Association of the serotonin transporter and 5HT1Dβ receptor genes with extreme, persistent and pervasive aggressive behaviour in children
Abstract
There is an inverse correlation between central nervous system serotonergic activity and human aggression, and aggressive traits are at least partially heritable. The present study sought to investigate the relationship between childhood aggression and polymorphisms of two serotonin system genes: the 5HT1Dbeta receptor gene and the serotonin transporter (5HTT) gene. Fifty children with a minimum 2-year history of aggression and scores above the 90th percentile on the Aggression subscales of both the Child Behaviour Checklist and the Teacher's Report Form were included in the study. All probands and locally recruited ethnically matched controls were genotyped for the 5HT1Dbeta G861C, 5HTTLPR (promoter) and 5HTT variable number of tandem repeats (VNTR) polymorphisms. Chi-square tests revealed a significantly reduced frequency of the 5HTT VNTR 10R allele in children displaying the high-aggression phenotype compared with normal controls (P=0.039). After correction for multiple comparisons, this association reached the level of a trend but was no longer significant. Probands also demonstrated an increased 5HT1Dbeta 861C allele frequency, but this was not statistically significant (P=0.156). 5HTTLPR was not found to be significantly associated with aggression, but our data support previous findings of an association between this polymorphism and attention deficit hyperactivity disorder (P=0.025). While these preliminary findings should be interpreted cautiously, our data suggest that the 5HTT VNTR polymorphism is associated with measures of aggressive behaviour in a sample of children displaying extreme, persistent and pervasive aggression.
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Other serotonin receptor encoding gene polymorphisms, including 5-hydroxytryptamine receptor 1B, 1E and 2C, demonstrated significant effects on childhood aggression.
“Other serotonin receptor encoding gene polymorphisms, including 5-hydroxytryptamine receptor 1B [93, 94], 1E [95] and 2 C [96] further demonstrated significant effects on childhood aggression”
From Genetics of child aggression, a systematic review (2024) · cites this paper as [93]
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Bersani, F. S., & Pasquini, M. (2018) · Springer eBooks · doi:10.1007/978-3-319-78202-7_7 · Cited by 1 · see citing works
Neural substrates of amphetamine induced impulsive behaviour
Twiston-Davies, F. L. (2013) · White Rose eTheses Online (University of Leeds, The University of Sheffield, University of York)
Hakulinen, C. A. (2013) · Työväentutkimus Vuosikirja
Risk and prediction of violent crime in forensic psychiatry
Gustavson, C. (2010) · Lund University Publications (Lund University)
A Contextual-Genetics Approach to Adolescent Drug Use and Sexual Risk Behavior
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Agitation, aggressives Verhalten, Erregungszustände
Hewer, W., Messer, T., & Haug, H. (2017) · Elsevier eBooks · doi:10.1016/b978-3-437-22881-0.00007-1
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School Social Relations and Child Development: Gene-Environment Interplay
Brendgen, M. R., & Kretschmer, T. (2022) · Springer eBooks · doi:10.1007/978-3-031-07109-6_4
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- Authors
- Davidge, K. M., Atkinson, L., Douglas, L., Lee, V., Shapiro, S., Kennedy, J. L., & Beitchman, J. H.
- Affiliations
- Centre for Addiction and Mental Health (CA)
- Corresponding author
- Beitchman, Joseph H.
- Venue
- Psychiatric Genetics
- Published
- 2004-09
- Volume
- 14
- Issue
- 3
- Pages
- 143-146
- ISSN
- 0955-8829 (ISSN-L)
- OpenAlex
- W1971817304
- Cited by
- 84
- References
- 23
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 1 · 2018: 5 · 2017: 2 · 2016: 6 · 2015: 6 · 2014: 6 · 2013: 3 · 2012: 4
- FWCI
- 1.29
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Psychiatric Genetics (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Keywords
- child aggression, serotonin transporter gene, 5-HTTLPR, genetic polymorphism, aggression, attention deficit hyperactivity disorder, serotonergic system
- MeSH terms
- Adolescent, Aggression, Mental Disorders, Child, Female, Gene Frequency, Genotype, Humans, Male, Membrane Glycoproteins, Nerve Tissue Proteins, Minisatellite Repeats, Polymorphism, Single Nucleotide, Membrane Transport Proteins, Receptor, Serotonin, 5-HT1B, Serotonin Plasma Membrane Transport Proteins
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