Chronic mild sleep restriction accentuates contextual memory impairments, and accumulations of cortical Aβ and pTau in a mouse model of Alzheimer's disease

Glutamate neurotoxicity and diseases of the nervous system

Choi, D. W. (1988) · Neuron · doi:10.1016/0896-6273(88)90162-6 · Cited by 8,152 · see citing works

Morris water maze: procedures for assessing spatial and related forms of learning and memory

Vorhees, C. V., & Williams, M. T. (2006) · Nature Protocols · doi:10.1038/nprot.2006.116 · Cited by 4,629 · see citing works

Triple-Transgenic Model of Alzheimer’s Disease with Plaques and Tangles

Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., & LaFerla, F. M. (2003) · Neuron · doi:10.1016/s0896-6273(03)00434-3 · Cited by 4,126 · see citing works

The cumulative cost of additional wakefulness: dose-response effects on neurobehavioral functions and sleep physiology from chronic sleep restriction and total sleep deprivation

Van Dongen, H. P. A., Maislin, G., Mullington, J. M., & Dinges, D. F. (2003) · Sleep · doi:10.1093/sleep/26.2.117 · Cited by 3,173 · see citing works

Neurocognitive consequences of sleep deprivation

Goel, N., Rao, H., Durmer, J., & Dinges, D. (2009) · Seminars in Neurology · doi:10.1055/s-0029-1237117 · Cited by 2,154 · see citing works

Exercise enhances learning and hippocampal neurogenesis in aged mice

van Praag, H., Shubert, T., Zhao, C., & Gage, F. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1731-05.2005 · Cited by 2,078 · see citing works

Cumulative Sleepiness, Mood Disturbance, and Psychomotor Vigilance Performance Decrements During a Week of Sleep Restricted to 4–5 Hours per Night

Dinges, D. F., Pack, F. M., Williams, K., Gillen, K. A., Powell, J. W., Ott, G. E., Trasande, C. A., & Pack, A. I. (1997) · SLEEP · doi:10.1093/sleep/20.4.267 · Cited by 2,018 · see citing works

Amyloid-β Dynamics Are Regulated by Orexin and the Sleep-Wake Cycle

Kang, J.-E., Lim, M. M., Bateman, R. J., Lee, J. J., Smyth, L. P., Cirrito, J. R., Fujiki, N., Nishino, S., & Holtzman, D. M. (2009) · Science · doi:10.1126/science.1180962 · Cited by 1,565 · see citing works

Behavioral and Physiological Consequences of Sleep Restriction

Banks, S., & Dinges, D. F. (2007) · Journal of Clinical Sleep Medicine · doi:10.5664/jcsm.26918 · Cited by 1,505 · see citing works

Glucocorticoids increase amyloid-β and tau pathology in a mouse model of alzheimer’s disease

Green, K. N., Billings, L. M., Roozendaal, B., McGaugh, J. L., & LaFerla, F. M. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.2797-06.2006 · Cited by 623 · see citing works

Sleep and Sleep Disorders in Older Adults

Crowley, K. E. (2011) · Neuropsychology Review · doi:10.1007/s11065-010-9154-6 · Cited by 618 · see citing works

Sleep deprivation selectively impairs memory consolidation for contextual fear conditioning

Graves, L. A., Heller, E. A., Pack, A. I., & Abel, T. (2003) · Learning & Memory · doi:10.1101/lm.48803 · Cited by 476 · see citing works

Circadian rest—activity rhythm disturbances in alzheimer's disease

Someren, E. J. W. V., Hagebeuk, E. E. O., Lijzenga, C., Scheltens, P., Rooij, S. E. J. A. D., Jonker, C., Pot, A. M., Mirmiran, M., & Swaab, D. F. (1996) · Biological Psychiatry · doi:10.1016/0006-3223(95)00370-3 · Cited by 453 · see citing works

Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia

Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M., & Morris, J. C. (2006) · American Journal of Psychiatry · doi:10.1176/appi.ajp.163.12.2164 · Cited by 426 · see citing works

Sleep deprivation induced by the modified multiple platform technique: quantification of sleep loss and recovery

Machado, R. B., Hipólide, D. C., Benedito‐Silva, A. A., & Tufik, S. (2004) · Brain Research · doi:10.1016/j.brainres.2004.01.019 · Cited by 424 · see citing works

Plasma Cortisol and Progression of Dementia in Subjects With Alzheimer-Type Dementia

Csernansky, J. G., Dong, H., Fagan, A. M., Wang, L., Xiong, C., Holtzman, D. M., & Morris, J. C. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.12.2164 · Cited by 421 · see citing works

Sundowning and Circadian Rhythms in Alzheimer’s Disease

Volicer, L., Harper, D. G., Manning, B. C., Goldstein, R., & Satlin, A. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.5.704 · Cited by 382 · see citing works

Modulation of hippocampal cell proliferation, memory, and amyloid plaque deposition in APPsw (Tg2576) mutant mice by isolation stress

Dong, H., Goico, B., Martin, M., Csernansky, C. A., Bertchume, A., & Csernansky, J. G. (2004) · Neuroscience · doi:10.1016/j.neuroscience.2004.05.040 · Cited by 342 · see citing works

The cognitive cost of sleep lost

McCoy, J. G., & Strecker, R. E. (2011) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2011.07.004 · Cited by 284 · see citing works

Functional neuroimaging insights into how sleep and sleep deprivation affect memory and cognition

Chee, M. W. L., & Chuah, L. Y. M. (2008) · Current Opinion in Neurology · doi:10.1097/wco.0b013e3283052cf7 · Cited by 261 · see citing works

Cortisol and Alzheimer's disease, I: Basal studies

Davis, K. L., Davis, B. J., GREENWALD, B. S., Mohs, R. C., Mathé, A. A., Johns, C. A., & Horvath, T. (1986) · American Journal of Psychiatry · doi:10.1176/ajp.143.3.300 · Cited by 246 · see citing works

Characteristics of Sleep Disturbance in Community-Dwelling Alzheimer's Disease Patients

McCurry, S. M., Logsdon, R. G., Teri, L. L., Gibbons, L. E., Kukull, W. A., Bowen, J. D., McCormick, W. C., & Larson, E. B. (1999) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/089198879901200203 · Cited by 246 · see citing works

Chronic stress accelerates learning and memory impairments and increases amyloid deposition in APP V717I ‐CT100 transgenic mice, an Alzheimer's disease model

Jeong, Y. H., Park, C. H., Yoo, J., Shin, K. Y., Ahn, S., Kim, H., Lee, S. H., Emson, P. C., & Suh, Y. (2006) · The FASEB Journal · doi:10.1096/fj.05-4265fje · Cited by 241 · see citing works

Sleep deprivation inhibits adult neurogenesis in the hippocampus by elevating glucocorticoids

Mirescu, C., Peters, J. D., Noiman, L., & Gould, E. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0608644103 · Cited by 233 · see citing works

Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning

Hairston, I. S., Little, M. T. M., Scanlon, M. D., Barakat, M. T., Palmer, T. D., Sapolsky, R. M., & Heller, H. C. (2005) · Journal of Neurophysiology · doi:10.1152/jn.00218.2005 · Cited by 223 · see citing works

Sleep Disturbances in Patients With Mild-Stage Alzheimer's Disease

Vitiello, M. V., Prinz, P. N., Williams, D. E., Frommlet, M. S., & Ries, R. K. (1990) · Journal of Gerontology · doi:10.1093/geronj/45.4.m131 · Cited by 223 · see citing works

Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat

Suchecki, D., & Tufik, S. (2000) · Physiology & Behavior · doi:10.1016/s0031-9384(99)00181-x · Cited by 220 · see citing works

Toll-like receptor 3 inhibits memory retention and constrains adult hippocampal neurogenesis

Okun, E., Griffioen, K. J. S., Barak, B., Roberts, N. J., Castro, K., Pita, M. A., Cheng, A., Mughal, M. R., Wan, R., Ashery, U., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1005807107 · Cited by 207 · see citing works

Sleep deprivation impairs object recognition in mice

Palchykova, S., Winsky‐Sommerer, R., Meerlo, P., Dürr, R., & Tobler, I. (2006) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2005.11.005 · Cited by 192 · see citing works

Gene structure and organization of the human β‐secretase ( BACE ) promoter

Sambamurti, K., Kinsey, R., Maloney, B., Ge, Y., & Lahiri, D. K. (2004) · The FASEB Journal · doi:10.1096/fj.03-1378fje · Cited by 179 · see citing works

The amyloidogenic potential and behavioral correlates of stress

Catania, C., Sotiropoulos, I., Silva, R., Onofri, C., Breen, K. C., Sousa, N., & Almeida, O. F. X. (2007) · Molecular Psychiatry · doi:10.1038/sj.mp.4002101 · Cited by 175 · see citing works

Hippocampal gene expression patterns underlying the enhancement of memory by running in aged mice

Stranahan, A. M., Lee, K., Becker, K. G., Zhang, Y., Maudsley, S. R., Martin, B., Cutler, R. G., & Mattson, M. P. (2008) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2008.10.016 · Cited by 153 · see citing works

Behavioral and serotonergic consequences of decreasing or increasing hippocampus brain-derived neurotrophic factor protein levels in mice

Deltheil, T., Guiard, B. P., Cerdan, J., David, D. J., Tanaka, K. F., Repérant, C., Guilloux, J.-P., Coudoré, F., Hen, R., & Gardier, A. M. (2008) · Neuropharmacology · doi:10.1016/j.neuropharm.2008.08.001 · Cited by 153 · see citing works

Corticosterone and related receptor expression are associated with increased β-amyloid plaques in isolated Tg2576 mice

Dong, H., Yuede, C. M., Yoo, H.-S., Martin, M. V., Deal, C., Mace, A. G., & Csernansky, J. G. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2008.05.017 · Cited by 112 · see citing works

Effects of 42 hr of total sleep deprivation on component processes of verbal working memory.

Turner, T. H., Drummond, S. P. A., Salamat, J. S., & Brown, G. G. (2007) · Neuropsychology · doi:10.1037/0894-4105.21.6.787 · Cited by 103 · see citing works

Increased glucocorticoid production and altered cortisol metabolism in women with mild to moderate Alzheimer’s disease

Rasmuson, S., Andrew, R., Näsman, B., Seckl, J. R., Walker, B. R., & Olsson, T. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01015-5 · Cited by 99 · see citing works

3xTgAD mice exhibit altered behavior and elevated Aβ after chronic mild social stress

Rothman, S. M., Herdener, N. D., Camandola, S., Texel, S. J., Mughal, M. R., Cong, W., Martin, B., & Mattson, M. P. (2011) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2011.07.005 · Cited by 95 · see citing works

Plasma cortisol levels in elderly female subjects with Alzheimer’s disease: a cross-sectional and longitudinal study

Umegaki, H., Ikari, H., Nakahata, H., Endo, H., Suzuki, Y., Ogawa, O., Nakamura, A., Yamamoto, T., & Iguchi, A. (2000) · Brain Research · doi:10.1016/s0006-8993(00)02847-x · Cited by 92 · see citing works

REM latency in Alzheimer's disease

Bliwise, D. L., Tinklenberg, J. R., Yesavage, J. A., Davies, H. D., Pursley, A. M., Petta, D., Widrow, L., Guilleminault, C., Zarcone, V. P., & Dement, W. C. (1989) · Biological Psychiatry · doi:10.1016/0006-3223(89)90179-0 · Cited by 92 · see citing works

Nongenetic Factors as Modifiers of the Age of Onset of Familial Alzheimer’s Disease

Mejía-Arango, S., Giraldo, M., Pineda, D. A., Lopera, F. J., & Ardila, A. (2003) · International Psychogeriatrics · doi:10.1017/s1041610203009591 · Cited by 73 · see citing works

Genetically Increased Risk of Sleep Disruption in Alzheimer's Disease

Craig, D., Hart, D. J., & Passmore, A. P. (2006) · SLEEP · doi:10.1093/sleep/29.8.1003 · Cited by 66 · see citing works

Bright lighting conditions during testing increase thigmotaxis and impair water maze performance in BALB/c mice

Huang, Y. Y., Zhou, W., & Zhang, Y. (2011) · Behavioural Brain Research · doi:10.1016/j.bbr.2011.08.043 · Cited by 65 · see citing works

Aging and Circadian Disruption: Causes and Effects

Brown, S. A., Schmitt, K., & Eckert, A. (2011) · Aging · doi:10.18632/aging.100366 · Cited by 50 · see citing works

Proteomic analysis of the effects and interactions of sleep deprivation and aging in mouse cerebral cortex

Pawlyk, A. C., Ferber, M. F., Shah, A., Pack, A. I., & Naidoo, N. N. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.04949.x · Cited by 42 · see citing works

The effect of corticosteroids on amyloid β precursor protein/amyloid precursor-like protein expression and processing in vivo

Budas, G. R., Coughlan, C. M., Seckl, J. R., & Breen, K. C. (1999) · Neuroscience Letters · doi:10.1016/s0304-3940(99)00790-9 · Cited by 37 · see citing works

Functional Characterization of Amyloid β Precursor Protein Regulatory Elements: Rationale for the Identification of Genetic Polymorphism

Lahiri, D. K. (2004) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1329.035 · Cited by 27 · see citing works

Effect of Sleep Deprivation on the Corticosterone Secretion in an Experimental Model of Autoimmune Disease

Palma, B. D., Suchecki, D., Catallani, B., & Tufik, S. (2007) · NeuroImmunoModulation · doi:10.1159/000107421 · Cited by 17 · see citing works

Enhanced localization of amyloid β precursor protein in the rat hippocampus following long-term adrenalectomy

Islam, A., Kalaria, R. N., Winblad, B. G., & Adem, A. (1998) · Brain Research · doi:10.1016/s0006-8993(98)00711-2 · Cited by 11 · see citing works

Molecular and cellular mechanisms underlying the pathogenesis of Alzheimer’s disease

Guo, T., Zhang, D., Zeng, Y., Huang, T. Y., Xu, H., & Zhao, Y. (2020) · Molecular Neurodegeneration · doi:10.1186/s13024-020-00391-7 · Cited by 994 · see citing works

Mechanisms linking circadian clocks, sleep, and neurodegeneration

Musiek, E. S., & Holtzman, D. M. (2016) · Science · doi:10.1126/science.aah4968 · Cited by 878 · see citing works

β-Amyloid accumulation in the human brain after one night of sleep deprivation

Shokri-Kojori, E., Wang, G.-J., Wiers, C. E., Demiral, S. B., Guo, M., Kim, S. W., Lindgren, E., Ramirez, V., Zehra, A., Freeman, C., et al. (2018) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1721694115 · Cited by 893 · see citing works

Association between circadian rhythms and neurodegenerative diseases

Leng, Y., Musiek, E. S., Hu, K., Cappuccio, F. P., & Yaffe, K. S. (2019) · The Lancet Neurology · doi:10.1016/s1474-4422(18)30461-7 · Cited by 660 · see citing works

Slow wave sleep disruption increases cerebrospinal fluid amyloid-β levels

Ju, Y.-E. S., Ooms, S. J., Sutphen, C., Macauley, S. L., Zangrilli, M. A., Jerome, G., Fagan, A. M., Mignot, E., Zempel, J. M., Claassen, J. A. H. R., et al. (2017) · Brain · doi:10.1093/brain/awx148 · Cited by 604 · see citing works

Sleep, circadian rhythms, and the pathogenesis of Alzheimer disease

Musiek, E. S., Xiong, D. D., & Holtzman, D. M. (2015) · Experimental & Molecular Medicine · doi:10.1038/emm.2014.121 · Cited by 529 · see citing works

Sleep, Cognition, and Normal Aging

Scullin, M. K., & Bliwise, D. L. (2015) · Perspectives on Psychological Science · doi:10.1177/1745691614556680 · Cited by 504 · see citing works

Circadian rest-activity pattern changes in aging and preclinical Alzheimer disease

Musiek, E. S., Bhimasani, M., Zangrilli, M. A., Morris, J. C., Holtzman, D. M., & Ju, Y.-E. S. (2018) · JAMA Neurology · doi:10.1001/jamaneurol.2017.4719 · Cited by 465 · see citing works

Sleep: A Novel Mechanistic Pathway, Biomarker, and Treatment Target in the Pathology of Alzheimer's Disease?

Mander, B. A., Winer, J. R., Jagust, W. J., & Walker, M. P. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.05.002 · Cited by 467 · see citing works

The gut microbiome in Alzheimer’s disease: what we know and what remains to be explored

Chandra, S., Sisodia, S. S., & Vassar, R. J. (2023) · Molecular Neurodegeneration · doi:10.1186/s13024-023-00595-7 · Cited by 278 · see citing works

Sleep Deprivation and Neurological Disorders

Bishir, M., Bhat, A., Essa, M. M., Ekpo, O. E., Ihunwo, A. O., Veeraraghavan, V. P., Surapaneni, K. M., Mahalakshmi, A. M., Ray, B., Tuladhar, S., et al. (2020) · BioMed Research International · doi:10.1155/2020/5764017 · Cited by 253 · see citing works

Candidate mechanisms underlying the association between sleep-wake disruptions and Alzheimer's disease

Cedernaes, J., Osorio, R. S., Varga, A. W., Kam, K., Schiöth, H. B., & Benedict, C. (2016) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2016.02.002 · Cited by 200 · see citing works

Prolonged sleep duration as a marker of early neurodegeneration predicting incident dementia

Westwood, A. J., Beiser, A., Jain, N., Himali, J. J., DeCarli, C. S., Auerbach, S. H., Pase, M. P., & Seshadri, S. S. (2017) · Neurology · doi:10.1212/wnl.0000000000003732 · Cited by 192 · see citing works

Exercise and BDNF reduce Aβ production by enhancing α‐secretase processing of APP

Nigam, S. M., Xu, S., Kritikou, J. S., Marosi, K., Brodin, L., & Mattson, M. P. (2017) · Journal of Neurochemistry · doi:10.1111/jnc.14034 · Cited by 186 · see citing works

Imaging the Perivascular Space as a Potential Biomarker of Neurovascular and Neurodegenerative Diseases

Ramirez, J., Berezuk, C., McNeely, A. A., Gao, F., McLaurin, J., & Black, S. E. (2016) · Cellular and Molecular Neurobiology · doi:10.1007/s10571-016-0343-6 · Cited by 161 · see citing works

Impact of sleep duration on executive function and brain structure

Tai, X. Y., Chen, C., Manohar, S., & Masud Husain, B. (2022) · Communications Biology · doi:10.1038/s42003-022-03123-3 · Cited by 149 · see citing works

The role of sleep deprivation and circadian rhythm disruption as risk factors of Alzheimer’s disease

Wu, H., Dunnett, S. L., Ho, J. Y. S., & Chang, R. C. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100764 · Cited by 151 · see citing works

Sleep and β-Amyloid Deposition in Alzheimer Disease: Insights on Mechanisms and Possible Innovative Treatments

Cordone, S., Annarumma, L., Rossini, P. M., & Gennaro, L. D. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00695 · Cited by 139 · see citing works

Chronic sleep disturbance and neural injury: links to neurodegenerative disease

Videnović, A., & Abbott, S. M. (2016) · Nature and Science of Sleep · doi:10.2147/nss.s78947 · Cited by 129 · see citing works

Sleep Disturbance as a Potential Modifiable Risk Factor for Alzheimer’s Disease

Minakawa, E. N., Wada, K., & Nagai, Y. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20040803 · Cited by 118 · see citing works

The effect of insomnia on development of Alzheimer’s disease

Sadeghmousavi, S., Eskian, M., Rahmani, F., & Rezaei, N. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01960-9 · Cited by 113 · see citing works

Neural consequences of chronic sleep disruption

Zamore, Z. H., & Veasey, S. C. (2022) · Trends in Neurosciences · doi:10.1016/j.tins.2022.05.007 · Cited by 105 · see citing works

Sleep oscillation-specific associations with Alzheimer’s disease CSF biomarkers: novel roles for sleep spindles and tau

Kam, K., Parekh, A., Sharma, R. A., Andrade, A. G., Lewin, M. P., Castillo, B., Bubu, O. M., Chua, N. J., Miller, M. D., Mullins, A. E., et al. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0309-5 · Cited by 105 · see citing works

Is the glymphatic system the missing link between sleep impairments and neurological disorders? Examining the implications and uncertainties

Christensen, J., Yamakawa, G. R., Shultz, S. R., & Mychasiuk, R. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101917 · Cited by 105 · see citing works

Biomarkers of dementia in obstructive sleep apnea

Baril, A., Carrier, J., Lafrenière, A., Warby, S. C., Poirier, J., Osorio, R. S., Ayas, N., Dubé, M., Petit, D., & Gosselin, N. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.08.001 · Cited by 96 · see citing works

Local Sleep and Alzheimer’s Disease Pathophysiology

Mander, B. A. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.525970 · Cited by 97 · see citing works

Chronic Sleep Deprivation Exacerbates Learning-Memory Disability and Alzheimer’s Disease-Like Pathologies in AβPPswe/PS1ΔE9 Mice

Qiu, H., Zhong, R., Liu, H., Zhang, F., Li, S., & Le, W. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150774 · Cited by 94 · see citing works

Physiological changes in neurodegeneration—mechanistic insights and clinical utility

Ahmed, R. M., Ke, Y. D., Vucic, S., Ittner, L. M., Seeley, W., Hodges, J. R., Piguet, O., Halliday, G., & Kiernan, M. C. (2018) · Nature Reviews Neurology · doi:10.1038/nrneurol.2018.23 · Cited by 91 · see citing works

Elevated tau and interleukin-6 concentrations in adults with obstructive sleep apnea

Motamedi, V., Kanefsky, R. Z., Matsangas, P., Mithani, S., Jeromin, A., Brock, M. S., Mysliwiec, V., & Gill, J. (2017) · Sleep Medicine · doi:10.1016/j.sleep.2017.11.1121 · Cited by 89 · see citing works

Impact of sleep disturbances on neurodegeneration: Insight from studies in animal models

Owen, J. E., & Veasey, S. C. (2020) · Neurobiology of Disease · doi:10.1016/j.nbd.2020.104820 · Cited by 90 · see citing works

Alteration in sleep architecture and electroencephalogram as an early sign of Alzheimer's disease preceding the disease pathology and cognitive decline

Zhang, F., Zhong, R., Li, S., Fu, Z., Wang, R., Wang, T., Huang, Z., & Le, W. (2019) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.12.004 · Cited by 84 · see citing works

The effect of sleep deprivation and disruption on DNA damage and health of doctors

Cheung, V., Yuen, V. M.-Y., Wong, G. T. C., & Choi, S. W. (2019) · Anaesthesia · doi:10.1111/anae.14533 · Cited by 81 · see citing works

Effects of experimental sleep deprivation on anxiety-like behavior in animal research: Systematic review and meta-analysis

Pires, G. N., Bezerra, A. G., Tufik, S. B., & Andersen, M. L. (2016) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2016.06.028 · Cited by 79 · see citing works

Sleep and Neurodegeneration

Pillai, J. A., & Leverenz, J. B. (2017) · CHEST Journal · doi:10.1016/j.chest.2017.01.002 · Cited by 80 · see citing works

Roles of aging in sleep

Zhong, H., Yu, B., Luo, D., Yang, L.-Y., Zhang, J., Jiang, S., Hu, S., Luo, Y., Yang, M.-W., Hong, F., et al. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.01.013 · Cited by 74 · see citing works

Low-grade inflammation in the relationship between sleep disruption, dysfunctional adiposity, and cognitive decline in aging

Atienza, M., Ziontz, J., & Cantero, J. L. (2018) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2018.08.002 · Cited by 72 · see citing works

Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders

Sałaciak, K., & Pytka, K. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.10.037 · Cited by 71 · see citing works

Sleep and its regulation: An emerging pathogenic and treatment frontier in Alzheimer’s disease

Kent, B. A., Feldman, H., & Nygaard, H. B. (2020) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2020.101902 · Cited by 68 · see citing works

A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

Peng, X., Fan, R., Xie, L., Shi, X., Dong, K., Zhang, S., Tao, J., Xu, W., Ma, D., Chen, J., et al. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23010504 · Cited by 68 · see citing works

Is Sleep Disruption a Cause or Consequence of Alzheimer’s Disease? Reviewing Its Possible Role as a Biomarker

Lloret, M.-A., Cervera-Ferri, A., Nepomuceno, M., Monllor, P., Esteve, D., & Lloret, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21031168 · Cited by 68 · see citing works

The Sleep Side of Aging and Alzheimer’s Disease

Romanella, S. M., Roe, D., Tatti, E., Cappon, D., Paciorek, R., Testani, E., Rossi, A., Rossi, S., & Santarnecchi, E. (2020) · Sleep Medicine · doi:10.1016/j.sleep.2020.05.029 · Cited by 69 · see citing works

Sleep and hippocampal neurogenesis: Implications for Alzheimer’s disease

Kent, B. A., & Mistlberger, R. E. (2017) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2017.02.004 · Cited by 64 · see citing works

Ketogenic diet prevents chronic sleep deprivation-induced Alzheimer’s disease by inhibiting iron dyshomeostasis and promoting repair via Sirt1/Nrf2 pathway

Yang, Y., Wang, X., Xiao, A., Han, J., Wang, Z., & Wen, M. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.998292 · Cited by 65 · see citing works

The relationship between gut microbiota and inflammatory response, learning and memory in mice by sleep deprivation

Zhang, M., Zhang, M., Kou, G., & Li, Y. (2023) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2023.1159771 · Cited by 63 · see citing works

Sleep–wake regulation and the hallmarks of the pathogenesis of Alzheimer’s disease

Egroo, M. V., Narbutas, J., Chylinski, D., González, P. V., Maquet, P., Salmon, É., Bastin, C., Collette, F., & Vandewalle, G. (2019) · SLEEP · doi:10.1093/sleep/zsz017 · Cited by 62 · see citing works

Evidence for altered insulin receptor signaling in Alzheimer's disease

Griffith, C. M., Eid, T., Rose, G. M., & Patrylo, P. R. (2018) · Neuropharmacology · doi:10.1016/j.neuropharm.2018.01.008 · Cited by 61 · see citing works

Central and peripheral circadian clocks and their role in Alzheimer's disease

Chauhan, R., Chen, K.-F., Kent, B. A., & Crowther, D. C. (2017) · Disease Models & Mechanisms · doi:10.1242/dmm.030627 · Cited by 58 · see citing works

Sleep-Wake Cycle Dysfunction in the TgCRND8 Mouse Model of Alzheimer’s Disease: From Early to Advanced Pathological Stages

Colby-Milley, J., Cavanagh, C., Jego, S., Breitner, J. C. S., Quirion, R., & Adamantidis, A. (2015) · PLoS ONE · doi:10.1371/journal.pone.0130177 · Cited by 59 · see citing works

Chronic sleep fragmentation exacerbates amyloid β deposition in Alzheimer’s disease model mice

Minakawa, E. N., Miyazaki, K., Maruo, K., Yagihara, H., Fujita, H., Wada, K., & Nagai, Y. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.05.054 · Cited by 59 · see citing works

Targeting psychologic stress signaling pathways in Alzheimer’s disease

Futch, H. S., Croft, C. L., Truong, V., Krause, E. G., & Golde, T. E. (2017) · Molecular Neurodegeneration · doi:10.1186/s13024-017-0190-z · Cited by 60 · see citing works

Enhanced sleep reverses memory deficits and underlying pathology in drosophila models of Alzheimer's disease

Dissel, S., Klose, M. K., Donlea, J. M., Cao, L., English, D., Winsky‐Sommerer, R., van Swinderen, B., & Shaw, P. J. (2016) · Neurobiology of Sleep and Circadian Rhythms · doi:10.1016/j.nbscr.2016.09.001 · Cited by 54 · see citing works

Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE 1‐Antisense Activation

Zhao, H., Wu, H., He, J., Zhuang, J., Liu, Z., Huang, L., & Zhao, Z. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12667 · Cited by 53 · see citing works

Neuroinflammation and Tau Interact with Amyloid in Predicting Sleep Problems in Aging Independently of Atrophy

Fjell, A. M., Idland, A., Sala‐Llonch, R., Watne, L. O., Borza, T., Brækhus, A., Lona, T., Zetterberg, H., Blennow, K., Wyller, T. B., et al. (2017) · Cerebral Cortex · doi:10.1093/cercor/bhx157 · Cited by 52 · see citing works

Sleep deprivation accelerates the progression of alzheimer’s disease by influencing Aβ-related metabolism

Chen, L., Huang, J., Yang, L., Zeng, X., Zhang, Y. P., Wang, X., Chen, M., Li, X., Zhang, Y., & Zhang, M. (2017) · Neuroscience Letters · doi:10.1016/j.neulet.2017.04.047 · Cited by 51 · see citing works

The Neurobiological Basis of Sleep and Sleep Disorders

Joiner, W. J. (2018) · Physiology · doi:10.1152/physiol.00013.2018 · Cited by 51 · see citing works

The Treatment of Sleep Dysfunction in Neurodegenerative Disorders

Voysey, Z. J., Barker, R. A., & Lázár, A. S. (2020) · Neurotherapeutics · doi:10.1007/s13311-020-00959-7 · Cited by 47 · see citing works

Circadian and sleep/wake-dependent variations in tau phosphorylation are driven by temperature

Guisle, I., Gratuze, M., Petry, S., Morin, F., Keraudren, R., Whittington, R. A., Hébert, S. S., Mongrain, V., & Planel, E. (2019) · SLEEP · doi:10.1093/sleep/zsz266 · Cited by 46 · see citing works

Sleep-Based Interventions in Alzheimer’s Disease: Promising Approaches from Prevention to Treatment along the Disease Trajectory

Cordone, S., Scarpelli, S., Alfonsi, V., Gennaro, L. D., & Gorgoni, M. (2021) · Pharmaceuticals · doi:10.3390/ph14040383 · Cited by 49 · see citing works

The sleep and circadian problems of Huntington’s disease: when, why and their importance

Voysey, Z., Fazal, S. V., Lázár, A. S., & Barker, R. (2020) · Journal of Neurology · doi:10.1007/s00415-020-10334-3 · Cited by 44 · see citing works

Early Life Sleep Deprivation and Brain Development: Insights From Human and Animal Studies

Alrousan, G., Hassan, A., Pillai, A. A., Atrooz, F., & Salim, S. (2022) · Frontiers in Neuroscience · doi:10.3389/fnins.2022.833786 · Cited by 47 · see citing works

Metabolic determinants of Alzheimer’s disease: A focus on thermoregulation

Tournissac, M., Leclerc, M., Valentin‐Escalera, J., Vandal, M., Bosoi, C. R., Planel, E., & Calon, F. (2021) · Ageing Research Reviews · doi:10.1016/j.arr.2021.101462 · Cited by 41 · see citing works

Amyloid‐β induces sleep fragmentation that is rescued by fatty acid binding proteins in <i>Drosophila</i>

Gerstner, J. R., Lenz, O., Vanderheyden, W. M., Chan, M. T., Pfeiffenberger, C., & Pack, A. I. (2017) · Journal of Neuroscience Research · doi:10.1002/jnr.23778 · Cited by 40 · see citing works

Understanding neuron-glia crosstalk and biological clocks in insomnia

Carvalhas-Almeida, C., Serra, J., Moita, J. J., Cavadas, C., & Álvaro, A. R. (2023) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2023.105100 · Cited by 39 · see citing works

Review Paper: Tau Pathology of Alzheimer Disease: Possible Role of Sleep Deprivation

Ahmadian, N., Hejazi, S., Mahmoudi, J., & Talebi, M. (2018) · Basic and Clinical Neuroscience Journal · doi:10.32598/bcn.9.5.307 · Cited by 38 · see citing works

Sleep disorders and the risk of cognitive decline or dementia: an updated systematic review and meta-analysis of longitudinal studies

Zhang, J., Ou, J., Lu, X., Wang, T., Dang, W., Ding, L., Liu, Y., Xu, J., Yan, B., & Yu, H. (2025) · Journal of Neurology · doi:10.1007/s00415-025-13372-x · Cited by 38 · see citing works

Bidirectional relationships between sleep and amyloid-beta in the hippocampus

Dufort‐Gervais, J., Mongrain, V., & Brouillette, J. (2018) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2018.06.009 · Cited by 36 · see citing works

Bidirectional Relationship Between Sleep Disturbances and Parkinson's Disease

Minakawa, E. N. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.927994 · Cited by 35 · see citing works

Jujuboside A prevents sleep loss-induced disturbance of hippocampal neuronal excitability and memory impairment in young APP/PS1 mice

Tabassum, S., Misrani, A. A., Tang, B., Chen, J., Yang, L., & Long, C. (2019) · Scientific Reports · doi:10.1038/s41598-019-41114-3 · Cited by 36 · see citing works

Rapid eye movement sleep deprivation impairs neuronal plasticity and reduces hippocampal neuronal arborization in male albino rats: Noradrenaline is involved in the process

Giri, S., Ranjan, A., Kumar, A., Amar, M., & Mallick, B. N. (2021) · Journal of Neuroscience Research · doi:10.1002/jnr.24838 · Cited by 35 · see citing works

Chronic sleep deprivation exacerbates cognitive and synaptic plasticity impairments in APP/PS1 transgenic mice

Wang, C., Gao, W.-R., Yin, J., Wang, Z.-J., Qi, J., Cai, H.-Y., & Wu, M. (2021) · Behavioural Brain Research · doi:10.1016/j.bbr.2021.113400 · Cited by 35 · see citing works

Integrating Sleep and Alzheimer’s Disease Pathophysiology: Hints for Sleep Disorders Management

Proserpio, P., Arnaldi, D., Nobili, F. M., & Nobili, L. (2018) · Journal of Alzheimer s Disease · doi:10.3233/jad-180041 · Cited by 34 · see citing works

Human genetics and sleep behavior

Shi, G., Wu, D., Ptáček, L. J., & Fu, Y. (2017) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2017.02.015 · Cited by 34 · see citing works

Evolutionarily Conserved Regulation of Sleep by the Protein Translational Regulator PERK

Ly, S., Lee, D. A., Strus, E., Prober, D. A., & Naidoo, N. N. (2020) · Current Biology · doi:10.1016/j.cub.2020.02.030 · Cited by 33 · see citing works

Pharmacological profiling of zebrafish behavior using chemical and genetic classification of sleep-wake modifiers

Nishimura, Y., Okabe, S., Sasagawa, S., Murakami, S., Ashikawa, Y., Yuge, M., Kawaguchi, K., Kawase, R., & Tanaka, T. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00257 · Cited by 31 · see citing works

Alterations in the expression of Per1 and Per2 induced by Aβ31-35 in the suprachiasmatic nucleus, hippocampus, and heart of C57BL/6 mouse

Wang, X., Wang, L., Yu, Q., Xu, Y., Zhang, L., Zhao, X., Cao, X., Li, Y., & Li, L. (2016) · Brain Research · doi:10.1016/j.brainres.2016.03.026 · Cited by 31 · see citing works

Interaction between therapeutic interventions for Alzheimer’s disease and physiological Aβ clearance mechanisms

Morrone, C. D., Liu, M., Black, S. E., & McLaurin, J. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00064 · Cited by 29 · see citing works

Role of amyloid beta (25−35) neurotoxicity in the ferroptosis and necroptosis as modalities of regulated cell death in Alzheimer's disease

Naderi, S., Khodagholi, F., Pourbadie, H. G., Naderi, N., Rafiei, S., Janahmadi, M., Sayehmiri, F., & Motamedi, F. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.11.003 · Cited by 29 · see citing works

Neuromodulation of the Pineal Gland via Electrical Stimulation of Its Sympathetic Innervation Pathway

Lumsden, S. C., Clarkson, A. N., & Çakmak, Y. Ö. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.00264 · Cited by 28 · see citing works

On the relationships between epilepsy, sleep, and Alzheimer’s disease: A narrative review

Hanke, J.-M., Schindler, K. A., & Seiler, A. (2022) · Epilepsy & Behavior · doi:10.1016/j.yebeh.2022.108609 · Cited by 27 · see citing works

Sex and Sleep Disruption as Contributing Factors in Alzheimer’s Disease

Johnson, C. E., Duncan, M. J., & Murphy, M. P. (2023) · Journal of Alzheimer s Disease · doi:10.3233/jad-230527 · Cited by 34 · see citing works

Associations between self-reported sleep characteristics and incident mild cognitive impairment: The Heinz Nixdorf Recall Cohort Study

Brachem, C., Winkler, A., Tebrügge, S., Weimar, C., Erbel, R., Jöckel, K., Stang, A., Dragano, N., Moebus, S., Kowall, B., et al. (2020) · Scientific Reports · doi:10.1038/s41598-020-63511-9 · Cited by 27 · see citing works

Sleep–Wake Disorders in Alzheimer’s Disease: A Review

Sun, Y.-Y., Wang, Z., Zhou, H.-Y., & Huang, H. (2022) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.2c00097 · Cited by 27 · see citing works

Current Perspectives: Obesity and Neurodegeneration - Links and Risks

Kueck, P. J., Morris, J. K., & Stanford, J. A. (2024) · Degenerative Neurological and Neuromuscular Disease · doi:10.2147/dnnd.s388579 · Cited by 29 · see citing works

Epigenetic Regulation of BMAL1 with Sleep Disturbances and Alzheimer’s Disease

Hulme, B., Didikoğlu, A., Bradburn, S., Robinson, A., Canal, M. M., Payton, A., Pendleton, N., & Murgatroyd, C. (2020) · Journal of Alzheimer s Disease · doi:10.3233/jad-200634 · Cited by 25 · see citing works

Sleep, Pain, and Neurodegeneration: A Mendelian Randomization Study

Grover, S., & Sharma, M. (2022) · Frontiers in Neurology · doi:10.3389/fneur.2022.765321 · Cited by 23 · see citing works

DOTA: Deep Learning Optimal Transport Approach to Advance Drug Repositioning for Alzheimer’s Disease

Chyr, J., Gong, H., & Zhou, X. (2022) · Biomolecules · doi:10.3390/biom12020196 · Cited by 24 · see citing works

Aberrant waste disposal in neurodegeneration: why improved sleep could be the solution

Wafford, K. A. (2021) · Cerebral Circulation - Cognition and Behavior · doi:10.1016/j.cccb.2021.100025 · Cited by 24 · see citing works

Chronic rapid eye movement sleep deprivation aggravates the pathogenesis of Alzheimer’s disease by decreasing brain O-GlcNAc cycling in mice

Kim, D. Y., Kim, S.-M., & Han, I. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03179-4 · Cited by 23 · see citing works

Familial natural short sleep mutations reduce Alzheimer pathology in mice

Dong, Q., Gentry, N. W., McMahon, T., Yamazaki, M., Benitez-Rivera, L., Wang, T., Gan, L., Ptáček, L. J., & Fu, Y. (2022) · iScience · doi:10.1016/j.isci.2022.103964 · Cited by 21 · see citing works

The mechanisms of mitochondrial abnormalities that contribute to sleep disorders and related neurodegenerative diseases

Zhang, W., Liu, D., Yuan, M., & Zhu, L. (2024) · Ageing Research Reviews · doi:10.1016/j.arr.2024.102307 · Cited by 25 · see citing works

REM sleep deprivation induced by the modified multi-platform method has detrimental effects on memory: A systematic review and meta-analysis

Diao, H., Li, Y., Sun, W., Zhang, J., Wang, M., Chen, Y., Zhou, F., & Li, X. (2023) · Behavioural Brain Research · doi:10.1016/j.bbr.2023.114652 · Cited by 21 · see citing works

Chronic sleep deprivation differentially affects short and long-term operant memory in Aplysia

Krishnan, H. C., Noakes, E. J., & Lyons, L. C. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.08.013 · Cited by 21 · see citing works

Sleep, neuronal hyperexcitability, inflammation and neurodegeneration: Does early chronic short sleep trigger and is it the key to overcoming Alzheimer’s disease?

Ahnaou, A., & Drinkenburg, W. H. I. M. (2021) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2021.06.039 · Cited by 23 · see citing works

The Potential Roles of Ghrelin in Metabolic Syndrome and Secondary Symptoms of Alzheimer’s Disease

Kim, S., Nam, Y., Shin, S. J., Park, Y., Jeon, S. G., Kim, J.-I., Kim, M., & Moon, M. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.583097 · Cited by 20 · see citing works

Circadian Disruption Reveals a Correlation of an Oxidative GSH/GSSG Redox Shift with Learning and Impaired Memory in an Alzheimer’s Disease Mouse Model

LeVault, K. R., Tischkau, S. A., & Brewer, G. J. (2015) · Journal of Alzheimer s Disease · doi:10.3233/jad-150026 · Cited by 20 · see citing works

Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance

Brice, K. N., Hagen, C. W., Peterman, J. L., Figg, J., Braden-Kuhle, P. N., Chumley, M. J., & Boehm, G. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113128 · Cited by 19 · see citing works

Acute sleep deprivation in mice generates protein pathology consistent with neurodegenerative diseases

Rowe, R. K., Schulz, P., He, P., Mannino, G. S., Opp, M. R., & Sierks, M. R. (2024) · Frontiers in Neuroscience · doi:10.3389/fnins.2024.1436966 · Cited by 18 · see citing works

Insomnia and risk of all-cause dementia: A systematic review and meta-analysis

Meng, M., Shen, X., Xie, Y., Lan, R., & Zhu, S. (2025) · PLoS ONE · doi:10.1371/journal.pone.0318814 · Cited by 18 · see citing works

With mouse age comes wisdom: A review and suggestions of relevant mouse models for age-related conditions

Drechsler, S., Lynch, M. A., Novella, S., Navarro, H. G., Hecimovic, S. K., Barini, E., Tucci, V., Castro, R. E., Vandenbroucke, R. E., Osuchowski, M. F., et al. (2016) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2016.07.005 · Cited by 18 · see citing works

A restless night makes for a rising tide of amyloid

Mander, B. A., Winer, J. R., & Walker, M. P. (2017) · Brain · doi:10.1093/brain/awx174 · Cited by 18 · see citing works

Chronic sleep restriction increases soluble hippocampal Aβ-42 and impairs cognitive performance

Brice, K. N., Hagen, C. W., Peterman, J. L., Figg, J., Braden-Kuhle, P. N., Chumley, M. J., & Boehm, G. W. (2020) · Physiology & Behavior · doi:10.1016/j.physbeh.2020.113128 · Cited by 19 · see citing works

Chronic Sleep Restriction Induces Cognitive Deficits and Cortical Beta‐Amyloid Deposition in Mice via BACE 1‐Antisense Activation

Zhao, H., Wu, H., He, J., Zhuang, J., Liu, Z., Huang, L., & Zhao, Z. (2017) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12667 · Cited by 53 · see citing works

P1‐182: CHRONIC SLEEP RESTRICTION INDUCES Aβ ACCUMULATION BY DISRUPTING THE BALANCE OF Aβ PRODUCTION AND CLEARANCE IN RATS

Zhao, B., & Qu, Q. (2018) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2018.06.186

Chronic sleep restriction promotes brain inflammation and synapse loss, and potentiates memory impairment induced by amyloid-β oligomers in mice

Kincheski, G. C., Valentim, I. S., Clarke, J. R., Cozachenco, D., Castelo-Branco, M. T. L., Ramos-Lobo, A. M., Rumjanek, V. M. B. D., Donato, J., De Felice, F. G., & Ferreira, S. T. (2017) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2017.04.007 · Cited by 117 · see citing works

Oxidative stress mediated neuroinflammation induced by chronic sleep restriction as triggers for Alzheimer’s disease

Parameswari, R. P., Ramesh, G., Chidambaram, S. B., & Thangavelu, L. P. (2022) · Alzheimer s & Dementia · doi:10.1002/alz.059016 · Cited by 6 · see citing works