Intracisternal Interleukin-1 Receptor Antagonist Prevents Postoperative Cognitive Decline and Neuroinflammatory Response in Aged Rats

Modality-Specific Retrograde Amnesia of Fear

Kim, J. J., & Fanselow, M. S. (1992) · Science · doi:10.1126/science.1585183 · Cited by 2,483 · see citing works

Long-term postoperative cognitive dysfunction in the elderly: ISPOCD1 study

Møller, J. T., Cluitmans, P. P., Rasmussen, L., Houx, P. J., Rasmussen, H., Canet, J., Rabbitt, P., Jolles, J., Larsen, K., Hanning, C. D., et al. (1998) · The Lancet · doi:10.1016/s0140-6736(97)07382-0 · Cited by 2,407 · see citing works

Predictors of Cognitive Dysfunction after Major Noncardiac Surgery

Monk, T. G., Weldon, B. C., Garvan, C. W., Dede, D. E., van der Aa, M. T., Heilman, K. M., & GRAVENSTEIN, J. S. (2008) · Anesthesiology · doi:10.1097/01.anes.0000296071.19434.1e · Cited by 1,532 · see citing works

Exaggerated neuroinflammation and sickness behavior in aged mice after activation of the peripheral innate immune system

Godbout, J. P., Chen, J., Abraham, J., Richwine, A. F., Berg, B. M., Kelley, K. W., & Johnson, R. W. (2005) · The FASEB Journal · doi:10.1096/fj.05-3776fje · Cited by 813 · see citing works

Central and Systemic Endotoxin Challenges Exacerbate the Local Inflammatory Response and Increase Neuronal Death during Chronic Neurodegeneration

Cunningham, C., Wilcockson, D. C., Campion, S., Lunnon, K., & Perry, V. H. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.2614-05.2005 · Cited by 768 · see citing works

Role of interleukin‐1β in postoperative cognitive dysfunction

Cibelli, M., Fidalgo, A. R., Terrando, N., Ma, D., Monaco, C. G., Feldmann, M., Takata, M., Lever, I. J., Nanchahal, J., Fanselow, M. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22082 · Cited by 742 · see citing works

Peripheral lipopolysaccharide (LPS) challenge promotes microglial hyperactivity in aged mice that is associated with exaggerated induction of both pro-inflammatory IL-1β and anti-inflammatory IL-10 cytokines

Henry, C. J., Huang, Y., Wynne, A. M., & Godbout, J. P. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.002 · Cited by 565 · see citing works

Does anaesthesia cause postoperative cognitive dysfunction? A randomised study of regional versus general anaesthesia in 438 elderly patients

Rasmussen, L. S., Johnson, T., Kuipers, H. M., Kristensen, D., Siersma, V., Vila, P., Jolles, J., Papaioannou, A. A., Abildstrøm, H., Silverstein, J. H., et al. (2003) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2003.00057.x · Cited by 558 · see citing works

The assessment of postoperative cognitive function

Rasmussen, L. S., Larsen, K., Houx, P. J., Skovgaard, L. T., Hanning, C. D., Møller, J., & the ISPOCD group (2001) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2001.045003275.x · Cited by 548 · see citing works

ADVERSE CEREBRAL EFFECTS OF ANÆSTHESIA ON OLD PEOPLE

Bedford, P. D. (1955) · The Lancet · doi:10.1016/s0140-6736(55)92689-1 · Cited by 477 · see citing works

Neuroinflammation and disruption in working memory in aged mice after acute stimulation of the peripheral innate immune system

Chen, J., Buchanan, J. B., Sparkman, N. L., Godbout, J. P., Freund, G. G., & Johnson, R. W. (2007) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2007.08.014 · Cited by 396 · see citing works

Cognitive dysfunction 1–2 years after non‐cardiac surgery in the elderly

Abildstrøm, H., Rasmussen, L. S., Rentowl, P., Hanning, C. D., Rasmussen, H., Kristensen, P. A., Møller, J. T., & the ISPOCD group (2000) · Acta Anaesthesiologica Scandinavica · doi:10.1034/j.1399-6576.2000.441010.x · Cited by 394 · see citing works

Aging, microglial cell priming, and the discordant central inflammatory response to signals from the peripheral immune system

Dilger, R. N., & Johnson, R. W. (2008) · Journal of Leukocyte Biology · doi:10.1189/jlb.0208108 · Cited by 391 · see citing works

Peripheral infection and aging interact to impair hippocampal memory consolidation

Barrientos, R. M., Higgins, E. A., Biedenkapp, J. C., Sprunger, D. B., Wright-Hardesty, K. J., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2006) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2005.03.010 · Cited by 330 · see citing works

Increased interleukin-6 expression by microglia from brain of aged mice

Ye, S.-M., & Johnson, R. W. (1999) · Journal of Neuroimmunology · doi:10.1016/s0165-5728(98)00217-3 · Cited by 327 · see citing works

Bi-directional immune–brain communication: implications for understanding stress, pain, and cognition

Maier, S. F. (2003) · Brain Behavior and Immunity · doi:10.1016/s0889-1591(03)00032-1 · Cited by 300 · see citing works

Neuroinflammation and cognitive function in aged mice following minor surgery

Rosczyk, H. A., Sparkman, N. L., & Johnson, R. W. (2008) · Experimental Gerontology · doi:10.1016/j.exger.2008.06.004 · Cited by 271 · see citing works

Memory for context is impaired by a post context exposure injection of interleukin-1 beta into dorsal hippocampus.

Barrientos, R., Higgins, E. A., Sprunger, D. B., Watkins, L., Rudy, J., & Maier, S. (2002) · Behavioural Brain Research · doi:10.1016/s0166-4328(02)00043-8 · Cited by 259 · see citing works

Time course of hippocampal IL-1 β and memory consolidation impairments in aging rats following peripheral infection

Barrientos, R. M., Frank, M. G., Hein, A. M., Higgins, E. A., Watkins, L. R., Rudy, J. W., & Maier, S. F. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.07.002 · Cited by 226 · see citing works

Pharmacokinetics, safety and immunomodulatory effects of human recombinant interleukin-1 receptor antagonist in healthy humans

Granowitz, E. V., Porat, R., Mier, J. W., Pribble, J. P., Stiles, D., Bloedow, D. C., Catalano, M. A., Wolff, S. M., & Dinarello, C. A. (1992) · Cytokine · doi:10.1016/1043-4666(92)90078-6 · Cited by 220 · see citing works

Little Exercise, Big Effects: Reversing Aging and Infection-Induced Memory Deficits, and Underlying Processes

Barrientos, R. M., Frank, M. G., Crysdale, N. Y., Chapman, T. R., Ahrendsen, J. T., Day, H. E. W., Campeau, S., Watkins, L. R., Patterson, S. L., & Maier, S. F. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2266-11.2011 · Cited by 148 · see citing works

Systemic inflammation enhances surgery-induced cognitive dysfunction in mice

Fidalgo, A. R., Cibelli, M., White, J. P. M., Nagy, I., Maze, M., & Ma, D. (2011) · Neuroscience Letters · doi:10.1016/j.neulet.2011.04.063 · Cited by 137 · see citing works

Consuming a diet supplemented with resveratrol reduced infection-related neuroinflammation and deficits in working memory in aged mice

Abraham, J., & Johnson, R. W. (2009) · Rejuvenation Research · doi:10.1089/rej.2009.0888 · Cited by 131 · see citing works

Cognitive and neuroinflammatory consequences of mild repeated stress are exacerbated in aged mice

Buchanan, J. B., Sparkman, N. L., Chen, J., & Johnson, R. W. (2008) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2008.02.013 · Cited by 126 · see citing works

Aging and a Peripheral Immune Challenge Interact to Reduce Mature Brain-Derived Neurotrophic Factor and Activation of TrkB, PLCγ1, and ERK in Hippocampal Synaptoneurosomes

Cortese, G. P., Barrientos, R. M., Maier, S. F., & Patterson, S. L. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5818-10.2011 · Cited by 119 · see citing works

Aging sensitizes rapidly isolated hippocampal microglia to LPS ex vivo

Frank, M. G., Barrientos, R. M., Watkins, L. R., & Maier, S. F. (2010) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2010.05.022 · Cited by 109 · see citing works

IL-1RA blocks E. coli-induced suppression of Arc and long-term memory in aged F344 × BN F1 rats

Frank, M. G., Barrientos, R. M., Hein, A. M., Biedenkapp, J. C., Watkins, L. R., & Maier, S. F. (2009) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2009.10.005 · Cited by 78 · see citing works

Synaptic Correlates of Increased Cognitive Vulnerability with Aging: Peripheral Immune Challenge and Aging Interact to Disrupt Theta-Burst Late-Phase Long-Term Potentiation in Hippocampal Area CA1

Chapman, T. R., Barrientos, R. M., Ahrendsen, J. T., Maier, S. F., & Patterson, S. L. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.5172-09.2010 · Cited by 72 · see citing works

Depth of anaesthesia and post‐operative cognitive dysfunction

Steinmetz, J., Funder, K. S., Dahl, B., & Rasmussen, L. S. (2009) · Acta Anaesthesiologica Scandinavica · doi:10.1111/j.1399-6576.2009.02098.x · Cited by 71 · see citing works

Abdominal Surgery Decreases Food-reinforced Operant Responding in Rats

Martin, T. J., Kahn, W., & Eisenach, J. C. (2005) · Anesthesiology · doi:10.1097/00000542-200509000-00028 · Cited by 36 · see citing works

Prior laparotomy or corticosterone potentiates lipopolysaccharide-induced fever and sickness behaviors

Hains, L. E., Loram, L. C., Taylor, F. R., Strand, K. A., Wieseler, J. L., Barrientos, R. M., Young, J. J., Frank, M. G., Sobesky, J. L., Martin, T. J., et al. (2011) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2011.08.011 · Cited by 25 · see citing works

Effect of High-Fat Diets on Oxidative Stress, Cellular Inflammatory Response and Cognitive Function

Tan, B. L., & Norhaizan, M. E. (2019) · Nutrients · doi:10.3390/nu11112579 · Cited by 525 · see citing works

Microglia Priming with Aging and Stress

Niraula, A., Sheridan, J. F., & Godbout, J. P. (2017) · Neuropsychopharmacology · doi:10.1038/npp.2016.185 · Cited by 398 · see citing works

The Role of Neuroinflammation in Postoperative Cognitive Dysfunction: Moving From Hypothesis to Treatment

Safavynia, S. A., & Goldstein, P. A. (2019) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2018.00752 · Cited by 350 · see citing works

Neuroinflammation in the normal aging hippocampus

Barrientos, R. M., Kitt, M. M., Watkins, L. R., & Maier, S. F. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.03.007 · Cited by 316 · see citing works

Postoperative cognitive dysfunction: Involvement of neuroinflammation and neuronal functioning

Hovens, I. B., Schoemaker, R. G., van der Zee, E. A., Absalom, A. R., Heineman, E., & van Leeuwen, B. L. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.02.002 · Cited by 299 · see citing works

Biomarkers of postoperative delirium and cognitive dysfunction

Androsova, G., Krause, R., Winterer, G., & Schneider, R. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00112 · Cited by 255 · see citing works

The relationship between inflammation and neurocognitive dysfunction in obstructive sleep apnea syndrome

Liu, X., Ma, Y., Ouyang, R., Zeng, Z., Zhan, Z., Lu, H., Cui, Y., Dai, Z., Luo, L., He, C., et al. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-01905-2 · Cited by 241 · see citing works

Evidence for a Dysregulated Immune System in the Etiology of Psychiatric Disorders

Gibney, S. M., & Drexhage, H. A. (2013) · Journal of Neuroimmune Pharmacology · doi:10.1007/s11481-013-9462-8 · Cited by 237 · see citing works

Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats

Netto, M. B., de Oliveira, A. N., Goldim, M. P. D. S., Mathias, K., Fileti, M. E., da Rosa, N., Laurentino, A. O. M., de Farias, B. X., Costa, A. B., Rezin, G. T., et al. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.016 · Cited by 228 · see citing works

Microglial aging in the healthy CNS: phenotypes, drivers, and rejuvenation

Wong, W. T. (2013) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2013.00022 · Cited by 227 · see citing works

High-fat diet and aging interact to produce neuroinflammation and impair hippocampal- and amygdalar-dependent memory

Spencer, S. J., D’Angelo, H. M., Soch, A., Watkins, L. R., Maier, S. F., & Barrientos, R. M. (2017) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2017.06.014 · Cited by 213 · see citing works

Transcriptional and epigenetic decoding of the microglial aging process

Li, X., Li, Y., Jin, Y., Zhang, Y., Wu, J., Xu, Z., Huang, Y., Cai, L., Gao, S., Liu, T., et al. (2023) · Nature Aging · doi:10.1038/s43587-023-00479-x · Cited by 225 · see citing works

Role of Peripheral Inflammatory Markers in Postoperative Cognitive Dysfunction (POCD): A Meta-Analysis

Peng, L., Xu, L., & Ouyang, W. (2013) · PLoS ONE · doi:10.1371/journal.pone.0079624 · Cited by 188 · see citing works

A novel method for evaluating microglial activation using ionized calcium-binding adaptor protein-1 staining: cell body to cell size ratio

Hovens, I. B., Nyakas, C. J., & Schoemaker, R. (2014) · Neuroimmunology and Neuroinflammation · doi:10.4103/2347-8659.139719 · Cited by 181 · see citing works

Dietary intervention rescues maternal obesity induced behavior deficits and neuroinflammation in offspring

Kang, S. S., Kurti, A., Fair, D. A., & Fryer, J. D. (2014) · Journal of Neuroinflammation · doi:10.1186/s12974-014-0156-9 · Cited by 167 · see citing works

IL-17A contributes to perioperative neurocognitive disorders through blood-brain barrier disruption in aged mice

Ni, P., Dong, H., Wang, Y., Zhou, Q., Xu, M., Qian, Y., & Sun, J. (2018) · Journal of Neuroinflammation · doi:10.1186/s12974-018-1374-3 · Cited by 160 · see citing works

Neuroinflammation as the Underlying Mechanism of Postoperative Cognitive Dysfunction and Therapeutic Strategies

Li, Z., Zhu, Y., Kang, Y., Qin, S., & Chai, J. (2022) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2022.843069 · Cited by 162 · see citing works

High-fat diet consumption disrupts memory and primes elevations in hippocampal IL-1β, an effect that can be prevented with dietary reversal or IL-1 receptor antagonism

Sobesky, J. L., Barrientos, R. M., May, H. S. D., Thompson, B. M., Weber, M. D., Watkins, L. R., & Maier, S. F. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.06.017 · Cited by 160 · see citing works

The Potential Role of the NLRP3 Inflammasome Activation as a Link Between Mitochondria ROS Generation and Neuroinflammation in Postoperative Cognitive Dysfunction

Wei, P., Yang, F., Zheng, Q., Tang, W., & Li, J. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00073 · Cited by 155 · see citing works

Depression as a risk factor for Alzheimer’s disease: Genes, steroids, cytokines and neurogenesis – What do we need to know?

Herbert, J., & Lucassen, P. J. (2016) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2015.12.001 · Cited by 150 · see citing works

Aspirin‐triggered resolvin D1 prevents surgery‐induced cognitive decline

Terrando, N., Gómez‐Galán, M., Yang, T., Carlström, M., Gustavsson, D., Harding, R. E., Lindskog, M., & Eriksson, L. I. (2013) · The FASEB Journal · doi:10.1096/fj.13-230276 · Cited by 147 · see citing works

Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation

Luo, A., Yan, J., Tang, X., Zhao, Y., Zhou, B., & Li, S. (2019) · Inflammopharmacology · doi:10.1007/s10787-018-00559-0 · Cited by 144 · see citing works

Hyperammonemia induces glial activation, neuroinflammation and alters neurotransmitter receptors in hippocampus, impairing spatial learning: reversal by sulforaphane

Hernández‐Rabaza, V., Cabrera‐Pastor, A., Taoro‐González, L., Malaguarnera, M., Agustí, A., Llansola, M., & Felipo, V. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0505-y · Cited by 144 · see citing works

Postoperative cognitive dysfunction and neuroinflammation; Cardiac surgery and abdominal surgery are not the same

Hovens, I. B., van Leeuwen, B. L., Mariani, M. A., Kraneveld, A. D., & Schoemaker, R. G. (2016) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2016.02.003 · Cited by 140 · see citing works

The Alarmin HMGB1 Mediates Age-Induced Neuroinflammatory Priming

Fonken, L. K., Frank, M. G., Kitt, M. M., D'Angelo, H. M., Norden, D. M., Weber, M. D., Barrientos, R. M., Godbout, J. P., Watkins, L. R., & Maier, S. F. (2016) · The Journal of Neuroscience · doi:10.1523/jneurosci.1161-16.2016 · Cited by 139 · see citing works

Adding fuel to the fire: the impact of stress on the ageing brain

Prenderville, J. A., Kennedy, P. J., Dinan, T. G., & Cryan, J. F. (2015) · Trends in Neurosciences · doi:10.1016/j.tins.2014.11.001 · Cited by 136 · see citing works

Neuroinflammation: The central enabler of postoperative cognitive dysfunction

Liu, Y., Yang, W., Xue, J., Chen, J., Liu, S., Zhang, S., Zhang, X., Gu, X., Dong, Y., & Qiu, P. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115582 · Cited by 136 · see citing works

NADPH oxidase 2-derived reactive oxygen species in the hippocampus might contribute to microglial activation in postoperative cognitive dysfunction in aged mice

Qiu, L., Ji, M., Zhang, H., Yang, J., Sun, X.-R., Tang, H., Wang, J., Liu, W., & Yang, J.-J. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.08.002 · Cited by 131 · see citing works

Synapse-specific IL-1 receptor subunit reconfiguration augments vulnerability to IL-1β in the aged hippocampus

Prieto, G. A., Snigdha, S., Baglietto-Vargas, D., Smith, E. D., Berchtold, N. C., Tong, L., Ajami, D., LaFerla, F. M., Rebek, J., & Cotman, C. W. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1514486112 · Cited by 126 · see citing works

Enhanced neuroinflammation mediated by DNA methylation of the glucocorticoid receptor triggers cognitive dysfunction after sevoflurane anesthesia in adult rats subjected to maternal separation during the neonatal period

Zhu, Y., Wang, Y., Yao, R., Hao, T., Cao, J., Huang, H., Wang, L., & Wu, Y. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0782-5 · Cited by 126 · see citing works

Neuroinflammatory changes negatively impact on LTP: A focus on IL-1β

Lynch, M. A. (2015) · Brain Research · doi:10.1016/j.brainres.2014.08.040 · Cited by 115 · see citing works

TNFα and IL-1β but not IL-18 Suppresses Hippocampal Long-Term Potentiation Directly at the Synapse

Prieto, G. A., Tong, L., Smith, E. D., & Cotman, C. W. (2018) · Neurochemical Research · doi:10.1007/s11064-018-2517-8 · Cited by 118 · see citing works

Postoperative cognitive dysfunction and microglial activation in associated brain regions in old rats

Hovens, I. B., van Leeuwen, B. L., Nyakas, C. J., Heineman, E., van der Zee, E. A., & Schoemaker, R. G. (2014) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2014.11.009 · Cited by 113 · see citing works

Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction

Li, Y., Pan, K., Chen, L. V., Ning, J.-L., Li, X., Yang, T., Terrando, N., Gu, J., & Tao, G. (2016) · Journal of Neuroinflammation · doi:10.1186/s12974-016-0740-2 · Cited by 114 · see citing works

Dexmedetomidine Inhibits Neuroinflammation by Altering Microglial M1/M2 Polarization Through MAPK/ERK Pathway

Qiu, Z., Lu, P., Wang, K., Zhao, X., Li, Q., Wen, J., Zhang, H., Li, R., Wei, H., Lv, Y., et al. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02922-1 · Cited by 112 · see citing works

Cytokines and cytokine networks target neurons to modulate long-term potentiation

Prieto, G. A., & Cotman, C. W. (2017) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2017.03.005 · Cited by 111 · see citing works

The effect of N-acetylcysteine (NAC) on human cognition – A systematic review

Skvarc, D., Dean, O. M., Byrne, L. K., Gray, L. J., Lane, S. E., Lewis, M., Fernandes, B. S., Berk, M., & Marriott, A. (2017) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2017.04.013 · Cited by 108 · see citing works

Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms

Skelly, D., Griffin, É. W., Murray, C., Harney, S. C., O’Boyle, C., Hennessy, E., Dansereau, M., Nazmi, A., Tortorelli, L. S., Rawlins, J. N. P., et al. (2018) · Molecular Psychiatry · doi:10.1038/s41380-018-0075-8 · Cited by 109 · see citing works

Scopolamine promotes neuroinflammation and delirium-like neuropsychiatric disorder in mice

Cheon, S. Y., Koo, B., Kim, S. Y., Kam, E. H., Nam, J., & Kim, E. J. (2021) · Scientific Reports · doi:10.1038/s41598-021-87790-y · Cited by 97 · see citing works

Acetylcholinesterase Inhibitors Reduce Neuroinflammation and -Degeneration in the Cortex and Hippocampus of a Surgery Stress Rat Model

Kalb, A., von Haefen, C., Sifringer, M., Tegethoff, A., Paeschke, N., Kostova, M. H., Feldheiser, A., & Spies, C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0062679 · Cited by 93 · see citing works

Stress and aging act through common mechanisms to elicit neuroinflammatory priming

Fonken, L. K., Frank, M. G., Gaudet, A. D., & Maier, S. F. (2018) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2018.07.012 · Cited by 94 · see citing works

Activation of cannabinoid receptor type 2 attenuates surgery-induced cognitive impairment in mice through anti-inflammatory activity

Sun, L., Dong, R., Xu, X., Yang, X., & Peng, M. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0913-7 · Cited by 92 · see citing works

The Impact of Surgery and Anesthesia on Post-Operative Cognitive Decline and Alzheimer's Disease Development: Biomarkers and Preventive Strategies

Kapila, A. K., Watts, H. R., Wang, T., & Ma, D. (2014) · Journal of Alzheimer s Disease · doi:10.3233/jad-132258 · Cited by 86 · see citing works

Depiction of microglial activation in aging and dementia: Positron emission tomography with [ 11 C]DPA713 versus [ 11 C]( R )PK11195

Yokokura, M., Terada, T., Bunai, T., Nakaizumi, K., Takebayashi, K., Iwata, Y., Yoshikawa, E., Futatsubashi, M., Suzuki, K., Mori, N., et al. (2016) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1177/0271678x16646788 · Cited by 85 · see citing works

The relationship between interleukin‐1 receptor antagonist and cognitive function in older adults with bipolar disorder

Lotrich, F. E., Butters, M. A., Aizenstein, H. J., Marron, M. M., Reynolds, C. F., & Gildengers, A. G. (2013) · International Journal of Geriatric Psychiatry · doi:10.1002/gps.4048 · Cited by 83 · see citing works

High-fat diet worsens the impact of aging on microglial function and morphology in a region-specific manner

Spencer, S. J., Basri, B., Sominsky, L., Soch, A., Ayala, M. T., Reineck, P., Gibson, B. C., & Barrientos, R. M. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.10.018 · Cited by 80 · see citing works

Berberine alleviates postoperative cognitive dysfunction by suppressing neuroinflammation in aged mice

Zhang, Z., Li, X., Li, F., & An, L. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.06.031 · Cited by 81 · see citing works

Aging triggers an upregulation of a multitude of cytokines in the male and especially the female rodent hippocampus but more discrete changes in other brain regions

Porcher, L., Bruckmeier, S., Burbano, S. D., Finnell, J. E., Gorny, N., Klett, J., Wood, S. K., & Kelly, M. P. (2021) · Journal of Neuroinflammation · doi:10.1186/s12974-021-02252-6 · Cited by 78 · see citing works

Targeting neuroinflammation as a preventive and therapeutic approach for perioperative neurocognitive disorders

Cheng, C., Wan, H., Cong, P., Huang, X., Wu, T., He, M., Zhang, Q., Xiong, L., & Li, T. (2022) · Journal of Neuroinflammation · doi:10.1186/s12974-022-02656-y · Cited by 80 · see citing works

Brain immune interactions and air pollution: macrophage inhibitory factor (MIF), prion cellular protein (PrPC), Interleukin-6 (IL-6), interleukin 1 receptor antagonist (IL-1Ra), and interleukin-2 (IL-2) in cerebrospinal fluid and MIF in serum differentiate urban children exposed to severe vs. low air pollution

Calderón‐Garcidueñas, L., Cross, J. V., Franco-Lira, M., Aragón-Flores, M., Kavanaugh, M., Torres‐Jardón, R., Chao, C., Thompson, C., Chang, J., Hongtu Zhu, B., et al. (2013) · Frontiers in Neuroscience · doi:10.3389/fnins.2013.00183 · Cited by 79 · see citing works

Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala

Butler, M. J., Cole, R. M., Deems, N. P., Belury, M. A., & Barrientos, R. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.06.010 · Cited by 80 · see citing works

Pyrrolidine dithiocarbamate attenuates surgery-induced neuroinflammation and cognitive dysfunction possibly via inhibition of nuclear factor κB

Zhang, J., Jiang, W., & Zuo, Z. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.12.034 · Cited by 76 · see citing works

Anthocyanins control neuroinflammation and consequent memory dysfunction in mice exposed to lipopolysaccharide

Carvalho, F. B., Gutierres, J. M., Bueno, A., Agostinho, P. M., Zago, A. M., Vieira, J. M., Frühauf, P., Cechella, J. L., Nogueira, C. W., Oliveira, S. M., et al. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-9900-8 · Cited by 76 · see citing works

Neuroinflammatory challenges compromise neuronal function in the aging brain: Postoperative cognitive delirium and Alzheimer’s disease

Cortese, G. P., & Bürger, C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.08.027 · Cited by 74 · see citing works

Dysfunction of Inflammation-Resolving Pathways Is Associated with Exaggerated Postoperative Cognitive Decline in a Rat Model of the Metabolic Syndrome

Su, X., Feng, X., Terrando, N., Yan, Y., Chawla, A., Koch, L. G., Britton, S. L., Matthay, M. A., & Maze, M. (2012) · Molecular Medicine · doi:10.2119/molmed.2012.00351 · Cited by 72 · see citing works

Dietary Luteolin Reduces Proinflammatory Microglia in the Brain of Senescent Mice

Burton, M. D., Rytych, J. L., Amin, R., & Johnson, R. W. (2016) · Rejuvenation Research · doi:10.1089/rej.2015.1708 · Cited by 69 · see citing works

Research Progress on the Role of Inflammatory Mechanisms in the Development of Postoperative Cognitive Dysfunction

Tan, X.-X., Qiu, L.-L., & Sun, J. (2021) · BioMed Research International · doi:10.1155/2021/3883204 · Cited by 68 · see citing works

The presence of elevated circulating trimethylamine N-oxide exaggerates postoperative cognitive dysfunction in aged rats

Meng, F., Li, N., Li, D., Song, B., & Li, L. (2019) · Behavioural Brain Research · doi:10.1016/j.bbr.2019.111902 · Cited by 67 · see citing works

Surgery-induced behavioral changes in aged rats

Hovens, I. B., Schoemaker, R. G., van der Zee, E. A., Heineman, E., Nyakas, C. J., & van Leeuwen, B. L. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.07.011 · Cited by 66 · see citing works

Glucocorticoids Mediate Short-Term High-Fat Diet Induction of Neuroinflammatory Priming, the NLRP3 Inflammasome, and the Danger Signal HMGB1

Sobesky, J. L., D’Angelo, H. M., Weber, M. D., Anderson, N. D., Frank, M. G., Watkins, L. R., Maier, S. F., & Barrientos, R. M. (2016) · eNeuro · doi:10.1523/eneuro.0113-16.2016 · Cited by 64 · see citing works

Caffeic Acid Phenethyl Ester Suppresses Oxidative Stress and Regulates M1/M2 Microglia Polarization via Sirt6/Nrf2 Pathway to Mitigate Cognitive Impairment in Aged Mice following Anesthesia and Surgery

Wang, Y., Cai, Z., Zhan, G., Li, X., Li, S., Wang, X., Li, S., & Luo, A. (2023) · Antioxidants · doi:10.3390/antiox12030714 · Cited by 63 · see citing works

Surgery-Induced Hippocampal Angiotensin II Elevation Causes Blood-Brain Barrier Disruption via MMP/TIMP in Aged Rats

Li, Z., Mo, N., Li, L., Cao, Y., Wang, W., Liang, Y., Deng, H., Xing, R., Yang, L., Ni, C., et al. (2016) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2016.00105 · Cited by 62 · see citing works

Inhibiting NLRP3 inflammasome with MCC950 ameliorates perioperative neurocognitive disorders, suppressing neuroinflammation in the hippocampus in aged mice

Fu, Q., Li, J., Qiu, L., Ruan, J., Mao, M., Li, S., & Mao, Q.-H. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.106317 · Cited by 61 · see citing works

Elevated Expression of MiR-17 in Microglia of Alzheimer’s Disease Patients Abrogates Autophagy-Mediated Amyloid-β Degradation

Estfanous, S. Z. K., Daily, K. P., Eltobgy, M. M., Deems, N. P., Anne, M. N. K., Krause, K., Badr, A., Hamilton, K., Carafice, C., Hegazi, A., et al. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.705581 · Cited by 63 · see citing works

Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: A systematic review

Schreuder, L., Eggen, B. J. L., Biber, K. P. H., Schoemaker, R. G., Laman, J. D., & de Rooij, S. E. (2017) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2017.01.010 · Cited by 59 · see citing works

Nox-2-Mediated Phenotype Loss of Hippocampal Parvalbumin Interneurons Might Contribute to Postoperative Cognitive Decline in Aging Mice

Qiu, L.-L., Luo, D., Zhang, H., Shi, Y. S., Li, Y.-J., Wu, D., Chen, J., Ji, M., & Yang, J. (2016) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2016.00234 · Cited by 59 · see citing works

Pre-administration of curcumin prevents neonatal sevoflurane exposure-induced neurobehavioral abnormalities in mice

Ji, M., Qiu, L.-L., Yang, J., Zhang, H., Sun, X., Zhu, S., Li, W., & Yang, J. (2014) · NeuroToxicology · doi:10.1016/j.neuro.2014.11.003 · Cited by 58 · see citing works

PGE 2‐ EP 3 signaling exacerbates hippocampus‐dependent cognitive impairment after laparotomy by reducing expression levels of hippocampal synaptic plasticity‐related proteins in aged mice

Xiao, J., Xiong, B., Zhang, W., Zhou, W., Yang, H., Gao, F., Xiang, H., Manyande, A., Tian, X., & Tian, Y. (2018) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.12832 · Cited by 57 · see citing works

Dexmedetomidine Ameliorates Postoperative Cognitive Dysfunction in Aged Mice

Xie, X., Shen, Z., Hu, C., Zhang, K., Guo, M., Fei, W., & Qin, K. (2021) · Neurochemical Research · doi:10.1007/s11064-021-03386-y · Cited by 57 · see citing works

Postoperative impairment of cognitive function in old mice: a possible role for neuroinflammation mediated by HMGB1, S100B, and RAGE

Li, R., Zhang, Z., Peng, M., Wu, Y., Zhang, J., Wang, C., & Wang, Y. (2013) · Journal of Surgical Research · doi:10.1016/j.jss.2013.06.043 · Cited by 56 · see citing works

Esketamine alleviates postoperative cognitive decline via stimulator of interferon genes/ TANK‐binding kinase 1 signaling pathway in aged rats

Li, Y., Wu, Z., Zheng, W., Wang, J., Yue-Xin, Song, R., & Gao, J. (2022) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2022.07.004 · Cited by 54 · see citing works

Protective effects of omega-3 fatty acids in a blood–brain barrier-on-chip model and on postoperative delirium-like behaviour in mice

Yang, T., Velagapudi, R., Kong, C., Ko, U., Kumar, V., Brown, P., Franklin, N. O., Zhang, X., Caceres, A. I., Min, H., et al. (2022) · British Journal of Anaesthesia · doi:10.1016/j.bja.2022.05.025 · Cited by 52 · see citing works

Targeting microglial autophagic degradation of the NLRP3 inflammasome for identification of thonningianin A in Alzheimer’s disease

Zhou, X.-G., Qiu, W., Yu, L., Pan, R., Teng, J.-F., Sang, Z.-P., Law, B., Zhao, Y., Zhang, L., Yan, L., et al. (2022) · Inflammation and Regeneration · doi:10.1186/s41232-022-00209-7 · Cited by 51 · see citing works

Mycobacterium vaccae immunization protects aged rats from surgery-elicited neuroinflammation and cognitive dysfunction

Fonken, L. K., Frank, M. G., D’Angelo, H. M., Heinze, J. D., Watkins, L. R., Lowry, C. A., & Maier, S. F. (2018) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2018.07.012 · Cited by 53 · see citing works

Prophylactic angiotensin type 1 receptor antagonism confers neuroprotection in an aged rat model of postoperative cognitive dysfunction

Li, Z., Cao, Y., Li, L., Liang, Y., Tian, X., Mo, N., Liu, Y., Li, M., Chui, D., & Guo, X. (2014) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2014.04.153 · Cited by 52 · see citing works

Impaired Spatial Learning Memory after Isoflurane Anesthesia or Appendectomy in Aged Mice is Associated with Microglia Activation

Wang, H.-L., Ma, R., Fang, H., Xue, Z., & Liao, Q. (2015) · Journal of Cell Death · doi:10.4137/jcd.s30596 · Cited by 52 · see citing works

Postoperative cognitive dysfunction is made persistent with morphine treatment in aged rats

Muscat, S. M., Deems, N. P., D’Angelo, H. M., Kitt, M. M., Grace, P. M., Andersen, N. D., Silverman, S. N., Rice, K. C., Watkins, L. R., Maier, S. F., et al. (2020) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2020.11.008 · Cited by 50 · see citing works

Dexmedetomidine promotes the recovery of neurogenesis in aged mouse with postoperative cognitive dysfunction

Wang, W., Wu, Q., Liang, S., Zhang, X., Hu, Q., Chen, Q., Huang, H., Lin, X., & Lou, F.-Q. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.03.043 · Cited by 50 · see citing works

Preoperative Sleep Disturbance Exaggerates Surgery-Induced Neuroinflammation and Neuronal Damage in Aged Mice

Ni, P., Dong, H., Zhou, Q., Wang, Y., Sun, M., Qian, Y., & Sun, J. (2019) · Mediators of Inflammation · doi:10.1155/2019/8301725 · Cited by 50 · see citing works

Intranasal delivery of BDNF rescues memory deficits in AD11 mice and reduces brain microgliosis

Braschi, C., Capsoni, S., Narducci, R., Poli, A., Sansevero, G., Brandi, R., Maffei, L., Cattaneo, A., & Berardi, N. (2020) · Aging Clinical and Experimental Research · doi:10.1007/s40520-020-01646-5 · Cited by 49 · see citing works

Prior infection exacerbates postoperative cognitive dysfunction in aged rats

Hovens, I. B., van Leeuwen, B. L., Nyakas, C. J., Heineman, E., van der Zee, E. A., & Schoemaker, R. G. (2015) · American Journal of Physiology-Regulatory, Integrative and Comparative Physiology · doi:10.1152/ajpregu.00002.2015 · Cited by 46 · see citing works

Deferoxamine pre-treatment protects against postoperative cognitive dysfunction of aged rats by depressing microglial activation via ameliorating iron accumulation in hippocampus.

Pan, K., Li, X., Chen, Y., Zhu, D., Li, Y., Tao, G.-C., & Zuo, Z. (2016) · Neuropharmacology · doi:10.1016/j.neuropharm.2016.09.004 · Cited by 45 · see citing works

Analysis of postoperative cognitive dysfunction and influencing factors of dexmedetomidine anesthesia in elderly patients with colorectal cancer

Zhang, J., Liu, G., Zhang, F., Fang, H., Zhang, D., Liu, S., Chen, B., & Xiao, H. (2019) · Oncology Letters · doi:10.3892/ol.2019.10611 · Cited by 46 · see citing works

Erythropoietin Attenuates Postoperative Cognitive Dysfunction by Shifting Macrophage Activation toward the M2 Phenotype

Lee, J. H., Kam, E. H., Kim, S. Y., Cheon, S. Y., Kim, E. J., Chung, S., Jeong, J., & Koo, B. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00839 · Cited by 45 · see citing works

Higher Circulating Trimethylamine N-oxide Sensitizes Sevoflurane-Induced Cognitive Dysfunction in Aged Rats Probably by Downregulating Hippocampal Methionine Sulfoxide Reductase A

Zhao, L., Zhang, C., Cao, G., Dong, X., Li, D., & Jiang, L. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02868-4 · Cited by 46 · see citing works

Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome

Zhang, Z., Ma, Q., Velagapudi, R., Barclay, W. E., Rodriguiz, R. M., Wetsel, W. C., Yang, T., Shinohara, M. L., & Terrando, N. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.856254 · Cited by 44 · see citing works

Feeding the beast: Can microglia in the senescent brain be regulated by diet?

Johnson, R. W. (2014) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2014.09.022 · Cited by 44 · see citing works

Acetate attenuates perioperative neurocognitive disorders in aged mice

Wen, C., Xie, T., Pan, K., Deng, Y., Zhao, Z., Li, N., Bian, J., Deng, X., & Zha, Y. (2020) · Aging · doi:10.18632/aging.102856 · Cited by 44 · see citing works

Effects of propofol and surgery on neuropathology and cognition in the 3xTgAD Alzheimer transgenic mouse model

Mardini, F., Tang, J. X., Li, J. C., Arroliga, M. J., Eckenhoff, R. G., & Eckenhoff, M. F. (2016) · British Journal of Anaesthesia · doi:10.1093/bja/aew397 · Cited by 43 · see citing works

Disruption of the GABAergic system contributes to the development of perioperative neurocognitive disorders after anesthesia and surgery in aged mice

Zhang, W., Xiong, B., Zhang, L., Huang, X., Zhou, W., Zou, Q., Manyande, A., Wang, J., Tian, X., & Tian, Y. (2020) · CNS Neuroscience & Therapeutics · doi:10.1111/cns.13388 · Cited by 42 · see citing works

Epigenetics of Delirium and Aging: Potential Role of DNA Methylation Change on Cytokine Genes in Glia and Blood Along With Aging

Shinozaki, G., Braun, P., Hing, B. W. Q., Ratanatharathorn, A. D., Klisares, M. J., Duncan, G. N., Jellison, S. S., Heinzman, J. T., Nagahama, Y., Close, L. N., et al. (2018) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2018.00311 · Cited by 41 · see citing works

MicroRNA-572 Improves Early Post-Operative Cognitive Dysfunction by Down-Regulating Neural Cell Adhesion Molecule 1

Yu, X., Liu, S., Li, J., Fan, X., Chen, Y., Bi, X., Liu, S., & Deng, X. (2015) · PLoS ONE · doi:10.1371/journal.pone.0118511 · Cited by 41 · see citing works

PPARγ activation ameliorates postoperative cognitive decline probably through suppressing hippocampal neuroinflammation in aged mice

Zhang, Z., Yuan, H., Zhao, H., Qi, B., Li, F., & An, L. (2016) · International Immunopharmacology · doi:10.1016/j.intimp.2016.12.003 · Cited by 40 · see citing works

Hofbauer cells and fetal brain microglia share transcriptional profiles and responses to maternal diet-induced obesity

Batorsky, R., Ceasrine, A. M., Shook, L. L., Kışlal, S., Bordt, E. A., Devlin, B. A., Perlis, R. H., Slonim, D. K., Bilbo, S. D., & Edlow, A. G. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114326 · Cited by 38 · see citing works

Protective effect against brain tissues oxidative damage as a possible mechanism for beneficial effects of L -arginine on lipopolysaccharide induced memory impairment in rats

Hosseini, M., Anaeigoudari, A., Beheshti, F., Soukhtanloo, M., & Nosratabadi, R. (2017) · Drug and Chemical Toxicology · doi:10.1080/01480545.2017.1336173 · Cited by 38 · see citing works

Acute neuroinflammation, sickness behavior and working memory responses to acute systemic LPS challenge following noradrenergic lesion in mice

O′Neill, E., Griffin, É. W., O'Sullivan, R., Murray, C., Ryan, L., Yssel, J. D., Harkin, A., & Cunningham, C. M. (2020) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2020.12.002 · Cited by 38 · see citing works

TREM2 ameliorates anesthesia and surgery-induced cognitive impairment by regulating mitophagy and NLRP3 inflammasome in aged C57/BL6 mice

Jiang, W., Liu, F., Li, H., Wang, K., Cao, X., Xu, X., Zhou, Y., Zou, J., Zhang, X., & Cui, X. (2022) · NeuroToxicology · doi:10.1016/j.neuro.2022.04.005 · Cited by 38 · see citing works

An enriched environment reduces hippocampal inflammatory response and improves cognitive function in a mouse model of stroke

Meng, Z., Wang, X., Zhou, H., Huai, Y., Jin, X. Y., Yan, P., Tang, X., Wang, J.-Y., Shi, N., & Niu, M. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.338999 · Cited by 39 · see citing works

Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, attenuates postoperative cognitive dysfunction in aging mice

Jia, M., Liu, W., Sun, H.-L., Chang, Y.-Q., Yang, J., Ji, M.-H., Yang, J.-J., & Feng, C. (2015) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2015.00052 · Cited by 37 · see citing works

Preoperative gut microbiota of POCD patients induces pre- and postoperative cognitive impairment and systemic inflammation in rats

Wei, X., Xing, F., Xu, Y., Zhang, F., Cheng, D., Zhou, Y., Zheng, F., & Zhang, W. (2024) · Journal of Neuroinflammation · doi:10.1186/s12974-024-03220-6 · Cited by 36 · see citing works

Role of interleukin‐1β in postoperative cognitive dysfunction

Cibelli, M., Fidalgo, A. R., Terrando, N., Ma, D., Monaco, C. G., Feldmann, M., Takata, M., Lever, I. J., Nanchahal, J., Fanselow, M. S., et al. (2010) · Annals of Neurology · doi:10.1002/ana.22082 · Cited by 742 · see citing works

Icariin reduces cognitive dysfunction induced by surgical trauma in aged rats by inhibiting hippocampal neuroinflammation

Wang, L., Peng, G., Chen, L., Guo, M., Wang, B., Zhang, Y., Zhou, J., Zhong, M., & Ye, J. (2023) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2023.1162009 · Cited by 16 · see citing works

Age exacerbates surgery-induced cognitive impairment and neuroinflammation in Sprague-Dawley rats: the role of IL-4

Li, Z., Liu, F., Ma, H., White, P. F., Yumul, R., Jiang, Y., Wang, N., & Cao, X. (2017) · Brain Research · doi:10.1016/j.brainres.2017.04.004 · Cited by 44 · see citing works

Inhibiting tumor necrosis factor-α signaling attenuates postoperative cognitive dysfunction in aged rats

Ma, Y., Cheng, Q., Wang, E., Li, L., & ZHANG, X. (2015) · Molecular Medicine Reports · doi:10.3892/mmr.2015.3744 · Cited by 35 · see citing works

Peripheral surgical wounding may induce cognitive impairment through interlukin-6-dependent mechanisms in aged mice

Xie, Z., Dong, Y., Xu, Z., Huang, L., & Zhang, Y. (2016) · Medical Gas Research · doi:10.4103/2045-9912.196899 · Cited by 28 · see citing works