Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

An integrated encyclopedia of DNA elements in the human genome

The ENCODE Project Consortium (2012) · Nature · doi:10.1038/nature11247 · Cited by 18,072

Anthracyclines: Molecular Advances and Pharmacologic Developments in Antitumor Activity and Cardiotoxicity

Minotti, G., Menna, P., Salvatorelli, E., Cairo, G., & Gianni, L. (2004) · Pharmacological Reviews · doi:10.1124/pr.56.2.6 · Cited by 3,868

DNA methylation landscapes: Provocative insights from epigenomics

Suzuki, M. M., & Bird, A. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2341 · Cited by 3,039

The ENCODE (ENCyclopedia Of DNA Elements) Project

(2004) · Science · doi:10.1126/science.1105136 · Cited by 2,390

Hotspots of aberrant epigenomic reprogramming in human induced pluripotent stem cells

Lister, R., Pelizzola, M., Kida, Y. S., Hawkins, R. D., Nery, J. R., Hon, G. C., Antosiewicz‐Bourget, J., O’Malley, R. C., Castanon, R., Klugman, S. A., et al. (2011) · Nature · doi:10.1038/nature09798 · Cited by 1,595

Doxorubicin-induced cardiomyopathy: From molecular mechanisms to therapeutic strategies

Octavia, Y., Tocchetti, C. G., Gabrielson, K. L., Janssens, S. P., Crijns, H. J. G. M., & Moens, A. L. (2012) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2012.03.006 · Cited by 1,425

Nitric Oxide Synthases: Properties and Catalytic Mechanism

Griffith, O. W., & Stuehr, D. J. (1995) · Annual Review of Physiology · doi:10.1146/annurev.ph.57.030195.003423 · Cited by 1,311

Cardiotoxicity of doxorubicin is mediated through mitochondrial iron accumulation

Ichikawa, Y., Ghanefar, M., Bayeva, M., Wu, R., Khechaduri, A., Prasad, S. V. N., Mutharasan, R. K., Naik, T. J., & Ardehali, H. (2014) · Journal of Clinical Investigation · doi:10.1172/jci72931 · Cited by 881

Injectable Magnolol-Peptide Hydrogel as a Minimally Invasive Treatment for Doxorubicin-Induced Cardiomyopathy via Inhibition of Aberrant Mitochondrial Fission

Hua, Y., Chen, H., Wu, Y., Wu, Y., Hu, C., Zeng, Y., Shen, M., Zhan, J. P., Meng, R., & Cai, Y. (2025) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5c20219

Prophylactic Effect of Lipoic Acid against Doxorubicin-Induced Biochemical and Histological Alterations in Rat Kidney

Palanichamy, M. K., Rajagopalan, S., & Swathanthiram, M. (2025) · Toxicology International · doi:10.18311/ti/2025/v32i4/51116

Cardiotoxicity Induced by Doxorubicin: Exploring Research Frontiers, Co-word Analysis, Trends, and Thematic Development

Abdelwahab, S. İ., Taha, M. M. E., Farasani, A. M., Abdullah, S. M., Moshi, J. M., Khamjan, N. A., Alshahrani, S., Sahli, K. A., Alsaadi, K. H., Qadri, M. M., et al. (2026) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.1177/0976500x251411634

Exercise improves doxorubicin-induced cardiotoxicity by regulating mitochondrial quality control through activation of the SIRT1-FOXO1 pathwayPreprint

Fang, J., Ren, Q., Liu, Y., Danzeng, C., Qiang, W., Wu, B., Zhu, H., & Shang, L. (2026) · Research Square · doi:10.21203/rs.3.rs-8426076/v1

Therapy-Related Cardio-Oncology in Hepatocellular Carcinoma: Mechanistic Insights and Strategies for Enhancing Efficacy While Reducing Toxicity

Zhong, J., & Shi, Y. (2026) · Journal of Biosciences and Medicines · doi:10.4236/jbm.2026.141022

CD44 Receptor-Mediated Delivery of ROS/pH Dual-Sensitive Nanoparticles Based on Poly(Ethylene Glycol)-b-Poly(Doxorubicin)-b-Hyaluronic Acid Copolymer

Kim, T. H., Kim, W., Kim, W.-J., Park, J.-S., Park, S.-Y., Jeong, Y., Kim, H., & Kim, S.-J. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s569702

A Diffusion-based Model of Doxorubicin Release from Liposomes: Effects of Size and Membrane Permeability

Illya, G. (2025) · BULETIN FISIKA · doi:10.24843/bf.2025.v26.i02.p09

Diosmin-Hesperidin Combination Improves Post-Ischemic Cardiac Recovery Via AKT/mTORC1 Modulation in Doxorubicin-Treated Rats

Hesari, M., Shackebaei, D., Mohammadi, P., Miraghaee, S., Yari, K., Haghighi, Z. M. S., Majnooni, M. B., & Yarmohammadi, F. (2026) · Cell Biochemistry and Biophysics · doi:10.1007/s12013-026-02000-8

Stem cell–derived exosomes in the treatment of chemotherapy-induced cardiotoxicity: A systematic review of in vivo and in vitro studies

Rad, M. R., Dabaghi, G. G., Sadri, H., Darouei, B., Amani-Beni, R., Golkar, Z., & Izadan, M. (2026) · Biomedical Research and Therapy · doi:10.15419/3eppqh79

Associations of cardiovascular–kidney–metabolic syndrome stages with long-term mortality among US cancer survivors: a prospective cohort study

Zheng, Y., Li, T., & Song, J. (2026) · Cardio-Oncology · doi:10.1186/s40959-026-00450-w

Exploring the Antioxidant and Anti-inflammatory Effects of Pumpkin and Olive Oil on Doxorubicin-induced Renal Toxicity in Rats

Alam, M. F., Hazazi, A. M. A., Al-Kasim, M. A., Jali, A. M., Hanbashi, A., Alshahrani, S., Alshamrani, A. A., Mawkili, W., Oraiby, M. E., Ibrahim, S., et al. (2026) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.1177/0976500x261417397

P-glycoprotein-mediated impairment of doxorubicin clearance in inflammatory bowel disorders: Mechanistic insights from rat studies and whole-body physiologically based pharmacokinetic modeling

Alsmadi, M. M. (2026) · Drug Metabolism and Disposition · doi:10.1016/j.dmd.2026.100254

Dry ice carbonation approach for the synthesis of calcium carbonate-based magnetic composites

Ghariani, M., O’Sullivan, C., Rafferty, A., & Gun’ko, Y. K. (2026) · Journal of Materials Chemistry C · doi:10.1039/d5tc02966j

Targeting the metabolic fingerprint of amino acids to identify novel metabolic characteristics in osteosarcoma patients undergoing anthracycline treatment

Li, S., Hong, Y., & Cui, L. (2026) · Scientific Reports · doi:10.1038/s41598-026-41411-8

Ехосонографічна оцінка структурно-функціонального стану серця та кардіопротекторна дія кондиційованого середовища мезенхімальних стовбурових клітин при комбінованій кардіотоксичності доксорубіцину і целекоксибу

Drobner, I., Hladkykh, F. V., Student, V. O., Liadova, T. I., Matvieienko, M. S., & Rubleva, T. V. (2026) · Ukrainian Journal of Cardiology · doi:10.31928/2664-4479-2026.1.6074

Charting the Current Landscape and Future Prospects of Cancer Therapy-Related Cardiovascular Toxicity in Cancer Survivors: From Bench to Bedside

Tao, S., Yu, L., Zhang, L., Li, J., Wu, J., & Tan, Y. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s572304

Eleutheroside E Attenuates Doxorubicin-Induced Cardiotoxicity by Suppressing Ferroptosis Through Activation of the Nrf2/SLC7A11/GPX4 Signaling Pathway

Sun, P., Chen, L., Chen, X., Zhang, X., Guan, J., Mo, H., Liang, Y., Li, J., Yan, J., Chen, D., et al. (2026) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/10742484261428559

Antrodia cinnamomea Reduces Oxidative Injury and Protects Cardiac Histology in Doxorubicin-Induced Cardiotoxicity

Yakut, S., & Özkanlar, S. (2026) · Kocatepe Veterinary Journal · doi:10.30607/kvj.1789570

Deep tumor penetration of supramolecular Fmoc-Glyco/ Fmoc-diphenylalanine-DOX drug loaded nanorods for targeted chemotherapy

Zhang, Y., Peng, L., Ye, B., Lu, G., Li, S., Zhou, J., Barboiu, M. D., & Chen, J. (2026) · Nano Today · doi:10.1016/j.nantod.2026.103019

Network pharmacology-based therapeutic intervention of Mentha arvensis targeting cancer and doxorubicin-induced cardiotoxicity

Kaur, S., Navik, U., Bhatti, G. K., & Bhatti, J. S. (2026) · Investigational New Drugs · doi:10.1007/s10637-026-01595-2

Revolutionizing leukemia therapy with liposomes and niosomes: Targeted delivery and improved efficacy

Pareek, A., Gandhi, S. M., Laware, R. B., Kashid, V. A., Gayke, A. U., & Kapoor, D. U. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-44000-7.00001-2

Erythrocyte membrane-camouflaged doxorubicin nanoparticles for enhancing therapeutic efficacy in primary liver cancer

Hu, T.-T., Ding, Y., Yao, Y., Zhang, X., Zhang, X.-W., & Gu, Y. (2026) · Journal of drug targeting · doi:10.1080/1061186x.2026.2647068

Repurposing of piracetam to alleviate doxorubicin-induced cardiotoxicity in rats: targeting TLR2/MyD88/AP-1/NF-κB and VEGF/eNOS signaling pathways

Refaie, M. M. M., Rifaai, R. A., Hasan, A. A., Habib, H. A., Saleh, N. E. H., Sherkawy, H. S., Rahman, E. S. M. A. E., Shehata, S., Fathy, E., & Beshay, O. N. (2026) · Toxicology Mechanisms and Methods · doi:10.1080/15376516.2026.2651369

Safety and Treatment Efficacy of Systemic, Locoregional, and Nanoparticle Encapsulated Anthracycline Chemotherapy: Insights Into Cardiotoxicity

Hammond, S. T., Brandt, L., Kong, A. L., White, S. B., Lewandowski, D., & Beyer, A. (2026) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.125.319865

NanoRam - Caractérisation cellulaire et tissulaire des stratégies de nanovectorisation par imagerie Raman

Assaad, A. A. (2023) · theses.fr (ABES) · doi:10.70675/d21af1f0z83eaz4ec6z8b74z6815eb479999

Synthesis and evaluation of stimuli-responsive polymer prodrugs for combination therapy and subcutaneous administration of irritant anticancer drugs

Guerassimoff, L. (2023) · theses.fr (ABES) · doi:10.70675/3810ebc2z5b92z4113za5baz282aca460ffe

Combination of Zonisamide and Dexrazoxane in the Modulation of Doxorubicin-Induced Renal Damage in Rats

Sabra, M. S., Rasool, A. M. A., Allam, E. A. H., Darwish, M. H. A., Abdelhafez, E. A., Nabil, A., Hamad, N., Abdelaziz, M. W., Sherkawy, H. S., Elsaied, H., et al. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10612-z

Cardiac reprogramming via transient overexpression of P-glycoprotein alleviates doxorubicin-induced cardiotoxicity in mice and pigs

Zhang, Y., Li, W., Xiao, Y., Luo, L., Ai, J., Mo, S., Li, L., Deng, J., Wang, X., Li, Q., et al. (2026) · Nature Communications · doi:10.1038/s41467-026-71843-9

Macrophage membrane-encapsulated liposomes of protopanaxadiol-type doxorubicin hydrochloride improve formulation stability for the treatment of triple-negative breast cancer

Bai, X., Wang, Z., Yu, Y., Yang, M., Li, D., Yao, F., Wu, Y., He, Y., & Fan, H. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2655894

Targeting the Apelin–APJ Axis: A Promising Strategy to Mitigate Anthracycline-Induced Cardiotoxicity

Desai, V. G. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10107-w

Cardioprotective Role of Taxifolin and Saroglitazar Against Doxorubicin Induced Cardiotoxicity in Wistar Rats: Evidence from In-silico, Hemodynamic, Biochemical and Histopathological Studies

Rathi, A., Parihar, L., Nagar, M., Alam, S., & Singh, A. P. (2026) · Journal of Pharmaceutical Innovation · doi:10.1007/s12247-026-10671-2

Catalytic oxygen generation and drug delivery via manganese dioxide nanoparticles to enhance radiotherapy in glioblastoma

Alghmadi, M., Hill, S., Formánek, P., Werner, C., & Newland, B. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.126896

Comparative Effects Of Absorbable Monofilament (Polyglecaprone), Absorbable Multifilament (Polyglactin 910), And Non-Absorbable Multifilament (Silk) Sutures On Collagen And Fibroblast Density In Primary Tracheal Repair: An Experimental Study In New Zealand Rabbits.

Suryani, D. Y., Sahudi, S., & Wibowo, M. D. (2026) · International Journal of Drug Delivery Technology · doi:10.25258/ijddt.16.18s.3

Design, Synthesis, and Protective Activity against Doxorubicin-Induced Cardiotoxicity of Novel Water-Soluble Small-Molecule GPx Mimics

Yu, Z., Shi, W., Qian, Z., Mei, X., Huang, X., Chen, X., Wang, W., Zhang, T., Chen, X., Li, Z., et al. (2026) · ACS Medicinal Chemistry Letters · doi:10.1021/acsmedchemlett.6c00185

Total flavonoids from Dracocephalum moldavica alleviate doxorubicin cardiotoxicity by regulating NLRP3/ASC/Caspase-1 axis

Ran, K., Wang, Y., Xing, J., Zhang, Y., & Zheng, R. (2026) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2026.04.005

The Effects of Angiotensin Receptor Neprilysin Inhibitor on Endoplasmic Reticulum Stress in Doxorubicin‐Mediated Cardiomyopathy‐Associated Heart Failure Model in Rats

Unvan, M., Karagül, M. İ., Demirbağ, H. O., & Ballı, E. (2026) · Journal of Applied Toxicology · doi:10.1002/jat.70212

Fabrication of β-glucan nanocarriers for enhanced encapsulation and delivery of doxorubicin for triple negative breast cancer treatment

Servatan, M., Bozkurt, F. Z., Hitit, Z. Y., Şahin, B., Parıltı, D. N., Ertunç, S., & Mutlu, P. (2026) · Bioscience Biotechnology and Biochemistry · doi:10.1093/bbb/zbag066

Dual-responsive doxorubicin and ICG-loaded Pluronic-poly(β-amino ester) polymersomes functionalized with folic acid for chemo-photothermal therapy of breast cancer

Sheikhi‐Mohammareh, S., Ramezani, M., Nazari, M., Abnous, K., Taghdisi, S. M., & Alibolandi, M. (2026) · European Polymer Journal · doi:10.1016/j.eurpolymj.2026.114782

Luteolin based metal-polyphenol networks enable synergistic chemotherapy with attenuated cardiotoxicity via AKR1B1 inhibition

Yang, Y., Zhao, F., Qian, Y., Shan, X., & Shan, L. (2026) · Materials Today Communications · doi:10.1016/j.mtcomm.2026.115308

Co-Delivery of Micellar Berberine and Doxorubicin: A Promising Cardioprotective Strategy and Prospective Therapeutic Anticancer Approach Using Cardiomyocyte and Ovarian Adenocarcinoma Cell Lines as Models

Alyasari, N. K. H., & Almzaiel, A. J. (2026) · Medical Journal of Babylon · doi:10.4103/mjbl.mjbl_814_23

Protective Effect of Edaravone on Doxorubicin-Induced Thyroid Dysfunction in Rats Revealed by 99mTc Pertechnetate Thyroid Gland Scintigraphy and Biochemical Methods

Kalın, M., Aygun, H., Karakullukçu, H. K., Karakullukcu, M., Arslan, A., Gül, S. Ş., Özkan, Ö. F., & Ercan, G. (2026) · Medicina · doi:10.3390/medicina62050894

Protocatechuic Acid Ethyl Ester Protects Against Doxorubicin-induced Cardiotoxicity in Rats

Safaeian, L., Farsiabi, M., Haghighatian, Z., & Asghari-Varzaneh, M. (2026) · Drug Research · doi:10.1055/a-2829-7178

Anthracycline-induced cardiorenal toxicity: from molecular mechanisms to clinical management

Jiao, L., Yuan, C., Wang, L., Zhao, Y., Zhang, G., Yang, X., Gao, Y., Yang, F., Li, X., Na, A., et al. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1811848

Antibacterial and antibiofilm activities of novel bacterial topoisomerase inhibitors against Staphylococcus aureus and other clinically relevant pathogens

Zorman, M., Minovski, N., Zajec, Ž., Anderluh, M., Golob, M., Radaković, N., Atanasković, M., Šenerović, L., & Hrast, M. (2026) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2026.118993

Exercise prevents cardiac electrical remodeling in doxorubicin-treated female mice but does not provide cardioprotection in malesPreprint

Melcher, A. V., Haflett, L., Tang, L., Trampel, K. A., Bodapotula, M., & George, S. A. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.28.728478

Safety, pharmacokinetics, pharmacodynamics and antitumor activity of legubicin in patients with advanced solid tumors, including lung cancer: a phase 1 dose-escalation and expansion trial

Lin, F., Xue, J., Li, Q., Tang, W., Zhao, W., Xue, L., Zhou, J., Liu, Y., Jin, W., Sun, H., et al. (2026) · BMC Cancer · doi:10.1186/s12885-026-16261-2

Dual-targeted glutathione-glutamate functionalized Bismuth-Niosomes hybrid nanosystem for co-delivery of doxorubicin and Pi3K inhibitor into U87 glioblastoma cells

Bigdelou, Z., Gharbavi, M., Bagherpour, G., Rezaeejam, H., & Johari, B. (2026) · Scientific Reports · doi:10.1038/s41598-026-54715-6

ReCardioids: a robust human heart organoid platform to model doxorubicin- and radiotherapy-induced cardiotoxicityPreprint

Rehnberg, E., Baselet, B., Etlioglu, E., Janssen, Z., Cools, B., Rompay, C. V., Vermeesen, R., Moroni, L., Baatout, S., & Tabury, K. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.05.29.728705

Natural polymer–based drug delivery system for breast cancer: a systematic review of pectin and chitosan

Pabisa, L., Mayasari, E., Raya, I., Mandey, F., & Mubaraq, W. (2026) · Polymer Bulletin · doi:10.1007/s00289-026-06472-9

SIMVASTATIN as a potential protective strategy against doxorubicin-induced cardiotoxicity

Pala, B., Piscione, M., Marcantonio, M. C. D., Cribari, F., Vitale, R., Baldi, T., Popolo, A., & Mincione, G. (2026) · Frontiers in Cardiovascular Medicine · doi:10.3389/fcvm.2026.1846253

In vivo evaluation of the cardioprotective efficacy of Annona squamosa L. extract and its phytosome formulation against doxorubicin-induced cardiotoxicity

Patil, P. P., Lele, K. A., Mudhol, S., & Havaldar, S. U. (2026) · Systems Ethnopharmacology and Sustainable Bioresources · doi:10.1016/j.sesb.2026.100018

Antitumor effect of dipyridamole mediated by inhibiting the interaction between platelets and tumor cells

Xue, J., Deng, J., Qin, H., Li, Y., Jing, Z., Zhao, Z. Y., & Wang, H. (2026) · Discover Oncology · doi:10.1007/s12672-026-05365-7

P2Y12-AMPKα2 signaling contributes to cardiomyocyte senescence in doxorubicin-induced heart failure

Niu, Q., Wang, H. W., Zhao, M., Zhang, H., Hao, R., Liu, P., Guo, L., Chen, B., Xi, Y., Li, P., et al. (2026) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-026-05593-z

Serial cardiac MR assessment and histopathological evaluation of doxorubicin-induced cardiomyopathy in a miniature swine model

Shi, R., Zeng, W., Shen, L.-T., Xu, R., Liu, X., Li, Y., Li, Z., Xia, C., & Yang, Z. (2026) · BMC Cardiovascular Disorders · doi:10.1186/s12872-026-06152-6

Engineering Coil-Coiled Domains for the Design of Modular Theranostic Agents: Galectin-3 as a Targeting Moiety

Burgio, C., Girón, M. D., Ortega‐Muñoz, M., Lucena, D., & Salto, R. (2026) · Biomacromolecules · doi:10.1021/acs.biomac.6c00502

Apelin, Cortisol, and Doxorubicin-Induced Cardiotoxicity: A Triangle of Actions

Dziobiak, K., Owe-Larsson, M., Chwil, M., & Janiuk, I. R. (2026) · Cells · doi:10.3390/cells15131187

Integrative computational and experimental insights into the multitargeted anticancer potential of Curcuma caesia against triple-negative breast cancer: molecular docking and pharmacokinetic assessment

Lenka, J., Singh, V., Kar, B., Kumar, A. T. R., Panda, S., & Sahoo, S. (2026) · South African Journal of Botany · doi:10.1016/j.sajb.2026.06.033

Dnmt1 associated Gja1 promoter methylation changes are implicated in Cx43 remodeling during acute myocardial ischemia/reperfusion injury

Liu, Y., Wang, Z., Zhao, Y., Ma, Y., Yi, J., Song, Y., Liu, Y., An, L., Pan, Z., Gao, H., et al. (2026) · Epigenetics · doi:10.1080/15592294.2026.2694817

A synergistic dual-action nanotherapeutic platform for osteosarcoma treatment

Agamey, A. T., Yahia, S. A. A., & El-sherbiny, I. M. (2026) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2026.108663

Interplay of oxidative stress and inflammatory mechanisms in doxorubicin-induced cardiomyopathy

Narasimhulu, C. A., Imaralu, O. E., Khan, M., & Singla, D. K. (2026) · American Journal of Physiology-Heart and Circulatory Physiology · doi:10.1152/ajpheart.00187.2026 · Cited by 1

HIF1α Attenuates Doxorubicin‐Induced Cardiotoxicity by Activating TEX264‐Associated ER‐phagy

Wang, X., Zhan, G., Li, J., Yang, X. L., Wen, Y., Tang, Y., Zhang, P., Xia, Y., & Yang, X. (2026) · Journal of the American Heart Association · doi:10.1161/jaha.125.047158

Cardioprotective effects of paeonol: modulation of mitochondrial dynamics and mechanistic insights with focus on doxorubicin-induced cardiotoxicity

Mubeen, M., Arshad, K., Sarfraz, M., Ahmed, F., Khalil, E. R., & Kumar, K. (2026) · Journal of Cardio-oncology · doi:10.1097/co9.0000000000000023

Natural-Origin Compounds as Future Precision Partners in Combination Cancer Therapy

Pešić, M., Rijo, P. M., & Djordjević, N. Z. (2026) · Medicina · doi:10.3390/medicina62071344

Single cell and bulk transcriptomics reveal metabolic reprogramming biomarker signatures during extracorporeal membrane oxygenation for cardiogenic shock

Zhou, X. Y., Aierken, D., Sun, L., Chang, X., Xu, L., & Guo, Z. W. (2026) · Scientific Reports · doi:10.1038/s41598-026-62728-4

A Self-Assembling Peptide Platform for Intratumoral Doxorubicin Delivery and Preliminary Immune-Related Modulation in B16-F10 Melanoma

Ying, X., Peng, J., Ben, Z., Bao, X., Wu, L., Tan, X., Sun, X., Yang, Y., Shen, Y., Zhang, Z., et al. (2026) · Biomedicines · doi:10.3390/biomedicines14071624

ATP Synthase Inhibitory Factor-1 Deficiency Attenuates Doxorubicin Cardiotoxicity by Preserving Mitochondrial Structure and Function

Mobasheran, P., Aryal, A., Aguilar, J., Jennings, S., Lauterboeck, L., Young, K., & Yang, Q. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146360

Amifostine Attenuates Doxorubicin-Induced Subacute Hepatic and Renal Toxicity in Rats

Jacevic, V. M., Dragojevic-Simic, V. M., Grujić-Milanović, J. D., Dobrić, S., Bokonjić, D., Milovanovic, Z., Milanović, S., & Simić, R. (2026) · International Journal of Molecular Sciences · doi:10.3390/ijms27146419

Mechanistic exploration of Wenyang Zhenshuai granules in doxorubicin-induced cardiotoxicity: integrating network pharmacology and experimental validation

Deng, X., Li, X., Cai, J., Xu, Z., Chen, X., Yao, K., & Luo, Y. (2026) · Journal of Cardiothoracic Surgery · doi:10.1186/s13019-026-04631-7

A scheme to tackle the dilemma from hepatoma cells under doxorubicin-resistant surroundings: a brightness or a silhouette

Oh, K., Kwon, G.-H., Eom, J.-A., Lee, K. J., Kim, D. J., & Suk, K. T. (2026) · Artificial Cells Nanomedicine and Biotechnology · doi:10.1080/21691401.2026.2694920

Machine Learning in Drug-induced Adverse Reaction Modeling: Case Studies of Drug-induced Cardiotoxicity Modeling

Liu, J., Guo, W., Patterson, T. A., & Hong, H. (2026) · Royal Society of Chemistry eBooks · doi:10.1039/9781837070206-00462

SIRT5 Attenuates Doxorubicin-Induced Acute Cardiac Injury by Modulating PHB2 Succinylation and the Mitophagic Response

Zeng, A., LIU, H. J., Song, X., Yan, J., Zhou, Y., Sun, D., & Chen, A. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10165-0

Tailoring pH-responsive charge-conversional interfaces in ionizable lipid-based nanoliposomes for synchronized co-delivery and synergistic therapy of triple-negative breast cancer

Choi, Y., Choung, K.-H., Jin, M., Yoon, M. S., Lee, S., Jo, Y., Bang, J.-H., Lim, S., Lee, S., Baek, J.-S., et al. (2026) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2026.119795

Cardiovascular Protection with Sulfasalazine During Doxorubicin Challenge: Evidence from Oxidative and Histologic Endpoints

Özhan, O., Kaya, E., Taşolar, M. H., Balkar, M. E., Yıldız, A., Dogru, F., Ulutaş, Z., Küçükakçalı, Z., & Parlakpınar, H. (2026) · Biomolecules · doi:10.3390/biom16081085

V2C MXene-amplified electrochemical sensor for trace-level monitoring of the anticancer drug Doxorubicin in pharmaceutical and biological samples

Maleh, H. K., Zare, N., Ye, J., Moradialvand, M., Dong, X., & Jiang, J. (2026) · Microchemical Journal · doi:10.1016/j.microc.2026.119198

L-Arginine effectively alleviates doxorubicin-induced cardiac dysfunction by inhibiting myocardial fibrosis

Zhu, M., Hao, R., zhao, M.-Y., Liu, P., Zhang, H.-D., Li, P., Yin, Y.-L., Liu, H.-J., Ren, G.-Q., Zhang, J., et al. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12440-3

Dual blockade of ferroptosis and apoptosis: Tiron attenuates doxorubicin cardiotoxicity

Motafeghi, F., Rahmani, P., Barghi, E. G., Gharab, J. G., Mortazavi, P., Dehpanah, M., & Ghassemi-Barghi, N. (2026) · European journal of medical research · doi:10.1186/s40001-026-04943-3

FGF21/sirtuin 1 axis mediates the cardioprotective effects of high‐intensity interval training against doxorubicin‐induced cardiotoxicity by reducing inflammatory and oxidative stress

Farahani, M., Gaeini, A. A., Afousi, A. G., & Fard, M. B. (2026) · Experimental Physiology · doi:10.1113/ep093527

Study on the structure, cardioprotective function, and mechanism of an inulin-type fructan in Platycodon grandiflorum and its resource development

Jiang, S., Gong, H., Wang, H., Zhang, F., & Chen, W. (2026) · Medicinal Plant Biology · doi:10.48130/mpb-0026-0013

Comparative Antioxidant Effects of Allopurinol and Febuxostat in Doxorubicin-Treated Rats

Kanaan, A. G., & Almukhtar, H. M. (2026) · Tikrit Journal of Pharmaceutical Sciences · doi:10.25130/tjphs.2026.20.1.8.78.86

Unlocking the brain: Biodistribution insights into tween 80 nanoliposomes in healthy brains

Khatibi, M., Hosseinikhah, S. M., Alavizdaeh, S. H., Gheybi, F., Jaafari, M. R., Efati, Z., Afshari, F., Yaghoubi, S., & Norouzi, P. (2026) · International Journal of Pharmaceutics X · doi:10.1016/j.ijpx.2026.100636

Early cardiac proteomic profiling in a long-latency doxorubicin cardiomyopathy model exhibits sexual dimorphism for cardioprotection

Sedighi, S., Chen, L., Wang, Y., Lebarbenchon, K. P., Yi, J., Menghani, T., Shah, F. A., Yang, S., Saeki, H., Ito, T., et al. (2026) · Journal of Molecular and Cellular Cardiology Plus · doi:10.1016/j.jmccpl.2026.100861

Ginkgolide B mitigates doxorubicin-induced cardiotoxicity by regulating AMPK-mediated mitochondrial fission via P-Drp1/OPA1 and apoptosis

Rong, Z., & Shao, J. (2026) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2026.110979

Forsythiaside B alleviates DOX-induced myocardial injury by enhancing the interaction between HSP90AA1 and CYP1A1 to inhibit ferroptosis

Hu, S., Lv, L., & Huang, Z. (2026) · Translational research · doi:10.1016/j.trsl.2026.08.008

Liquiritigenin-glycyrrhiza polysaccharide self-assembled nanomicelles ameliorate doxorubicin-induced cardiotoxicity by inhibiting Nrf2-mediated ferroptosis

Gao, Y.-F., Yu, Y., Wang, J.-H., Wang, L., Zhang, Y.-N., Guo, R., Zheng, Y., Lv, M.-J., Zang, J., Deng, Y.-Y., et al. (2026) · Materials & Design · doi:10.1016/j.matdes.2026.116852

Integrated Multi-omics Reveals CDKN1A Suppression and Metabolic Regulation as Key Mechanisms of Huangqi Guizhi Wuwu Decoction Against Doxorubicin-Induced Cardiotoxicity

Hou, Q., Yu, X., Wu, K., Chen, S., Mao, X., Qian, X., Li, C., Sheng, L., Wang, R., & Huang, Y. (2026) · Cardiovascular Toxicology · doi:10.1007/s12012-026-10168-x

Cardiovascular Toxicity in Cancer Therapy: Potential Mechanisms of Ferroptosis and Treatment Strategies

Dai, J., Wang, Y., Jin, C., Song, L., Xie, Y., Jia, L., & Xiang, M. (2026) · Cells · doi:10.3390/cells15171507

Molecular hydrogen in cancer: reprogramming oncogenic signaling pathways and emerging pharmacological potential

Maity, A. K., Mallick, A., Crans, D. C., Goswami, S., & Roy, S. (2026) · Frontiers in Chemical Biology · doi:10.3389/fchbi.2026.1915345

Protective effect of Pinus eldarica bark extract on doxorubicin-induced cardiotoxicity in rats

Izadi, M. S., Jalali, M., Safaeian, L., & Zolfaghari, B. (2026) · Proceedings of the Indian National Science Academy · doi:10.1007/s43538-026-00891-y

Preventive Effect of Protocatechuic Acid Ethyl Ester against Doxorubicin-Induced Toxicity in Cardiomyocytes

Safaeian, L., Zeinosalehin, A., & Rashidi, N. (2026) · International Journal of Preventive Medicine · doi:10.4103/ijpvm.ijpvm_10_25

Alogliptin mitigates doxorubicin-induced cardiotoxicity in rats: Implications of SIRT3/NRF2 pathway and miRNA-133a

Elmongy, N. F., ABBAS, M. A. M., Elshora, S. Z., Meawad, S. B., Atwa, A., Allam, A., Elshamy, A. I., & El‐Gendy, Z. A. (2026) · Tissue and Cell · doi:10.1016/j.tice.2026.103910

MMP-responsive multiwalled carbon nanotubes enable tumor-selective drug delivery with altered intracellular trafficking and reduced off-target toxicity

Bhattarai, P., Iqbal, A., Yadav, U., Qadri, S. M., Ara, N., Mandal, S., Foote, A., Castillo, K., Cheng, S. K. S., Sheng, J., et al. (2026) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2026.127606

Endothelial and Vascular Toxicity Signals Associated With Doxorubicin: A Pharmacovigilance Analysis of the FDA Adverse Event Reporting System ( FAERS ) Database

Cerbito, E. F., Kattan, L., Dhulkifle, H., Korashy, H. M., & Maayah, Z. H. (2026) · Pharmacoepidemiology and Drug Safety · doi:10.1002/pds.70474

Hematologic profile of stage IIIB breast cancer patients receiving doxorubicin-cyclophosphamide versus docetaxel-doxorubicin-cyclophosphamide regimens: An observational pilot study

Liana, P., Hafy, Z., Oktariana, D., Waruwu, Y. P., Djamili, P. Y., & Umar, T. P. (2026) · Meditsinskiy sovet = Medical Council · doi:10.21518/ms2026-226

Acteoside ameliorates doxorubicin-induced cardiotoxicity by suppressing ferroptosis through activation of the KEAP1/NRF2 pathway

Wang, M., Wang, C., Liu, Z., Du, X., Tian, L., Li, Q., Zhang, F., Chen, Y., & Lu, C. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179349

Targeting MicroRNAs in doxorubicin-induced cardiotoxicity: A systematic review of transfection studies

Dhami, I. S., Kaur, S., Bhatti, G. K., Mastana, S. S., & Bhatti, J. S. (2026) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2026.179359

Synergistic electrocatalytic enhancement by an RGO-NiFe₂O₄ nanocomposite for high-performance electrochemical detection of doxorubicin

Rostami, F., Mazloum‐Ardakani, M., & Mohammadian-Sarcheshmeh, H. (2026) · Chemical Papers · doi:10.1007/s11696-026-05336-w

Mitochondrial Transplantation Rejuvenates Aging Heart by Restoring Mitophagy Flux via the HIF ‐3α‐ BNIP3 Axis

Jin, N., Zhou, L., Gui, H., Tang, J., 黃小珍, Wang, W., Jin, G., Cheng, H., Liang, Y., Geng, X., et al. (2026) · Aging Cell · doi:10.1111/acel.70720

Therapeutic Potential of Tadalafil in Doxorubicin-Induced Pulmonary and Hematological Toxicities in Wistar Rats.

Adeneye, A. A., Olomu, F. M., Olorundare, O. E., Ojewale, A. O., & Okoye, I. (2025) · Nigerian Journal of Physiological Sciences · doi:10.54548/njps.v40i1.15

Shikonin attenuates doxorubicin-induced myocardial senescence and fibrosis in association with improved redox and mitochondrial homeostasis

Ren, G.-Q., He, M., Guo, Y., Li, Z.-X., Liu, H.-J., Li, J., Zhang, J., & Yang, J. (2026) · Molecular Biology Reports · doi:10.1007/s11033-026-12790-y

Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart

Tiwari, V., Salgar, S., Jorvekar, S. B., Kumbhar, B. M., Arava, S. K., Borkar, R. M., & Banerjee, S. K. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167692 · Cited by 5

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, A., Cunha‐Oliveira, T., Simões, R. F., Carvalho, F. S., Burgeiro, A., Nordgren, K. K. S., Wallace, K. B., & Oliveira, P. J. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.011 · Cited by 78

Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature

Chen, Y., Huang, T., Shi, W., Fang, J., Deng, H., & Cui, G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.150 · Cited by 31

Pathophysiology of Doxorubicin-Mediated Cardiotoxicity

Arrigoni, R., Jirillo, E., & Caiati, C. (2025) · Toxics · doi:10.3390/toxics13040277 · Cited by 37

Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress and apoptosis.

Saleh, M. F., El‐Sayad, M. E., & Goda, A. E. (2021) · PubMed · doi:10.26355/eurrev_202111_27100 · Cited by 6