Social stability attenuates the stress in the modified multiple platform method for paradoxical sleep deprivation in the rat
Abstract
The instrumental methods to induce paradoxical sleep (PS) deprivation are stressful. The modified multiple platform method (MMPM), in which animals are placed with new cohorts inside the water tanks, results in augmented ACTH and corticosterone (CORT) responses. We hypothesised that this increased response could be attributed to social instability. In addition, we tested a new environmental control, a grid (GR) placed on the tank floor. Animals were submitted to the MMPM for 4 days as socially unstable (UG--coming from several cages) or stable groups (SG--coming from one cage), placed either on narrow platforms or on the grid. All UG animals presented higher ACTH levels than their SG counterparts, including home-cage controls. CORT levels of manipulated animals were higher than controls only in the stable group. UG animals presented heavier adrenals than their SG counterparts. Only adrenals from SG animals placed on the grid were similar to cage controls. SG rats lost less weight than UG animals. While UG animals ate the same amount of chow as home-cage controls, SG animals ate more than control and UG animals. These results suggest that the stress of the MMPM can be attenuated in stable groups. The introduction of a grid on the tank floor may serve an adequate environmental control as far as stress-related variables are considered.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In another study, only women showed an association between greater difficulty falling asleep and frequency of sleep disturbances (both PSQI subcomponents) with higher levels of IL-6.
“in another study only women showed an association between greater difficulty falling asleep and frequency of sleep disturbances (both PSQI subcomponents) with higher levels of IL-6”
From The Sleep-Immune Crosstalk in Health and Disease (2019) · cites this paper as [529]
Cites
Regulation of pituitary ACTH secretion during chronic stress
Aguilera, G. (1994) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1994.1013 · Cited by 557 · see citing works
Attack and defensive behaviour in the albino rat
Blanchard, R. J., Blanchard, D. C., Takahashi, T., & Kelley, M. J. (1977) · Animal Behaviour · doi:10.1016/0003-3472(77)90113-0 · Cited by 371 · see citing works
Levitt, R. A. (1966) · Science · doi:10.1126/science.153.3731.85 · Cited by 345 · see citing works
Glucocorticoids and insulin: reciprocal signals for energy balance
Strack, A. M., Sebastian, R. J., Schwartz, M. W., & Dallman, M. F. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.1.r142 · Cited by 334 · see citing works
The temporal dynamics of the stress response
Koolhaas, J. M., Meerlo, P., de Boer, S. F., STRUBBE, J. H., & Bohus, B. (1997) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(96)00057-7 · Cited by 331 · see citing works
Martı́, O., Martı́, J., & Armario, A. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90055-8 · Cited by 305 · see citing works
Cohen, H. B., & Dement, W. C. (1965) · Science · doi:10.1126/science.150.3701.1318 · Cited by 240 · see citing works
Changes in Behaviour and Body Weight Following a Single or Double Social Defeat in Rats
Meerlo, P., Overkamp, G. J. F., Daan, S., van den Hoofdakker, R. H., & Koolhaas, J. M. (1996) · Stress · doi:10.3109/10253899609001093 · Cited by 215 · see citing works
Sleep Deprivation in the Rat: IV. Paradoxical Sleep Deprivation
Kushida, C. A., Bergmann, B. M., & Rechtschaffen, A. (1989) · SLEEP · doi:10.1093/sleep/12.1.22 · Cited by 191 · see citing works
Suchecki, D., Lobo, L. L., Hipólide, D. C., & Tufik, S. (1998) · Journal of Sleep Research · doi:10.1046/j.1365-2869.1998.00122.x · Cited by 180 · see citing works
Self-citationStress induced by three procedures of deprivation of paradoxical sleep
Coenen, A. M. L., & VANLUIJTELAAR, E. (1985) · Physiology & Behavior · doi:10.1016/0031-9384(85)90130-1 · Cited by 136 · see citing works
Noradrenergic activity in rat brain during rapid eye movement sleep deprivation and rebound sleep
Porkka‐Heiskanen, T., Smith, S. E., Taira, T., Urban, J. H., Levine, J. E., Turek, F. W., & Stenberg, D. (1995) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1995.268.6.r1456 · Cited by 111 · see citing works
Pattern of Adenohypophyseal Hormone Changes in Male Rats Following Chronic Stress
Taché, Y., Ruisseau, P. D., DUCHARME, J. R., et al. (2008) · Neuroendocrinology · doi:10.1159/000122828 · Cited by 109 · see citing works
Body weight gain, food intake and adrenal development in chronic noise stressed rats
Alario, P., Gamallo, A., Beato, M., & Trancho, G. J. (1987) · Physiology & Behavior · doi:10.1016/0031-9384(87)90181-8 · Cited by 104 · see citing works
Paradoxical sleep deprivation and locomotor activity in rats
Hulzen, Z. J. M. V., & Coenen, A. M. L. (1981) · Physiology & Behavior · doi:10.1016/0031-9384(81)90250-x · Cited by 92 · see citing works
Mormède, P., Lemaire, V., Castanon, N., Dulluc, J., Laval, M., & Moal, M. L. (1990) · Physiology & Behavior · doi:10.1016/0031-9384(90)90358-b · Cited by 89 · see citing works
Buwalda, B., de Boer, S. F., van Kalkeren, A. A., & Koolhaas, J. M. (1997) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(97)00032-2 · Cited by 89 · see citing works
Klein, F., Lemaire, V., Sandi, C., Vitiello, S., van der Logt, J. T. M., Laurent, P. E., Neveu, P. J., Moal, M. L., & Mormède, P. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90475-5 · Cited by 74 · see citing works
FADDA, P., & FRATTA, W. (1997) · Pharmacological Research · doi:10.1006/phrs.1997.0155 · Cited by 72 · see citing works
Postweaning social experience and adult aggression in rats
Lore, R. K., & Stipo-Flaherty, A. (1984) · Physiology & Behavior · doi:10.1016/0031-9384(84)90373-1 · Cited by 64 · see citing works
Ledoux, L., Sastre, J., Buda, C., Luppi, P., & Jouvet, M. (1996) · Brain Research · doi:10.1016/0006-8993(96)00599-9 · Cited by 60 · see citing works
Tufik, S. B., Troncone, L. R. P., Braz, S., Silva-Filho, A. R., & Neumann, B. G. (1987) · European Journal of Pharmacology · doi:10.1016/0014-2999(87)90808-9 · Cited by 57 · see citing works
Self-citationHotta, M., Shibasaki, T., Yamauchi, N., Ohno, H., Benoit, R., LING, N. C., & Demura, H. (1991) · Life Sciences · doi:10.1016/0024-3205(91)90186-f · Cited by 56 · see citing works
Stress-related behavior and central norepinephrine concentrations in the REM sleep-deprived rat
Brock, J. W., Farooqui, S. M., Ross, K. D., Payne, S., & Prasad, C. (1994) · Physiology & Behavior · doi:10.1016/0031-9384(94)90380-8 · Cited by 38 · see citing works
Patchev, V. K., Felszeghy, K., & Korányi, L. (1991) · PubMed · Cited by 37 · see citing works
Kawanishi, C., Fukuda, M., Tamura, R., Nishijo, H., & Ono, T. (1997) · Physiology & Behavior · doi:10.1016/s0031-9384(97)00248-5 · Cited by 28 · see citing works
Effects of stress on drug-induced yawning: Constant Vs. intermittent stress
Tufik, S. (1995) · Physiology & Behavior · doi:10.1016/0031-9384(95)00043-i · Cited by 28 · see citing works
Self-citationRegulation of catecholamine-synthesizing enzymes in adrenals of Wistar rats under chronic stress
Lemaire, V., Moal, M. L., & Mormède, P. (1993) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.1993.264.5.r957 · Cited by 26 · see citing works
Seabra, M. D. L. V., & Tufik, S. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90303-w · Cited by 19 · see citing works
Self-citationPsychoneuroendocrine outcomes of short-term crowding stress
Chaouloff, F., & Zamfir, O. (1993) · Physiology & Behavior · doi:10.1016/0031-9384(93)90089-x · Cited by 18 · see citing works
STUDIES OF THE TROPHIC ACTION OF ACTH*
Ramachandran, J., Rao, A. J., & Liles, S. (1977) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1977.tb41865.x · Cited by 16 · see citing works
Social dominance, adrenal weight, and the reticuloendothelial system in rats
Taylor, L. R., & Costanzo, D. J. (1975) · Behavioral Biology · doi:10.1016/s0091-6773(75)91818-0 · Cited by 7 · see citing works
Elomaa, E. (1985) · PubMed · Cited by 7 · see citing works
Metabolic Effects of Chronic ACTH Administration, Interaction with Response to Stress
Armario, A., Campmany, L., & Hidalgo, J. (2008) · Pharmacology · doi:10.1159/000138221 · Cited by 5 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
The Sleep-Immune Crosstalk in Health and Disease
Besedovsky, L., Lange, T., & Haack, M. (2019) · Physiological Reviews · doi:10.1152/physrev.00010.2018 · Cited by 1,479 · see citing works
The reinterpretation of dreams: An evolutionary hypothesis of the function of dreaming
Revonsuo, A. (2000) · Behavioral and Brain Sciences · doi:10.1017/s0140525x00004015 · Cited by 676 · see citing works
Rothman, S. M., Herdener, N., Frankola, K. A., Mughal, M. R., & Mattson, M. P. (2013) · Brain Research · doi:10.1016/j.brainres.2013.07.010 · Cited by 172 · see citing works
Cell Injury and Repair Resulting from Sleep Loss and Sleep Recovery in Laboratory Rats
Everson, C. A., Henchen, C. J., Szabo, A., & Hogg, N. (2014) · Sleep · doi:10.5665/sleep.4244 · Cited by 136 · see citing works
Koban, M., Le, W. W., & Hoffman, G. E. (2006) · Endocrinology · doi:10.1210/en.2005-0695 · Cited by 85 · see citing works
Sleep-deprivation reduces NK cell number and function mediated by β-adrenergic signalling
De Lorenzo, B. H. P., de Oliveira Marchioro, L., Greco, C. R., & Suchecki, D. (2015) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2015.04.006 · Cited by 85 · see citing works
Self-citationPalma, B. D., Gabriel, A., Colugnati, F. A. B., & Tufik, S. (2006) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00186.2006 · Cited by 74 · see citing works
Self-citationParadoxical sleep deprivation induces muscle atrophy
Dattilo, M., Antunes, H. K. M., Medeiros, A., Mônico‐neto, M., Souza, H. D. S., Lee, K. S., Tufik, S., & de Mello, M. T. (2012) · Muscle & Nerve · doi:10.1002/mus.22322 · Cited by 66 · see citing works
Self-citationEverson, C. A., Thalacker, C. D., & Hogg, N. (2008) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.90623.2008 · Cited by 35 · see citing works
REM sleep deprivation increases the expression of interleukin genes in mice hypothalamus
Kang, W. S., Park, H. J., Chung, J.-H., & Kim, J. W. (2013) · Neuroscience Letters · doi:10.1016/j.neulet.2013.09.050 · Cited by 33 · see citing works
Sleep Deprivation Induces Changes in Immunity in <i>Trichinella spiralis</i> -Infected Rats
Ibarra-Coronado, E. G., Velazquéz-Moctezuma, J., Diaz, D., Becerril-Villanueva, L. E., Pavón, L., & Morales-Montor, J. (2015) · International Journal of Biological Sciences · doi:10.7150/ijbs.11907 · Cited by 30 · see citing works
- Authors
- Suchecki, D., & Tufik, S.
- Affiliations
- Universidade Federal de São Paulo (BR)
- Corresponding author
- Suchecki, Deborah
- ORCID
- Suchecki, Deborah
- Venue
- Physiology & Behavior
- Publisher
- Elsevier BV
- Published
- 2000-01
- Volume
- 68
- Issue
- 3
- Pages
- 309-316
- ISSN
- 0031-9384 (ISSN-L)
- OpenAlex
- W1997311794
- Cited by
- 220
- References
- 34
- Citations by year
- 2026: 6 · 2025: 3 · 2024: 9 · 2023: 12 · 2022: 11 · 2021: 11 · 2020: 10 · 2019: 13 · 2018: 10 · 2017: 12 · 2016: 8 · 2015: 18 · 2014: 16 · 2013: 12 · 2012: 6
- FWCI
- 3.01
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Physiology & Behavior (publishedVersion)
- PubMed (publishedVersion)
- UNIFESP Institutional Repository (Universidade Federal de São Paulo) (submittedVersion)
- Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Topics
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Health Sciences › Veterinary › Small Animals › Animal Behavior and Welfare Studies
- Keywords
- REM sleep deprivation, social stability, social instability, stress, ACTH, corticosterone, adrenal weight, dietary intake, weight loss, environmental control, rats
- MeSH terms
- Adrenocorticotropic Hormone, Animals, Arousal, Corticosterone, Eating, Habituation, Psychophysiologic, Humans, Male, Sleep Deprivation, Social Environment, Stress, Psychological, Rats, Wistar, Rats
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review