Dopamine and serotonin transporter genotypes moderate sensitivity to maternal expressed emotion: the case of conduct and emotional problems in attention deficit/hyperactivity disorder
Open accessAbstract
Background: Mothers’ positive emotions expressed about their children with attention deficit/hyperactivity disorder (ADHD) are associated with a reduced likelihood of comorbid conduct problems (CP). We examined whether this association with CP, and one with emotional problems (EMO), is moderated by variants within three genes, previously reported to be associated with ADHD and to moderate the impact of environmental risks on conduct and/or emotional problems; the dopamine transporter gene (SLC6A3/DAT1), the dopamine D4 receptor gene (DRD4) and the serotonin transporter gene (SLC6A4/5HTT). Methods: Seven hundred and twenty‐eight males between the ages of 5 and 17 with a DSM‐IV research diagnosis of combined type ADHD were included in these analyses. Parents and teachers rated children’s conduct and emotional problems. Positive maternal expressed emotion (PMEE) was coded by independent observers on comments made during a clinical assessment with the mother based on current or recent medication‐free periods. Results: Sensitivity to the effects of PMEE on CP was moderated by variants of the DAT1 and 5HTT genes. Only children who did not carry the DAT1 10R/10R or the 5HTT l/l genotypes showed altered levels of CP when exposed to PMEE. The effect was most marked where the child with ADHD had both these genotypes. For EMO, sensitivity to PMEE was found only with those who carried the DAT1 9R/9R. There was no effect of DRD4 on CP or EMO. Conclusion: The gene–environment interactions observed suggested that genetic make‐up can alter the degree of sensitivity an ADHD patients has to their family environment. Further research should focus on distinguishing general sensitivity genotypes from those conferring risk or protective qualities.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
SLC6A4 genotypes may moderate environmental effects on conduct disorders in children and teenagers with ADHD.
“Previous research also suggests that SLC6A4 genotypes may moderate the environmental e ff ects on conduct disorders in children and teenagers with ADHD”
From ADHD, CD, and ODD: Systematic review of genetic and environmental risk factors (2018) · cites this paper as Sonuga-Barke et al., 2009
The Conduct problems section reports that serotonin-transporter (5HTT/SLC6A4) genotype significantly moderated the association between positive maternal expressed emotion and conduct-problem scores. However, the study measured conduct problems rather than effects on diagnosed conduct disorder, and its sample was limited to boys with ADHD aged 5–17 (Participants; Measures). (LLM, conf=0.84)
Experimental — accuracy not yet measuredOnly a small handful of molecular genetic studies implicate DA candidate genes, including DAT1, DRD2, and DRD4, in the development of conduct problems.
“only a small handful of molecular genetic studies implicate DA candidate genes, including DAT1, DRD2, and DRD4, in the development of conduct problems [656-659]”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [659]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
The Strengths and Difficulties Questionnaire: A research note
Goodman, R. (1997) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1997.tb01545.x · Cited by 14,908 · see citing works
Influence of life stress on depression: moderation by a polymorphism in the 5-HTT gene
Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., McClay, J., Mill, J., Martin, J., Braithwaite, A., et al. (2003) · Science · doi:10.1126/science.1083968 · Cited by 8,120 · see citing works
(1982) · Medical Entomology and Zoology · Cited by 2,951 · see citing works
Eysenck, H. J. (1983) · Behaviour Research and Therapy · doi:10.1016/0005-7967(83)90055-4 · Cited by 2,386 · see citing works
Molecular genetics of attention-deficit/hyperactivity disorder
Faraone, S. V., Perlis, R. H., Doyle, A. E., Smoller, J. W., Goralnick, J. J., Holmgren, M. A., & Sklar, P. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.11.024 · Cited by 2,357 · see citing works
Self-citationGoodman, R., Ford, T., Simmons, H., Gatward, R., & Meltzer, H. (2000) · British Journal of Psychiatry · doi:10.1192/bjp.177.6.534 · Cited by 1,818 · see citing works
For Better <i>and</i> For Worse: Differential Susceptibility to Environmental Influences
Belsky, J., Bakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2007) · Current Directions in Psychological Science · doi:10.1111/j.1467-8721.2007.00525.x · Cited by 1,515 · see citing works
Attention-deficit/hyperactivity disorder: a selective overview.
Biederman, J. (2005) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.10.020 · Cited by 1,439 · see citing works
Johnston, C., & Mash, E. J. (2001) · Clinical Child and Family Psychology Review · doi:10.1023/a:1017592030434 · Cited by 1,162 · see citing works
Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., & Moffitt, T. E. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001851 · Cited by 1,158 · see citing works
Gene-environment interplay and psychopathology: multiple varieties but real effects
Rutter, M., Moffitt, T. E., & Caspi, A. (2006) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2005.01557.x · Cited by 1,058 · see citing works
Conners' rating scales-revised : technical manual
Conners, C. K. (1997) · Medical Entomology and Zoology · Cited by 1,014 · see citing works
ADHD Comorbidity Findings From the MTA Study: Comparing Comorbid Subgroups
JENSEN, P. S., HINSHAW, S. P., KRAEMER, H. C., LENORA, N., NEWCORN, J. H., ABIKOFF, H. B., MARCH, J. S., ARNOLD, L. E., CANTWELL, D. P., CONNERS, C. K., et al. (2001) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-200102000-00009 · Cited by 974 · cited 1× · see citing works
“Attention deficit/hyperactivity disorder (ADHD) frequently presents comorbid with conduct problems (CP; Biederman, 2005; Lahey, McBurnett, & Loeber, 2000) and emotional disorders (EMO; i.e., anxiety – Tannock, 2000; depression – Jensen et al., 2001).”
BackgroundEarly identification of chronic offenders: Who is the fledgling psychopath?
Lynam, D. R. (1996) · Psychological Bulletin · doi:10.1037/0033-2909.120.2.209 · Cited by 804 · see citing works
Achenbach, T. M., Becker, A., Döpfner, M., Heiervang, E. R., Roessner, V., Steinhausen, H., & Rothenberger, A. (2008) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.2007.01867.x · Cited by 681 · see citing works
Self-citationKendler, K. S., Kuhn, J. W., Vittum, J., Prescott, C. A., & Riley, B. P. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.5.529 · Cited by 669 · see citing works
Gene–environment interaction analysis of serotonin system markers with adolescent depression
Eley, T. C., Sugden, K., Corsico, A., Gregory, A. M., Sham, P., McGuffin, P., Plomin, R., & Craig, I. W. (2004) · Molecular Psychiatry · doi:10.1038/sj.mp.4001546 · Cited by 663 · see citing works
Li, D.-W., Sham, P., Owen, M., & He, L. (2006) · Human Molecular Genetics · doi:10.1093/hmg/ddl152 · Cited by 611 · see citing works
Brookes, K., Xu, X., Chen, W., Zhou, K., Neale, B., Lowe, N., Aneey, R., Franke, B., Gill, M., Ebstein, R., et al. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001869 · Cited by 533 · see citing works
Self-citationBakermans-Kranenburg, M. J., & van IJzendoorn, M. H. (2006) · Developmental Psychobiology · doi:10.1002/dev.20152 · Cited by 526 · see citing works
Hyperactivity and conduct problems as risk factors for adolescent development.
Taylor, E., Chadwick, O., Heptinstall, E., & Danckaerts, M. (1996) · Journal of the American Academy of Child and Adolescent Psychiatry · doi:10.1097/00004583-199609000-00019 · Cited by 484 · see citing works
Hinshaw, S. P. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037//0022-006x.60.6.893 · Cited by 452 · see citing works
Molecular Genetics of Attention Deficit Hyperactivity Disorder
Faraone, S. V., & Mick, E. (2010) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2009.12.004 · Cited by 411 · see citing works
Self-citationGene–Environment Interaction: Definitions and Study Design
Ottman, R. (1996) · Preventive Medicine · doi:10.1006/pmed.1996.0117 · Cited by 332 · see citing works
Brookes, K., Mill, J., Guindalini, C., Curran, S., Xu, X.-H., Knight, J., Chen, C.-K., Huang, Y.-S., Sethna, V., Taylor, E., et al. (2006) · Archives of General Psychiatry · doi:10.1001/archpsyc.63.1.74 · Cited by 315 · see citing works
Self-citationHinshaw, S. P. (1992) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.60.6.893 · Cited by 312 · see citing works
Kahn, R. S., Khoury, J. C., Nichols, W. C., & Lanphear, B. P. (2003) · The Journal of Pediatrics · doi:10.1016/s0022-3476(03)00208-7 · Cited by 284 · see citing works
Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtype
Neuman, R. J., Lobos, E., Reich, W., Henderson, C. A., Sun, L.-W., & Todd, R. D. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.08.049 · Cited by 277 · see citing works
Reif, A., Rösler, M., Freitag, C. M., Schneider, M., Eujen, A., Kissling, C., Wenzler, D., Jacob, C. P., Retz-Junginger, P., Thome, J., et al. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301359 · Cited by 277 · see citing works
Mill, J., & Petronis, A. (2008) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2008.01909.x · Cited by 228 · see citing works
Caspi, A., Langley, K., Milne, B., Moffitt, T. E., O’Donovan, M., Owen, M. J., Polo Tomas, M., Poulton, R., Rutter, M., Taylor, A., et al. (2008) · Archives of General Psychiatry · doi:10.1001/archgenpsychiatry.2007.24 · Cited by 221 · see citing works
Guo, G., Roettger, M. E., & Shih, J. C. (2006) · Human Genetics · doi:10.1007/s00439-006-0244-8 · Cited by 220 · see citing works
The Epidemiology of Childhood Hyperactivity
Garralda, M. E. (1992) · Archives of Disease in Childhood · doi:10.1136/adc.67.8.1060-b · Cited by 217 · see citing works
Maternal programming of defensive responses through sustained effects on gene expression
Zhang, T.-Y., Bagot, R., Parent, C., Nesbitt, C., Bredy, T. W., Caldji, C., Fish, E., Anisman, H., Szyf, M., & Meaney, M. J. (2006) · Biological Psychology · doi:10.1016/j.biopsycho.2006.01.009 · Cited by 206 · see citing works
Cicchetti, D., Rogosch, F. A., & Sturge-Apple, M. L. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000600 · Cited by 204 · see citing works
Laucht, M., Skowronek, M. H., Becker, K., Schmidt, M., Esser, G., Schulze, T., & Rietschel, M. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.5.585 · Cited by 185 · see citing works
Yang, B., Chan, R., Jing, J., Li, T., Sham, P., & Chen, R. Y. L. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30453 · Cited by 184 · see citing works
Schachar, R. J., & Tannock, R. (1995) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-199505000-00016 · Cited by 157 · see citing works
Pfiffner, L. J., McBurnett, K., Rathouz, P. J., & Judice, S. (2005) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-005-6737-4 · Cited by 157 · see citing works
Kent, L., Doerry, U., Hardy, E., Parmar, R., Gingell, K., Hawi, Z., Kirley, A., Lowe, N., Fitzgerald, M., Gill, M., et al. (2002) · Molecular Psychiatry · doi:10.1038/sj.mp.4001100 · Cited by 153 · see citing works
Diagnostic Specificity of a Brief Measure of Expressed Emotion: a Community Study of Children
Stubbe, D. E., Zahner, G. E. P., Goldstein, M. J., & Leckman, J. F. (1993) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1993.tb00976.x · Cited by 151 · see citing works
Thapar, A., Langley, K., Asherson, P. J., & Gill, M. (2006) · The British Journal of Psychiatry · doi:10.1192/bjp.bp.106.027003 · Cited by 150 · see citing works
Self-citationPropper, C. B., Willoughby, M. T., Halpern, C. T., Carbone, M. A., & Cox, M. J. (2007) · Developmental Psychobiology · doi:10.1002/dev.20249 · Cited by 144 · see citing works
Interaction of dopamine transporter genotype with prenatal smoke exposure on ADHD symptoms
Becker, K., El-Faddagh, M., Schmidt, M. H., Esser, G., & Laucht, M. (2008) · The Journal of Pediatrics · doi:10.1016/j.jpeds.2007.07.004 · Cited by 142 · see citing works
Ostrander, R. S., & Herman, K. C. (2006) · Journal of Consulting and Clinical Psychology · doi:10.1037/0022-006x.74.1.89 · Cited by 134 · see citing works
Daley, D., Sonuga-Barke, E. J. S., & Thompson, M. J. J. (2003) · British Journal of Clinical Psychology · doi:10.1348/014466503762842011 · Cited by 131 · see citing works
Self-citationAsherson, P., Brookes, K., Franke, B., Chen, W., Gill, M., Ebstein, R. P., Buitelaar, J., Banaschewski, T., Sonuga-Barke, E., Eisenberg, J., et al. (2007) · American Journal of Psychiatry · doi:10.1176/appi.ajp.164.4.674 · Cited by 128 · see citing works
Self-citationChanges in Family Function and Relationships in Children Who Respond to Methylphenidate
Schachar, R. J., Taylor, E., Wieselberg, M., Thorley, G., & Rutter, M. L. (1987) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198709000-00019 · Cited by 123 · see citing works
Baker, B. L., Heller, T. L., & Henker, B. A. (2000) · Journal of Child Psychology and Psychiatry · doi:10.1111/1469-7610.00678 · Cited by 120 · see citing works
Haberstick, B. C., Smolen, A., & Hewitt, J. K. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2005.10.008 · Cited by 112 · see citing works
Lahey, B. B., McBurnett, K., & Loeber, R. (2000) · Springer eBooks · doi:10.1007/978-1-4615-4163-9_23 · Cited by 109 · see citing works
Sonuga-Barke, E., Lasky-Su, J., Neale, B., Oades, R., Chen, W., Franke, B., Buitelaar, J., Banaschewski, T., Ebstein, R., Gill, M., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30860 · Cited by 104 · see citing works
Self-citationDopamine transporter polymorphism associated with externalizing behavior problems in children.
Young, S., Smolen, A., Corley, R., Krauter, K., Defries, J., Crowley, T., & Hewitt, J. (2002) · American journal of medical genetics · doi:10.1002/ajmg.10155 · Cited by 101 · see citing works
Maternal Expressed Emotion in Conduct and Emotional Disorders of Childhood
Vostanis, P., Nicholls, J., & Harrington, R. (1994) · Journal of Child Psychology and Psychiatry · doi:10.1111/j.1469-7610.1994.tb01168.x · Cited by 94 · see citing works
Oades, R. D. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(01)00440-5 · Cited by 92 · see citing works
Self-citationMaternal Programming of Defensive Responses Through Sustained Effects on Gene Expression
Meaney, M. J. (2007) · Oxford University Press eBooks · doi:10.1093/acprof:oso/9780195306255.003.0007 · Cited by 92 · see citing works
Pfiffner, L. J., & McBurnett, K. (2006) · Research on Child and Adolescent Psychopathology · doi:10.1007/s10802-006-9060-9 · Cited by 79 · see citing works
Nobile, M., Giorda, R., Marino, C., Carlet, O., Pastore, V., Vanzin, L., Bellina, M., Molteni, M., & Battaglia, M. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000594 · Cited by 72 · see citing works
Mothers’ expressed emotion toward their school-aged sons
Psychogiou, L., Daley, D., Thompson, M. J. J., & Sonuga-Barke, E. J. S. (2007) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-007-0619-y · Cited by 58 · see citing works
Self-citationLi, J., Wang, Y.-F., Zhou, R., Zhang, H.-B., Yang, L., Wang, B., & Faraone, S. (2007) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30373 · Cited by 55 · see citing works
Self-citationMaternal Care and Individual Differences in Defensive Responses
Parent, C. I., Zhang, T., Caldji, C., Bagot, R., Champagne, F. A., Pruessner, J. C., & Meaney, M. J. (2005) · Current Directions in Psychological Science · doi:10.1111/j.0963-7214.2005.00370.x · Cited by 53 · see citing works
Family Characteristics of Anxious ADHD Children
Kepley, H. O., & Ostrander, R. S. (2007) · Journal of Attention Disorders · doi:10.1177/1087054706288102 · Cited by 52 · see citing works
Lee, S. S., Lahey, B. B., Waldman, I. D., Hulle, C. A. V., Rathouz, P. J., Pelham, W. E., Loney, J., & Cook, E. H. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30447 · Cited by 47 · see citing works
Schmidt, L. A., Fox, N. A., & Hamer, D. H. (2007) · Development and Psychopathology · doi:10.1017/s0954579407000569 · Cited by 45 · see citing works
Kim, J.-W., Kim, B., & Cho, S.-C. (2005) · Journal of Psychiatric Research · doi:10.1016/j.jpsychires.2005.11.002 · Cited by 44 · see citing works
Gerra, G., Zaimovic, A., Garofano, L., Ciusa, F., Moi, G., Avanzini, P., Talarico, E., Gardini, F., Brambilla, F., Manfredini, M., et al. (2006) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30388 · Cited by 43 · see citing works
The role of epigenetics in mental disorders.
Peedicayil, J. (2007) · PubMed · Cited by 40 · see citing works
Genetic heterogeneity in ADHD: DAT1 gene only affects probands without CD
Zhou, K., Chen, W., Buitelaar, J. K., Banaschewski, T., Oades, R. D., Franke, B., Sonuga-Barke, E. J. S., Ebstein, R. P., Eisenberg, J., Gill, M., et al. (2007) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30644 · Cited by 40 · see citing works
Self-citationAltink, M., Arias-Vásquez, A., Franke, B., Slaats-Willemse, D., Buschgens, C., Rommelse, N., Fliers, E., Anney, R., Brookes, K., Chen, W., et al. (2008) · Journal of Child Psychology and Psychiatry and Allied Disciplines · doi:10.1111/j.1469-7610.2008.01998.x · Cited by 37 · see citing works
Self-citationLasky-Su, J., Banaschewski, T., Buitelaar, J., Franke, B., Brookes, K., Sonuga-Barke, E., Ebstein, R., Eisenberg, J., Gill, M., Manor, I., et al. (2007) · Biological Psychiatry · doi:10.1016/j.biopsych.2007.03.006 · Cited by 29 · see citing works
Differential dopamine receptor D4 allele association with ADHD dependent of proband season of birth
Brookes, K., Neale, B., Xu, X., Thapar, A., Gill, M., Langley, K., Hawi, Z., Mill, J., Taylor, E., Franke, B., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30562 · Cited by 26 · see citing works
Self-citationSakai, J. T., Lessem, J. M., Haberstick, B. C., Hopfer, C. J., Smolen, A., Ehringer, M. A., Timberlake, D. S., & Hewitt, J. K. (2007) · Psychiatric Genetics · doi:10.1097/ypg.0b013e32809913c8 · Cited by 22 · see citing works
Sonuga-Barke, E., Brookes, K., Buitelaar, J., Anney, R., Bitsakou, P., Baeyens, D., Buschgens, C., Chen, W., Christiansen, H., Eisenberg, J., et al. (2008) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30596 · Cited by 22 · see citing works
Self-citationXu, X., Aysimi, E., Anney, R., Brookes, K. J., Franke, B., Zhou, K., Buschgens, C. J. M., Chen, W., Christiansen, H., Eisenberg, J., et al. (2008) · American Journal of Medical Genetics Part B Neuropsychiatric Genetics · doi:10.1002/ajmg.b.30737 · Cited by 20 · see citing works
Self-citationAttention-Deficit Disorders and Comorbidities in Children, Adolescents, and Adults
Goldstein, S. (2000) · Psychiatric Services · doi:10.1176/appi.ps.51.10.1320 · Cited by 1 · see citing works
Flagged first, then by citations
Research works printed but not linked: 1
- Chen, W., & Taylor, E. (2006). PACS interview and genetic research of ADHD. In R. Oades, (Ed.), Atten- tion deficit/hyperactivity disorder HKS: Current ideas and ways forward (pp. 3-20). New York: Nova Science Publishers.
Cited by
Sorted by citations
Beyond diathesis stress: differential susceptibility to environmental influences
Belsky, J., & Pluess, M. (2009) · Psychological Bulletin · doi:10.1037/a0017376 · Cited by 3,039 · see citing works
Shared heritability of attention-deficit/hyperactivity disorder and autism spectrum disorder
Rommelse, N. N. J., Franke, B., Geurts, H. M., Hartman, C. A., & Buitelaar, J. K. (2010) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0092-x · Cited by 564 · see citing works
Self-citationEuropean guidelines on managing adverse effects of medication for ADHD
(for the European Guidelines Group), Graham, J., Banaschewski, T., Buitelaar, J., Coghill, D., Danckaerts, M., Dittmann, R. W., Döpfner, M., Hamilton, R., Hollis, C., et al. (2011) · European Child & Adolescent Psychiatry · doi:10.1007/s00787-010-0140-6 · Cited by 374 · see citing works
Self-citationNeuroinflammation as a risk factor for attention deficit hyperactivity disorder
Dunn, G. A., Nigg, J. T., & Sullivan, E. L. (2019) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2019.05.005 · Cited by 299 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder
Nigg, J., Nikolas, M., & Burt, S. A. (2010) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1016/j.jaac.2010.01.025 · Cited by 259 · see citing works
Oades, R. D., Dauvermann, M. R., Schimmelmann, B. G., Schwarz, M. J., & Myint, A.-M. (2010) · Behavioral and Brain Functions · doi:10.1186/1744-9081-6-29 · Cited by 151 · see citing works
Self-citationWeeland, J., Overbeek, G., de Castro, B. O., & Matthys, W. (2015) · Clinical Child and Family Psychology Review · doi:10.1007/s10567-015-0196-4 · Cited by 138 · see citing works
Stevens, S. E., Kumsta, R., Kreppner, J. M., Brookes, K. J., Rutter, M., & Sonuga‐Barke, E. J. S. (2009) · American Journal of Medical Genetics Part B: Neuropsychiatric Genetics · doi:10.1002/ajmg.b.31010 · Cited by 89 · see citing works
Self-citationADHD, CD, and ODD: Systematic review of genetic and environmental risk factors
Azeredo, A., Moreira, D., & Barbosa, F. (2018) · Research in Developmental Disabilities · doi:10.1016/j.ridd.2017.12.010 · Cited by 75 · see citing works
Harvey, E. A., Breaux, R. P., & Lugo-Candelas, C. I. (2016) · Journal of Abnormal Psychology · doi:10.1037/abn0000090 · Cited by 84 · see citing works
Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., & Cook, E. H. (2011) · Journal of Abnormal Psychology · doi:10.1037/a0021133 · Cited by 63 · see citing works
An international multicenter association study of the serotonin transporter gene in persistent ADHD
Landaas, E. T., Johansson, S., Jacobsen, K. K., Ribasés, M., Bosch, R., Sánchez‐Mora, C., Jacob, C. P., Boreatti‐Hümmer, A., Kreiker, S., Lesch, K. ‐., et al. (2010) · Genes, Brain and Behavior · doi:10.1111/j.1601-183x.2010.00567.x · Cited by 55 · see citing works
Prenatal SSRI exposure: Effects on later child development
Hermansen, T. K., & Melinder, A. (2015) · Child Neuropsychology · doi:10.1080/09297049.2014.942727 · Cited by 38 · see citing works
Gene–Environment Interactions in the Etiology of Human Violence
Laucht, M., Brandeis, D., & Zohsel, K. (2013) · Current Topics in Behavioral Neurosciences · doi:10.1007/7854_2013_260 · Cited by 18 · see citing works
Parent emotion expression and autonomic-linked emotion dysregulation in childhood ADHD
Musser, E. D., Lugo, Y., Ward, A. R., Tenenbaum, R. B., Morris, S., Brijmohan, N., & Martinez, J. (2018) · Journal of Psychopathology and Behavioral Assessment · doi:10.1007/s10862-018-9685-3 · Cited by 15 · see citing works
Parenting Interacts With Plasticity Genes in Predicting Behavioral Outcomes in Preschoolers
Letourneau, N. L., de Koning, A. P. J., Sekhon, B., Ntanda, H. N., Kobor, M., Deane, A. J., Morin, A. M., Dewey, D., Campbell, T. S., Giesbrecht, G. F., et al. (2020) · Canadian Journal of Nursing Research · doi:10.1177/0844562119863612 · Cited by 12 · see citing works
- Authors
- Sonuga‐Barke, E. J. S., Oades, R. D., Psychogiou, L., Chen, W., Franke, B., Buitelaar, J., Banaschewski, T., Ebstein, R. P., Gil, M., Anney, R., Miranda, A., Roeyers, H., Rothenberger, A., Sergeant, J., Steinhausen, H. C., Thompson, M., Asherson, P., & Faraone, S. V.
- Affiliations
- University of Duisburg-Essen (DE)
- University of Oxford (GB)
- University of London (GB)
- Radboud University Nijmegen (NL)
- University of Mannheim (DE)
- Herzog Hospital (IL)
- Trinity College Dublin (IE)
- Universitat de València (ES)
- Ghent University (BE)
- University of Göttingen (DE)
- Vrije Universiteit Amsterdam (NL)
- University of Basel (CH)
- University of Southampton (GB)
- SUNY Upstate Medical University (US)
- ORCID
- Venue
- Journal of Child Psychology and Psychiatry
- Publisher
- Wiley
- Published
- 2009-08-24
- Volume
- 50
- Issue
- 9
- Pages
- 1052-1063
- ISSN
- 0021-9630 (ISSN-L)
- 1469-7610
- OpenAlex
- W2136189691
- Cited by
- 131
- References
- 75
- Citations by year
- 2025: 3 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 3 · 2020: 4 · 2019: 9 · 2018: 5 · 2017: 8 · 2016: 15 · 2015: 13 · 2014: 13 · 2013: 13 · 2012: 9
- FWCI
- 8.01
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Child Psychology and Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- VU Research Portal (publishedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich) (acceptedVersion)
- UWA Profiles and Research Repository (UWA) (submittedVersion)
- Ghent University Academic Bibliography (Ghent University) (submittedVersion)
- Digital Academic REpository of VU University Amsterdam (Vrije Universiteit Amsterdam) (submittedVersion)
- DuEPublico (University of Duisburg-Essen) (submittedVersion)
- ePrints Soton (University of Southampton) (submittedVersion)
- ORCA Online Research @Cardiff (Cardiff University) (submittedVersion)
- Research Portal (King's College London) (submittedVersion)
- GoeScholar The Publication Server of the Georg-August-Universität Göttingen (Georg-August-Universität Göttingen) (submittedVersion, cc-by)
- Radboud Repository (Radboud University) (submittedVersion)
- Zurich Open Repository and Archive (University of Zurich) (submittedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion, other-oa)
- Zurich Open Repository and Archive (University of Zurich)
- Funders
- Eli Lilly and Company
- Pfizer
- National Institutes of Health
- National Institute of Mental Health (R01 MH 62873, R01MH062873)
- UCB Pharma
- Cilag
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Social Sciences › Psychology › Clinical Psychology › Child and Adolescent Psychosocial and Emotional Development
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- attention deficit hyperactivity disorder, conduct problems, emotional problems, gene-environment interaction, dopamine transporter gene, dopamine transporter, serotonin transporter gene, serotonin transporter, dopamine D4 receptor gene, DRD4, genetic polymorphism, comorbidities
- MeSH terms
- Adolescent, Attention Deficit Disorder with Hyperactivity, Child, Child Behavior Disorders, Child, Preschool, Female, Genotype, Humans, Male, Mother-Child Relations, Expressed Emotion, Dopamine Plasma Membrane Transport Proteins, Serotonin Plasma Membrane Transport Proteins, Receptors, Dopamine D4
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
