Variable foraging demand rearing: sustained elevations in cisternal cerebrospinal fluid corticotropin-releasing factor concentrations in adult primates
Abstract
Background The authors previously reported elevated cerebrospinal fluid (CSF) corticotropin-releasing factor (CRF) concentrations in juvenile primates nursed by mothers undergoing experimentally imposed unpredictable foraging conditions in comparison to normally reared controls. The purpose of the present study was to determine if these changes would endure into young adulthood.Methods Cisternal CSF samples were obtained from those unpredictably reared young adult primates who had been previously studied as juveniles and age-matched ad libitum normally reared controls. Samples were assayed for CSF CRF.Results Concentrations of CSF CRF were significantly elevated in the unpredictably reared sample in comparison to the ad libitum-reared control group. A significant positive correlation was noted between juvenile and young adult CSF CRF values within the unpredictably reared cohort.Conclusions Disturbances of maternal-infant attachment processes have an enduring impact on primate CRF function into young adulthood. The CRF elevations following unpredictable maternal foraging conditions appear traitlike in nature.
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Uncertainty in the food supply for rhesus monkey mothers leads to increased emotionality in offspring and possibly an earlier onset of obesity and diabetes.
“For example, uncertainty in the food supply for rhesus monkey mothers leads to increased emotionality in offspring and possibly an earlier onset of obesity and diabetes (Coplan et al., 2001).”
From Central effects of stress hormones in health and disease: understanding the protective and damaging effects of stress and stress mediators (2008) · cites this paper as Coplan et al., 2001
Uncertainty in the food supply for rhesus monkey mothers leads to increased emotionality in offspring and possibly an earlier onset of obesity and diabetes.
“For example, uncertainty in the food supply for rhesus monkey mothers leads to increased emotionality in offspring and possibly an earlier onset of obesity and diabetes. 51”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [51]
Maternal anxiety in the variable foraging demand model in rhesus monkeys leads to chronic anxiety in the offspring, as well as signs of metabolic syndrome.
“Maternal anxiety in the variable foraging demand model in rhesus monkeys leads to chronic anxiety in the offspring, as well as signs of metabolic syndrome.”
From Neurobiological and Systemic Effects of Chronic Stress (2017) · cites this paper as [89]
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- Authors
- Coplan, J. D., Smith, E. L. P., Altemus, M., Scharf, B. A., Owens, M. J., Nemeroff, C. B., Gorman, J. M., & Rosenblum, L. A.
- Affiliations
- State University of New York (US)
- SUNY Downstate Health Sciences University (US)
- Cornell University (US)
- Emory University (US)
- Columbia University (US)
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-08
- Volume
- 50
- Issue
- 3
- Pages
- 200-204
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2013360275
- Cited by
- 129
- References
- 33
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 2 · 2022: 2 · 2021: 2 · 2020: 3 · 2019: 2 · 2018: 4 · 2017: 4 · 2016: 5 · 2015: 8 · 2014: 7 · 2013: 6 · 2012: 5
- FWCI
- 2.77
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (MH-58911, MH 59990, P50MH058911, R01MH059990)
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Social Sciences › Psychology › Social Psychology › Primate Behavior and Ecology
- Keywords
- corticotropin-releasing factor, cerebrospinal fluid, maternal-infant attachment, early life stress, cisternal CSF
- MeSH terms
- Age Factors, Animals, Anxiety Disorders, Behavior, Animal, Corticotropin-Releasing Hormone, Feeding Behavior, Female, Hypothalamo-Hypophyseal System, Macaca radiata, Male, Pituitary-Adrenal System, Radioimmunoassay, Random Allocation
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