Doxorubicin-induced cardiotoxicity: An update on the molecular mechanism and novel therapeutic strategies for effective management

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Different Mechanisms in Doxorubicin-Induced Neurotoxicity: Impact of BRCA Mutations

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Nanoaggregates of Biphilic Carboxyl-Containing Copolymers as Carriers for Ionically Bound Doxorubicin

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New insights in aptamer-targeted nanoliposomes for the treatment of breast cancer

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Intracellular Trafficking of Size-Tuned Nanoparticles for Drug Delivery

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Exploring the mechanism of curcumin in the treatment of doxorubicin-induced cardiotoxicity based on network pharmacology and molecular docking technology

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Metal–Organic Frameworks-Based Nanoplatform for Treatment of Breast Cancer

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Early detection of anthracycline-induced cardiotoxicity

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Tumor Microenvironment-Responsive Nanomedicine: Monitoring and Modulating the Tumor Microenvironment for Precision Cancer Therapy

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Self-assembling dendrimer nanodrug formulations for decreased hERG-related toxicity and enhanced therapeutic efficacy

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The Relevance of Telomerase and Telomere-Associated Proteins in B-Acute Lymphoblastic Leukemia

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Low‐intensity pulsed ultrasound alleviates doxorubicin‐induced cardiotoxicity via inhibition of S100a8/a9‐mediated cardiac recruitment of neutrophils

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Conjugation of Doxorubicin and Carbon-based-nanostructures for Drug Delivery against HT-29 Colon Cancer Cells

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Water Extract of Capsella bursa-pastoris Mitigates Doxorubicin-Induced Cardiotoxicity by Upregulating Antioxidant Enzymes

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Circ-0006332 stimulates cardiomyocyte pyroptosis via the miR-143/TLR2 axis to promote doxorubicin-induced cardiac damage

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Iron metabolism in doxorubicin-induced cardiotoxicity: From mechanisms to therapies

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Multifaceted Cardioprotective Potential of Reduced Glutathione Against Doxorubicin-Induced Cardiotoxicity via Modulating Inflammation–Oxidative Stress Axis

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Overexpression of Programmed Cell Death 1 Prevents Doxorubicin-Induced Apoptosis Through Autophagy Induction in H9c2 Cardiomyocytes

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Synthesis of Amphiphilic Copolymers of N-Vinyl-2-pyrrolidone and Allyl Glycidyl Ether for Co-Delivery of Doxorubicin and Paclitaxel

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Epigenetic Mechanisms Governing Nrf2 Expression and Its Role in Ferroptosis

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Eupatilin attenuates doxorubicin-induced cardiotoxicity by activating the PI3K-AKT signaling pathway in mice

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Lady’s Bedstraw as a Powerful Antioxidant for Attenuation of Doxorubicin-Induced Cardiotoxicity

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Phloretin alleviates doxorubicin-induced cardiotoxicity through regulating Hif3a transcription via targeting transcription factor Fos

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Utilization of Quince (Cydonia oblonga) Peel and Exploration of Its Metabolite Profiling and Cardioprotective Potential Against Doxorubicin-Induced Cardiotoxicity in Wistar Rats

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Upregulation of TRIM16 mitigates doxorubicin-induced cardiotoxicity by modulating TAK1 and YAP/Nrf2 pathways in mice

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Activation of AMPK/mTOR-Driven Autophagy and Suppression of the HMGB1/TLR4 Pathway with Pentoxifylline Attenuates Doxorubicin-Induced Hepatic Injury in Rats

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Protective effects of phosphocreatine against Doxorubicin-Induced cardiotoxicity through mitochondrial function enhancement and apoptosis suppression via AMPK/PGC-1α signaling pathway

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Nanozyme-based synergistic therapeutic strategies against tumors

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Regulators of epigenetic change in ferroptosis‑associated cancer (Review)

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Role of mesenchymal stem cells‐derived exosomes on inflammation, apoptosis, fibrosis and telocyte modulation in doxorubicin‐induced cardiotoxicity: A closer look at the structural level

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The NEDD8 activating enzyme inhibitor MLN4924 mitigates doxorubicin-induced cardiotoxicity in mice

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Potential of Natural Phenolic Compounds against Doxorubicin-Induced Chemobrain: Biological and Molecular Mechanisms Involved

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Fabrication of Rhenium Disulfide/Mesoporous Silica Core–Shell Nanoparticles for a pH-Responsive Drug Release and Combined Chemo-Photothermal Therapy

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The significance of the apelinergic system in doxorubicin-induced cardiotoxicity

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The interplay between doxorubicin chemotherapy, antioxidant system, and cardiotoxicity: Unrevealing of the protective potential of tannic acid

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Neutrophil Biomarkers Can Predict Cardiotoxicity of Anthracyclines in Breast Cancer

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Small Molecules Targeting Mitochondria: A Mechanistic Approach to Combating Doxorubicin-Induced Cardiotoxicity

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Ophiopogon japonicus polysaccharide reduces doxorubicin-induced myocardial ferroptosis injury by activating Nrf2/GPX4 signaling and alleviating iron accumulation

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Lutein protection against doxorubicin-induced liver damage in rats is associated with inhibition of oxido-inflammatory stress and modulation of Beclin-1/mTOR activities

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Overexpression of hnRNPK and inhibition of cytoplasmic translocation ameliorate lipid disorder in doxorubicin-induced cardiomyopathy via PINK1/Parkin-mediated mitophagy

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Mechanistic Insights into Flavonoid Subclasses as Cardioprotective Agents Against Doxorubicin-Induced Cardiotoxicity: A Comprehensive Review

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Anthracycline- and HER2-induced cardiotoxicity: mechanisms, current strategies, and the emerging role of dapagliflozin as a targeted cardioprotective agent

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Anti-Leukemic Activity of Brassica-Derived Bioactive Compounds in HL-60 Myeloid Leukemia Cells

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Targeting the Na+/K+ ATPase DR-region with DR-Ab improves doxorubicin-induced cardiotoxicity

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Recent advances in marine oligosaccharides: A review of bioactivities and application

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Epidermal growth factor receptor targeted doxorubicin and vitexin loaded niosomes for enhanced breast cancer therapy

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Ling-Gui-Zhu-Gan decoction protects against doxorubicin-induced myocardial injury by downregulating ferroptosis

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FGF12 restrains mitochondria‐dependent ferroptosis in doxorubicin‐induced cardiomyocytes through the activation of FGFR1/AMPK/NRF2 signaling

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Modulation of the Sirtuin-1 signaling pathway in doxorubicin-induced nephrotoxicity (synergistic amelioration by resveratrol and pirfenidone)

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AP39, a novel mitochondria-targeted hydrogen sulfide donor ameliorates doxorubicin-induced cardiotoxicity by regulating the AMPK/UCP2 pathway

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The impact of PPAR-γ/Nrf-2/HO-1, NF-κB/IL-6/ Keap-1, and Bcl-2/caspase-3/ATG-5 pathways in mitigation of DOX-induced cardiotoxicity in an animal model: The potential cardioprotective role of oxyresveratrol and/or dapagliflozin

El-Sawy, W. S. M., El‐Bahrawy, A. H., Messiha, B. A. S., Hemeida, R. A. M., & Khalaf, M. M. (2024) · Food and Chemical Toxicology · doi:10.1016/j.fct.2024.114863 · Cited by 13

In vivo cardioprotective effect of zinc oxide nanoparticles against doxorubicin-induced myocardial infarction by enhancing the antioxidant system and nitric oxide production

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Cordyceps sinensis -mediated biotransformation of notoginsenoside R1 into 25-OH-20( S / R )-R2 with elevated cardioprotective effect against DOX-induced cell injury

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Pregnenolone Inhibits Doxorubicin-Induced Cardiac Oxidative Stress, Inflammation, and Apoptosis—Role of Matrix Metalloproteinase 2 and NADPH Oxidase 1

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Protective effect of urotensin II receptor antagonist urantide and exercise training on doxorubicin-induced cardiotoxicity

Sun, J., Zhou, J., Sun, S., Lin, H., Zhang, H., Zhong, Z., Chi, J., & Guo, H. (2023) · Scientific Reports · doi:10.1038/s41598-023-28437-y · Cited by 12

Nanomedicines Based on Responsive Nanocarriers for Cancer Therapy

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Diosmin alleviates doxorubicin-induced chemobrain in rats via inhibition of oxido-inflammation, apoptosis and modulation of autophagy

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Mesenchymal Stem Cell-Derived Exosomes Ameliorate Doxorubicin-Induced Cardiotoxicity

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Novel hybrid compounds of sclareol and doxorubicin as potential anticancer nanotherapy for glioblastoma

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Follistatin-like protein 1 attenuates doxorubicin-induced cardiomyopathy by inhibiting MsrB2-mediated mitophagy

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Efficacy of SGLT2 inhibitors for anthracycline-induced cardiotoxicity: a meta-analysis in cancer patients

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Enhanced Drug Delivery with Oil‐in‐Water Nanoemulsions: Stability and Sustained Release of Doxorubicin

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MiR-24-3p modulates cardiac function in doxorubicin -induced heart failure via the Sp1/PI3K signaling pathway

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Potential of NRF2 Inhibitors—Retinoic Acid, K67, and ML-385—In Overcoming Doxorubicin Resistance in Promyelocytic Leukemia Cells

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Praeruptorin A screened by a ferrous ion probe inhibited DMT1 and ferroptosis to attenuate Doxorubicin-induced cardiomyopathy

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Identifying common pathways for doxorubicin and carfilzomib-induced cardiotoxicities: transcriptomic and epigenetic profiling

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Spermine alleviates myocardial cell aging by inhibiting mitochondrial oxidative stress damage

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Bridging Cancer and Cardiovascular Health: A Comprehensive Review of Cardiotoxicity in Modern Oncology

Rajpoot, A., & Sharma, V. (2025) · Heart and Mind · doi:10.4103/hm.hm-d-24-00148 · Cited by 13

Enhancing drug efficacy through nanoparticle-based delivery systems: a study on targeted cancer therapy

Alrohaimi, A. H., Mostafa, M. A. H., Alnour, T. M. S., Alghamdi, S., AlMuraikhi, N. A., Mirdad, D. S. A., Alghamdi, H., & Senbel, A. M. (2025) · International Journal of Surgery · doi:10.1097/js9.0000000000002702 · Cited by 12

Cinnamamide derivatives with 4-hydroxypiperidine moiety enhance effect of doxorubicin to cancer cells and protect cardiomyocytes against drug-induced toxicity through CBR1 inhibition mechanism

Koczurkiewicz, P., Gąsiorkiewicz, B., Piska, K., Gunia‐Krzyżak, A., Jamrozik, M., Bucki, A., Słoczyńska, K., Bojdo, P., Wójcik‐Pszczoła, K., Władyka, B., et al. (2022) · Life Sciences · doi:10.1016/j.lfs.2022.120777 · Cited by 12

Targeting Energy Protection as a Novel Strategy to Disclose Di’ao Xinxuekang against the Cardiotoxicity Caused by Doxorubicin

Wang, T., Yuan, C., Liu, J., Deng, L., Li, W., He, J., Liu, H., Qu, L., Wu, J., & Zou, W. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24020897 · Cited by 12

Combination of chemotherapy with low-dose doxorubicin/Lycium barbarum polysaccharide and photothermal therapy with polypyrrole nanoparticles for treating breast cancer

Sun, L., Ma, B., Zuo, C., Liu, X., Xia, Y., Wang, X., Guo, Y., & Han, M. (2023) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2023.104442 · Cited by 12

CTRP5 Attenuates Doxorubicin-Induced Cardiotoxicity Via Inhibiting TLR4/NLRP3 Signaling

Zhang, Z., Peng, J., Hu, Y., Zeng, G., Du, W., & Shen, C. (2023) · Cardiovascular Drugs and Therapy · doi:10.1007/s10557-023-07464-x · Cited by 12

The Protective Role of Glutathione against Doxorubicin-Induced Cardiotoxicity in Human Cardiac Progenitor Cells

Lee, E. J., Jang, W. B., Choi, J., Lim, H. J., Park, S., Rethineswaran, V. K., Ha, J. S., Yun, J., Hong, Y. J., Choi, Y. J., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241512070 · Cited by 12

A novel flavonol glycoside and six derivatives of quercetin and kaempferol from Clematis flammula with antioxidant and anticancer potentials

Medjahed, Z., Chaher, N., Atmani-Kilani, D., Ahmane, N., Ruiz‐Larrea, M. B., Ruiz-Sanz, J. I., Charid, I., Amant, F. C., Valls, J., Saidène, N., et al. (2023) · Fitoterapia · doi:10.1016/j.fitote.2023.105642 · Cited by 12

The Role of mTOR in Doxorubicin-Altered Cardiac Metabolism: A Promising Therapeutic Target of Natural Compounds

Yarmohammadi, F., Hesari, M., & Shackebaei, D. (2023) · Cardiovascular Toxicology · doi:10.1007/s12012-023-09820-7 · Cited by 12

Drug delivery with Mn‐doped MoO 2 for photothermal‐enhanced chemotherapy in fighting cancers

Zhao, P., Zheng, H. L., Peng, J., Li, X., Raziq, F., Liu, X., Yu, H., Tang, J., Kang, Y., & Huang, W. (2024) · Rare Metals · doi:10.1007/s12598-023-02568-7 · Cited by 12

Expanding roles of circRNAs in cardiovascular diseases

Liu, X., Yao, X., & Chen, L. (2024) · Non-coding RNA Research · doi:10.1016/j.ncrna.2024.02.001 · Cited by 12

Mesoporous Organosilica-Based Hydrogen Sulfide Nanogenerator for Enhanced Tumor Chemotherapy

Xu, J. F., Zhu, W., Yao, X., Mai, S., Li, C., Zhang, M., Shu, D., & Yang, W. (2023) · ACS Applied Nano Materials · doi:10.1021/acsanm.3c01824 · Cited by 11

Rifampicin efficacy against doxorubicin-induced cardiotoxicity in mice

Basal, O. A., Zahran, R. F. K., & Saad, E. A. (2023) · The Egyptian Heart Journal · doi:10.1186/s43044-023-00403-z · Cited by 11

Exploration of Key Immune-Related Transcriptomes Associated with Doxorubicin-Induced Cardiotoxicity in Patients with Breast Cancer

Xiong, D.-Q., Yang, J., Li, D., & Wang, J. (2023) · Cardiovascular Toxicology · doi:10.1007/s12012-023-09806-5 · Cited by 11

Inorganic sulfides prevent osimertinib-induced mitochondrial dysfunction in human iPS cell-derived cardiomyocytes

Kondo, M., Nakamura, Y., Kato, Y., Nishimura, A., Fukata, M., Moriyama, S., Ito, T., Umezawa, K., Urano, Y., Akaike, T., et al. (2024) · Journal of Pharmacological Sciences · doi:10.1016/j.jphs.2024.07.007 · Cited by 12

“The protective effect of nano curcumin supplementation on doxorubicin induced cardiotoxicity in breast cancer patients; a randomized, double-blind clinical trial”

Tohidi, M., Allahyari, A., Azimi, S. A., Alimi, H., Elyasi, S., Seraj, F. Q. M., & Mehrad‐Majd, H. (2024) · Journal of Oncology Pharmacy Practice · doi:10.1177/10781552241277958 · Cited by 11

Fluconazole induces cardiovascular toxicity in zebrafish by promoting oxidative stress, apoptosis, and disruption of key developmental genes

Wu, H., Zhao, G., Feng, W., Yang, C., & Jiang, Y. (2025) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2025.111391 · Cited by 11

Vericiguat Improves Cardiac Remodelling and Function in Rats with Doxorubicin-Induced Cardiomyopathy

Chen, W., Wu, Y., Li, J., Song, M., Xu, K., Wu, M., & Lin, L. (2025) · ESC Heart Failure · doi:10.1002/ehf2.15186 · Cited by 11

Hollow mesoporous Prussian blue nanozymes alleviate doxorubicin-induced cardiotoxicity by restraining oxidative stress associated with Nrf2 signaling

Wang, F., Wang, K., Fang, B., Geng, S., Li, Y., Qian, H., Lin, Y., & Yu, Z. (2025) · Journal of Colloid and Interface Science · doi:10.1016/j.jcis.2025.02.033 · Cited by 11

Sensor-integrated gut-on-a-chip for monitoring senescence-mediated changes in the intestinal barrier

Brandauer, K., Lorenz, A., Schobesberger, S., Schuller, P., Frauenlob, M., Spitz, S., & Ertl, P. (2025) · Lab on a Chip · doi:10.1039/d4lc00896k · Cited by 11

Remote Co-Loading of Doxorubicin and Hydralazine into PEGylated Liposomes: In Vitro Anti-Proliferative Effect Against Breast Cancer

Alshaer, W., Lafi, Z., Nsairat, H., AlQuaissi, B., Alqudah, D. A., Zureigat, H., & Hamad, I. M. (2025) · Molecules · doi:10.3390/molecules30071549 · Cited by 11

From Chemical Composition to Antiproliferative Effects Through In Vitro Studies: Honey, an Ancient and Modern Hot Topic Remedy

Nan, A., Dumitraşcu, V., Flangea, C., Dumitrescu, G., Puscasiu, D. A., Vlad, T., Popescu, R., & Vlad, C. S. (2025) · Nutrients · doi:10.3390/nu17091595 · Cited by 11

Vitamin C as a Cardioprotective Agent Against Doxorubicin‐Induced Cardiotoxicity

Nsairat, H., Lafi, Z., Abualsoud, B. M., Al-Najjar, B. O., Al-Samydai, A. M., Oriquat, G. A., Alshaer, W., Ibrahim, A. A., & Dellinger, A. L. (2025) · Journal of the American Heart Association · doi:10.1161/jaha.125.042534 · Cited by 12

Progress on the efficacy and mechanism of action of panax ginseng monomer saponins treat toxicity

Wang, X.-Y., Rongcan, W. A. N. G., Yong-Fei, Q. I. A. O., & Li, Y. (2022) · Frontiers in Pharmacology · doi:10.3389/fphar.2022.1022266 · Cited by 11

Seaweed Sargassum aquifolium extract ameliorates cardiotoxicity induced by doxorubicin in rats

Samir, R., Hassan, E. A., Saber, A. A., Haneen, D. S. A., & Saleh, E. M. R. M. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26259-z · Cited by 14

Anti-arrhythmia potential of honey-processed licorice in zebrafish model: Antioxidant, histopathological and tissue distribution

Wang, W., Yu, Y., Chen, H., Sun, P., Lu, L., Yan, S., 刘训红, Lu, T., Li, W., Lu, T., et al. (2023) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2023.116724 · Cited by 11

The Essential Oil from Conyza bonariensis (L.) Cronquist (Asteraceae) Exerts an In Vitro Antimelanoma Effect by Inducing Apoptosis and Modulating the MAPKs, NF-κB, and PKB/AKT Signaling Pathways

Ferreira, R. C., Duarte, S. S., de Sousa, V. M., de Souza, R. R. M., Marques, K. K. G., de Abrantes, R. A., do Nascimento, Y. M., de Sousa, N. F., Scotti, M. T., Scotti, L., et al. (2023) · Pharmaceuticals · doi:10.3390/ph16111553 · Cited by 13

Different Mechanisms in Doxorubicin-Induced Cardiomyopathy: Impact of BRCA1 and BRCA2 Mutations

Nguyen, H. C., Frisbee, J. C., & Singh, K. K. (2024) · Hearts · doi:10.3390/hearts5010005 · Cited by 11

Doxorubicin-induced phosphorylation of lamin A/C enhances DNMT1 and activates cardiomyocyte death via suppressing GATA-4 and Bcl-xL in rat heart

Tiwari, V., Salgar, S., Jorvekar, S. B., Kumbhar, B. M., Arava, S. K., Borkar, R. M., & Banerjee, S. K. (2025) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2025.167692 · Cited by 5

Altered mitochondrial epigenetics associated with subchronic doxorubicin cardiotoxicity

Ferreira, A., Cunha‐Oliveira, T., Simões, R. F., Carvalho, F. S., Burgeiro, A., Nordgren, K. K. S., Wallace, K. B., & Oliveira, P. J. (2017) · Toxicology · doi:10.1016/j.tox.2017.08.011 · Cited by 78

Potential targets for intervention against doxorubicin-induced cardiotoxicity based on genetic studies: a systematic review of the literature

Chen, Y., Huang, T., Shi, W., Fang, J., Deng, H., & Cui, G. (2019) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2019.11.150 · Cited by 31

Pathophysiology of Doxorubicin-Mediated Cardiotoxicity

Arrigoni, R., Jirillo, E., & Caiati, C. (2025) · Toxics · doi:10.3390/toxics13040277 · Cited by 37

Mitigation of doxorubicin-induced cardiotoxicity by dichloroacetate: potential roles of restoration of PGC-1α/SIRT3 signaling and suppression of oxidative stress and apoptosis.

Saleh, M. F., El‐Sayad, M. E., & Goda, A. E. (2021) · PubMed · doi:10.26355/eurrev_202111_27100 · Cited by 6