Functional Connectivity of the Striatum in Schizophrenia and Psychotic Bipolar Disorder
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Background The striatum is abnormal in schizophrenia and possibly represents a common neurobiological mechanism underlying psychotic disorders. Resting-state functional magnetic resonance imaging studies have not reached a consensus regarding striatal dysconnectivity in schizophrenia, although these studies generally find impaired frontoparietal and salience network connectivity. The goal of the current study was to clarify the pattern of corticostriatal connectivity, including whether corticostriatal dysconnectivity is transdiagnostic and extends into psychotic bipolar disorder. Methods We examined corticostriatal functional connectivity in 60 healthy subjects and 117 individuals with psychosis, including 77 with a schizophrenia spectrum illness and 40 with psychotic bipolar disorder. We conducted a cortical seed-based region-of-interest analysis with follow-up voxelwise analysis for any significant results. Further, a striatum seed-based analysis was conducted to examine group differences in connectivity between the striatum and the whole cortex. Results Cortical region-of-interest analysis indicated that overall connectivity of the salience network with the striatum was reduced in psychotic disorders, which follow-up voxelwise analysis localized to the left putamen. Striatum seed-based analyses showed reduced ventral rostral putamen connectivity with the salience network portion of the medial prefrontal cortex in both schizophrenia and psychotic bipolar disorder. Conclusions The current study found evidence of transdiagnostic corticostriatal dysconnectivity in both schizophrenia and psychotic bipolar disorder, including reduced salience network connectivity, as well as reduced connectivity between the putamen and the medial prefrontal cortex. Overall, the current study points to the relative importance of salience network hypoconnectivity in psychotic disorders.
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Various conditions including Parkinson's disease and psychiatric disorders are accompanied by striatal dysfunction.
“APOE4 non-carriers demonstrated a distinct pattern of reduced striatal intracellular integrity (caudate RI) with cognitive impairment, which may point to AD-independent striatal contributions to clinical symptoms, as various conditions including Parkinson’s disease and psychiatric disorders are accompanied by striatal dysfunction [52, 53].”
From Effects of APOE2 and APOE4 on brain microstructure in older adults: modification by age, sex, and cognitive status (2024) · cites this paper as [53]
The Introduction links striatal abnormalities and altered cortico-striatal connectivity to schizophrenia and other psychotic disorders. It does not address Parkinson’s disease, so this source supports only the psychiatric-disorders part of the attributed claim. (LLM, conf=0.88)
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- Authors
- Karcher, N. R., Rogers, B. P., & Woodward, N. D.
- Affiliations
- Washington University in St. Louis (US)
- Vanderbilt University (US)
- Vanderbilt University Medical Center (US)
- Corresponding author
- Karcher, Nicole R.
- Venue
- Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
- Publisher
- Elsevier BV
- Published
- 2019-11
- Volume
- 4
- Issue
- 11
- Pages
- 956-965
- ISSN
- 2451-9022 (ISSN-L)
- PMC
- PMC6842092
- OpenAlex
- W2949896284
- Cited by
- 65
- References
- 72
- Citations by year
- 2026: 1 · 2025: 8 · 2024: 13 · 2023: 9 · 2022: 17 · 2021: 6 · 2020: 11
- FWCI
- 4.94
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Biological Psychiatry Cognitive Neuroscience and Neuroimaging (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Mental Health
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Keywords
- striatum, corticostriatal connectivity, schizophrenia, psychotic bipolar disorder, salience network, putamen, medial prefrontal cortex, resting-state functional connectivity, psychosis
- MeSH terms
- Adult, Affective Disorders, Psychotic, Bipolar Disorder, Cerebral Cortex, Corpus Striatum, Female, Humans, Magnetic Resonance Imaging, Male, Nerve Net, Psychotic Disorders, Putamen, Schizophrenia, Prefrontal Cortex, Young Adult, Connectome
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