Cited by 33Pluripotent Stem Cells ResearchAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders Research

Modeling motor neuron disease: the matter of time

Arbab, Mandana, Baars, Susanne, Geijsen, Niels·2014·Trends in Neurosciences

Abstract

Stem cell technologies have created new opportunities to generate unlimited numbers of human neurons in the lab and study neurodegenerative disorders such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). Although some disease hallmarks have been reported in patient-derived stem cell models, it is proving more difficult to recapitulate the full phenotypic extent of these disorders. The problem with these stem cell models lies in the disparity between the advanced age of onset of neurodegenerative disorders and the embryonic nature of the in vitro derived cell types. In this review we discuss experimental methods of in vitro aging of neural cell types as a means to elicit late-onset symptoms in induced pluripotent stem cell (iPSC) models of neurodegenerative disease.

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Crossref · 10.1016/j.tins.2014.07.008

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141 of 141 references verified0 citation errors · 0 not checkable

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  • iPSC neurons exhibit a fetal neuronal identity that might not be optimally suited to model all disease-relevant phenotypes.

    “They are also known to exhibit a fetal neuronal identity that might not be optimally suited to model all disease-relevant phenotypes (Arbab et al., 2014; Luo et al., 2016; Patterson et al., 2012).”

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Authors
Arbab, M., Baars, S., & Geijsen, N.
Affiliations
  • Utrecht University (NL)
  • University Medical Center Utrecht (NL)
Corresponding author
Geijsen, Niels
Venue
Trends in Neurosciences
Publisher
Elsevier BV
Published
2014-11
Volume
37
Issue
11
Pages
642-652
ISSN
0166-2236 (ISSN-L)
OpenAlex
W2101631778
Cited by
33
References
141
Citations by year
2026: 1 · 2025: 2 · 2023: 2 · 2022: 2 · 2021: 5 · 2020: 3 · 2019: 3 · 2018: 2 · 2017: 3 · 2016: 6 · 2015: 4
FWCI
0.41
Type
journal article
Language
en
Open access
closed
Locations
  • Trends in Neurosciences (publishedVersion)
  • PubMed (publishedVersion)
  • Data Archiving and Networked Services (DANS) (submittedVersion)
  • Utrecht University Repository (Utrecht University) (submittedVersion)
  • KNAW Research Portal (The Royal Netherlands Academy of Arts and Sciences) (submittedVersion)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
  • Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
  • Health Sciences › Medicine › Genetics › Neurogenetic and Muscular Disorders Research
Keywords
motor neuron disease, amyotrophic lateral sclerosis, spinal muscular atrophy, induced pluripotent stem cells, in vitro aging, disease modeling, patient-derived neurons, neurodegeneration, late-onset symptoms
MeSH terms
Animals, Cell Differentiation, Disease Models, Animal, Humans, Motor Neurons, Stem Cells, Time Factors, Neurodegenerative Diseases

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