Long-term potentiation in the dentate gyrus is induced preferentially on the positive phase of θ-rhythm
Abstract
Long-term potentiation (LTP), a long lasting enhancement of synaptic efficacy is considered a model for learning and memory. In anesthetized rats, theta-rhythm was induced in the dentate gyrus by midbrain stimulation. Short trains of pulses were applied to the perforant pathway either at the peak of theta-rhythm or its trough. Trains applied at the peak of theta-rhythm induced LTP while trains applied at the trough produced a decrease of synaptic efficacy or had no effect. Thus, theta-rhythm may play a modulating role in the induction of LTP, suggesting a possible mnemonic function for the rhythm during the behaviors in which it occurs.
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Burst stimulation of CA1 inputs can induce LTP or LTD depending on whether it arrives at the peak or trough, respectively, of ongoing theta oscillations.
“Burst stimulation of CA1 inputs can induce LTP or LTD depending on whether it arrives at the peak or trough, respectively, of ongoing theta oscillations (561, 892).”
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- Authors
- Pavlides, C., Greenstein, Y. J., Grudman, M., & Winson, J.
- Affiliations
- Rockefeller University (US)
- Queens College, CUNY (US)
- Binghamton University (US)
- Corresponding author
- Pavlides, Constantine
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 1988-01
- Volume
- 439
- Issue
- 1-2
- Pages
- 383-387
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2058242738
- Cited by
- 485
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 8 · 2023: 16 · 2022: 13 · 2021: 14 · 2020: 13 · 2019: 8 · 2018: 26 · 2017: 17 · 2016: 9 · 2015: 12 · 2014: 16 · 2013: 10 · 2012: 12
- FWCI
- 2.62
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Brain Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health (5k02mh000232-10)
- National Institute of Mental Health (5-K02-MH 00232)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural dynamics and brain function
- Keywords
- long-term potentiation, dentate gyrus, theta oscillations, perforant path, synaptic efficacy, midbrain stimulation, theta phase, learning and memory, hippocampus
- MeSH terms
- Animals, Electric Stimulation, Electroencephalography, Evoked Potentials, Hippocampus, Mesencephalon, Synapses, Theta Rhythm, Rats
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