Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration
Abstract
Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.
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IRP2 may have the primary role in ferritin regulation in response to iron.
“These facts suggest that although both IRPs control ferritin expression in vitro (161), IRP2 may have the primary role in ferritin regulation in response to iron.”
From Intracellular iron transport and storage: from molecular mechanisms to health implications (2008) · cites this paper as [161]
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- Authors
- Kaur, D., Rajagopalan, S., Chinta, S., Kumar, J., Di Monte, D., Cherny, R. A., & Andersen, J. K.
- Affiliations
- Buck Institute for Research on Aging (US)
- Mental Health Research Institute (AU)
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2007-04
- Volume
- 1140
- Pages
- 188-194
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2050979983
- Cited by
- 36
- References
- 27
- Citations by year
- 2021: 1 · 2020: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 4
- FWCI
- 2.52
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
- Topics
- Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
- Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Keywords
- ferritin, iron overload, dopaminergic neurons, substantia nigra, midbrain, age-related neurodegeneration, Parkinson's disease, neurodegeneration
- MeSH terms
- Age Factors, Aging, Animals, Dopamine, Exploratory Behavior, Ferritins, Fluoresceins, Humans, Magnetic Resonance Imaging, Mice, Transgenic, Nerve Degeneration, Neurons, Organic Chemicals, Substantia Nigra, Tyrosine 3-Monooxygenase, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Gene Expression, Silver Staining, Mice
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