage in doxorubicin-induced cardiotoxicity by activating the SIRT1/PGC-1α signaling pathway

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Dapagliflozin and crocin ameliorate DOX-induced cardiotoxicity in rats via activating the Nrf-2/HO-1/NQO1 pathway: a comparative study

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Peroxiredoxin Ⅲ safeguards cardiac function against doxorubicin by regulating mitochondrial quality control via H2O2 detoxification

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The PI3K-AKT-VEGF Signaling Pathway Contributes to Doxorubicin-induced Chemotherapy-related Cognitive Impairment

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Mesoporous Silica Nanoparticles Modified with Zinc, Amine, and Graphene Oxide for Controlled Doxorubicin Delivery in Breast Cancer Therapy

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The gut–heart axis in cardio-oncology

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Modulation of Nrf2, CBR1, and TNF-a Expressions and Antioxidant Activity Mediated The Cardioprotective Effects of Zingiber Officinale and Moringa Oleifera Extracts Against Doxorubicin-Induced Toxicity

Conference, I. (2022) · Egyptian Journal of Chemistry · doi:10.21608/ejchem.2022.155718.6734 · Cited by 1

Terminalia muelleri Attenuates the Accumulation of Excess Iron, Inhibition of Topoisomerase 2ß and Oxidative Cardiac Damage in Doxorubicin-Induced Cardiotoxicity in Rats

Eltablawy, N. A., Sayed, I. E. T. E., Barry, H. M. A., Ibrahim, M. A., & ElDein, M. N. A. S. (2022) · Advances in Animal and Veterinary Sciences · doi:10.17582/journal.aavs/2023/11.1.176.188 · Cited by 1

Micellar Nanoformulation of Berberine to Mitigate Doxorubicin-induced Cardiotoxicity: A Cell-line Study

Alyasari, N. K. H., & Almzaiel, A. J. (2023) · Al- Anbar Medical Journal · doi:10.33091/amj.2023.141684.1254 · Cited by 1

Intraoperative Bone Cement Implantation Syndrome in a Pediatric Patient

Tansey, P. J., Wainwright, J. D., Johnson, B. A., & Montgomery, N. I. (2024) · JBJS Case Connector · doi:10.2106/jbjs.cc.24.00390 · Cited by 1

Targeting breast cancer senescence in 3D models of bone metastasis

Hamburger, E. C. B., Garakani, M. M., Ghazizadeh, S., Alfaisali, S., Ouellet, J. A., Weber, M. H., Garzia, L., Haglund, L., & Rosenzweig, D. H. (2026) · Breast Cancer · doi:10.1007/s12282-026-01857-0 · Cited by 1

A promising platform of hypoxia sensitive magnetosomes in hepatocellular carcinoma therapy

Deng, K., Wang, J., Zhou, X., Geng, Y., Liu, W., Zhang, Y., Liu, Y., & Jiang, W. (2025) · Scientific Reports · doi:10.1038/s41598-025-10353-y · Cited by 1

Interleukin-6-taregeted dual-drug nanoparticles enhance glioblastoma chemotherapy by facilitating blood-brain barrier penetration and alleviating cardiotoxicity

Sun, Z., Lin, J., Huang, Y., Liu, Q., Zhu, X., Yang, Y., Wen, Y., Shao, C., Liao, W., Song, Y., et al. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.165895 · Cited by 1

Inducing Oxidative Stress-Driven Senescent Phenotype in Induced Pluripotent Stem Cell Derived Cardiomyocytes

Emanet, H., DiPietro, F., Philip, S., & Acun, A. (2025) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-025-01854-8 · Cited by 1

Acylhydrazone Derivatives: An Overview of Biological Activities

Luong, L. Q., Linh, P. T. K., Phuong, C. T. H., Ngoc, N. T., & Vu, T. K. (2025) · Current Bioactive Compounds · doi:10.2174/0115734072409057250813101844 · Cited by 1

In vitro evaluation of CeO2 nanoparticles on doxorubicin induced cardiotoxicity: focused on oxidative stress, inflammation, apoptosis, and mitochondrial function

Alsaikhan, F. (2025) · DARU Journal of Pharmaceutical Sciences · doi:10.1007/s40199-025-00573-y · Cited by 1

Drug repurposing of natural depsipeptide from Eleftheria terrae isolated via iChip for anti-breast cancer therapy

Fhatonah, N., Rustandi, T., Abdelmohsen, U. R., Rasydy, L. O. A., Ma'sum, M., Elghanam, Y., Pashar, I., Nordin, Mahal, A., & Riski, A. (2025) · Frontiers in Pharmacology · doi:10.3389/fphar.2025.1694322 · Cited by 1

In vivo Therapeutic Inhibition of the Tp53-Induced Glycolysis and Apoptosis Regulator (TIGAR) by Intravenous Administration of an Anti-Oncological siRNA-Biopolymer, TI6752 (Tituxistatin), in a Preclinical Xenograft Model of Colorectal Cancer

Harrod, C. K., Hernandez, B. Y., Yates, C., & Harrod, R. (2025) · Journal of Experimental Pharmacology · doi:10.2147/jep.s546622 · Cited by 1

Angiotensin converting enzyme inhibitors (ACEIs) for anthracycline-induced cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials

Safwan, M., Bourgleh, M. S., Alshakaki, H., & Haider, K. H. (2025) · Annals of Saudi Medicine · doi:10.5144/0256-4947.2025.421 · Cited by 1

Synergistic Effects of Morin and Doxorubicin Overcome Chemoresistance in Ovarian Cancer: Preclinical Insights From in vitro and in vivo Models

Wu, R., Bostani, A., & Wang, J. (2026) · Cancer Management and Research · doi:10.2147/cmar.s567591 · Cited by 1

Transplantation of Mitochondria isolated from iPSC-MSCs mitigates doxorubicin-induced cardiomyopathy by inhibiting cardiomyocyte senescence

Yang, Q., Zhao, S., Zhao, J., Shen, Y., Hong, Y., Qiu, J., Li, Z. L., Lin, F., Ma, K., Hu, B., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.01.030 · Cited by 1

Role of Perindopril in Mitigating Doxorubicin’s Vascular Toxicity in a Rat Model

Marada, A., Stračina, T., Marhefka, F., Šůstková, L., Nádeníček, J., Smutná, J., Scheer, P., Hložková, J., Hendrych, M., Studenik, C. R., et al. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10092-0 · Cited by 1

Gain-of-Function Variant TRPC6 A404V Is Associated With Doxorubicin-Related Cardiomyopathy

Wu, Y., SUN, X., Wang, R. X., Reddy, J. S., Lee, H.-C., Norton, N., & Lu, T. (2026) · Circulation Genomic and Precision Medicine · doi:10.1161/circgen.125.005334 · Cited by 1

Molecular insights into doxorubicin-induced cardiotoxicity and phytochemical-based cardioprotection: challenges and future strategies

Shyam, M., Amrutha, M., Kommoju, N., Joshi, R. V., Srirangan, P., Vidya, R., Vashishth, R., & Prince, S. E. (2026) · Drug Metabolism Reviews · doi:10.1080/03602532.2026.2627345 · Cited by 1

Doxorubicin-induced Cardiotoxicity is Propagated by Paracrine Signaling through Small Extracellular Vesicles

Ronan, G., Celebi, L. E., Kowalczyk, N., Behnam, N., Hawthorne, L., Yang, J., Ketchum, F., Lowery, A., Kerin, M. J., & Zorlutuna, P. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.08.049 · Cited by 1

6‐Shogaol Attenuates Doxorubicin‐Induced Cardiac and Skeletal Muscle Atrophy by Inhibiting E3 Ubiquitin Ligases and Necroptosis

Sun, X., Wang, Y., Yang, Q., Xin, B., Huang, J., & Guo, C. (2026) · Phytotherapy Research · doi:10.1002/ptr.70276 · Cited by 1

Experimental evaluation of N-acetylcysteine against doxorubicin cardiotoxicity in rats

Tola, H. T., & Kılıç, S. (2026) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-025-01073-0 · Cited by 1

Doxorubicin combined with ultrasmall Prussian blue nanoparticles to achieve effective breast cancer chemotherapy and simultaneously alleviate myocardial toxicity

Li, Y., Qin, J., Zhou, Y., Fang, B., Wang, K., Wu, S., Qian, H., Xing, G., Li, X., Ye, Z., et al. (2026) · Journal of Materials Science · doi:10.1007/s10853-026-12940-4 · Cited by 1

Fisetin Supplementation Attenuates Premature Vascular Aging Induced by Doxorubicin via Suppression of Cellular Senescence and Mitochondrial Oxidative Stress

Darrah, M. A., Mahoney, S. A., Venkatasubramanian, R., VanDongen, N. S., Ludwig, K. R., Seals, D. R., Rossman, M. J., & Clayton, Z. S. (2026) · Aging Cell · doi:10.1111/acel.70535 · Cited by 1

Ganoderma lucidum polysaccharides alleviate doxorubicin-induced cardiotoxicity by inhibiting ferroptosis through modulation of the Nrf2/SLC7A11/GPX4 signaling pathway

Zhang, S., Li, R., Wu, K., Zhao, H., Song, J., Zhang, Y., Chen, Y., He, J., Kong, F., & Liu, Y. (2026) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2026.152584 · Cited by 1

A new 1,4-dihydropyridine-based L-/T-type calcium channel inhibitor, provides in- vivo and silico cardioprotective effects in doxorubicin toxicity in rats

Kale, O. E., Gündüz, M. G., Osonuga, I. O., Awodele, O., & Ekor, M. (2026) · Human & Experimental Toxicology · doi:10.1177/09603271261446916 · Cited by 1

Empagliflozin mitigates doxorubicin-induced cardiac dysfunction in association with preserved t-tubule integrity and improved Ca2+ handling: a structural mechanistic insight

Lin, R., Li, Y., Liu, X., Meng, F., Wang, X., 蒋田南, 蒋田南, Liu, C., Jin, S., Liu, T., et al. (2026) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2026.05.320 · Cited by 1

Complexed rifampicin with iron mitigates doxorubicin-induced nephrotoxicity

Basal, O. A., Saad, E. A., & Sadda, R. R. E. (2026) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-026-01161-9 · Cited by 1

Biochanin A attenuates doxorubicin-induced cardiotoxicity in rats with associated modulation of PI3K/Akt/mTOR and p38 MAPK signaling

AlMutairi, M. M., Alkreathy, H. M., Shaik, R. A., Alharbi, A. E., & Magadmi, R. M. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1843282 · Cited by 1

Taxifolin attenuates doxorubicin-induced heart, liver, and kidney toxicity in mice via targeting TLR4

Jiang, M., Jiang, S., Ye, X., Qian, X., & Li, J. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179136 · Cited by 1

Metal‐Based Materials for Redox Modulation in Biomedicine

Fan, Y., Zhang, J., Sun, N., Chen, M., Sun, L., Lin, J., Chen, K., & Zhang, H. (2026) · Rare Metals · doi:10.1002/rar2.70536 · Cited by 1

Plant-derived extracellular vesicles as a dual-functional nanoplatform resolving doxorubicin's efficacy-toxicity dilemma

Tang, J., Li, Z., Shang, Y., Li, J., Pan, R., Ye, H., Cao, G., Sun, Y., Ran, Z., Li, X., et al. (2026) · Chemical Engineering Journal · doi:10.1016/j.cej.2026.181791 · Cited by 1

Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart

Tiwari, V., Salgar, S., Jorvekar, S. B., Kumbhar, B. M., Arava, S. K., Borkar, R. M., & Banerjee, S. K. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167692 · Cited by 5

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, A., Cunha‐Oliveira, T., Simões, R. F., Carvalho, F. S., Burgeiro, A., Nordgren, K. K. S., Wallace, K. B., & Oliveira, P. J. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.011 · Cited by 78

Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature

Chen, Y., Huang, T., Shi, W., Fang, J., Deng, H., & Cui, G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.150 · Cited by 31

Pathophysiology of Doxorubicin-Mediated Cardiotoxicity

Arrigoni, R., Jirillo, E., & Caiati, C. (2025) · Toxics · doi:10.3390/toxics13040277 · Cited by 37

Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress and apoptosis.

Saleh, M. F., El‐Sayad, M. E., & Goda, A. E. (2021) · PubMed · doi:10.26355/eurrev_202111_27100 · Cited by 6