Family-Based Association Test of the 5HTTLPR and Aggressive Behavior in a General Population Sample of Children

Haberstick, Brett C.; Smolen, Andrew; Hewitt, John K.

doi:10.1016/j.biopsych.2005.10.008

Cited by 112Neurotransmitter Receptor Influence on BehaviorGenetic Associations and EpidemiologyChild and Adolescent Psychosocial and Emotional Development

Family-Based Association Test of the 5HTTLPR and Aggressive Behavior in a General Population Sample of Children

Haberstick, Brett C., Smolen, Andrew, Hewitt, John K.·2006·Biological Psychiatry

DOI 10.1016/j.biopsych.2005.10.008

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Abstract

Background A promoter polymorphism in the serotonin transporter (5HTTLPR) has functional effects on an important physiologic process involved in serotonin (5HT) signaling. Despite the fact that variation in the 5HT system has long been implicated in the etiology of aggressive behaviors, only a few association-based studies with mixed results have been reported.Methods We conducted family-based tests of association in a sample of 366 families from which 1187 genotypes of the 5HTTLPR were generated using polymerase chain reaction. Ratings of aggressive behavior were obtained from parents and teachers longitudinally using the Child Behavior Checklist (CBCL) and Teacher Report Form (TRF), instruments widely used in behavioral and psychiatric genetics.Results Within-family tests suggest an association between the s-allele of the 5HTTLPR and higher aggressive behavior in middle childhood. The strongest association was at age 9 and for an aggregate measure of teacher-rated aggressive behavior.Conclusions This is the first report of an association analysis of the 5HTTLPR in a general population sample of school-age children. The results provide some support for the hypothesis that the functional effects of the 5HTTLPR s-allele are associated with higher levels of aggressive behavior in middle childhood.

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The S-allele was significantly associated with teacher reported aggressive behaviors at age 9 for both boys and girls.
“Similarly, the S-allele was significantly associated with teacher reported aggressive behaviors at age 9 for both boys and girls [87] and with increased aggressive behaviors and hostility in a group of female Caucasian Russian swimmers [88].”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [87]

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Authors: Haberstick, B. C., Smolen, A., & Hewitt, J. K.
Affiliations: University of Colorado Boulder (US)
Corresponding author: Haberstick, Brett C.
ORCID: Smolen, Andrew
Hewitt, John K.
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2006-05
Volume: 59
Issue: 9
Pages: 836-843
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2005.10.008
OpenAlex: W2009142034
Cited by: 112
References: 67
Citations by year: 2026: 1 · 2024: 1 · 2023: 1 · 2022: 3 · 2020: 2 · 2019: 5 · 2018: 3 · 2017: 4 · 2016: 8 · 2015: 9 · 2014: 9 · 2013: 5 · 2012: 10
FWCI: 4.17
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute of Mental Health (MH043899, R01MH043899)
National Institute on Drug Abuse (DA 011015, P60DA011015)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD010333, HD07089, R01HD010333)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic Associations and Epidemiology
Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
Keywords: 5-HTTLPR, serotonin transporter gene, aggression, S-alleles, family-based association, middle childhood, gene-environment interaction, serotonin signaling, child aggression, genetic susceptibility
MeSH terms: Adolescent, Adult, Age Factors, Aggression, Alleles, Child, Child Behavior Disorders, DNA Mutational Analysis, Family Health, Female, Gene Frequency, Humans, Longitudinal Studies, Male, Personality Assessment, Polymorphism, Genetic, Prospective Studies, Psychiatric Status Rating Scales, Surveys and Questionnaires, Reference Values, Sampling Studies, Teaching, Observer Variation, Chi-Square Distribution, Genetic Predisposition to Disease, Serotonin Plasma Membrane Transport Proteins

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Family-Based Association Test of the 5HTTLPR and Aggressive Behavior in a General Population Sample of Children

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