Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning

Hairston, Ilana S.; Little, Milton T. M.; Scanlon, Michael D.; Barakat, Monique T.; Palmer, Theo D.; Sapolsky, Robert M.; Heller, H. Craig

doi:10.1152/jn.00218.2005

Cited by 223Sleep and Wakefulness ResearchNeurogenesis and neuroplasticity mechanismsMemory and Neural Mechanisms

Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning

Hairston, Ilana S., Little, Milton T. M., Scanlon, Michael D., Barakat, Monique T., Palmer, Theo D., Sapolsky, Robert M., Heller, H. Craig·2005·Journal of Neurophysiology

DOI 10.1152/jn.00218.2005

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Abstract

Sleep deprivation impairs hippocampal-dependent learning, which, in turn, is associated with increased survival of newborn cells in the hippocampus. We tested whether the deleterious effects of sleep restriction on hippocampus-dependent memory were associated with reduced cell survival in the hippocampus. We show that sleep restriction impaired hippocampus-dependent learning and abolished learning-induced neurogenesis. Animals were trained in a water maze on either a spatial learning (hippocampus-dependent) task or a nonspatial (hippocampus-independent) task for 4 days. Sleep-restricted animals were kept awake for one-half of their rest phase on each of the training days. Consistent with previous reports, animals trained on the hippocampus-dependent task expressed increased survival of newborn cells in comparison with animals trained on the hippocampus-independent task. This increase was abolished by sleep restriction that caused overall reduced cell survival in all animals. Sleep restriction also selectively impaired spatial learning while performance in the nonspatial task was, surprisingly, improved. Further analysis showed that in both training groups fully rested animals applied a spatial strategy irrespective of task requirements; this strategy interfered with performance in the nonspatial task. Conversely, in sleep-restricted animals, this preferred spatial strategy was eliminated, favoring the use of nonspatial information, and hence improving performance in the nonspatial task. These findings suggest that sleep loss altered behavioral strategies to those that do not depend on the hippocampus, concomitantly reversing the neurogenic effects of hippocampus-dependent learning.

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Sleep restriction by novelty exposure prevents the increased survival of new dentate gyrus neurons promoted by spatial training in a Morris water maze.
“Nevertheless, sleep restriction by novelty exposure, a more subtle method, prevented the increased survival of new dentate gyrus neurons promoted by spatial training in a Morris water maze.77”
From Sleep Deprivation and Circadian Disruption (2015) · cites this paper as [77]
Sleep restriction by novelty exposure prevents the increased survival of new dentate gyrus neurons promoted by spatial training in a Morris water maze.
“Nevertheless, sleep restriction by novelty exposure, a more subtle method, prevented the increased survival of new dentate gyrus neurons promoted by spatial training in a Morris water maze.31”
From Protective and damaging effects of stress mediators: central role of the brain (2006) · cites this paper as [31]

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Authors: Hairston, I. S., Little, M. T. M., Scanlon, M. D., Barakat, M. T., Palmer, T. D., Sapolsky, R. M., & Heller, H. C.
Affiliations: University of California, Berkeley (US)
ORCID: Hairston, Ilana S.
Little, Milton T. M.
Barakat, Monique T.
Palmer, Theo D.
Sapolsky, Robert M.
Heller, H. Craig
Venue: Journal of Neurophysiology
Publisher: American Physiological Society
Published: 2005-12
Volume: 94
Issue: 6
Pages: 4224-4233
ISSN: 0022-3077 (ISSN-L)
1522-1598
DOI: 10.1152/jn.00218.2005
OpenAlex: W2096232633
Cited by: 223
References: 57
Citations by year: 2026: 1 · 2025: 7 · 2024: 6 · 2023: 2 · 2022: 5 · 2021: 4 · 2020: 11 · 2019: 11 · 2018: 6 · 2017: 13 · 2016: 9 · 2015: 20 · 2014: 11 · 2013: 17 · 2012: 10
FWCI: 7.41
Type: journal article
Language: en
Open access: closed
Locations: Journal of Neurophysiology (publishedVersion)
PubMed (publishedVersion)
Funders: National Institutes of Health (5r01hd037315-05)
National Institute of Mental Health (F31-MH-65168-01, F31MH065168)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD37315)
Topics: Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
Keywords: sleep restriction, sleep deprivation, hippocampus-dependent learning, spatial learning, hippocampal neurogenesis, water maze, behavioral strategies, memory consolidation
MeSH terms: Doublecortin Domain Proteins, Animals, Behavior, Animal, Bromodeoxyuridine, Cell Count, Cell Survival, Corticosterone, Cues, Hippocampus, Immunohistochemistry, Learning, Microtubule-Associated Proteins, Neurons, Neuropeptides, Radioimmunoassay, Reaction Time, Sleep Deprivation, Spatial Behavior, Time Factors, Chi-Square Distribution, Polysomnography, Maze Learning, Rats

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Sleep restriction suppresses neurogenesis induced by hippocampus-dependent learning

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