Cited by 485Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsNeural dynamics and brain function

Long-term potentiation in the dentate gyrus is induced preferentially on the positive phase of θ-rhythm

Pavlides, Constantine, Greenstein, Yoram J., Grudman, Mark, Winson, Jonathan·1988·Brain Research

Abstract

Long-term potentiation (LTP), a long lasting enhancement of synaptic efficacy is considered a model for learning and memory. In anesthetized rats, theta-rhythm was induced in the dentate gyrus by midbrain stimulation. Short trains of pulses were applied to the perforant pathway either at the peak of theta-rhythm or its trough. Trains applied at the peak of theta-rhythm induced LTP while trains applied at the trough produced a decrease of synaptic efficacy or had no effect. Thus, theta-rhythm may play a modulating role in the induction of LTP, suggesting a possible mnemonic function for the rhythm during the behaviors in which it occurs.

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Crossref · 10.1016/0006-8993(88)91499-0

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  • Burst stimulation of CA1 inputs can induce LTP or LTD depending on whether it arrives at the peak or trough, respectively, of ongoing theta oscillations.

    “Burst stimulation of CA1 inputs can induce LTP or LTD depending on whether it arrives at the peak or trough, respectively, of ongoing theta oscillations (561, 892).”

    From About Sleep's Role in Memory (2013) · cites this paper as [892]

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Authors
Pavlides, C., Greenstein, Y. J., Grudman, M., & Winson, J.
Affiliations
  • Rockefeller University (US)
  • Queens College, CUNY (US)
  • Binghamton University (US)
Corresponding author
Pavlides, Constantine
Venue
Brain Research
Publisher
Elsevier BV
Published
1988-01
Volume
439
Issue
1-2
Pages
383-387
ISSN
0006-8993 (ISSN-L)
OpenAlex
W2058242738
Cited by
485
References
0
Citations by year
2026: 4 · 2025: 5 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 26 · 2017: 17 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 12
FWCI
2.62
Type
journal article
Language
en
Open access
closed
Locations
  • Brain Research (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k02mh000232-10)
  • National Institute of Mental Health (5-K02-MH 00232)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
Keywords
long-term potentiation, dentate gyrus, theta oscillations, perforant path, synaptic efficacy, midbrain stimulation, theta phase, learning and memory, hippocampus
MeSH terms
Animals, Electric Stimulation, Electroencephalography, Evoked Potentials, Hippocampus, Mesencephalon, Synapses, Theta Rhythm, Rats

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