Age-Related Changes in Frontal and Temporal Lobe Volumes in Men: A Magnetic Resonance Imaging Study
Abstract
Background Imaging and postmortem studies provide converging evidence that, beginning in adolescence, gray matter volume declines linearly until old age, while cerebrospinal fluid volumes are stable in adulthood (age 20-50 years). Given the fixed volume of the cranium in adulthood, it is surprising that most studies observe no white matter volume expansion after approximately age 20 years. We examined the effects of the aging process on the frontal and temporal lobes. Methods Seventy healthy adult men aged 19 to 76 years underwent magnetic resonance imaging. Coronal images focused on the frontal and temporal lobes were acquired using pulse sequences that maximized gray vs white matter contrast. The volumes of total frontal and temporal lobes as well as the gray and white matter subcomponents were evaluated. Results Age-related linear loss in gray matter volume in both frontal (r= −0.62,P<.001) and temporal (r= −0.48,P<.001) lobes was confirmed. However, the quadratic function best represented the relationship between age and white matter volume in the frontal (P<.001) and temporal (P<.001) lobes. Secondary analyses indicated that white matter volume increased until age 44 years for the frontal lobes and age 47 years for the temporal lobes and then declined. Conclusions The changes in white matter suggest that the adult brain is in a constant state of change roughly defined as periods of maturation continuing into the fifth decade of life followed by degeneration. Pathological states that interfere with such maturational processes could result in neurodevelopmental arrests in adulthood.
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Cerebral white matter increases in the first four decades because of axonal myelination and may partially explain the observed GM loss.
“Cerebral white matter increases in the first four decades because of axonal myelination (40) and may partially explain the observed GM loss (41, 42).”
From Dynamic mapping of human cortical development during childhood through early adulthood (2004) · cites this paper as [40]
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Lefterov, I., Wolfe, C. M., Fitz, N. F., Nam, K. N., Letronne, F., Biedrzycki, R. J., Kofler, J., Han, X., Wang, J., Schug, J., et al. (2019) · Alzheimer's Research & Therapy · doi:10.1186/s13195-019-0558-0 · Cited by 74 · see citing works
Iodine Deficiency and the Brain: Effects and Mechanisms
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Oligodendrocytes are a Novel Source of Amyloid Peptide Generation
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NF-κB signaling regulates myelination in the CNS
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Acetylcholinesterase inhibitors may improve myelin integrity
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Self-citationMok, K. K., Yeung, S. H., Cheng, G. W., Ma, I. W., Lee, R. H., Herrup, K., & Tse, K. (2023) · Journal of Neurochemistry · doi:10.1111/jnc.15748 · Cited by 37 · see citing works
Rapid Mental Fatigue Amplifies Age-Related Attentional Deficits
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White matter as a monitoring biomarker for neurodevelopmental disorder intervention studies
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The role of executive functions in psychiatric disorders
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A Therapeutic Approach for Senile Dementias: Neuroangiogenesis
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Neurochemical sex differences in adult ADHD patients: an MRS study
Endres, D., Tebartz van Elst, L., Maier, S. J., Feige, B., Goll, P., Meyer, S. A., Matthies, S., Domschke, K., Lange, T., Sobanski, E., et al. (2019) · Biology of Sex Differences · doi:10.1186/s13293-019-0264-4 · Cited by 14 · see citing works
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Brain structure and verbal function across adulthood while controlling for cerebrovascular risks
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Salminen, L. E. (2016) · IRL - University of Missouri, St. Louis (University of Missouri–St. Louis)
- Authors
- Bartzokis, G., Beckson, M., Lu, P. H., Nuechterlein, K. H., Edwards, N., & Mintz, J.
- Affiliations
- Central Arkansas Veterans Healthcare System (US)
- Corresponding author
- Bartzokis, George
- Venue
- Archives of General Psychiatry
- Publisher
- American Medical Association (AMA)
- Published
- 2001-05-01
- Volume
- 58
- Issue
- 5
- Pages
- 461
- ISSN
- 0003-990X (ISSN-L)
- OpenAlex
- W2137579871
- Cited by
- 14
- References
- 46
- Citations by year
- 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 2 · 2014: 4
- FWCI
- 0.00
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Archives of General Psychiatry (publishedVersion)
- Funders
- National Institute of Mental Health (MH 51928, MH 37705)
- National Institute on Drug Abuse (1YO1 DA 50038)
- Topics
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Advanced Neuroimaging Techniques and Applications
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Cognitive Abilities and Testing
- Keywords
- brain aging, frontal lobe, temporal lobe, gray matter volume, white matter volume, brain volume changes, men, brain development, brain maturation, neurodegeneration
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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