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Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry
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“A large body of preclinical research has established the mechanistic pathways by which environments impact the developing brain prenatally.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [19]
In the citing paper
“Similarly, changes in maternal inflammatory profiles have been shown to associate with altered brain structure in rodent and non-human primate models, including via direct modifications of neural progenitors and indirect effects on neurodevelopmental processes such as synaptic pruning.19”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [19]
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“Among these mechanistic pathways are stress-sensitive systems like the hypothalamic-pituitary-adrenal axis, maternal inflammation or immune activation, and epigenetic modifications,16–19 see References 16 – 19 for comprehensive reviews of this research.”
From Prenatal Social Determinants of Health: Narrative review of maternal environments and neonatal brain development (2024) · cites this paper as [19]
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Recognition of double-stranded RNA and activation of NF-κB by Toll-like receptor 3
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Common polygenic variation contributes to risk of schizophrenia and bipolar disorder
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Synaptic Pruning by Microglia Is Necessary for Normal Brain Development
Paolicelli, R. C., Bolasco, G., Pagani, F., Maggi, L., Scianni, M., Panzanelli, P., Giustetto, M., Ferreira, T. A., Guiducci, E., Dumas, L., et al. (2011) · Science · doi:10.1126/science.1202529 · Cited by 4,244
Control of Synaptic Strength by Glial TNFα
Beattie, E. C., Stellwagen, D., Morishita, W., Bresnahan, J. C., Ha, B. K., Von Zastrow, M., Beattie, M. S., & Malenka, R. C. (2002) · Science · doi:10.1126/science.1067859 · Cited by 1,344
The maternal interleukin-17a pathway in mice promotes autism-like phenotypes in offspring
Choi, G. B., Yim, Y. S., Wong, H., Kim, S., Kim, H., Kim, S. V., Hoeffer, C. A., Littman, D. R., & Huh, J. R. (2016) · Science · doi:10.1126/science.aad0314 · Cited by 1,214
Maternal influenza infection causes marked behavioral and pharmacological changes in the offspring
Shi, L., Fatemi, S. H., Sidwell, R. W., & Patterson, P. H. (2003) · The Journal of Neuroscience · doi:10.1523/jneurosci.23-01-00297.2003 · Cited by 1,025
Extrapolating brain development from experimental species to humans
Clancy, B., Finlay, B. L., Darlington, R. B., & Anand, K. J. S. (2007) · NeuroToxicology · doi:10.1016/j.neuro.2007.01.014 · Cited by 812
Meyer, U., Nyffeler, M., Engler, A., Urwyler, A., Schedlowski, M., Knuesel, I., Yee, B. K., & Feldon, J. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.0099-06.2006 · Cited by 774
Prenatal Poly(I:C) Exposure and Other Developmental Immune Activation Models in Rodent Systems
Meyer, U. (2014) · Biological Psychiatry · doi:10.1016/j.biopsych.2013.07.011 · Cited by 626
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Metadata
- Authors
- Gumusoglu, S. B., & Stevens, H. E.
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2019-01
- Volume
- 85
- Issue
- 2
- Pages
- 107-121
- ISSN
- 0006-3223
- Cited by
- 220
- References
- 33
- Language
- en
- Funders
- Roy J. Carver Charitable Trust
- Graduate College, University of Iowa
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Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry. https://app.cochat.ai/papers/10.1016/j.biopsych.2018.08.008
- The paper
- Gumusoglu, S. B., & Stevens, H. E. (2019). Maternal Inflammation and Neurodevelopmental Programming: A Review of Preclinical Outcomes and Implications for Translational Psychiatry. Biological Psychiatry. https://doi.org/10.1016/j.biopsych.2018.08.008
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.