Quinolines derivatives as novel sunscreening agents
Abstract
Currently, the research and development of sunscreens play an important role on the synthesis of actives that are stable in various kinds of formulations-in addition to their efficiency and broad spectrum of protection against ultraviolet radiation. Our objective here was to synthesize new sunscreening chemical agents using quinoline as a base molecule. Twelve quinoline derivatives were synthesized, four of them novel molecules, and their photoprotective activity was determined in vitro using diffuse transmittance spectrophotometry. We determined their SPF, UVAPF, UVA/UVB ratio, critical wavelength and Boots Star Rating. The quinolines derivatives presented a varied profile of photoprotection, their SPF ranging from 2 to 11 and their UVAPF from 2 to 7. In terms of the critical wavelength, all molecules were considered of broad-spectrum by different classifications. Regarding the Boots Star Rating, one compound received no rating, seven of them received a three stars rating, three received a four stars rating and three were given a five stars rating. The molecules showed in the present work have a wide range of possibilities for creating new sunscreen products, once they have good SPF or UVAPF for single molecules, and they also possess other different qualities that can act synergistically.
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Quinoline derivative 176 is considered the most promising compound among 167-178, with the highest SPF value.
“Other potential synthetic UV filters with different scaffolds have been described, namely those with heterocyclic rings, such as the new UV absorbers 167–178 based on quinoline derivatives with SPF and λc values between 2 and 11 and 376 and 388 nm, respectively, being the quinoline derivative 176 considered as the most promising compound with the highest SPF value [143].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [143]
Quinoline derivatives 167-178 have λc values between 376 and 388 nm.
“Other potential synthetic UV filters with different scaffolds have been described, namely those with heterocyclic rings, such as the new UV absorbers 167–178 based on quinoline derivatives with SPF and λc values between 2 and 11 and 376 and 388 nm, respectively, being the quinoline derivative 176 considered as the most promising compound with the highest SPF value [143].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [143]
Quinoline derivatives 167-178 have SPF values between 2 and 11.
“Other potential synthetic UV filters with different scaffolds have been described, namely those with heterocyclic rings, such as the new UV absorbers 167–178 based on quinoline derivatives with SPF and λc values between 2 and 11 and 376 and 388 nm, respectively, being the quinoline derivative 176 considered as the most promising compound with the highest SPF value [143].”
From UV Filters: Challenges and Prospects (2022) · cites this paper as [143]
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- Authors
- Polonini, H. C., Dias, R. M. P., Souza, I. O., Gonçalves, K. M., Gomes, T. B. B., Raposo, N. R. B., & da Silva, A. D.
- Affiliations
- Universidade Federal de Juiz de Fora (BR)
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 23
- Issue
- 16
- Pages
- 4506-4510
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2025073554
- Cited by
- 13
- References
- 19
- Citations by year
- 2024: 3 · 2022: 2 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2015: 2 · 2014: 1
- FWCI
- 1.17
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Fundação de Amparo à Pesquisa do Estado de Minas Gerais
- Universidade Federal de Juiz de Fora
- Pró-Reitoria de Pesquisa, Universidade Federal do Rio Grande do Sul
- Topics
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Physical Sciences › Materials Science › Materials Chemistry › Photochromic and Fluorescence Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Synthesis and biological activity
- Keywords
- quinoline derivatives, UV filters, photoprotection, sun protection factor, UV absorption, critical wavelength, UV protection, chemical synthesis
- MeSH terms
- Chemistry, Pharmaceutical, Quinolines, Spectrophotometry, Sunscreening Agents, Molecular Structure
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