Protective effect of Opuntia ficus-indica L. cladodes against UVA-induced oxidative stress in normal human keratinocytes
Abstract
Opuntia ficus-indica L. is known for its beneficial effects on human health, but still little is known on cladodes as a potent source of antioxidants. Here, a direct, economic and safe method was set up to obtain water extracts from Opuntia ficus-indica cladodes rich in antioxidant compounds. When human keratinocytes were pre-treated with the extract before being exposed to UVA radiations, a clear protective effect against UVA-induced stress was evidenced, as indicated by the inhibition of stress-induced processes, such as free radicals production, lipid peroxidation and GSH depletion. Moreover, a clear protective effect against apoptosis in pre-treated irradiated cells was evidenced. We found that eucomic and piscidic acids were responsible for the anti-oxidative stress action of cladode extract. In conclusion, a bioactive, safe, low-cost and high value-added extract from Opuntia cladodes was obtained to be used for skin health/protection.
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Water extracts from Opuntia ficus-indica L. cladodes have beneficial effects on human keratinocytes.
“In another paper, we showed the beneficial effects of water extracts from Opuntia ficus-indica L. cladodes on human keratinocytes [91].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [91]
Eucomic and piscidic acids were the main active molecules responsible for protection of keratinocytes against UVA-induced oxidative stress and apoptosis.
“In particular, the phenolic compounds eucomic and piscidic acids were found to be the main active molecules responsible for the protection of keratinocytes against the UVA-induced oxidative stress and apoptosis [91].”
From Antioxidants from Plants Protect against Skin Photoaging (2018) · cites this paper as [91]
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- Authors
- Petruk, G., Di Lorenzo, F., Imbimbo, P., Silipo, A., Bonina, A., Rizza, L., Piccoli, R., Monti, D. M., & Lanzetta, R.
- Affiliations
- University of Naples Federico II (IT)
- Bionap Srl (Italy) (IT)
- Istituto Nazionale Biostrutture e Biosistemi (IT)
- Corresponding author
- Monti, Daria Maria
- Lanzetta, Rosa
- Venue
- Bioorganic & Medicinal Chemistry Letters
- Publisher
- Elsevier BV
- Published
- 2017-12
- Volume
- 27
- Issue
- 24
- Pages
- 5485-5489
- ISSN
- 0960-894X (ISSN-L)
- OpenAlex
- W2765287340
- Cited by
- 45
- References
- 27
- Citations by year
- 2026: 3 · 2025: 3 · 2024: 6 · 2023: 7 · 2022: 7 · 2021: 7 · 2020: 4 · 2019: 5 · 2018: 3
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Bioorganic & Medicinal Chemistry Letters (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Food Science › Botanical Research and Applications
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- Opuntia ficus-indica, cladodes, UVA, oxidative stress, keratinocytes, antioxidant activity, lipid peroxidation, glutathione depletion, apoptosis, skin protection, aqueous extract
- MeSH terms
- Antioxidants, Cell Line, Cell Survival, Glutathione, Humans, Plant Extracts, Ultraviolet Rays, Keratinocytes, Reactive Oxygen Species, Oxidative Stress, Protective Agents, Opuntia
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