Cited by 72Advanced Neuroimaging Techniques and ApplicationsNeural and Behavioral Psychology StudiesCognitive Abilities and Testing

Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study

Bartzokis, George, Beckson, Mace, Lu, Po H., Nuechterlein, Keith H., Edwards, Nancy, Mintz, Jim·2001·Archives of General Psychiatry

Abstract

Background Imaging and postmortem studies provide converging evidence that, beginning in adolescence, gray matter volume declines linearly until old age, while cerebrospinal fluid volumes are stable in adulthood (age 20-50 years). Given the fixed volume of the cranium in adulthood, it is surprising that most studies observe no white matter volume expansion after approximately age 20 years. We examined the effects of the aging process on the frontal and temporal lobes. Methods Seventy healthy adult men aged 19 to 76 years underwent magnetic resonance imaging. Coronal images focused on the frontal and temporal lobes were acquired using pulse sequences that maximized gray vs white matter contrast. The volumes of total frontal and temporal lobes as well as the gray and white matter subcomponents were evaluated. Results Age-related linear loss in gray matter volume in both frontal (r= −0.62,P<.001) and temporal (r= −0.48,P<.001) lobes was confirmed. However, the quadratic function best represented the relationship between age and white matter volume in the frontal (P<.001) and temporal (P<.001) lobes. Secondary analyses indicated that white matter volume increased until age 44 years for the frontal lobes and age 47 years for the temporal lobes and then declined. Conclusions The changes in white matter suggest that the adult brain is in a constant state of change roughly defined as periods of maturation continuing into the fifth decade of life followed by degeneration. Pathological states that interfere with such maturational processes could result in neurodevelopmental arrests in adulthood.

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Crossref · 10.1001/archpsyc.58.5.461

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  • Cerebral white matter increases in the first four decades because of axonal myelination and may partially explain the observed GM loss.

    “Cerebral white matter increases in the first four decades because of axonal myelination (40) and may partially explain the observed GM loss (41, 42).”

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Authors
Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J.
Affiliations
Central Arkansas Veterans Healthcare System (US)
Corresponding author
Bartzokis, George
Venue
Archives of General Psychiatry
Published
2001-05-01
Volume
58
Issue
5
Pages
461
ISSN
0003-990X (ISSN-L)
OpenAlex
W2137579871
Cited by
14
References
46
Citations by year
2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4
FWCI
0.00
Type
journal article
Language
en
Open access
closed
Locations
Archives of General Psychiatry (publishedVersion)
Funders
  • National Institute of Mental Health (MH 51928, MH 37705)
  • National Institute on Drug Abuse (1YO1 DA 50038)
Topics
  • Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
Keywords
brain aging, frontal lobe, temporal lobe, gray matter volume, white matter volume, brain volume changes, men, brain development, brain maturation, neurodegeneration

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