Acetylcholinesterase inhibitors may improve myelin integrity

Bartzokis, George

doi:10.1016/j.biopsych.2006.08.020

Cited by 41Cholinesterase and Neurodegenerative DiseasesMultiple Sclerosis Research StudiesNeuroscience and Neuropharmacology Research

Acetylcholinesterase inhibitors may improve myelin integrity

Bartzokis, George·2007·Biological Psychiatry

DOI 10.1016/j.biopsych.2006.08.020

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Abstract

Recent clinical trials have revealed that cholinergic treatments are efficacious in a wide spectrum of neuropsychiatric disorders that span the entire human lifespan and include disorders without cholinergic deficits. Furthermore, some clinical and epidemiological data suggest that cholinergic treatments have disease modifying/preventive effects. It is proposed that these observations can be usefully understood in a myelin-centered model of the human brain. The model proposes that the human brain's extensive myelination is the central evolutionary change that defines our uniqueness as a species and our unique vulnerability to highly prevalent neuropsychiatric disorders. Within the framework of this model the clinical, biochemical, and epidemiologic data can be reinterpreted to suggest that nonsynaptic effects of cholinergic treatments on the process of myelination and myelin repair contributes to their mechanism of action and especially to their disease modifying/preventive effects. The ability to test the model in human populations with safe and noninvasive imaging technologies makes it possible to undertake novel clinical trial efforts directed at primary prevention of some of the most prevalent and devastating of human disorders.

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Disturbances in myelin are associated with an increased rate of AD progression and byproducts of homeostatic myelin maintenance can promote the formation of amyloid plaques.
“Consistent with this possibility, disturbances in myelin have been associated with an increased rate of AD progression and byproducts of homeostatic myelin maintenance can promote the formation of amyloid plaques (Bartzokis, 2007, 2011).”
From Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination (2016) · cites this paper as Bartzokis, 2007

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Alzheimer's disease as homeostatic responses to age-related myelin breakdown
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Authors: Bartzokis, G.
Affiliations: University of California, Los Angeles (US)
Corresponding author: Bartzokis, George
Venue: Biological Psychiatry
Publisher: Elsevier BV
Published: 2007-08
Volume: 62
Issue: 4
Pages: 294-301
ISSN: 0006-3223 (ISSN-L)
DOI: 10.1016/j.biopsych.2006.08.020
OpenAlex: W1992127864
Cited by: 41
References: 127
Citations by year: 2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 1 · 2019: 1 · 2017: 2 · 2016: 4 · 2014: 2 · 2013: 2 · 2012: 8
FWCI: 0.37
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations: Biological Psychiatry (publishedVersion)
PubMed (publishedVersion)
Funders: National Institute on Aging (R01AG027342, P50AG016570, AG 16570)
National Institute of Mental Health (MH0266029)
Topics: Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
Health Sciences › Medicine › Pathology and Forensic Medicine › Multiple Sclerosis Research Studies
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
Keywords: acetylcholinesterase inhibitors, myelin integrity, myelination, remyelination, disease-modifying effects, primary prevention, neuropsychiatric disorders, cholinergic deficit
MeSH terms: Animals, Brain, Cholinergic Fibers, Cholinesterase Inhibitors, Humans, Models, Neurological, Myelin Sheath, Neuropsychology

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Acetylcholinesterase inhibitors may improve myelin integrity

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