The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Exercise-induced improvement in cognitive performance after traumatic brain injury in rats is dependent on BDNF activation
Open accessAbstract
We have previously shown that voluntary exercise upregulates brain-derived neurotrophic factor (BDNF) within the hippocampus and is associated with an enhancement of cognitive recovery after a lateral fluid-percussion injury (FPI). In order to determine if BDNF is critical to this effect we used an immunoadhesin chimera (TrkB-IgG) that inactivates free BDNF. This BDNF inhibitor was administered to adult male rats two weeks after they had received a mild fluid percussion injury (FPI) or sham surgery. These animals were then housed with or without access to a running wheel (RW) from post-injury-day (PID) 14 to 20. On PID 21, rats were tested for spatial learning in a Morris Water Maze. Results showed that exercise counteracted the cognitive deficits associated with the injury. However this exercise-induced cognitive improvement was attenuated in the FPI-RW rats that were treated with TrkB-IgG. Molecules important for synaptic plasticity and learning were measured in a separate group of rats that were sacrificed immediately after exercise (PID 21). Western blot analyses showed that exercise increased the mature form of BDNF, synapsin I and cyclic-AMP response-element-binding protein (CREB) in the vehicle treated Sham-RW group. However, only the mature form of BDNF and CREB were increased in the vehicle treated FPI-RW group. Blocking BDNF (pre administration of TrkB-IgG) greatly reduced the molecular effects of exercise in that exercise-induced increases of BDNF, synapsin I and CREB were not observed. These studies provide evidence that BDNF has a major role in exercise's cognitive effects in traumatically injured brain.
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Cites
Be smart, exercise your heart: Exercise effects on brain and cognition
Hillman, C. H., Erickson, K. I., & Kramer, A. F. (2008) · Nature Reviews Neuroscience · doi:10.1038/nrn2298 · Cited by 3,563
Silva, A. J., Kogan, J. H., Frankland, P. W., & Kida, S. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.127 · Cited by 1,462
Exercise and brain neurotrophins
Neeper, S. A., Góauctemez-Pinilla, F., Choi, J., & Cotman, C. (1995) · Nature · doi:10.1038/373109a0 · Cited by 1,066 · cited 1×
“Voluntary exercise has been found to increase brain derived neurotrophic factor (BDNF) within the hippocampus (Cotman and Berchtold, 2002; Neeper et al., 1995) and this exercise-induced increase in BDNF has been proposed as one of the main mechanisms for the effects of exercise on cognition.”
BackgroundLevine, E. S., Dreyfus, C. F., Black, I. B., & Plummer, M. R. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.17.8074 · Cited by 611
Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation
Kang, H., Welcher, A. A., Shelton, D., & Schuman, E. M. (1997) · Neuron · doi:10.1016/s0896-6273(00)80378-5 · Cited by 481
Levine, E. S., Crozier, R. A., Black, I. B., & Plummer, M. R. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.17.10235 · Cited by 412
Vaynman, S., Ying, Z., & Gomez-Pinilla, F. (2003) · Neuroscience · doi:10.1016/j.neuroscience.2003.08.001 · Cited by 396
Grønli, J., Bramham, C., Murison, R., Kanhema, T., Fiske, E., Bjorvatn, B., Ursin, R., & Portas, C. M. (2006) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2006.11.021 · Cited by 260
Exercise differentially regulates synaptic proteins associated to the function of BDNF
Vaynman, S. S., Ying, Z., Yin, D., & Gomez-Pinilla, F. (2006) · Brain Research · doi:10.1016/j.brainres.2005.11.062 · Cited by 248
Giza, C. C., Griesbach, G. S., & Hovda, D. A. (2005) · Behavioural Brain Research · doi:10.1016/j.bbr.2004.06.003 · Cited by 135 · cited 1×
“Similar measures have previously been utilized to measure behavioral outcome after TBI (Fineman et al., 2000; Giza et al., 2005; Griesbach et al., 2009; Gurkoff et al., 2006).”
MethodSelf-citation
Cited by
Exercise, brain, and cognition across the life span.
Voss, M. W., Nagamatsu, L. S., Liu-Ambrose, T., & Kramer, A. F. (2011) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00210.2011 · Cited by 601
The Influence of Exercise on Cognitive Abilities
Gomez‐Pinilla, F., & Hillman, C. (2013) · Comprehensive Physiology · doi:10.1002/cphy.c110063 · Cited by 599
Self-citationEnergy intake and exercise as determinants of brain health and vulnerability to injury and disease
Mattson, M. P. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.08.012 · Cited by 434
Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents
Massa, S. M., Yang, T., Xie, Y., Shi, J., Bilgen, M., Joyce, J. N., Nehama, D., Rajadas, J., & Longo, F. M. (2010) · Journal of Clinical Investigation · doi:10.1172/jci41356 · Cited by 406
Exercise Plays a Preventive Role Against Alzheimer's Disease
Radak, Z., Hart, N., Sarga, L., Koltai, E., Atalay, M., Ohno, H., & Boldogh, I. (2010) · Journal of Alzheimer's Disease · doi:10.3233/jad-2010-091531 · Cited by 316
Metadata
- Authors
- Griesbach, G. S., Hovda, D. A., & Gomez-Pinilla, F.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2009-09
- Volume
- 1288
- Pages
- 105-115
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2088754913
- Cited by
- 276
- References
- 10
- FWCI
- 8.53
- Type
- journal article
- Language
- en
- Open access
- green
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