The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
Eyeglasses-based tear biosensing system: Non-invasive detection of alcohol, vitamins and glucose
Open accessAbstract
We report on a wearable tear bioelectronic platform, integrating a microfluidic electrochemical detector into an eyeglasses nose-bridge pad, for non-invasive monitoring of key tear biomarkers. The alcohol-oxidase (AOx) biosensing fluidic system allowed real-time tear collection and direct alcohol measurements in stimulated tears, leading to the first wearable platform for tear alcohol monitoring. Placed outside the eye region this fully wearable tear-sensing platform addresses drawbacks of sensor systems involving direct contact with the eye as the contact lenses platform. Integrating the wireless electronic circuitry into the eyeglasses frame thus yielded a fully portable, convenient-to-use fashionable sensing device. The tear alcohol sensing concept was demonstrated for monitoring of alcohol intake in human subjects over multiple drinking courses, displaying good correlation to parallel BAC measurements. We also demonstrate for the first time the ability to monitor tear glucose outside the eye and the utility of wearable devices for monitoring vitamin nutrients in connection to enzymatic flow detector and rapid voltammetric scanning, respectively. These developments pave the way to build an effective eyeglasses system capable of chemical tear analysis.
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“Despite some efforts, several challenges remain, such as difficulty in sampling tears, small sample volumes, issues with fast evaporation, dependence of tear composition on emotional or mechanical stimulation, and reliable operation of fully integrated wireless sensing platforms [126,152].”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [152]
In the citing paper
“In one of the most recent works, Sempionatto et al. [152] used a non-invasive wearable tear biosensor system mounted on eyeglasses for real-time monitoring of different analytes, including alcohol, vitamins such as vitamin B2 and B6, and glucose in tears (Figure 6c).”
From The emergence of AI-based wearable sensors for digital health technology: a review (2023) · cites this paper as [152]
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Cites
Fully integrated wearable sensor arrays for multiplexed in situ perspiration analysis
Gao, W., Emaminejad, S., Nyein, H. Y. Y., Challa, S., Chen, K., Peck, A., Fahad, H. M., Ota, H., Shiraki, H., Kiriya, D., et al. (2016) · Nature · doi:10.1038/nature16521 · Cited by 5,087 · cited 1×
“Wearable chemical sensors have thus been integrated into a variety of body conformable platforms ranging from wristbands (Gao et al., 2016) and temporary tattoos (Bandodkar et al., 2015) to textiles (Jeerapan et al., 2016) and from mouthguard (Kim et al., 2015) to contact lenses (Park et al.,…”
BackgroundLab-on-Skin: A Review of Flexible and Stretchable Electronics for Wearable Health Monitoring
Liu, Y., Pharr, M., & Salvatore, G. A. (2017) · ACS Nano · doi:10.1021/acsnano.7b04898 · Cited by 1,725
Bariya, M., Nyein, H. Y. Y., & Javey, A. (2018) · Nature Electronics · doi:10.1038/s41928-018-0043-y · Cited by 1,486
Wearable sensors: modalities, challenges, and prospects
Heikenfeld, J., Jajack, A., Rogers, J., Gutruf, P., Tian, L., Pan, T., Li, R., Khine, M., Kim, J., Wang, J., et al. (2018) · Lab on a Chip · doi:10.1039/c7lc00914c · Cited by 1,434
Self-citationGrant, B. F., Chou, S. P., Saha, T. D., Pickering, R. P., Kerridge, B. T., Ruan, W. J., Huang, B., Jung, J., Zhang, H., Fan, A., et al. (2017) · JAMA Psychiatry · doi:10.1001/jamapsychiatry.2017.2161 · Cited by 1,362
Wearable and flexible electronics for continuous molecular monitoring
Yang, Y., & Gao, W. (2019) · Chemical Society Reviews · doi:10.1039/c7cs00730b · Cited by 1,315 · cited 1×
“(Bariya et al., 2018; Heikenfeld et al., 2018; Yang and Gao, 2019).”
Wearable smart sensor systems integrated on soft contact lenses for wireless ocular diagnostics
Kim, J., Kim, M., Lee, M.-S., Kim, K., Ji, S., Kim, Y.-T., Park, J., Na, K., Bae, K.-H., Kyun Kim, H., et al. (2017) · Nature Communications · doi:10.1038/ncomms14997 · Cited by 951
Self-citationWearable Chemical Sensors: Present Challenges and Future Prospects
Bandodkar, A. J., Jeerapan, I., & Wang, J. (2016) · ACS Sensors · doi:10.1021/acssensors.6b00250 · Cited by 778
Self-citationWearable salivary uric acid mouthguard biosensor with integrated wireless electronics
Kim, J., Imani, S., de Araujo, W. R., Warchall, J., Valdés-Ramírez, G., Paixão, T. R. L. C., Mercier, P. P., & Wang, J. (2015) · Biosensors and Bioelectronics · doi:10.1016/j.bios.2015.07.039 · Cited by 678
Self-citationSoft, smart contact lenses with integrations of wireless circuits, glucose sensors, and displays
Park, J., Kim, J., Kim, S.-Y., Cheong, W. H., Jang, J., Park, Y.-G., Na, K., Kim, Y.-T., Heo, J. H., Lee, C. Y., et al. (2018) · Science Advances · doi:10.1126/sciadv.aap9841 · Cited by 671
Self-citation
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Cited by
Sorted by citations
Electrochemical glucose sensors in diabetes management: an updated review (2010–2020)
Teymourian, H., Barfidokht, A., & Wang, J. (2020) · Chemical Society Reviews · doi:10.1039/d0cs00304b · Cited by 915
The emergence of AI-based wearable sensors for digital health technology: a review
Shajari, S., Kuruvinashetti, K., Komeili, A., & Sundararaj, U. (2023) · Sensors · doi:10.3390/s23239498 · Cited by 535
“Despite some efforts, several challenges remain, such as difficulty in sampling tears, small sample volumes, issues with fast evaporation, dependence of tear composition on emotional or mechanical stimulation, and reliable operation of fully integrated wireless sensing platforms [126,152].”
BackgroundFundamentals, Applications, and Future Directions of Bioelectrocatalysis
Chen, H., Simoska, O., Lim, K., Grattieri, M., Yuan, M., Dong, F., Lee, Y. S., Beaver, K., Weliwatte, N. S., Gaffney, E. M., et al. (2020) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00472 · Cited by 510
Wearable Electrochemical Sensors for the Monitoring and Screening of Drugs
Teymourian, H., Parrilla, M., Sempionatto, J. R., Montiel, N. F., Barfidokht, A., Echelpoel, R. V., Wael, K. D., & Wang, J. (2020) · ACS Sensors · doi:10.1021/acssensors.0c01318 · Cited by 437
From Diagnosis to Treatment: Recent Advances in Patient-Friendly Biosensors and Implantable Devices
Li, P., Lee, G., Kim, S. Y., Kwon, S. Y., Kim, H., & Park, S. (2021) · ACS Nano · doi:10.1021/acsnano.0c06688 · Cited by 368
Metadata
- Authors
- Sempionatto, J. R., Brazaca, L. C., García-Carmona, L., Bolat, G., Campbell, A. S., Martin, A., Tang, G., Shah, R., Mishra, R. K., Kim, J., Zucolotto, V., Escarpa, A., & Wang, J.
- Affiliations
- University of California San Diego (US)
- Universidade de São Paulo (BR)
- Universidad de Alcalá (ES)
- Corresponding author
- Wang, Joseph
- ORCID
- Venue
- Biosensors and Bioelectronics
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 137
- Pages
- 161-170
- ISSN
- 0956-5663 (ISSN-L)
- PMC
- PMC8372769
- OpenAlex
- W2944569697
- Cited by
- 315
- References
- 54
- Citations by year
- 2026: 27 · 2025: 58 · 2024: 48 · 2023: 56 · 2022: 50 · 2021: 42 · 2020: 29 · 2019: 5
- FWCI
- 11.03
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Biosensors and Bioelectronics (acceptedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- Defense Threat Reduction Agency Joint Science
- Technology Office for Chemical and Biological Defense (HDTRA 1-16-1-0013)
- Conselho Nacional de Desenvolvimento Científico e Tecnológico (216981/2014-0)
- Sao Paulo Research Foundation (FAPESP) (2017/03779-0)
- University of Alcala
- Scientific and Technological Research Council of Turkey (TUBITAK 2219)
- NIH NIAAA T32 (AA013525)
- Topics
- Physical Sciences › Chemistry › Analytical Chemistry › Electrochemical sensors and biosensors
- Physical Sciences › Engineering › Biomedical Engineering › Advanced Sensor and Energy Harvesting Materials
- Physical Sciences › Engineering › Biomedical Engineering › Biosensors and Analytical Detection
- Keywords
- spectacle, wearable sensors, alcohol detection, alcohol oxidase, tear glucose, non-invasive monitoring, blood alcohol concentration, wireless devices
- MeSH terms
- Wearable Electronic Devices, Alcohols, Eyeglasses, Glucose, Humans, Monitoring, Physiologic, Tears, Vitamins, Biosensing Techniques
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