Maternal care and hippocampal plasticity: evidence for experience-dependent structural plasticity, altered synaptic functioning, and differential responsiveness to glucocorticoids and stress
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Maternal licking and grooming (LG) in infancy influences stress responsiveness and cognitive performance in the offspring. We examined the effects of variation in the frequency of pup LG on morphological, electrophysiological, and behavioral aspects of hippocampal synaptic plasticity under basal and stress-like conditions. We found shorter dendritic branch length and lower spine density in CA1 cells from the adult offspring of low compared with high LG offspring. We also observed dramatic effects on long-term potentiation (LTP) depending on corticosterone treatment. Low LG offspring, in contrast to those of high LG mothers, displayed significantly impaired LTP under basal conditions but surprisingly a significantly enhanced LTP in response to high corticosterone in vitro. This enhanced plasticity under conditions that mimic those of a stressful event was apparent in vivo. Adult low LG offspring displayed enhanced memory relative to high LG offspring when tested in a hippocampal-dependent, contextual fear-conditioning paradigm. Hippocampal levels of glucocorticoid and mineralocorticoid receptors were reduced in low compared with high LG offspring. Such effects, as well as the differences in dendritic morphology, likely contribute to LTP differences under resting conditions, as well as to the maternal effects on synaptic plasticity and behavior in response to elevated corticosterone levels. These results suggest that maternal effects may modulate optimal cognitive functioning in environments varying in demand in later life, with offspring of high and low LG mothers showing enhanced learning under contexts of low and high stress, respectively.
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The physiological and morphological changes induced by low-quality maternal care in rats enhance learning and memory under stressful conditions.
“they actually enhance learning and memory processes under stressful conditions”
From The Adaptive Calibration Model of stress responsivity (2011) · cites this paper as Champagne et al., 2008
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- Authors
- Champagne, D. L., Bagot, R. C., van Hasselt, F., Ramakers, G., Meaney, M. J., de Kloet, E. R., Joels, M., & Krugers, H.
- Affiliations
- University of Amsterdam (NL)
- Douglas Mental Health University Institute (CA)
- Netherlands Institute for Neuroscience (NL)
- Venue
- Journal of Neuroscience
- Publisher
- Society for Neuroscience
- Published
- 2008-06-04
- Volume
- 28
- Issue
- 23
- Pages
- 6037-6045
- ISSN
- 0270-6474 (ISSN-L)
- 1529-2401
- PMC
- PMC6670331
- OpenAlex
- W2074810352
- Cited by
- 661
- References
- 60
- Citations by year
- 2026: 15 · 2025: 15 · 2024: 16 · 2023: 16 · 2022: 28 · 2021: 25 · 2020: 28 · 2019: 39 · 2018: 33 · 2017: 33 · 2016: 41 · 2015: 44 · 2014: 53 · 2013: 54 · 2012: 54
- FWCI
- 24.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Neuroscience (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- UvA-DARE (University of Amsterdam) (publishedVersion)
- KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (publishedVersion)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- KNAW research portal (Royal Academy of Art and Sciences (KNAW)) (submittedVersion)
- Funders
- Koninklijke Nederlandse Akademie van Wetenschappen
- Top Institute Pharma
- Topics
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- hippocampal synaptic plasticity, dendritic spine density, long-term potentiation, corticosterone, glucocorticoid receptor, mineralocorticoid receptor, stress responsiveness, contextual fear conditioning, memory, maternal effects, offspring cognitive function
- MeSH terms
- Animals, Animals, Newborn, Female, Glucocorticoids, Hippocampus, Maternal Behavior, Neuronal Plasticity, Stress, Psychological, Synapses, Rats, Long-Evans, Rats
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