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Cholesterol, triglycerides, and the Five-Factor Model of personality
Open accessAbstract
Unhealthy lipid levels are among the leading controllable risk factors for coronary heart disease. To identify the psychological factors associated with dyslipidemia, this study investigates the personality correlates of cholesterol (total, LDL, and HDL) and triglycerides. A community-based sample (N=5532) from Sardinia, Italy, had their cholesterol and triglyceride levels assessed and completed a comprehensive personality questionnaire, the NEO-PI-R. All analyses controlled for age, sex, BMI, smoking, drinking, hypertension, and diabetes. Low Conscientiousness and traits related to impulsivity were associated with lower HDL cholesterol and higher triglycerides. Compared to the lowest 10%, those who scored in top 10% on Impulsivity had a 2.5 times greater risk of exceeding the clinical threshold for elevated triglycerides (OR=2.51, CI=1.56-4.07). In addition, sex moderated the association between trait depression (a component of Neuroticism) and HDL cholesterol, such that trait depression was associated with lower levels of HDL cholesterol in women but not men. When considering the connection between personality and health, unhealthy lipid profiles may be one intermediate biomarker between personality and morbidity and mortality.
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“Second, the increasing inclusion of biomarkers in personality-longevity studies is beginning to illuminate biological pathways such as systemic inflammation [65, 66, 218, 219] and artery calcification [220, 221]”
From Personality and Longevity: Knowns, Unknowns, and Implications for Public Health and Personalized Medicine (2011) · cites this paper as [221]
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“Second, the increasing inclusion of biomarkers in personality-longevity studies is beginning to illuminate biological pathways such as systemic inflammation [65, 66, 218, 219] and artery calcification [220, 221], but many other pathways are theoretically plausible.”
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Metadata
- Authors
- Sutin, A. R., Terracciano, A., Deiana, B., Uda, M., Schlessinger, D., Lakatta, E. G., & Costa Jr., P. T.
- Affiliations
- National Institutes of Health (US)
- Institute of Genetic and Biomedical Research (IT)
- Corresponding author
- Sutin, Angelina R.
- Venue
- Biological Psychology
- Publisher
- Elsevier BV
- Published
- 2010-05
- Volume
- 84
- Issue
- 2
- Pages
- 186-191
- ISSN
- 0301-0511 (ISSN-L)
- PMC
- PMC2933037
- OpenAlex
- W2070292687
- Cited by
- 109
- References
- 61
- Citations by year
- 2026: 1 · 2025: 4 · 2024: 7 · 2023: 5 · 2022: 6 · 2021: 4 · 2020: 7 · 2019: 7 · 2018: 8 · 2017: 7 · 2016: 4 · 2015: 7 · 2014: 9 · 2013: 8 · 2012: 10
- FWCI
- 11.63
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (Z99 AG999999)
- National Institute on Aging (ZIAAG000180, ZIAAG000197, ZIAAG000183)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Traits and Psychology
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiac Health and Mental Health
- Keywords
- dyslipidemia, cholesterol, triglycerides, Big Five personality traits, personality traits, impulsivity, conscientiousness, trait depression, neuroticism, HDL cholesterol, LDL cholesterol, coronary heart disease risk, sex differences, Sardinia
- MeSH terms
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Blood Chemical Analysis, Cholesterol, Female, Humans, Italy, Male, Middle Aged, Personality, Personality Inventory, Residence Characteristics, Sex Factors, Triglycerides, Logistic Models, Young Adult
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