Cited by 36Parkinson's Disease Mechanisms and TreatmentsNeurological diseases and metabolismIron Metabolism and Disorders

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration

Kaur, Deepinder, Rajagopalan, Subramanian, Chinta, Shankar, Kumar, Jyothi, Di Monte, Donato, Cherny, Robert A., Andersen, Julie K.·2007·Brain Research

Abstract

Ferritin elevation has been reported by some laboratories to occur within the substantia nigra (SN), the area of the brain affected in Parkinson's disease (PD), but whether such an increase could be causatively involved in neurodegeneration associated with the disorder is unknown. Here, we report that chronic ferritin elevation in midbrain dopamine-containing neurons results in a progressive age-related neurodegeneration of these cells. This provides strong evidence that chronic ferritin overload could be directly involved in age-related neurodegeneration such as occurs in Parkinson's and other related diseases.

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Crossref · 10.1016/j.brainres.2006.03.006

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Authors
Kaur, D., Rajagopalan, S., Chinta, S., Kumar, J., Di Monte, D., Cherny, R. A., & Andersen, J. K.
Affiliations
  • Buck Institute for Research on Aging (US)
  • Mental Health Research Institute (AU)
Venue
Brain Research
Publisher
Elsevier BV
Published
2007-04
Volume
1140
Pages
188-194
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2050979983
Cited by
36
References
27
Citations by year
2021: 1 · 2020: 1 · 2017: 3 · 2016: 1 · 2015: 1 · 2014: 4 · 2013: 1 · 2012: 4
FWCI
2.52
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health
  • National Institute of Neurological Disorders and Stroke (R01NS041264, NS41264)
Topics
  • Health Sciences › Medicine › Neurology › Parkinson's Disease Mechanisms and Treatments
  • Life Sciences › Neuroscience › Neurology › Neurological diseases and metabolism
  • Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Keywords
ferritin, iron overload, dopaminergic neurons, substantia nigra, midbrain, age-related neurodegeneration, Parkinson's disease, neurodegeneration
MeSH terms
Age Factors, Aging, Animals, Dopamine, Exploratory Behavior, Ferritins, Fluoresceins, Humans, Magnetic Resonance Imaging, Mice, Transgenic, Nerve Degeneration, Neurons, Organic Chemicals, Substantia Nigra, Tyrosine 3-Monooxygenase, 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine, Gene Expression, Silver Staining, Mice

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