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The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies
Open accessAbstract
Alzheimer's disease constitutes a growing cause of cognitive impairment in aging population. Given that current treatments do not produce the desired therapeutic effects, the need for finding alternative biological and pharmacological approaches is critical. Accumulating evidence suggests inflammatory and oxidative stress responses as potential causal factors of cognitive impairments in Alzheimer's disease and healthy aging. Curcumin has received increased interest due to its unique molecular structure that targets inflammatory and antioxidant pathways as well as (directly) amyloid aggregation; one of the major hallmarks of Alzheimer's disease. Therefore, this review summarizes preclinical and clinical findings on curcumin as a potential cognitive enhancer in Alzheimer's disease and normal aging. Databases used for literature searches include PubMed, EMBASE and Web of Science; in addition, clinicaltrials.gov was used to search for clinical studies. Overall, animal research has shown very promising results in potentiating cognition, both physiologically and behaviourally. However, human studies are limited and results are less consistent, complicating their interpretation. These inconsistencies may be related to differences in methodology and the included population. Taking into account measurements of important inflammatory and antioxidant biomarkers, optimal dosages of curcumin, food interactions, and duration of treatment would increase our understanding on curcumin's promising effects on cognition. In addition, increasing curcumin's bioavailability could benefit future research.
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“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
From The Multifaceted Role of Neuroprotective Plants in Alzheimer’s Disease Treatment (2022) · cites this paper as [162]
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Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
The Amyloid Hypothesis of Alzheimer’s Disease: Progress and Problems on the Road to Therapeutics
Hardy, J., & Selkoe, D. J. (2002) · Science · doi:10.1126/science.1072994 · Cited by 13,864
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · Annals of Internal Medicine · doi:10.7326/0003-4819-151-4-200908180-00136 · Cited by 10,349
Curcumin: A Review of Its Effects on Human Health
Hewlings, S., & Kalman, D. (2017) · Foods · doi:10.3390/foods6100092 · Cited by 2,720
Lim, G. P., Chu, T., Yang, F., Beech, W., Frautschy, S. A., & Cole, G. M. (2001) · The Journal of Neuroscience · doi:10.1523/jneurosci.21-21-08370.2001 · Cited by 1,530
Dose escalation of a curcuminoid formulation
Lao, C. D., Ruffin, M. T., Normolle, D. P., Heath, D. D., Murray, S. I., Bailey, J. M., Boggs, M. E., Crowell, J. A., Rock, C. L., & Brenner, D. E. (2006) · BMC Complementary and Alternative Medicine · doi:10.1186/1472-6882-6-10 · Cited by 1,400
Inflammation in neurodegenerative diseases
Amor, S., Puentes, F., Baker, D., & Van Der Valk, P. (2010) · Immunology · doi:10.1111/j.1365-2567.2009.03225.x · Cited by 1,355
The role of oxidative stress in neurodegenerative diseases
Kim, G. H., Kim, J. E., Rhie, S. J., & Yoon, S. (2015) · Experimental Neurobiology · doi:10.5607/en.2015.24.4.325 · Cited by 1,355
Clinical Neurology and Epidemiology of the Major Neurodegenerative DiseasesPreprint
Erkkinen, M. G., Kim, M., & Geschwind, M. D. (2017) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a033118 · Cited by 1,231
Jurenka, J. S. (2009) · PubMed · Cited by 1,212
Research works printed but not linked: 2
- Wang, 2011, Effects of curcumin on hippocampal Bax and Bcl-2 expression and cognitive function of a rat model of Alzheimer's disease, Neural Regen. Res., 6
- Wang, 2013, Amelioration of β-amyloid-induced cognitive dysfunction and hippocampal axon degeneration by curcumin is associated with suppression of CRMP-2 hyperphosphorylation, Neurosci. Lett., 557, 112, 10.1016/j.neulet.2013.10.024 · DOI · Paper page
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Ornish, D. M., Madison, C. A., Kivipelto, M., Kemp, C., McCulloch, C. E., Galasko, D., Artz, J., Rentz, D. M., Lin, J., Norman, K., et al. (2024) · Alzheimer s Research & Therapy · doi:10.1186/s13195-024-01482-z · Cited by 174
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Ashrafizadeh, M., Zarrabi, A., Hashemi, F., Zabolian, A., Saleki, H., Bagherian, M., Azami, N., Bejandi, A. K., Hushmandi, K., Ang, H. L., et al. (2020) · Pharmaceutics · doi:10.3390/pharmaceutics12111084 · Cited by 129
Shabbir, U., Rubab, M., Tyagi, A., & Oh, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010196 · Cited by 120
Dhapola, R., Sarma, P., Medhi, B., Prakash, A., & HariKrishnaReddy, D. (2021) · Molecular Neurobiology · doi:10.1007/s12035-021-02612-6 · Cited by 112
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Chiu, H., Venkatakrishnan, K., & Wang, C. (2020) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2020.03.008 · Cited by 86
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Ineichen, B. V., Furrer, E., Grüninger, S., Zürrer, W. E., & Macleod, M. R. (2024) · PLoS Biology · doi:10.1371/journal.pbio.3002667 · Cited by 117
Fanlo-Ucar, H., Picón-Pagès, P., Herrera-Fernández, V., ILL‐Raga, G., & Muñoz, F. J. (2024) · Antioxidants · doi:10.3390/antiox13101208 · Cited by 94
Zamanian, M., Alsaab, H., Golmohammadi, M., Yumashev, A., Jabba, A. M., Abid, M. K., Joshi, A., Alawadi, A., Jafer, N. S., Kianifar, F., et al. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4030 · Cited by 81
Fukutomi, R., Ohishi, T., Koyama, Y., Pervin, M., Nakamura, Y., & Isemura, M. (2021) · Molecules · doi:10.3390/molecules26020415 · Cited by 78
Albaqami, J. J., Hamdi, H., Narayanankutty, A., Visakh, N. U., Sasidharan, A., Kuttithodi, A. M., Famurewa, A. C., & Pathrose, B. (2022) · Antibiotics · doi:10.3390/antibiotics11111547 · Cited by 71
Kandezi, N., Mohammadi, M., Ghaffari, M., Gholami, M., Motaghinejad, M., & Safari, S. (2020) · PubMed Central · doi:10.22088/ijmcm.bums.9.1.1 · Cited by 67
Puentes-Díaz, N., Chaparro, D., Morales-Morales, D., Flores-Gaspar, A., & Alí-Torres, J. (2023) · ACS Omega · doi:10.1021/acsomega.2c06939 · Cited by 67
Sintov, A. C. (2020) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2020.119725 · Cited by 67
Nagori, K., Nakhate, K. T., Yadav, K., Ajazuddin, & Pradhan, M. (2023) · Future Pharmacology · doi:10.3390/futurepharmacol3040053 · Cited by 61
Grabarczyk, M., Szczepańska, W., Czpakowska, J., Smolińska, E., Szychowska, A., Glabinski, A. R., & Szpakowski, P. (2024) · Antioxidants · doi:10.3390/antiox13111364 · Cited by 66
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Ahmad, S., & Hafeez, A. (2022) · Molecular Neurobiology · doi:10.1007/s12035-022-03089-7 · Cited by 45
Torres, S. E., López, R. C., Sotomayor, M. D. P. T., Hidalgo, J. C. T., Picasso, G., & Khan, S. (2023) · Polymers · doi:10.3390/polym15163332 · Cited by 45
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Song, H., Chen, Y., Chen, Y., Park, J., Zheng, M., Surh, Y., Kim, U., Park, J. W., Yu, R., Chung, H., et al. (2020) · Free Radical Research · doi:10.1080/10715762.2020.1791843 · Cited by 44
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Topal, F., Ertaş, B., Güler, E., Gurbuz, F., Ozcan, G. S., Aydemir, O., Böcekçı, V. G., Duruksu, G., Cam, C. S., Yazır, Y., et al. (2022) · Biomaterials Advances · doi:10.1016/j.bioadv.2022.212870 · Cited by 45
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Tsai, I., Hsu, C., Chang, C.-H., Tseng, P., & Chang, K. C. (2021) · Pharmaceuticals · doi:10.3390/ph14121235 · Cited by 40
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Scassellati, C., Galoforo, A. C., Esposito, C., Ciani, M., Ricevuti, G., & Bonvicini, C. (2021) · Aging and Disease · doi:10.14336/ad.2021.0122 · Cited by 34
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“Although research has demonstrated that curcumin in combination with vitamin C, B vitamins, piperine, and other dietary supplements has neuroprotective and synergistic effects, further research is necessary to conclusively state curcumin’s ability at ameliorating cognitive function in humans [146,162,169].”
BackgroundIslam, M. R., Rauf, A., Akter, S., Akter, H., Al‐Imran, M. I. K., Fakir, M. N. H., Thufa, G. K., Islam, M. T., Hemeg, H. A., Abdulmonem, W. A., et al. (2025) · Journal of Biochemical and Molecular Toxicology · doi:10.1002/jbt.70369 · Cited by 35
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Ferroptosis and Alzheimer’s: unveiling new avenues for the treatment and prevention
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Metadata
- Authors
- Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C.
- Affiliations
- Maastricht University (NL)
- Amsterdam UMC Location University of Amsterdam (NL)
- Corresponding author
- Voulgaropoulou, S.D.
- Venue
- Brain Research
- Publisher
- Elsevier BV
- Published
- 2019-12
- Volume
- 1725
- Pages
- 146476
- ISSN
- 0006-8993 (ISSN-L)
- OpenAlex
- W2976713729
- Cited by
- 243
- References
- 89
- Citations by year
- 2026: 20 · 2025: 42 · 2024: 53 · 2023: 36 · 2022: 35 · 2021: 39 · 2020: 16 · 2019: 1
- FWCI
- 1.50
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Pure Amsterdam UMC (publishedVersion, other-oa)
- Data Archiving and Networked Services (DANS) (submittedVersion)
- Research Publications (Maastricht University) (submittedVersion, cc-by)
- Research Publications (Maastricht University) (submittedVersion, other-oa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- curcumin, Alzheimer's disease, healthy aging, cognitive impairment, neuroinflammation, oxidative stress, amyloid fibril formation, cognitive enhancement, curcumin bioavailability, dietary interactions, clinical trials
- MeSH terms
- Healthy Aging, Aging, Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Cognition, Curcumin, Humans, Treatment Outcome, Oxidative Stress
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