Oxytozin: Evidenz für ein therapeutisches Potenzial des sozialen Neuromodulators
Abstract
Only few substances have achieved such a great prominence in recent years as the hypothalamic neuropeptide oxytocin, which is also widely known as the love hormone. Oxytocin is a potent neuromodulator which can improve social cognitive functions including empathy, trust, cooperation and social learning. However, oxytocin can also promote negative social behavior and increase poor memory and feelings of fear in social situations. Positive data from initial clinical trials give rise to the hope that oxytocin will prove to be a substance which is suitable for targeted treatment of poor social-cognitive behavior in neuropsychiatric diseases. This review article summarizes the most important recent preclinical and clinical human studies and discusses the findings presented with respect to current concepts of personal and contextual influences.
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Exogenous oxytocin administration has wide ranging prosocial effects.
“Largely as a result of the reported wide ranging prosocial effects of exogenous OXT administration (Eckstein and Hurlemann, 2013; Scheele et al, 2013; Striepens et al, 2011), the OXT system is considered to be a promising drug target for pharmacological treatment of the various symptoms of social impairment in ASD, including reduced interest in giving or receiving social touch.”
From An oxytocin-induced facilitation of neural and emotional responses to social touch correlates inversely with autism traits (2014) · cites this paper as Eckstein and Hurlemann, 2013
Intranasal oxytocin produces anxiolytic-like effects as a result of dampened amygdala reactivity to threat.
“Studies of intranasally delivered exogenous OXT (OXT IN ) have shown that the peptide produces anxiolytic-like effects as a result of dampened amygdala reactivity to threat (Eckstein and Hurlemann, 2013;Domes et al, 2007, but see Lischke et al, 2012)”
From Oxytocin Facilitates Pavlovian Fear Learning in Males (2016) · cites this paper as Eckstein and Hurlemann, 2013
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Oxytocin Facilitates Pavlovian Fear Learning in Males
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- Authors
- Eckstein, M., & Hurlemann, R.
- Affiliations
- University Hospital Bonn (DE)
- Corresponding author
- Hurlemann, R.
- Venue
- Der Nervenarzt
- Published
- 2013-10-30
- Volume
- 84
- Issue
- 11
- Pages
- 1321-1328
- ISSN
- 0028-2804 (ISSN-L)
- 1433-0407
- OpenAlex
- W2412551345
- Cited by
- 28
- References
- 67
- Citations by year
- 2025: 1 · 2024: 1 · 2023: 1 · 2021: 1 · 2019: 3 · 2018: 3 · 2017: 4 · 2016: 4 · 2015: 3 · 2014: 7
- FWCI
- 6.98
- Type
- journal article
- Language
- de
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Der Nervenarzt (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Keywords
- oxytocin, social cognition, empathy, trust, cooperation, social learning, social behavior, memory, fear, neuropsychiatric disorders, clinical trials, contextual factors
- MeSH terms
- Cognition Disorders, Humans, Oxytocin, Social Behavior Disorders, Neurotransmitter Agents, Evidence-Based Medicine
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