Cited by 220Sleep and Wakefulness ResearchStress Responses and CortisolAnimal Behavior and Welfare Studies

Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat

Suchecki, Deborah, Tufik, Sergio·2000·Physiology & Behavior

Abstract

The instrumental methods to induce paradoxical sleep (PS) deprivation are stressful. The modified multiple platform method (MMPM), in which animals are placed with new cohorts inside the water tanks, results in augmented ACTH and corticosterone (CORT) responses. We hypothesised that this increased response could be attributed to social instability. In addition, we tested a new environmental control, a grid (GR) placed on the tank floor. Animals were submitted to the MMPM for 4 days as socially unstable (UG--coming from several cages) or stable groups (SG--coming from one cage), placed either on narrow platforms or on the grid. All UG animals presented higher ACTH levels than their SG counterparts, including home-cage controls. CORT levels of manipulated animals were higher than controls only in the stable group. UG animals presented heavier adrenals than their SG counterparts. Only adrenals from SG animals placed on the grid were similar to cage controls. SG rats lost less weight than UG animals. While UG animals ate the same amount of chow as home-cage controls, SG animals ate more than control and UG animals. These results suggest that the stress of the MMPM can be attenuated in stable groups. The introduction of a grid on the tank floor may serve an adequate environmental control as far as stress-related variables are considered.

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Crossref · 10.1016/s0031-9384(99)00181-x

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  • In another study, only women showed an association between greater difficulty falling asleep and frequency of sleep disturbances (both PSQI subcomponents) with higher levels of IL-6.

    “in another study only women showed an association between greater difficulty falling asleep and frequency of sleep disturbances (both PSQI subcomponents) with higher levels of IL-6”

    From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [529]

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Authors
Suchecki, D., & Tufik, S.
Affiliations
Universidade Federal de São Paulo (BR)
Corresponding author
Suchecki, Deborah
Venue
Physiology & Behavior
Publisher
Elsevier BV
Published
2000-01
Volume
68
Issue
3
Pages
309-316
ISSN
0031-9384 (ISSN-L)
OpenAlex
W1997311794
Cited by
220
References
34
Citations by year
2026: 6 · 2025: 3 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 18 · 2014: 16 · 2013: 12 · 2012: 6
FWCI
3.01
Type
journal article
Language
en
Open access
closed
Locations
  • Physiology & Behavior (publishedVersion)
  • PubMed (publishedVersion)
  • UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
Funders
Fundação de Amparo à Pesquisa do Estado de São Paulo
Topics
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
Keywords
REM sleep deprivation, social stability, social instability, stress, ACTH, corticosterone, adrenal weight, dietary intake, weight loss, environmental control, rats
MeSH terms
Adrenocorticotropic Hormone, Animals, Arousal, Corticosterone, Eating, Habituation, Psychophysiologic, Humans, Male, Sleep Deprivation, Social Environment, Stress, Psychological, Rats, Wistar, Rats

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