A two-step model for colon adenoma initiation and progression caused by APC loss

Phelps, Reid A.; Chidester, Stephanie; Dehghanizadeh, Somaye; Phelps, Jason; Sandoval, Imelda T.; Rai, Kunal; Broadbent, Talmage; Sarkar, Sharmistha; Burt, Randall W.; Jones, David A.

doi:10.1016/j.cell.2009.02.037

Cited by 288Wnt/β-catenin signaling in development and cancerGenetic factors in colorectal cancerColorectal Cancer Treatments and Studies

A two-step model for colon adenoma initiation and progression caused by APC loss

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Phelps, Reid A., Chidester, Stephanie, Dehghanizadeh, Somaye, Phelps, Jason, Sandoval, Imelda T., Rai, Kunal, Broadbent, Talmage, Sarkar, Sharmistha +2 more·2009·Cell

DOI 10.1016/j.cell.2009.02.037PMC PMC2706149

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Abstract

Aberrant Wnt/beta-catenin signaling following loss of the tumor suppressor adenomatous polyposis coli (APC) is thought to initiate colon adenoma formation. Using zebrafish and human cells, we show that homozygous loss of APC causes failed intestinal cell differentiation but that this occurs in the absence of nuclear beta-catenin and increased intestinal cell proliferation. Therefore, loss of APC is insufficient for causing beta-catenin nuclear localization. APC mutation-induced intestinal differentiation defects instead depend on the transcriptional corepressor C-terminal binding protein-1 (CtBP1), whereas proliferation defects and nuclear accumulation of beta-catenin require the additional activation of KRAS. These findings suggest that, following APC loss, CtBP1 contributes to adenoma initiation as a first step, whereas KRAS activation and beta-catenin nuclear localization promote adenoma progression to carcinomas as a second step. Consistent with this model, human FAP adenomas showed robust upregulation of CtBP1 in the absence of detectable nuclear beta-catenin, whereas nuclear beta-catenin was detected in carcinomas.

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The accepted causal relationship between mutated APC, dysregulated Wnt signaling, proliferation and colorectal cancer development does not hold at least during the earliest stages of malignant transformation.
“improved diagnostic tools and better access to early lesions have found that this is not the case, at least during the earliest stages of malignant transformation [6–8]”
From Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells (2018) · cites this paper as [8]

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A genetic model for colorectal tumorigenesis
Fearon, E. R., & Vogelstein, B. (1990) · Cell · doi:10.1016/0092-8674(90)90186-i · Cited by 12,132 · see citing works
Wnt/β-Catenin Signaling in Development and Disease
Clevers, H. (2006) · Cell · doi:10.1016/j.cell.2006.10.018 · Cited by 5,568 · see citing works
Lessons from hereditary colorectal cancer
Kinzler, K. W., & Vogelstein, B. (1996) · Cell · doi:10.1016/s0092-8674(00)81333-1 · Cited by 4,919 · see citing works
Identification of c- MYC as a Target of the APC Pathway
He, T.-C., Sparks, A. B., Rago, C., Hermeking, H., Zawel, L., da Costa, L. T., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · Science · doi:10.1126/science.281.5382.1509 · Cited by 4,566 · see citing works
Activation of β-Catenin-Tcf Signaling in Colon Cancer by Mutations in β-Catenin or APC
Morin, P. J., Sparks, A. B., Kořínek, V., Barker, N., Clevers, H. C., Vogelstein, B., & Kinzler, K. W. (1997) · Science · doi:10.1126/science.275.5307.1787 · Cited by 3,983 · see citing works
β-Catenin regulates expression of cyclin D1 in colon carcinoma cells
Tetsu, O., & McCormick, F. (1999) · Nature · doi:10.1038/18884 · Cited by 3,601 · see citing works
Prevalence of ras gene mutations in human colorectal cancers
Bos, J. L., Fearon, E. R., Hamilton, S. R., Vries, M. V., BOOM, J. H. V., van der Eb, A. J., & Vogelstein, B. (1987) · Nature · doi:10.1038/327293a0 · Cited by 1,860 · see citing works
Linking Colorectal Cancer to Wnt Signaling
Bienz, M., & Clevers, H. C. (2000) · Cell · doi:10.1016/s0092-8674(00)00122-7 · Cited by 1,516 · see citing works
Detection of high incidence of K-ras oncogenes during human colon tumorigenesis
Forrester, K., Almoguera, C., Han, K., Grizzle, W. E., & Perucho, M. (1987) · Nature · doi:10.1038/327298a0 · Cited by 1,061 · see citing works
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer.
Sparks, A. B., Morin, P. J., Vogelstein, B., & Kinzler, K. W. (1998) · PubMed · Cited by 1,008 · see citing works
Prostaglandin E 2 Promotes Colon Cancer Cell Growth Through a G s -Axin-ß-Catenin Signaling Axis
Castellone, M. D., Teramoto, H., Williams, B. O., Druey, K. M., & Gutkind, J. S. (2005) · Science · doi:10.1126/science.1116221 · Cited by 884 · see citing works
Loss of Apc in vivo immediately perturbs Wnt signaling, differentiation, and migrationPreprint
Sansom, O. J., Reed, K. R., Hayes, A. J., Ireland, H., Brinkmann, H., Newton, I. P., Batlle, E., Simon-Assmann, P. M., Clevers, H. C., Näthke, I. S., et al. (2004) · Genes & Development · doi:10.1101/gad.287404 · Cited by 799 · see citing works
The oncogenic activation of β-catenin
Polakis, P. G. (1999) · Current Opinion in Genetics & Development · doi:10.1016/s0959-437x(99)80003-3 · Cited by 651 · see citing works
Multicenter Phase II Study of the Oral MEK Inhibitor, CI-1040, in Patients With Advanced Non-Small-Cell Lung, Breast, Colon, and Pancreatic Cancer
Rinehart, J., Adjei, A. A., LoRusso, P. M., Waterhouse, D., Hecht, J. R., Natale, R. B., Hamid, O., Varterasian, M., Asbury, P., Kaldjian, E. P., et al. (2004) · Journal of Clinical Oncology · doi:10.1200/jco.2004.01.185 · Cited by 645 · see citing works
Differential effects of oncogenic K-Ras and N-Ras on proliferation, differentiation and tumor progression in the colon
Haigis, K. M., Kendall, K. R., Wang, Y., Cheung, A., Haigis, M. C., Glickman, J. N., Niwa-Kawakita, M., Sweet-Cordero, A., Sebolt-Leopold, J., Shannon, K. M., et al. (2008) · Nature Genetics · doi:10.1038/ng.115 · Cited by 610 · see citing works
Rac1 Activation Controls Nuclear Localization of β-catenin during Canonical Wnt Signaling
Wu, X., Tu, X., Joeng, K. S., Hilton, M. J., Williams, D. A., & Long, F. (2008) · Cell · doi:10.1016/j.cell.2008.01.052 · Cited by 481 · see citing works
Phosphorylation of β-Catenin by Cyclic AMP-dependent Protein Kinase
Taurin, S., Sandbo, N. K., Qin, Y., Browning, D. D., & Dulin, N. O. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m508778200 · Cited by 450 · see citing works
The Wnt/β-catenin pathway regulates cardiac valve formation
Hurlstone, A. F. L., Haramis, A.-P. G., Wienholds, E., Begthel, H., Korving, J., Eeden, F. V., Cuppen, E. P. J. G., Živković, D., Plasterk, R. H. A., & Clevers, H. C. (2003) · Nature · doi:10.1038/nature02028 · Cited by 398 · see citing works
The APC tumor suppressor counteracts β-catenin activation and H3K4 methylation at Wnt target genesPreprint
Sierra, J., Yoshida, T., Joazeiro, C. A. P., & Jones, K. A. (2006) · Genes & Development · doi:10.1101/gad.1385806 · Cited by 385 · see citing works
Mouse Model of Colonic Adenoma-Carcinoma Progression Based on Somatic Apc Inactivation
Hinoi, T., Akyol, A., Theisen, B. K., Ferguson, D. O., Greenson, J. K., Williams, B. O., Cho, K. R., & Fearon, E. R. (2007) · Cancer Research · doi:10.1158/0008-5472.can-07-2735 · Cited by 314 · see citing works
APC and Oncogenic KRAS Are Synergistic in Enhancing Wnt Signaling in Intestinal Tumor Formation and Progression
Janssen, K., Alberici, P., Fsihi, H., Gaspar, C., Breukel, C., Franken, P., Rosty, C., Abal, M., El Marjou, F., Smits, R., et al. (2006) · Gastroenterology · doi:10.1053/j.gastro.2006.08.011 · Cited by 298 · see citing works
Importance of epidermal growth factor receptor signaling in establishment of adenomas and maintenance of carcinomas during intestinal tumorigenesis
Roberts, R. B., Lu, M., Washington, M. K., Olsen, S. J., Settle, S. H., Coffey, R. J., & Threadgill, D. W. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.032678499 · Cited by 275 · see citing works
Activation of the beta-catenin gene by interstitial deletions involving exon 3 in primary colorectal carcinomas without adenomatous polyposis coli mutations.
Iwao, K., Nakamori, S., Kameyama, M., Imaoka, S., Kinoshita, M., Fukui, T., Ishiguro, S., Nakamura, Y., & Miyoshi, Y. (1998) · PubMed · Cited by 275 · see citing works
Loss of beta-catenin regulation by the APC tumor suppressor protein correlates with loss of structure due to common somatic mutations of the gene.
Rubinfeld, B., Albert, I., Porfiri, E., Munemitsu, S. M., & Polakis, P. G. (1997) · PubMed · Cited by 225 · see citing works
Beta-catenin mutations are more frequent in small colorectal adenomas than in larger adenomas and invasive carcinomas.
Samowitz, W. S., Powers, M. D., Spirio, L. N., Nollet, F., Roy, F. M. V., & Slattery, M. L. (1999) · PubMed · Cited by 225 · see citing works
Prostaglandin E2 Stimulates the β-Catenin/T Cell Factor-dependent Transcription in Colon Cancer
Shao, J., Jung, C., Liu, C., & Sheng, H. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m413056200 · Cited by 215 · see citing works
Structural basis of the Axin–adenomatous polyposis coli interaction
Spink, K. E., Polakis, P. G., & Weis, W. I. (2000) · The EMBO Journal · doi:10.1093/emboj/19.10.2270 · Cited by 211 · see citing works
Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K- ras oncogene in vivo
Sansom, O. J., Méniel, V. S., Wilkins, J. A., Cole, A. M., Oien, K. A., Marsh, V. L., Jamieson, T. J., Guerra, C. E., Ashton, G. H. S., Barbacid, M., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0604130103 · Cited by 185 · see citing works
Rac1b, a tumor associated, constitutively active Rac1 splice variant, promotes cellular transformation
Singh, A., Karnoub, A. E., Palmby, T. R., Lengyel, E. R., Sondek, J., & Der, C. J. (2004) · Oncogene · doi:10.1038/sj.onc.1208182 · Cited by 174 · see citing works
C‐terminal‐binding protein directly activates and represses Wnt transcriptional targets in Drosophila
Fang, M., Li, J., Blauwkamp, T. A., Bhambhani, C., Campbell, N. H., & Cadigan, K. M. (2006) · The EMBO Journal · doi:10.1038/sj.emboj.7601153 · Cited by 164 · see citing works
Adenomatous polyposis coli‐deficient zebrafish are susceptible to digestive tract neoplasia
Haramis, A.-P. G., Hurlstone, A. F. L., van der Velden, Y. U., Begthel, H., van den Born, M., Offerhaus, G. J. A., & Clevers, H. C. (2006) · EMBO Reports · doi:10.1038/sj.embor.7400638 · Cited by 163 · see citing works
Casein Kinase 1: A Wnt'er of Disconnect
Polakis, P. G. (2002) · Current Biology · doi:10.1016/s0960-9822(02)00969-7 · Cited by 154 · see citing works
The APC Tumor Suppressor Binds to C-Terminal Binding Protein to Divert Nuclear β-Catenin from TCF
Hamada, F., & Bienz, M. (2004) · Developmental Cell · doi:10.1016/j.devcel.2004.08.022 · Cited by 154 · see citing works
A target-selected Apc -mutant rat kindred enhances the modeling of familial human colon cancer
Amos-Landgraf, J. M., Kwong, L. N., Kendziorski, C. M., Reichelderfer, M., Torrealba, J. R., Weichert, J. P., Haag, J. D., Chen, K.-S., Waller, J. L., Gould, M. N., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0611690104 · Cited by 144 · see citing works
Non-traditional roles for the Adenomatous Polyposis Coli (APC) tumor suppressor protein
Hanson, C. A., & Miller, J. R. (2005) · Gene · doi:10.1016/j.gene.2005.07.024 · Cited by 122 · see citing works
Intestinal dysplasia and adenoma in transgenic mice after overexpression of an activated beta-catenin.
Romagnolo, B., Berrebi, D. D., Saadi-Keddoucci, S., Porteu, A., Pichard, A., Peuchmaur, M. M., Vandewalle, A., Kahn, A., & Perret, C. (1999) · PubMed · Cited by 118 · see citing works
Apc Deficiency Is Associated with Increased Egfr Activity in the Intestinal Enterocytes and Adenomas of C57BL/6J-Min/+ Mice
Moran, A. E., Hunt, D. H., Javid, S. H., Redston, M. S., Carothers, A. M., & Bertagnolli, M. M. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m404276200 · Cited by 112 · see citing works
Subcellular distribution of Wnt pathway proteins in normal and neoplastic colon
Anderson, C. B., Neufeld, K. L., & White, R. L. (2002) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.122235399 · Cited by 108 · see citing works
Further delineation of the phenotype resulting from BRAF or MEK1 germline mutations helps differentiate cardio‐facio‐cutaneous syndrome from Costello syndrome
Gripp, K. W., Lin, A. E., Nicholson, L., Allen, W., Cramer, A. E., Jones, K. L., Kutz, W. E., Peck, D. S., Rebolledo, M. A., Wheeler, P. G., et al. (2007) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.31815 · Cited by 95 · see citing works
Adenomatous polyposis coli proteins and cell adhesion
Bienz, M., & Hamada, F. (2004) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2004.08.001 · Cited by 80 · see citing works
Adenomatous Polyposis Coli Control of Retinoic Acid Biosynthesis Is Critical for Zebrafish Intestinal Development and Differentiation
Nadauld, L. D., Sandoval, I. T., Chidester, S., Yost, H. J., & Jones, D. A. (2004) · Journal of Biological Chemistry · doi:10.1074/jbc.m408830200 · Cited by 74 · see citing works
Self-citation
Activation of Tumor-Specific Splice Variant Rac1b by Dishevelled Promotes Canonical Wnt Signaling and Decreased Adhesion of Colorectal Cancer Cells
Esufali, S., Charames, G. S., Pethe, V. V., Buongiorno, P., & Bapat, B. V. (2007) · Cancer Research · doi:10.1158/0008-5472.can-06-2843 · Cited by 66 · see citing works
Dysregulated expression of β-catenin marks early neoplastic change in Apc mutant mice, but not all lesions arising in Msh2 deficient mice
Kongkanuntn, R., Bubb, V. J., Sansom, O. J., Wyllie, A. H., Harrison, D. J., & Clarke, A. R. (1999) · Oncogene · doi:10.1038/sj.onc.1203181 · Cited by 60 · see citing works
Adenomatous Polyposis Coli Control of C-terminal Binding Protein-1 Stability Regulates Expression of Intestinal Retinol Dehydrogenases
Nadauld, L. D., Phelps, R. A., Moore, B. C., Eisinger, A. L., Sandoval, I. T., Chidester, S., Peterson, P. W., Manos, E. J., Sklow, B., Burt, R. W., et al. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m602119200 · Cited by 60 · see citing works
Self-citation
Dual Positive and Negative Regulation of Wingless Signaling by Adenomatous Polyposis Coli
Takacs, C. M., Baird, J. R., Hughes, E. G., Kent, S. S., Benchabane, H., Paik, R., & Ahmed, Y. F. (2008) · Science · doi:10.1126/science.1151232 · Cited by 56 · see citing works
The Zebrafish Retinol Dehydrogenase, rdh1l, Is Essential for Intestinal Development and Is Regulated by the Tumor Suppressor Adenomatous Polyposis Coli
Nadauld, L. D., Shelton, D. N., Chidester, S., Yost, H. J., & Jones, D. A. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m504973200 · Cited by 45 · see citing works
Self-citation
Dual roles for adenomatous polyposis coli in regulating retinoic acid biosynthesis and Wnt during ocular development
Nadauld, L. D., Chidester, S., Shelton, D. N., Rai, K., Broadbent, T. J., Sandoval, I. T., Peterson, P. W., Manos, E. J., Ireland, C. M., Yost, H. J., et al. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0601634103 · Cited by 42 · see citing works
Self-citation
Somatic Mutations in Familial Adenomatous Polyps
Penzel, R., Sutter, C., Otto, H. F., Scholten, M., & Bläker, H. (2003) · American Journal of Clinical Pathology · doi:10.1309/4e4w-g3ay-gjnc-d11p · Cited by 36 · see citing works
Somatic Mutations in Familial Adenomatous Polyps: Nuclear Translocation of β-Catenin Requires More Than BiallelicAPCInactivation
Bläker, H., Scholten, M., Sutter, C., Otto, H. F., & Penzel, R. (2003) · American Journal of Clinical Pathology · doi:10.1309/4e4wg3aygjncd11p · Cited by 35 · see citing works
Retinoic Acid Inhibits β-Catenin through Suppression of Cox-2
Eisinger, A. L., Nadauld, L. D., Shelton, D. N., Prescott, S. M., Stafforini, D. M., & Jones, D. A. (2007) · Journal of Biological Chemistry · doi:10.1074/jbc.m609768200 · Cited by 25 · see citing works
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Castellone MD Teramoto H Williams BO Druey KM Gutkind JS 2005 Prostaglandin E2 promotes colon cancer cell growth through a Gs-axin-β-catenin signaling axis Science 310 1504 1510 16293724

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Boutin, A. T., Liao, W.-T., Wang, M., Hwang, S. S., Karpinets, T. V., Cheung, H., Chu, G. C., Jiang, S., Hu, J., Chang, K., et al. (2017) · Genes & Development · doi:10.1101/gad.293449.116 · Cited by 195 · see citing works
Wnt signaling and colon carcinogenesis: Beyond APC
Najdi, R., Holcombe, R. F., & Waterman, M. L. (2011) · Journal of Carcinogenesis · doi:10.4103/1477-3163.78111 · Cited by 185 · see citing works
Activating mutations in CTNNB1 in aldosterone producing adenomas
Åkerström, T., Maharjan, R., Willenberg, H. S., Cupisti, K., Ip, J. C. Y., Moser, A., Stalberg, P. L. H., Robinson, B. G., Iwen, K. A., Dralle, H., et al. (2016) · Scientific Reports · doi:10.1038/srep19546 · Cited by 178 · see citing works
FBXW7 influences murine intestinal homeostasis and cancer, targeting Notch, Jun, and DEK for degradation
Babaei‐Jadidi, R., Li, N., Saadeddin, A., Spencer‐Dene, B., Jandke, A., Muhammad, B. A., Ibrahim, E. E., Muraleedharan, R., Abuzinadah, M. F., Belnoue-Davis, H. L., et al. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20100830 · Cited by 172 · see citing works
Oncogenic KRAS signalling promotes the Wnt/β-catenin pathway through LRP6 in colorectal cancer
Lemieux, É., Cagnol, S., Beaudry, K., Carrier, J. C., & Rivard, N. (2014) · Oncogene · doi:10.1038/onc.2014.416 · Cited by 164 · see citing works
Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis.
Coleman, O., Lobner, E. M., Bierwirth, S., Sorbie, A., Waldschmitt, N., Rath, E., Berger, E., Lagkouvardos, I., Clavel, T., McCoy, K., et al. (2018) · Gastroenterology · doi:10.1053/j.gastro.2018.07.028 · Cited by 125 · see citing works
Vitamin D Receptor Deficiency Enhances Wnt/β-Catenin Signaling and Tumor Burden in Colon Cancer
Larriba, M. J., Ordóñez‐Morán, P., Chicote, I., Martín-Fernández, G., Puig, I., Múñoz, A., & Pálmer, H. G. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023524 · Cited by 148 · see citing works
Gut bacteria in health and disease: a survey on the interface between intestinal microbiology and colorectal cancer
Boleij, A., & Tjalsma, H. (2012) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2012.00218.x · Cited by 145 · see citing works
Similar but different: distinct roles for KRAS and BRAF oncogenes in colorectal cancer development and therapy resistance
Morkel, M., Riemer, P., Bläker, H., & Sers, C. (2015) · Oncotarget · doi:10.18632/oncotarget.4750 · Cited by 143 · see citing works
Wnt/β-catenin Signaling in Normal and Cancer Stem Cells
Valkenburg, K. C., Graveel, C. R., Diegel, C. R., Zhong, Z. A., & Williams, B. O. (2011) · Cancers · doi:10.3390/cancers3022050 · Cited by 141 · see citing works
KRT19 directly interacts with β-catenin/RAC1 complex to regulate NUMB-dependent NOTCH signaling pathway and breast cancer properties
Saha, S. K., Choi, H., Kim, B.-W., Dayem, A. A., Yang, G.-M., Kim, K. S., Yin, Y. F., & Cho, S.-G. (2016) · Oncogene · doi:10.1038/onc.2016.221 · Cited by 136 · see citing works
CtBP promotes metastasis of breast cancer through repressing cholesterol and activating TGF-β signaling
Zhao, Z., Hao, D., Wang, L., Li, J., Meng, Y., Li, P., Wang, Y., Zhang, C., Zhou, H., Gardner, K. L., et al. (2018) · Oncogene · doi:10.1038/s41388-018-0570-z · Cited by 134 · see citing works
A fresh look at zebrafish from the perspective of cancer research
Zhao, S., Huang, J., & Ye, J. (2015) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-015-0196-8 · Cited by 133 · see citing works
A Comprehensive Overview of Skeletal Phenotypes Associated with Alterations in Wnt/β-catenin Signaling in Humans and Mice
Maupin, K. A., Droscha, C. J., & Williams, B. O. (2013) · Bone Research · doi:10.4248/br201301004 · Cited by 133 · see citing works
A Quantitative Proteomic Approach of the Different Stages of Colorectal Cancer Establishes OLFM4 as a New Nonmetastatic Tumor Marker
Besson, D., Pavageau, A.-H., Valo, I., Bourreau, A., Bélanger, A., Eymerit-Morin, C., Moulière, A., Chassevent, A., Boisdron-Celle, M., Morel, A., et al. (2011) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m111.009712 · Cited by 128 · see citing works
Casein kinase 1α: biological mechanisms and theranostic potential
Jiang, S., Zhang, M., Sun, J., & Yang, X. (2018) · Cell Communication and Signaling · doi:10.1186/s12964-018-0236-z · Cited by 130 · see citing works
Differential WNT Activity in Colorectal Cancer Confers Limited Tumorigenic Potential and Is Regulated by MAPK Signaling
Horst, D. A., Chen, J., Morikawa, T., Ogino, S., Kirchner, T., & Shivdasani, R. A. (2012) · Cancer Research · doi:10.1158/0008-5472.can-11-3222 · Cited by 128 · see citing works
SLC25A22 Promotes Proliferation and Survival of Colorectal Cancer Cells With KRAS Mutations and Xenograft Tumor Progression in Mice via Intracellular Synthesis of Aspartate
Wong, C. C., Qian, Y., Li, X., Xu, J., Kang, W., TONG, J. H. M., To, K., Ye, J., Li, W., Chen, H., et al. (2016) · Gastroenterology · doi:10.1053/j.gastro.2016.07.011 · Cited by 127 · see citing works
T-cell factor 4 functions as a tumor suppressor whose disruption modulates colon cell proliferation and tumorigenesis
Angus-Hill, M. L., Elbert, K. M., Hidalgo, J., & Capecchi, M. R. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1102300108 · Cited by 118 · see citing works
Mechanisms linking pathogens-associated inflammation and cancer
Porta, C., Riboldi, E., & Sica, A. (2011) · Cancer Letters · doi:10.1016/j.canlet.2010.10.012 · Cited by 119 · see citing works
Regulation of Nur77 expression by β‐catenin and its mitogenic effect in colon cancer cells
Wu, H., Lin, Y., Li, W., Sun, Z., Gao, W., Zhang, H., Xie, L., Jiang, F., Qin, B. Y., Yan, T., et al. (2010) · The FASEB Journal · doi:10.1096/fj.10-166462 · Cited by 117 · see citing works
SHP2 Tyrosine Phosphatase Converts Parafibromin/Cdc73 from a Tumor Suppressor to an Oncogenic Driver
Takahashi, A., Tsutsumi, R., Kikuchi, I., Obuse, C., Saito, Y., Seidi, A., Karisch, R., Fernandez, M. M., Cho, T., Ohnishi, N., et al. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.05.014 · Cited by 114 · see citing works
Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling
Shah, K., & Kazi, J. U. (2022) · Frontiers in Oncology · doi:10.3389/fonc.2022.858782 · Cited by 116 · see citing works
The zebrafish as a model for cancer
Mione, M., & Trede, N. S. (2010) · Disease Models & Mechanisms · doi:10.1242/dmm.004747 · Cited by 111 · see citing works
C-terminal binding proteins: central players in development and disease
Stankiewicz, T. R., Gray, J. J., Winter, A. N., & Linseman, D. A. (2014) · BioMolecular Concepts · doi:10.1515/bmc-2014-0027 · Cited by 108 · see citing works
Dysregulation and crosstalk of cellular signaling pathways in colon carcinogenesis
Wu, W. K. K., Wang, X., Cheng, A. S. L., Luo, M. X. M., Ng, S. S. M., To, K. F., Chan, F. K. L., Cho, C. H., Sung, J. J. �., & Yu, J. Q. (2012) · Critical Reviews in Oncology/Hematology · doi:10.1016/j.critrevonc.2012.11.009 · Cited by 107 · see citing works
β‐catenin as a potential key target for tumor suppression
Fu, Y., Zheng, S., An, N., Athanasopoulos, T., Popplewell, L. J., Liang, A., Li, K., Hu, C., & Zhu, Y. (2011) · International Journal of Cancer · doi:10.1002/ijc.26102 · Cited by 101 · see citing works
The tumor suppressor adenomatous polyposis coli controls the direction in which a cell extrudes from an epithelium
Marshall, T. W., Lloyd, I. E., Delalande, J. M., Näthke, I. S., & Rosenblatt, J. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-05-0469 · Cited by 99 · see citing works
MicroRNA-224 sustains Wnt/β-catenin signaling and promotes aggressive phenotype of colorectal cancer
Li, T., Lai, Q., Wang, S., Cai, J., Xiao, Z., Deng, D., He, L., Jiao, H., Ye, Y., Liang, L., et al. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0287-1 · Cited by 92 · see citing works
DNA Demethylase Activity Maintains Intestinal Cells in an Undifferentiated State Following Loss of APC
Rai, K., Sarkar, S., Broadbent, T. J., Voas, M. G., Grossmann, K. F., Nadauld, L. D., Dehghanizadeh, S., Hagos, F. T., Li, Y., Toth, R. K., et al. (2010) · Cell · doi:10.1016/j.cell.2010.08.030 · Cited by 96 · see citing works
Self-citation
α-Catenin interacts with APC to regulate β-catenin proteolysis and transcriptional repression of Wnt target genesPreprint
Choi, S. H., Estarás, C., Moresco, J. J., Yates, J. R., & Jones, K. A. (2013) · Genes & Development · doi:10.1101/gad.229062.113 · Cited by 96 · see citing works
Musashi-1 promotes a cancer stem cell lineage and chemoresistance in colorectal cancer cells
Chiou, G., Yang, T.-W., Huang, C., Tang, C.-Y., Yen, J.-Y., Tsai, M., Chen, H., Fadhilah, N., Lin, C.-C., & Jong, Y. (2017) · Scientific Reports · doi:10.1038/s41598-017-02057-9 · Cited by 95 · see citing works
E‐cadherin can limit the transforming properties of activating β‐catenin mutations
Huels, D. J., Ridgway, R. A., Radulescu, S., Leushacke, M., Campbell, A. D., Biswas, S., Leedham, S. J., Serra, S., Chetty, R., Moreaux, G., et al. (2015) · The EMBO Journal · doi:10.15252/embj.201591739 · Cited by 95 · see citing works
Cancer stem cells in basic science and in translational oncology: can we translate into clinical application?
Schulenburg, A., Blatt, K., Cerny‐Reiterer, S., Sadovnik, I., Herrmann, H., Marian, B., Grunt, T. W., Zielinski, C. C., & Valent, P. (2015) · Journal of Hematology & Oncology · doi:10.1186/s13045-015-0113-9 · Cited by 94 · see citing works
β-Catenin Phosphorylated at Serine 45 Is Spatially Uncoupled from β-Catenin Phosphorylated in the GSK3 Domain: Implications for Signaling
Maher, M. T., Mo, R., Flozak, A. S., Peled, O. N., & Gottardi, C. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010184 · Cited by 103 · see citing works
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling
Jung, Y., Jun, S., Kim, M. J., Lee, S. H., Suh, H. N., Lien, E. M., Jung, H., Lee, S., Zhang, J., Yang, J., et al. (2018) · Nature Cell Biology · doi:10.1038/s41556-018-0219-8 · Cited by 93 · see citing works
Transcription factor co‐repressors in cancer biology: roles and targeting
Battaglia, S., Maguire, O., & Campbell, M. J. (2010) · International Journal of Cancer · doi:10.1002/ijc.25181 · Cited by 93 · see citing works
Cell type-dependent differential activation of ERK by oncogenic KRAS in colon cancer and intestinal epithelium
Brandt, R., Sell, T., Lüthen, M., Uhlitz, F., Klinger, B., Riemer, P., Giesecke‐Thiel, C., Schulze, S., El‐Shimy, I. A., Kunkel, D., et al. (2019) · Nature Communications · doi:10.1038/s41467-019-10954-y · Cited by 88 · see citing works
Epigenetic regulation of colon cancer and intestinal stem cells
Hammoud, S. S., Cairns, B. R., & Jones, D. A. (2013) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2013.01.007 · Cited by 91 · see citing works
Self-citation
Deconstructing the ßcatenin destruction complex: mechanistic roles for the tumor suppressor APC in regulating Wnt signaling
Roberts, D. M., Pronobis, M. I., Poulton, J. S., Waldmann, J. D., Stephenson, E. M., Hanna, S., & Peifer, M. A. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0871 · Cited by 90 · see citing works
Understanding the colon cancer stem cells and perspectives on treatment
Garza-Treviño, E. N., Said‐Fernández, S., & Martı́nez-Rodrı́guez, H. G. (2015) · Cancer Cell International · doi:10.1186/s12935-015-0163-7 · Cited by 89 · see citing works
Secreted Frizzled-Related Protein 4
Muley, A., Majumder, S., Kolluru, G. K., Parkinson, S., Viola, H. M., Hool, L. C., Arfuso, F., Ganß, R., Dharmarajan, A., & Chatterjee, S. (2010) · American Journal Of Pathology · doi:10.2353/ajpath.2010.090465 · Cited by 88 · see citing works
Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Jung, Y., Jun, S., Lee, S., Sharma, A., & Park, J. (2015) · Oncotarget · doi:10.18632/oncotarget.6133 · Cited by 88 · see citing works
Long-range epigenetic silencing of chromosome 5q31 protocadherins is involved in early and late stages of colorectal tumorigenesis through modulation of oncogenic pathways
Dallosso, A. R., Øster, B., Greenhough, A., Thorsen, K., Curry, T. J., Owen, C. I., Hancock, A. L., Szemes, M., Paraskeva, C., Frank, M., et al. (2012) · Oncogene · doi:10.1038/onc.2011.609 · Cited by 88 · see citing works
Therapeutic targeting of C-terminal binding protein in human cancer
Straza, M. W., Paliwal, S., Kovi, R. C., Rajeshkumar, B. R., Trenh, P., Parker, D., Whalen, G. F., Lyle, S. R., Schiffer, C. A., & Grossman, S. R. (2010) · Cell Cycle · doi:10.4161/cc.9.18.12936 · Cited by 86 · see citing works
USP8 positively regulates hepatocellular carcinoma tumorigenesis and confers ferroptosis resistance through β-catenin stabilization
Tang, J., Long, G., Liang, X., & Zhou, L. (2023) · Cell Death and Disease · doi:10.1038/s41419-023-05747-7 · Cited by 86 · see citing works
Fxr signaling and microbial metabolism of bile salts in the zebrafish intestine
Wen, J., Mercado, G. P., Volland, A., Doden, H. L., Lickwar, C. R., Crooks, T. A., Kakiyama, G., Kelly, C., Cocchiaro, J. L., Ridlon, J. M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abg1371 · Cited by 83 · see citing works
Tumor-suppressive microRNA-145 targets catenin δ-1 to regulate Wnt/β-catenin signaling in human colon cancer cells
Yamada, N. O., Noguchi, S., Mori, T., Naoe, T., Maruo, K., & Akao, Y. (2013) · Cancer Letters · doi:10.1016/j.canlet.2013.02.060 · Cited by 80 · see citing works
Oncogenic Effects of High MAPK Activity in Colorectal Cancer Mark Progenitor Cells and Persist Irrespective of RAS Mutations
Blaj, C., Schmidt, E. M., Lamprecht, S., Hermeking, H., Jung, A., Kirchner, T., & Horst, D. A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-16-2821 · Cited by 79 · see citing works
New perspectives on APC control of cell fate and proliferation in colorectal cancer
Phelps, R. A., Broadbent, T. J., Stafforini, D. M., & Jones, D. A. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9278 · Cited by 76 · see citing works
Self-citation
Patterns of DNA methylation in individual colonic crypts reveal aging and cancer-related field defects in the morphologically normal mucosa
Belshaw, N. J., Pal, N., Tapp, H. S., Dainty, J. R., Lewis, M. P., Williams, M. R., Lund, E. K., & Johnson, I. T. (2010) · Carcinogenesis · doi:10.1093/carcin/bgq077 · Cited by 76 · see citing works
Transcription Factor Oct1 Is a Somatic and Cancer Stem Cell Determinant
Maddox, J., Shakya, A., South, S., Shelton, D. N., Andersen, J. N., Chidester, S., Kang, J., Gligorich, K. M., Jones, D. A., Spangrude, G. J., et al. (2012) · PLoS Genetics · doi:10.1371/journal.pgen.1003048 · Cited by 75 · see citing works
Self-citation
Wnt signaling and colon tumorigenesis — A view from the periphery
Burgess, A. W., Faux, M. C., Layton, M. J., & Ramsay, R. G. (2011) · Experimental Cell Research · doi:10.1016/j.yexcr.2011.08.010 · Cited by 72 · see citing works
The molecular biology of colorectal carcinoma and its implications: A review
Harrison, S., & Benziger, H. (2011) · The Surgeon · doi:10.1016/j.surge.2011.01.011 · Cited by 71 · see citing works
Monensin Inhibits Canonical Wnt Signaling in Human Colorectal Cancer Cells and Suppresses Tumor Growth in Multiple Intestinal Neoplasia Mice
Tůmová, L., Pombinho, A. R., Vojtěchová, M., Stančíková, J., Gradl, D., Krausová, M., Šloncová, E., Horázná, M., Křı́ž, V., Machoňová, O., et al. (2014) · Molecular Cancer Therapeutics · doi:10.1158/1535-7163.mct-13-0625 · Cited by 71 · see citing works
Modulation of Wnt/β-catenin signaling and proliferation by a ferrous iron chelator with therapeutic efficacy in genetically engineered mouse models of cancer
Coombs, G. S., Schmitt, A., Canning, C. A., Alok, A., Low, I. C. C., Banerjee, N., Kaur, S. J., Utomo, V., Jones, C. M., Pervaiz, S., et al. (2011) · Oncogene · doi:10.1038/onc.2011.228 · Cited by 69 · see citing works
Updating the Wnt pathways
Yu, J., & Virshup, D. (2014) · Bioscience Reports · doi:10.1042/bsr20140119 · Cited by 74 · see citing works
Integration of the β-Catenin-Dependent Wnt Pathway with Integrin Signaling through the Adaptor Molecule Grb2
Crampton, S. P., Wu, B., Park, E. J., Kim, J.-H., Solomon, C., Waterman, M. L., & Hughes, C. C. W. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007841 · Cited by 68 · see citing works
MAGI-3 Competes With NHERF-2 to Negatively Regulate LPA2 Receptor Signaling in Colon Cancer Cells
Lee, S., Ritter, S. L., Zhang, H., Shim, H., Hall, R. A., & Yun, C. C. (2010) · Gastroenterology · doi:10.1053/j.gastro.2010.11.054 · Cited by 68 · see citing works
Role of retinoids in the prevention and treatment of colorectal cancer
Applegate, C. C., & Lane, M. A. (2015) · World Journal of Gastrointestinal Oncology · doi:10.4251/wjgo.v7.i10.184 · Cited by 65 · see citing works
Rac1 augments Wnt signaling by stimulating β-catenin–lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import
Jamieson, C., Lui, C., Brocardo, M. G., Martino‐Echarri, E., & Henderson, B. R. (2015) · Journal of Cell Science · doi:10.1242/jcs.167742 · Cited by 66 · see citing works
Mesalamine Inhibits Epithelial β-Catenin Activation in Chronic Ulcerative Colitis
Brown, J. B., Lee, G., Managlia, E. Z., Grimm, G. R., Dirisina, R., Goretsky, T., Cheresh, P., Blatner, N. R., Khazaie, K., Yang, G., et al. (2009) · Gastroenterology · doi:10.1053/j.gastro.2009.10.038 · Cited by 65 · see citing works
Expression of CtBP family protein isoforms in breast cancer and their role in chemoresistance
Birts, C. N., Harding, R., Soosaipillai, G., Halder, T., Azim-Araghi, A., Darley, M., Cutress, R., Bateman, A. C., & Blaydes, J. P. (2010) · Biology of the Cell · doi:10.1042/bc20100067 · Cited by 65 · see citing works
Intracellular Signals Activated by Canonical Wnt Ligands Independent of GSK3 Inhibition and β-Catenin Stabilization
de Herreros, A. G., & Duñach, M. (2019) · Cells · doi:10.3390/cells8101148 · Cited by 64 · see citing works
Bacterial Signaling at the Intestinal Epithelial Interface in Inflammation and Cancer
Coleman, O. I., & Haller, D. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2017.01927 · Cited by 65 · see citing works
Wnt Signaling in Mammary Glands: Plastic Cell Fates and Combinatorial SignalingPreprint
Alexander, C. M., Goel, S., Fakhraldeen, S. A., & Kim, S. (2012) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a008037 · Cited by 62 · see citing works
Transforming activity and therapeutic targeting of C-terminal-binding protein 2 in Apc-mutated neoplasia
Sumner, E. T., Chawla, A. T., Cororaton, A. D., Koblinski, J. E., Kovi, R. C., Love, I. M., Szomju, B. B., Korwar, S., Ellis, K. C., & Grossman, S. R. (2017) · Oncogene · doi:10.1038/onc.2017.106 · Cited by 61 · see citing works
Inactivation of promoter 1B of APC causes partial gene silencing: evidence for a significant role of the promoter in regulation and causative of familial adenomatous polyposis
Rohlin, A., Engwall, Y., Fritzell, K., Göransson, K., Bergsten, A., Einbeigi, Z., Nilbert, M. C., Karlsson, P., Björk, J. A., & Nordling, M. (2011) · Oncogene · doi:10.1038/onc.2011.201 · Cited by 61 · see citing works
Interaction of the Wnt/β-catenin and RAS-ERK pathways involving co-stabilization of both β-catenin and RAS plays important roles in the colorectal tumorigenesis
Lee, S.-K., Hwang, J.-H., & Choi, K.-Y. (2018) · Advances in Biological Regulation · doi:10.1016/j.jbior.2018.01.001 · Cited by 61 · see citing works
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression
Wang, C., Zhao, R., Huang, P., Yang, F., Quan, Z., Xu, N., & Xi, R. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.03.020 · Cited by 60 · see citing works
Zebrafish as a Model for the Study of Human Cancer
Etchin, J., Kanki, J. P., & Look, A. T. (2011) · Methods in cell biology · doi:10.1016/b978-0-12-381320-6.00013-8 · Cited by 59 · see citing works
WNT signaling and distant metastasis in colon cancer through transcriptional activity of nuclear β-Catenin depend on active PI3K signaling
Ormanns, S., Neumann, J. H. L., Horst, D. A., Kirchner, T., & Jung, A. (2014) · Oncotarget · doi:10.18632/oncotarget.1626 · Cited by 59 · see citing works
Colorectal cancers choosing sides
Albuquerque, C. M., Bakker, E. R. M., van Veelen, W., & Smits, R. (2011) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/j.bbcan.2011.07.005 · Cited by 59 · see citing works
Recent Updates on the Significance of KRAS Mutations in Colorectal Cancer Biology
László, L., Kurilla, A., Takács, T., Kudlik, G., Koprivanacz, K., Buday, L., & Vas, V. (2021) · Cells · doi:10.3390/cells10030667 · Cited by 58 · see citing works
Smooth Muscle Tension Induces Invasive Remodeling of the Zebrafish Intestine
Seiler, C., Davuluri, G., Abrams, J., Byfield, F. J., Janmey, P. A., & Pack, M. A. (2012) · PLoS Biology · doi:10.1371/journal.pbio.1001386 · Cited by 58 · see citing works

New perspectives on APC control of cell fate and proliferation in colorectal cancer
Phelps, R. A., Broadbent, T. J., Stafforini, D. M., & Jones, D. A. (2009) · Cell Cycle · doi:10.4161/cc.8.16.9278 · Cited by 76 · see citing works
Self-citation
Subcellular localization of β-catenin and APC proteins in colorectal preneoplastic and neoplastic lesions
Sena, P., Saviano, M., Monni, S., Losi, L., Roncucci, L., Marzona, L., & Pol, A. D. (2005) · Cancer Letters · doi:10.1016/j.canlet.2005.10.011 · Cited by 29 · see citing works
Nuclear β‐catenin expression and Wnt signalling: in defence of the dogma
Fodde, R., & Tomlinson, I. P. M. (2010) · The Journal of Pathology · doi:10.1002/path.2718 · Cited by 40 · see citing works
APC loss-induced intestinal tumorigenesis in Drosophila: Roles of Ras in Wnt signaling activation and tumor progression
Wang, C., Zhao, R., Huang, P., Yang, F., Quan, Z., Xu, N., & Xi, R. (2013) · Developmental Biology · doi:10.1016/j.ydbio.2013.03.020 · Cited by 60 · see citing works
APC loss promotes intestinal transformation through induction of bistable stem cell statesPreprint
Li, N., Myers, R., Zhu, Q., Tian, Y., Durning, K., Wang, X., Leu, N., Rhoades, J., Bankler-Jukes, D., Monaghan, K., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.03.06.641686 · Cited by 1 · see citing works

Authors: Phelps, R. A., Chidester, S., Dehghanizadeh, S., Phelps, J., Sandoval, I. T., Rai, K., Broadbent, T., Sarkar, S., Burt, R. W., & Jones, D. A.
Affiliations: University of Utah (US)
Corresponding author: Jones, David A.
ORCID: Chidester, Stephanie
Dehghanizadeh, Somaye
Sandoval, Imelda T.
Rai, Kunal
Sarkar, Sharmistha
Jones, David A.
Venue: Cell
Publisher: Elsevier BV
Published: 2009-05
Volume: 137
Issue: 4
Pages: 623-634
ISSN: 0092-8674 (ISSN-L)
DOI: 10.1016/j.cell.2009.02.037
PMC: PMC2706149
OpenAlex: W2018425992
Cited by: 286
References: 51
Citations by year: 2026: 2 · 2025: 3 · 2024: 5 · 2023: 9 · 2022: 8 · 2021: 13 · 2020: 11 · 2019: 14 · 2018: 14 · 2017: 18 · 2016: 22 · 2015: 23 · 2014: 17 · 2013: 23 · 2012: 28
FWCI: 13.97
Type: journal article
Language: en
Open access: bronze
doi.org
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/open-access/userlicense/1.0/ (vor, 1538 d)
Locations: Cell (publishedVersion)
PubMed (publishedVersion)
PubMed Central (acceptedVersion)
Funders: Huntsman Cancer Foundation
National Institutes of Health (5p01ca073992-15)
National Cancer Institute (R01CA116468, P01‐CA073992, CA96934, CA042014, CA073992, P30CA042014)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Wnt/β-catenin signaling in development and cancer
Health Sciences › Medicine › Pathology and Forensic Medicine › Genetic factors in colorectal cancer
Health Sciences › Medicine › Oncology › Colorectal Cancer Treatments and Studies
Keywords: colonic adenoma, APC loss, Wnt/β-catenin signaling, β-catenin nuclear localization, CtBP1, KRAS activation, intestinal cell differentiation, intestinal cell proliferation, familial adenomatous polyposis, colorectal cancer, zebrafish
MeSH terms: Adenoma, Alcohol Oxidoreductases, Animals, Cell Differentiation, Colonic Neoplasms, DNA-Binding Proteins, Humans, Peptide Fragments, Adenomatous Polyposis Coli, Zebrafish, Signal Transduction, Gene Expression Regulation, Neoplastic, ras Proteins, Proto-Oncogene Proteins c-raf, rac1 GTP-Binding Protein, Adenomatous Polyposis Coli Protein, beta Catenin

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A two-step model for colon adenoma initiation and progression caused by APC loss

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