Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non‐peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats

Hicks, C; Ramos, L; Reekie, T; Misagh, G H; Narlawar, R; Kassiou, M; McGregor, I S

doi:10.1111/bph.12613

Cited by 78Neuroendocrine regulation and behaviorNeuropeptides and Animal PhysiologyCardiovascular, Neuropeptides, and Oxidative Stress Research

Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non‐peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats

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Hicks, C, Ramos, L, Reekie, T, Misagh, G H, Narlawar, R, Kassiou, M, McGregor, I S·2014·British Journal of Pharmacology

DOI 10.1111/bph.12613PMC PMC4243861

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Abstract

BACKGROUND AND PURPOSE: There is current interest in oxytocin (OT) as a possible therapeutic in psychiatric disorders. However, the usefulness of OT may be constrained by peripheral autonomic effects, which may involve an action at both OT and vasopressin V1A receptors. Here, we characterized the cardiovascular and thermoregulatory effects of OT, vasopressin (AVP) and the non-peptide OT receptor agonist WAY 267,464 in rats, and assessed the relative involvement of the OT and V1A receptors in these effects. EXPERIMENTAL APPROACH: Biotelemetry in freely moving male Wistar rats was used to examine body temperature and heart rate after OT (0.01 - 1 mg kg(-1); i.p.), AVP (0.001 - 0.1 mg kg(-1); i.p.) or WAY 267,464 (10 and 100 mg kg(-1); i.p.). The actions of the OT receptor antagonist Compound 25 (C25, 5 and 10 mg kg(-1)) and V1A receptor antagonist SR49059 (1 and 10 mg kg(-1)) were studied, as well as possible V1A receptor antagonist effects of WAY 267,464. KEY RESULTS: OT and AVP dose-dependently reduced body temperature and heart rate. WAY 267,464 had similar, but more modest, effects. SR49059, but not C25, prevented the hypothermia and bradycardia induced by OT and AVP. WAY 267,464 (100 mg·kg(-1)) prevented the effects of OT, and to some extent AVP. CONCLUSIONS AND IMPLICATIONS: Peripherally administered OT and AVP have profound cardiovascular and thermoregulatory effects that appear to principally involve the V1A receptor rather than the OT receptor. Additionally, WAY 267,464 is not a simple OT receptor agonist, as it has functionally relevant V1A antagonist actions.

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Peripherally administered OT and AVP produce similar effects in reducing heart rate and body temperature, inducing contractions in ejaculatory tissues, and promoting seizure susceptibility in male rats and rabbits.
“Peripherally administered OT and AVP produce similar effects in reducing heart rate and body temperature, inducing contractions in ejaculatory tissues, and in promoting seizure susceptibility in male rats and rabbits [37; 38; 39].”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [37]
These effects of OT and AVP can be inhibited by selective V1aR antagonists but not by OTR antagonists.
“These effects of OT and AVP can be inhibited by selective V1aR but not OTR antagonists.”
From Cross-talk among oxytocin and arginine-vasopressin receptors: Relevance for basic and clinical studies of the brain and periphery (2018) · cites this paper as [37]

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Authors: Hicks, C., Ramos, L., Reekie, T., Misagh, G. H., Narlawar, R., Kassiou, M., & McGregor, I. S.
Affiliations: The University of Sydney (AU)
Corresponding author: McGregor, I S
ORCID: Hicks, C
Ramos, L
Reekie, T
Narlawar, R
Kassiou, M
McGregor, I S
Venue: British Journal of Pharmacology
Publisher: Wiley
Published: 2014-05-15
Volume: 171
Issue: 11
Pages: 2868-2887
ISSN: 0007-1188 (ISSN-L)
1476-5381
DOI: 10.1111/bph.12613
PMC: PMC4243861
OpenAlex: W1710717017
Cited by: 76
References: 67
Citations by year: 2025: 4 · 2024: 5 · 2023: 4 · 2022: 5 · 2021: 8 · 2020: 6 · 2019: 11 · 2018: 4 · 2017: 7 · 2016: 7 · 2015: 9 · 2014: 5
FWCI: 13.85
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations: British Journal of Pharmacology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: Australian Research Council
National Health and Medical Research Council
National Medical Research Council
Topics: Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Health Sciences › Medicine › Surgery › Cardiovascular, Neuropeptides, and Oxidative Stress Research
Keywords: oxytocin, vasopressin, oxytocin receptor, V1a receptor, body temperature, thermoregulation, heart rate, bradycardia, hypothermia, cardiovascular effects, autonomic effects, receptor antagonists, biotelemetry
MeSH terms: Animals, Benzodiazepines, Body Temperature, Heart Rate, Hormone Antagonists, Indoles, Male, Oxytocin, Pyrazoles, Pyrrolidines, Vasopressins, Rats, Wistar, Receptors, Vasopressin, Receptors, Oxytocin, Antidiuretic Hormone Receptor Antagonists

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Body temperature and cardiac changes induced by peripherally administered oxytocin, vasopressin and the non‐peptide oxytocin receptor agonist WAY 267,464: a biotelemetry study in rats

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