Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

A comprehensive genetic map of the human genome based on 5,264 microsatellites

Dib, C., Fauré, S., Fizames, C., Samson, D. S., Drouot, N., Alain Vignal, A., Millasseau, P., Marc, S., Kazan, J., Seboun, E., et al. (1996) · Nature · doi:10.1038/380152a0 · Cited by 2,927 · see citing works

The ferritins: molecular properties, iron storage function and cellular regulation

Harrison, P. M., & Arosio, P. (1996) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/0005-2728(96)00022-9 · Cited by 2,667 · see citing works

Multilocus linkage analysis in humans: detection of linkage and estimation of recombination.

Lathrop, M. G., Lalouel, J.-M., Julier, C., & Ott, J. (1985) · Europe PMC (PubMed Central) · Cited by 1,228 · see citing works

Altered Brain Metabolism of Iron as a Cause of Neurodegenerative Diseases?

Gerlach, M., Ben‐Shachar, D., Riederer, P. F., & Youdim, M. B. H. (1994) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.1994.63030793.x · Cited by 704 · see citing works

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

LaVaute, T., Smith, S., Cooperman, S., Iwai, K., Land, W., Meyron-Holtz, E., Drake, S. K., Miller, G., Abu-Asab, M., Tsokos, M., et al. (2001) · Nature Genetics · doi:10.1038/84859 · Cited by 509 · see citing works

Comparison of the three-dimensional structures of recombinant human H and horse L ferritins at high resolution 1 1Edited by R. Huber

Hempstead, P. D., Yewdall, S. J., Fernie, A. R., Lawson, D. M., Artymiuk, P. J., Rice, D. W., Ford, G. C., & Harrison, P. M. (1997) · Journal of Molecular Biology · doi:10.1006/jmbi.1997.0970 · Cited by 318 · see citing works

Alterations in levels of iron, ferritin, and other trace metals in neurodegenerative diseases affecting the basal ganglia

Dexter, D. T., Jenner, P. G., Schapira, A. H. V., & MARSDEN, C. D. (1992) · Annals of Neurology · doi:10.1002/ana.410320716 · Cited by 292 · see citing works

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

Hilditch-Maguire, P. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.19.2789 · Cited by 226 · see citing works

Histochemical Distribution of Non-Haem Iron in the Human Brain

Morris, C. M., Candy, J., Oakley, A. E., Bloxham, C. A., & Edwardson, J. A. (1992) · Cells Tissues Organs · doi:10.1159/000147312 · Cited by 218 · see citing works

Metals and free radicals in neurodegeneration

Olanow, C. W., & Arendash, G. W. (1994) · Current Opinion in Neurology · doi:10.1097/00019052-199412000-00013 · Cited by 196 · see citing works

An integrated metric physical map of human chromosome 19

Ashworth, L. K., Batzer, M. A., Brandriff, B. F., et al. (1995) · Nature Genetics · doi:10.1038/ng1295-422 · Cited by 163 · see citing works

Homozygosity mapping of Hallervorden–Spatz syndrome to chromosome 20p12.3–p13

Taylor, T. D., Litt, M. J., Kramer, P., Pandolfo, M., Angelini, L., Nardocci, N., Davis, S., Pineda, M., Hattori, H., Flett, P. J., et al. (1996) · Nature Genetics · doi:10.1038/ng1296-479 · Cited by 149 · see citing works

Human frataxin maintains mitochondrial iron homeostasis in Saccharomyces cerevisiae

Cavadini, P. (2000) · Human Molecular Genetics · doi:10.1093/hmg/9.17.2523 · Cited by 141 · see citing works

Characterization of a Nonsense Mutation in the Ceruloplasmin Gene Resulting in Diabetes and Neurodegenerative Disease

Takahashi, Y., Miyajima, H., Shirabe, S., Nagataki, S., Suenaga, A., & Gitlin, J. D. (1996) · Human Molecular Genetics · doi:10.1093/hmg/5.1.81 · Cited by 118 · see citing works

Cloning of the gene coding for human L apoferritin

Santoro, C., Marone, M., Ferrone, M., Costanzo, F. S., Colombo, M., Minganti, C., Cortese, R., & Silengo, L. (1986) · Nucleic Acids Research · doi:10.1093/nar/14.7.2863 · Cited by 101 · see citing works

Relative positions of two clusters of human α-L-fucosyltransferases in 19q (FUT1–FUT2) and 19p (FUT6–FUT3–FUT5) within the microsatellite genetic map of chromosome 19

Reguigne-Arnould, I., Couillin, P., Mollicone, R., et al. (2008) · Cytogenetics and Cell Genetics · doi:10.1159/000134098 · Cited by 81 · see citing works

Genetic Disorders Affecting Proteins of Iron Metabolism: Clinical Implications

Sheth, S., & Brittenham, G. M. (2000) · Annual Review of Medicine · doi:10.1146/annurev.med.51.1.443 · Cited by 74 · see citing works

Iron, metalloenzymes and cytotoxic reactions.

Nappi, A. J., & Vass, E. (2000) · PubMed · Cited by 56 · see citing works

Human ferritin H and L sequences lie on ten different chromosomes

McGill, J., Naylor, S. L., Sakaguchi, A. Y., Moore, C., Boyd, D. H., Barrett, K., Shows, T. B., & Drysdale, J. (1987) · Human Genetics · doi:10.1007/bf00283053 · Cited by 46 · see citing works

Human ferritin genes: chromosomal assignments and polymorphisms.

Gatti, R. A., Shaked, R., Mohandas, T. K., et al. (1987) · PubMed · Cited by 32 · see citing works

The diagnostic value of serum ferritin determinations for assessing iron status.

Worwood, M. (1987) · PubMed · Cited by 13 · see citing works

Cooperativity of Mutational Effects within a Six Amino Acid Residues Substitution That Induces a Major Conformational Change in Human H Ferritin

Jappelli, R., & Cesareni, G. (1998) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1998.9317 · Cited by 8 · see citing works

Mutational Analysis of Loading of Iron into Rat Liver Ferritin by Ceruloplasmin

Juan, S., & Aust, S. D. (1999) · Archives of Biochemistry and Biophysics · doi:10.1006/abbi.1998.0998 · Cited by 5 · see citing works

Regulation of ferritin genes and protein

Torti, F. M., & Torti, S. V. (2002) · Blood · doi:10.1182/blood.v99.10.3505 · Cited by 1,173 · see citing works

Iron metabolism and toxicity

Papanikolaou, G., & Pantopoulos, K. (2005) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.06.021 · Cited by 1,070 · see citing works

Imaging iron stores in the brain using magnetic resonance imaging

Haacke, E. M., Cheng, N. Y. C., House, M. J., Liu, Q., Neelavalli, J., Ogg, R. J., Khan, A., Ayaz, M., Kirsch, W., & Obenaus, A. (2005) · Magnetic Resonance Imaging · doi:10.1016/j.mri.2004.10.001 · Cited by 995 · see citing works

Ferritins: A family of molecules for iron storage, antioxidation and more

Arosio, P., Ingrassia, R., & Cavadini, P. (2009) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2008.09.004 · Cited by 886 · see citing works

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

Kaur, D., Yantiri, F., Rajagopalan, S., Kumar, J., Mo, J. Q., Boonplueang, R., Viswanath, V., Jacobs, R., Yang, L., Beal, M. F., et al. (2003) · Neuron · doi:10.1016/s0896-6273(03)00126-0 · Cited by 620 · see citing works

Copper and iron disorders of the brain

Madsen, E., & Gitlin, J. D. (2007) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.30.051606.094232 · Cited by 557 · see citing works

Intracellular iron transport and storage: from molecular mechanisms to health implications

Mackenzie, E. L., Iwasaki, K., & Tsuji, Y. (2008) · Antioxidants & Redox Signaling · doi:10.1089/ars.2007.1893 · Cited by 526 · see citing works

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

Zecca, L., Stroppolo, A., Gatti, A., Tampellini, D., Toscani, M., Gallorini, M., Giaveri, G., Arosio, P., Santambrogio, P., Fariello, R. G., et al. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0403495101 · Cited by 495 · see citing works

Mammalian iron metabolism and its control by iron regulatory proteins

Anderson, C. P., Shen, M., Eisenstein, R. S., & Leibold, E. A. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2012.05.010 · Cited by 493 · see citing works

Iron Toxicity in Diseases of Aging: Alzheimer's Disease, Parkinson's Disease and Atherosclerosis

Altamura, S., & Muckenthaler, M. U. (2009) · Journal of Alzheimer's Disease · doi:10.3233/jad-2009-1010 · Cited by 369 · see citing works

Clinical and genetic delineation of neurodegeneration with brain iron accumulation

Gregory, A., Polster, B. J., & Hayflick, S. J. (2009) · Journal of Medical Genetics · doi:10.1136/jmg.2008.061929 · Cited by 364 · see citing works

Mechanisms of Brain Iron Transport: Insight into Neurodegeneration and CNS Disorders

Mills, E., Dong, X.-P., Wang, F., & Xu, H. (2010) · Future Medicinal Chemistry · doi:10.4155/fmc.09.140 · Cited by 309 · see citing works

Molecular control of vertebrate iron homeostasis by iron regulatory proteins

Wallander, M. L., Leibold, E. A., & Eisenstein, R. S. (2006) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2006.05.004 · Cited by 287 · see citing works

Brain Iron Metabolism

Rouault, T. A., & Cooperman, S. (2006) · Seminars in Pediatric Neurology · doi:10.1016/j.spen.2006.08.002 · Cited by 280 · see citing works

The choreography of neuroinflammation in Huntington's disease

Crotti, A., & Glass, C. K. (2015) · Trends in Immunology · doi:10.1016/j.it.2015.04.007 · Cited by 276 · see citing works

Individual dopaminergic neurons show raised iron levels in Parkinson disease

Oakley, A. E., Collingwood, J. F., Dobson, J., Love, G., Perrott, H. R., Edwardson, J. A., Elstner, M., & Morris, C. M. (2007) · Neurology · doi:10.1212/01.wnl.0000262033.01945.9a · Cited by 273 · see citing works

In vivo detection of iron and Neuromelanin by transcranial sonography: a new approach for early detection of substantia nigra damage

Zecca, L., Berg, D., Arzberger, T., Ruprecht, P., Rausch, W. D., Musicco, M., Tampellini, D., Riederer, P., Gerlach, M., & Becker, G. (2005) · Movement Disorders · doi:10.1002/mds.20550 · Cited by 214 · see citing works

Clinical features and natural history of neuroferritinopathy caused by the FTL1 460InsA mutation

Chinnery, P. F., Crompton, D. E., Birchall, D., Jackson, M. J., Coulthard, A., Lombes, A., Quinn, N., Wills, A., Fletcher, N., Mottershead, J. P., et al. (2006) · Brain · doi:10.1093/brain/awl319 · Cited by 205 · see citing works

DNA and mRNA elements with complementary responses to hemin, antioxidant inducers, and iron control ferritin-L expression

Hintze, K. J., & Theil, E. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0505148102 · Cited by 199 · see citing works

A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease

Mastroberardino, P. G., Hoffman, E. K., Horowitz, M. P., Betarbet, R., Taylor, G., Cheng, D., Na, H. M., Gutekunst, C.-A., Gearing, M., Trojanowski, J. Q., et al. (2009) · Neurobiology of Disease · doi:10.1016/j.nbd.2009.02.009 · Cited by 195 · see citing works

“Pumping iron”—how macrophages handle iron at the systemic, microenvironmental, and cellular levels

Nairz, M., Theurl, I., Swirski, F. K., & Weiss, G. (2017) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-017-1944-8 · Cited by 178 · see citing works

Neurodegeneration with brain iron accumulation: update on pathogenic mechanisms

Levi, S., & Finazzi, D. (2014) · Frontiers in Pharmacology · doi:10.3389/fphar.2014.00099 · Cited by 164 · see citing works

Huntingtin-deficient zebrafish exhibit defects in iron utilization and development

Lumsden, A. L., Henshall, T. L., Dayan, S., Lardelli, M. T., & Richards, R. I. (2007) · Human Molecular Genetics · doi:10.1093/hmg/ddm138 · Cited by 156 · see citing works

Neurodegeneration with brain iron accumulation–clinical syndromes and neuroimaging

Schipper, H. M. (2012) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2011.06.016 · Cited by 141 · see citing works

Analysis of the biologic functions of H- and L-ferritins in HeLa cells by transfection with siRNAs and cDNAs: evidence for a proliferative role of L-ferritin

Cozzi, A., Corsi, B., Levi, S., Santambrogio, P., Biasiotto, G., & Arosio, P. (2004) · Blood · doi:10.1182/blood-2003-06-1842 · Cited by 132 · see citing works

Does cellular iron dysregulation play a causative role in Parkinson’s disease?

Kaur, D., & Andersen, J. (2004) · Ageing Research Reviews · doi:10.1016/j.arr.2004.01.003 · Cited by 123 · see citing works

Genetics of neurodegeneration with brain iron accumulation

Gregory, A., & Hayflick, S. J. (2011) · Current Neurology and Neuroscience Reports · doi:10.1007/s11910-011-0181-3 · Cited by 104 · see citing works

Mutant Ferritin L-chains That Cause Neurodegeneration Act in a Dominant-negative Manner to Reduce Ferritin Iron Incorporation

Luscieti, S., Santambrogio, P., Langlois d'Estaintot, B., Granier, T., Cozzi, A., Poli, M., Gallois, B., Finazzi, D., Cattaneo, A., Levi, S., et al. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.096404 · Cited by 51 · see citing works

Human L-ferritin deficiency is characterized by idiopathic generalized seizures and atypical restless leg syndrome

Cozzi, A., Santambrogio, P., Privitera, D., Broccoli, V., Rotundo, L. I., Garavaglia, B., Benz, R., Altamura, S., Goede, J. S., Muckenthaler, M. U., et al. (2013) · Journal of Experimental Medicine · doi:10.1084/jem.20130315 · Cited by 47 · see citing works

Neuroferritinopathy: a new inborn error of iron metabolism

Keogh, M. J., Jonas, P., Coulthard, A., Chinnery, P. F., & Burn, J. (2012) · Neurogenetics · doi:10.1007/s10048-011-0310-9 · Cited by 49 · see citing works

A mutant light-chain ferritin that causes neurodegeneration has enhanced propensity toward oxidative damage

Baraibar, M. A., Barbeito, A. G., Muhoberac, B. B., & Vidal, R. (2012) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2012.02.015 · Cited by 45 · see citing works

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

Kaur, D., & Andersen, J. K. (2002) · Aging Cell · doi:10.1046/j.1474-9728.2002.00001.x · Cited by 44 · see citing works

Characterization of the l-ferritin variant 460InsA responsible of a hereditary ferritinopathy disorder

Cozzi, A., Santambrogio, P., Corsi, B., Campanella, A., Arosio, P., & Levi, S. (2006) · Neurobiology of Disease · doi:10.1016/j.nbd.2006.05.004 · Cited by 38 · see citing works

Chronic ferritin expression within murine dopaminergic midbrain neurons results in a progressive age-related neurodegeneration

Kaur, D., Rajagopalan, S., Chinta, S., Kumar, J., Di Monte, D., Cherny, R. A., & Andersen, J. K. (2007) · Brain Research · doi:10.1016/j.brainres.2006.03.006 · Cited by 36 · see citing works

Iron loading-induced aggregation and reduction of iron incorporation in heteropolymeric ferritin containing a mutant light chain that causes neurodegeneration

Muhoberac, B. B., Baraibar, M. A., & Vidal, R. (2011) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2010.10.010 · Cited by 31 · see citing works

Parkinsonism and AIDS: a clinical comparative study before and after HAART

de Rosso, A. L. Z., de Mattos, J. P., Corrêa, R. B., et al. (2009) · Arquivos de Neuro-Psiquiatria · doi:10.1590/s0004-282x2009000500009 · Cited by 18 · see citing works

Parkinsonism among retired Filipino boxers

Jamora, R. D. G., Shu, L. L. S., Cenina, A. R., Dioquino, C. P. C., & Canto, P. A. D. (2017) · Basal Ganglia · doi:10.1016/j.baga.2017.07.001 · Cited by 4 · see citing works

[Parkinsonism due to the medication].

Louter, M., & Tromp, S. C. (2009) · PubMed · Cited by 4 · see citing works

Diagnosis of parkinsonism in the elderly

Rodnitzky, R. L. (2000) · Cambridge University Press eBooks · doi:10.1017/cbo9780511585012.003 · Cited by 1 · see citing works

Parkinsonism and inborn errors of metabolism

García‐Cazorla, À., & Duarte, S. T. (2014) · Journal of Inherited Metabolic Disease · doi:10.1007/s10545-014-9723-6 · Cited by 28 · see citing works