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Cited by 240Child and Adolescent Psychosocial and Emotional DevelopmentChild Abuse and TraumaNeural and Behavioral Psychology Studies

Neural Responses to Emotional Stimuli Are Associated with Childhood Family Stress

Taylor, Shelley E., Eisenberger, Naomi I., Saxbe, Darby, Lehman, Barbara J., Lieberman, Matthew D.·2006·Biological Psychiatry
DOI 10.1016/j.biopsych.2005.09.027
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Abstract

Background An early family environment marked by harsh parenting has been related to risk for multiple mental disorders in adulthood, risks that may be mediated, in part, by deficits in emotion regulation skills. This study examined neural mechanisms underlying these consequences of "risky" families (RF) by exploring neural activity to tasks involving responses to emotional stimuli. Methods Participants completed an assessment of RF and participated in a functional magnetic resonance imaging (fMRI) investigation that examined 1) amygdala reactivity to observation of fearful/angry faces; 2) amygdala and right ventrolateral prefrontal cortex (RVLPFC) reactivity to labeling emotions displayed in these faces; and 3) the relation between RVLPFC and amygdala activity during the labeling task. Results Offspring from nonrisky families showed expected amygdala reactivity to observing fearful/angry faces and expected activation of RVLPFC while labeling the emotions, which was significantly negatively correlated (-.44) with amygdala activation. Offspring from risky families showed little amygdala activation during the observation task and a strong positive correlation (+.66) between RVLPFC and amygdala activation in the labeling task, suggesting a possible dysregulation in the neural systems involved in responses to emotional stimuli. Conclusions Offspring from risky families exhibit atypical responses to emotional stimuli that are evident at the neural level.

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Crossref · 10.1016/j.biopsych.2005.09.027

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  • Variations in parental care associate with individual differences in neuroendocrine and autonomic responses to stress in humans and with emotional reactivity.

    “Likewise, variations in parental care associate with individual differences in neuroendocrine and autonomic responses to stress in humans as well as emotional reactivity.18,33-36”

    From Early life adversity and the epigenetic programming of hypothalamic-pituitary-adrenal function (2014) · cites this paper as [36]

  • Poorer childhood conditions are associated with differences in neural responses to negative emotional stimuli and differences in physiological reactivity to challenge in college-aged students.

    “Poorer childhood conditions have also been associated with differences in neural responses to negative emotional stimuli 199 as well as differences in physiological reactivity to challenge in college-aged students.84”

    From Socio‐economic differentials in peripheral biology: Cumulative allostatic load (2010) · cites this paper as [199]

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Authors
Taylor, S. E., Eisenberger, N. I., Saxbe, D., Lehman, B. J., & Lieberman, M. D.
Affiliations
University of California, Los Angeles (US)
Corresponding author
Taylor, Shelley E.
ORCID
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2006-08
Volume
60
Issue
3
Pages
296-301
ISSN
0006-3223 (ISSN-L)
DOI
10.1016/j.biopsych.2005.09.027
OpenAlex
W2104308564
Cited by
240
References
37
Citations by year
2026: 3 · 2025: 7 · 2024: 5 · 2023: 9 · 2022: 7 · 2021: 9 · 2020: 10 · 2019: 15 · 2018: 12 · 2017: 17 · 2016: 15 · 2015: 17 · 2014: 19 · 2013: 19 · 2012: 16
FWCI
8.49
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Mental Health (R01MH056880, R21MH066709, MH071521, MH66709, MH56880, R21MH071521)
Topics
  • Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
  • Social Sciences › Psychology › Clinical Psychology › Child Abuse and Trauma
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
Keywords
harsh parenting, amygdala reactivity, ventrolateral prefrontal cortex, emotion regulation, emotional face processing, affective neuroscience
MeSH terms
Adolescent, Adult, Amygdala, Analysis of Variance, Anger, Emotions, Facial Expression, Family, Fear, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Prospective Studies, Surveys and Questionnaires, Reaction Time, Reference Values, Risk Factors, Stress, Psychological, Prefrontal Cortex

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