Translating Oxytocin Neuroscience to the Clinic: A National Institute of Mental Health Perspective
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
There is a significant gap in understanding the neural systems responsive to oxytocin and vasopressin in primates, and intranasal oxytocin use in humans has advanced despite lack of knowledge of the mechanism or targets engaged.
“Specifically, there has been a significant gap in the understanding of the neural systems responsive to OT and AVP in primates, and the use of intranasal OT (IN-OT) in humans, in particular, has advanced rapidly despite a lack of knowledge of the mechanism or neurological targets engaged by this manipulation (11-13).”
From Comparative Perspectives on Oxytocin and Vasopressin Receptor Research in Rodents and Primates: Translational Implications (2016) · cites this paper as [13]
Our study may help facilitate efforts to better understand oxytocin treatment efficacy by identifying targets for oxytocin receptor engagement.
“our study may help facilitate efforts to better understand oxytocin treatment efficacy as it identifies targets for oxytocin receptor engagement, which can facilitate dose-ranging studies69,70.”
From Oxytocin pathway gene networks in the human brain (2019) · cites this paper as [70]
Exogenous oxytocin has behavioural effects in humans, particularly in social deficit-related psychiatric disorders such as autism and schizophrenia.
“Exogenous oxytocin in humans also appears to have behavioural effects, particularly in such social deficit-related psychiatric disorders as autism and schizophrenia9–13.”
From Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice (2019) · cites this paper as [10]
Intranasal oxytocin was initially assumed to have wide-ranging effects on human social processes.
“Indeed, these neuropeptides, and in particular OT, have generated tremendous enthusiasm for their potential translational influence on human social cognition and behavior (Insel, 2016).”
From Null results of oxytocin and vasopressin administration across a range of social cognitive and behavioral paradigms: Evidence from a randomized controlled trial (2019) · cites this paper as Insel, 2016
Cites
How to improve R&D productivity: the pharmaceutical industry's grand challenge
Paul, S. M., Mytelka, D. S., Dunwiddie, C. T., Persinger, C. C., Munos, B. H., Lindborg, S. R., & Schacht, A. L. (2010) · Nature Reviews Drug Discovery · doi:10.1038/nrd3078 · Cited by 3,566 · see citing works
Oxytocin, vasopressin, and the neurogenetics of sociality
Donaldson, Z. R., & Young, L. J. (2008) · Science · doi:10.1126/science.1158668 · Cited by 1,645 · see citing works
Insel, T. R. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.005 · Cited by 1,044 · see citing works
Self-citationNakajima, M., Görlich, A., & Heintz, N. (2014) · Cell · doi:10.1016/j.cell.2014.09.020 · Cited by 262 · see citing works
Interplay of oxytocin, vasopressin, and sex hormones in the regulation of social recognition
Gabor, C. S., Phan, A., Clipperton-Allen, A. E., Kavaliers, M., & Choleris, E. (2012) · Behavioral Neuroscience · doi:10.1037/a0026464 · Cited by 221 · see citing works
Freeman, S. M., Inoue, K., Smith, A. L., Goodman, M. M., & Young, L. J. (2014) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2014.03.023 · Cited by 185 · see citing works
Wigton, R., Radua, J., Allen, P., Averbeck, B., Meyer-Lindenberg, A., McGuire, P., Shergill, S. S., & Fusar-Poli, P. (2015) · Journal of Psychiatry and Neuroscience · doi:10.1503/jpn.130289 · Cited by 179 · see citing works
CSF and blood oxytocin concentration changes following intranasal delivery in macaque
Dal Monte, O., Noble, P. L., Turchi, J., Cummins, A., & Averbeck, B. B. (2014) · PLoS ONE · doi:10.1371/journal.pone.0103677 · Cited by 177 · see citing works
Receptor and behavioral pharmacology of WAY-267464, a non-peptide oxytocin receptor agonist
Ring, R. H., Schechter, L. E., Leonard, S. K., Dwyer, J. M., Platt, B. J., Graf, R., Grauer, S. M., Pulicicchio, C. M., Resnick, L., Rahman, Z. U., et al. (2009) · Neuropharmacology · doi:10.1016/j.neuropharm.2009.07.016 · Cited by 144 · see citing works
Hicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S. (2014) · British Journal of Pharmacology · doi:10.1111/bph.12613 · Cited by 76 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
Oxytocin pathway gene networks in the human brain
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova-Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2019) · Nature Communications · doi:10.1038/s41467-019-08503-8 · Cited by 354 · see citing works
Quintana, D. S., Lischke, A., Grace, S., Scheele, D., Ma, Y., & Becker, B. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00864-7 · Cited by 263 · see citing works
Song, Z., & Albers, H. E. (2018) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.10.004 · Cited by 244 · see citing works
A Cortical Circuit for Sexually Dimorphic Oxytocin-Dependent Anxiety Behaviors
Li, K., Nakajima, M., Ibañez-Tallon, I., & Heintz, N. (2016) · Cell · doi:10.1016/j.cell.2016.08.067 · Cited by 234 · see citing works
Kinetics and dose dependency of intranasal oxytocin effects on amygdala reactivity
Spengler, F. B., Schultz, J., Scheele, D., Essel, M., Maier, W., Heinrichs, M., & Hurlemann, R. (2017) · Biological Psychiatry · doi:10.1016/j.biopsych.2017.04.015 · Cited by 229 · see citing works
Freeman, S. M., & Young, L. J. (2016) · Journal of Neuroendocrinology · doi:10.1111/jne.12382 · Cited by 196 · see citing works
“that can selectively and reliably reveal the distributions of OXTR and AVPR1a in primate tissue (27). With this method, which combines the use of the radioligands mentioned above with selective competitor ligands, we have now successfully mapped OXTR in the brain of the most common NHP model organism used in biomedica…”
ResultVascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice
Yamamoto, Y., Liang, M., Munesue, S., Deguchi, K., Harashima, A., Furuhara, K., Yuhi, T., Zhong, J., Akther, S., Goto, H., et al. (2019) · Communications Biology · doi:10.1038/s42003-019-0325-6 · Cited by 171 · see citing works
Oxytocin and the Neurobiology of Prosocial Behavior
Marsh, N., Marsh, A. A., Lee, M. R., & Hurlemann, R. (2020) · The Neuroscientist · doi:10.1177/1073858420960111 · Cited by 149 · see citing works
The neurobiology of parenting: A neural circuit perspective
Kohl, J., Autry, A. E., & Dulac, C. G. (2016) · BioEssays · doi:10.1002/bies.201600159 · Cited by 131 · see citing works
Oxytocin and social functioning
Jones, C., Barrera, I., Brothers, S., Ring, R., & Wahlestedt, C. (2017) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2017.19.2/cjones · Cited by 132 · see citing works
Oxytocin pathways in the intergenerational transmission of maternal early life stress
Töpfer, P., Heim, C. C., Entringer, S., Binder, E. B., Wadhwa, P. D., & Buß, C. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.12.026 · Cited by 114 · see citing works
Quintana, D. S., Westlye, L. T., Alnæs, D., Rustan, Ø. G., Kaufmann, T., Smerud, K. T., Mahmoud, R. A., Djupesland, P. G., & Andreassen, O. A. (2016) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2016.04.010 · Cited by 102 · see citing works
Oxytocin and stress-related disorders: neurobiological mechanisms and treatment opportunities
Sippel, L. M., Allington, C. E., Pietrzak, R. H., Harpaz-Rotem, I., Mayes, L. C., & Olff, M. (2017) · Chronic Stress · doi:10.1177/2470547016687996 · Cited by 99 · see citing works
Evidence for Intranasal Oxytocin Delivery to the brain: Recent Advances and Future Perspectives
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · Therapeutic Delivery · doi:10.4155/tde-2018-0002 · Cited by 94 · see citing works
Kinetics of oxytocin effects on amygdala and striatal reactivity vary between women and men
Lieberz, J., Scheele, D., Spengler, F. B., Matheisen, T., Schneider, L., Stoffel‐Wagner, B., Kinfe, T. M., & Hurlemann, R. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0582-6 · Cited by 93 · see citing works
Oxytocin effects in schizophrenia: Reconciling mixed findings and moving forward
Bradley, E., & Woolley, J. D. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.05.007 · Cited by 88 · see citing works
Oxytocin receptor dynamics in the brain across development and species
Vaidyanathan, R., & Hammock, E. A. D. (2016) · Developmental Neurobiology · doi:10.1002/dneu.22403 · Cited by 82 · see citing works
Uhrig, S., Hirth, N., Broccoli, L., von Wilmsdorff, M., Bauer, M., Sommer, C., Zink, M., Steiner, J. H., Frodl, T., Malchow, B., et al. (2016) · Schizophrenia Research · doi:10.1016/j.schres.2016.04.019 · Cited by 75 · see citing works
Peled‐Avron, L., Abu-Akel, A. M., & Shamay‐Tsoory, S. (2020) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2020.04.023 · Cited by 73 · see citing works
Improving the precision of intranasal oxytocin research
Winterton, A., Westlye, L. T., Steen, N. E., Andreassen, O. A., & Quintana, D. S. (2020) · Nature Human Behaviour · doi:10.1038/s41562-020-00996-4 · Cited by 62 · see citing works
Erectile Dysfunction: Treatments, Advances and New Therapeutic Strategies
Argiolas, A., Argiolas, F. M., Argiolas, G., & Melis, M. R. (2023) · Brain Sciences · doi:10.3390/brainsci13050802 · Cited by 55 · see citing works
Selective localization of oxytocin receptors and vasopressin 1a receptors in the human brainstem
Freeman, S. M., Smith, A. L., Goodman, M. M., & Bales, K. L. (2017) · Social Neuroscience · doi:10.1080/17470919.2016.1156570 · Cited by 51 · see citing works
Effect of a novel nasal oxytocin spray with enhanced bioavailability on autism: a randomized trial
Yamasue, H., Kojima, M., Kuwabara, H., Kuroda, M., Matsumoto, K., Kanai, C., Inada, N., Owada, K., Ochi, K., Ono, N., et al. (2021) · Brain · doi:10.1093/brain/awab291 · Cited by 51 · see citing works
Nishi, S. K., Babió, N., Paz‐Graniel, I., Serra‐Majem, L., Vioqué, J., Fitó, M., Corella, D., Pintó, X., Bueno‐Cavanillas, A., Tur, J. A., et al. (2023) · BMC Medicine · doi:10.1186/s12916-023-02771-4 · Cited by 49 · see citing works
Oxytocin, Erectile Function and Sexual Behavior: Last Discoveries and Possible Advances
Melis, M. R., & Argiolas, A. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms221910376 · Cited by 44 · see citing works
Tabak, B. A., Teed, A. R., Castle, E., Dutcher, J. M., Meyer, M. L., Bryan, R., Irwin, M. R., Lieberman, M. D., & Eisenberger, N. I. (2019) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.04.019 · Cited by 43 · see citing works
Oxytocin and Anxiety Disorders: Translational and Therapeutic Aspects
Naja, W., & Aoun, M. P. (2017) · Current Psychiatry Reports · doi:10.1007/s11920-017-0819-1 · Cited by 40 · see citing works
Understanding the Oxytocin System and Its Relevance to Psychiatry
Shamay‐Tsoory, S., & Young, L. J. (2015) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.10.014 · Cited by 39 · see citing works
A dose-finding study of oxytocin using neurophysiological measures of social processing
Wynn, J. K., Green, M. F., Hellemann, G., Reavis, E. A., & Marder, S. R. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0165-y · Cited by 39 · see citing works
Finger, E. C., Berry, S. M., Cummings, J. L., Coleman, K. K. L., Hsiung, G. R., Feldman, H., & Boxer, A. L. (2018) · Alzheimer s Research & Therapy · doi:10.1186/s13195-018-0427-2 · Cited by 37 · see citing works
Intertwined associations between oxytocin, immune system and major depressive disorder
Jiang, J., Yang, M., Tian, M., Chen, Z., Xiao, L., & Gong, Y. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.114852 · Cited by 36 · see citing works
Oxytocin attenuates social and non-social avoidance: Re-thinking the social specificity of Oxytocin
Harari-Dahan, O., & Bernstein, A. (2017) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2017.04.005 · Cited by 34 · see citing works
Common and dissociable effects of oxytocin and lorazepam on the neurocircuitry of fear
Kreuder, A.-K., Scheele, D., Schultz, J., Hennig, J., Marsh, N., Dellert, T., Ettinger, U., Philipsen, A., Babasiz, M., Herscheid, A., et al. (2020) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1920147117 · Cited by 26 · see citing works
Marvar, P. J., Andero, R., Hurlemann, R., Lago, T. R., Zelikowsky, M., & Dabrowska, J. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.1647-20.2020 · Cited by 29 · see citing works
Coster, L. D., Lin, L. D., Mathalon, D. H., & Woolley, J. D. (2019) · Neuropsychopharmacology · doi:10.1038/s41386-019-0417-5 · Cited by 28 · see citing works
Cultural life: Theory and empirical testing
Baciu, D. C. (2020) · Biosystems · doi:10.1016/j.biosystems.2020.104208 · Cited by 24 · see citing works
Quintana, D. S. (2021) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2021.105642 · Cited by 21 · see citing works
Voncken, M. J., Dijk, C., Stöhr, F., Niesten, I. J. M., Schruers, K. R. J., & Kuypers, K. P. C. (2021) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2021.07.005 · Cited by 20 · see citing works
Sex differences in stress reactivity after intranasal oxytocin in recreational cannabis users
Reed, S. C., Haney, M., Manubay, J. M., Campagna, B. R., Reed, B., Foltin, R. W., & Evans, S. M. (2018) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2018.11.008 · Cited by 20 · see citing works
Hormonal abnormalities in alexithymia
Goerlich, K. S., & Votinov, M. (2023) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2022.1070066 · Cited by 15 · see citing works
Wigton, R. L., Tracy, D. K., Verneuil, T., Johns, M., White, T. P., Michalopoulou, P. G., Averbeck, B. B., & Shergill, S. S. (2021) · Schizophrenia Research Cognition · doi:10.1016/j.scog.2021.100221 · Cited by 14 · see citing works
Social Psychopharmacology: Novel Approaches to Treat Deficits in Social Motivation in Schizophrenia
Bershad, A. K., & de Wit, H. (2023) · Schizophrenia Bulletin · doi:10.1093/schbul/sbad094 · Cited by 12 · see citing works
Quintana, D. S. (2018) · OSF Preprints (OSF Preprints) · Cited by 12 · see citing works
Quintana, D. S., Rokicki, J., van der Meer, D., Alnæs, D., Kaufmann, T., Córdova‐Palomera, A., Dieset, I., Andreassen, O. A., & Westlye, L. T. (2017) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/149526 · Cited by 12 · see citing works
Neural Responses to Intranasal Oxytocin in Youths With Severe Irritability
Hwang, S., Suk, J.-W., Meffert, H., Lerdahl, A., Garvey, W. F., Edwards, R. D., DeLizza, A. A., Vaughan, B. S., Cordts, K. M. P., Leibenluft, E., et al. (2024) · American Journal of Psychiatry · doi:10.1176/appi.ajp.20230174 · Cited by 8 · see citing works
Municchi, D., Mancini, C., Nutarelli, S., Tiberi, M., D’Addario, S. L., Chila, G., Passeri, A., Massa, G., Segni, M. D., Babicola, L., et al. (2025) · Molecular Psychiatry · doi:10.1038/s41380-025-03437-8 · Cited by 4 · see citing works
Norholt, H. (2021) · Frontiers in Psychology · doi:10.3389/fpsyg.2020.590051 · Cited by 4 · see citing works
Sorenson, K., Kendall, E., Grell, H., Kang, M., Shaffer, C. L., & Hwang, S. (2023) · Journal of Psychiatry and Brain Science · doi:10.20900/jpbs.20230008 · Cited by 3 · see citing works
Cerami, C., Perini, G., Panzavolta, A., Ramusino, M. C., & Costa, A. C. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms231911550 · Cited by 3 · see citing works
Higashida, H., Gerasimenko, M., & Yamamoto, Y. (2022) · Comprehensive Psychoneuroendocrinology · doi:10.1016/j.cpnec.2022.100146 · Cited by 3 · see citing works
Solomon, D. T., Nietert, P. J., Calhoun, C. D., Smith, D. W., Back, S. E., Barden, E. P., Brady, K. T., & Flanagan, J. C. (2018) · Couple and Family Psychology Research and Practice · doi:10.1037/cfp0000103 · Cited by 2 · see citing works
Evidence for intranasal oxytocin delivery to the brain: recent advances and future perspectivesPreprint
Quintana, D. S., Smerud, K. T., Andreassen, O. A., & Djupesland, P. G. (2018) · doi:10.31219/osf.io/fnhx5 · Cited by 3 · see citing works
Nishi, S. K., Babió, N., Paz‐Graniel, I., Serra‐Majem, L., Vioqué, J., Fitó, M., Corella, D., Pintó, X., Bueno‐Cavanillas, A., Tur, J. A., et al. (2024) · doi:10.32920/26540941 · Cited by 1 · see citing works
Nishi, S. K., Babió, N., Paz‐Graniel, I., Serra‐Majem, L., Vioqué, J., Fitó, M., Corella, D., Pintó, X., Bueno‐Cavanillas, A., Tur, J. A., et al. (2024) · doi:10.32920/26540941.v1
Nishi, S. K., Babió, N., Paz‐Graniel, I., Serra‐Majem, L., Vioqué, J., Montserrat, F., Corella, D., Pintó, X., Bueno‐Cavanillas, A., Tur, J. A., et al. (2023) · Figshare · doi:10.6084/m9.figshare.22622923
Does intranasal oxytocin reduce symptoms of mental disorders? A meta-analysis of clinical trials
Bonnieux, J. N., Gumuchian, S. T., Harboun, A., Trespalacios, F., Bélisle, K.-A., Haddad, A., Quintus-Bosz, O., McLellan, A., Chester-Trudel, L., Garred, D., et al. (2026) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2026.106749
- Authors
- Insel, T. R.
- Affiliations
- National Institute of Mental Health (US)
- Corresponding author
- Insel, Thomas R.
- ORCID
- Insel, Thomas R.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2016-02
- Volume
- 79
- Issue
- 3
- Pages
- 153-154
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W2219415195
- Cited by
- 56
- References
- 10
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 3 · 2023: 7 · 2022: 2 · 2021: 7 · 2020: 6 · 2019: 5 · 2018: 7 · 2017: 8 · 2016: 8 · 2015: 1
- FWCI
- 13.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- oxytocin, vasopressin, intranasal administration, clinical translation, social behavior, stress, learning, neurohypophysis, disulfide bonds, neuropeptides, clinical trials
- MeSH terms
- Mental Disorders, Brain, Clinical Trials as Topic, Humans, Neurosciences, Oxytocin
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
