The enhanced lipid accumulation in oleaginous microalga by the potential continuous nitrogen-limitation (CNL) strategy
Abstract
A potential continuous nitrogen-limitation (CNL) strategy was proposed to enhance lipid accumulation by oleaginous Chlorella vulgaris in this study. The highest biomass (4.61 g/L) with CNL was nearly close to the maximum biomass (4.88 g/L) achieved by the traditional batch nitrogen-starvation strategy (BNS) under laboratory condition. CNL was further found to diminish the photosynthetic activity and trigger the degradation of nitrogenous compounds (e.g. protein, chlorophyll, DNA) consequently resulted in enhanced lipid accumulation. The maximal lipid productivity of 305.71 mg/L/d was accomplished by CNL, which presented 1.35-fold more than that of BNS. Furthermore, the identified lipid accumulation-related metabolic checkpoints (MDH and GPDH) provide the possibilities to develop high-lipid engineering microalgae. The aforementioned results imply that CNL nitrogen-deficiency strategy for lipid production on large-scale deserves further exploration.
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Nitrogen deficiency serves as a significant stimulus for lipid accumulation in various microalgae species, such as Acutodesmus dimorphus, Nephrochlamys yushanlensis, C. vulgaris, Scenedesmus quadricauda, and N. oceanica.
“Nitrogen deficiency serves as a significant stimulus for lipid accumulation in various microalgae species, such as Acutodesmus dimorphus [106], Nephrochlamys yushanlensis [107, 108], C. vulgaris [109], Scenedesmus quadricauda [110], and N. oceanica [111].”
From Microalgae biofuels: illuminating the path to a sustainable future amidst challenges and opportunities (2024) · cites this paper as [109]
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- Authors
- Liu, T., Li, Y., Liu, F., & Wang, C.
- Affiliations
- Xiangtan University (CN)
- Corresponding author
- Li, Yuqin
- ORCID
- Venue
- Bioresource Technology
- Publisher
- Elsevier BV
- Published
- 2016-03
- Volume
- 203
- Pages
- 150-159
- ISSN
- 0960-8524 (ISSN-L)
- OpenAlex
- W2204698309
- Cited by
- 72
- References
- 27
- Citations by year
- 2026: 12 · 2025: 7 · 2024: 6 · 2023: 4 · 2022: 8 · 2021: 5 · 2020: 8 · 2019: 3 · 2018: 8 · 2017: 9 · 2016: 2
- FWCI
- 1.88
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioresource Technology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (21306161)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Keywords
- lipid accumulation, oleaginous microalgae, Chlorella vulgaris, nitrogen starvation, photosynthetic activity, lipid productivity, metabolic checkpoint, malate dehydrogenase, glycerol-3-phosphate dehydrogenase
- MeSH terms
- Chlorophyll, Fatty Acids, Lipids, Nitrogen, Biomass, Chlorella vulgaris, Lipid Metabolism, Microalgae
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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