Cited by 243Curcumin's Biomedical ApplicationsAlzheimer's disease research and treatmentsMedicinal Plants and Neuroprotection

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The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

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Voulgaropoulou, S.D., van Amelsvoort, T.A.M.J., Prickaerts, J., Vingerhoets, C.·2019·Brain Research

DOI 10.1016/j.brainres.2019.146476

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Abstract

Alzheimer's disease constitutes a growing cause of cognitive impairment in aging population. Given that current treatments do not produce the desired therapeutic effects, the need for finding alternative biological and pharmacological approaches is critical. Accumulating evidence suggests inflammatory and oxidative stress responses as potential causal factors of cognitive impairments in Alzheimer's disease and healthy aging. Curcumin has received increased interest due to its unique molecular structure that targets inflammatory and antioxidant pathways as well as (directly) amyloid aggregation; one of the major hallmarks of Alzheimer's disease. Therefore, this review summarizes preclinical and clinical findings on curcumin as a potential cognitive enhancer in Alzheimer's disease and normal aging. Databases used for literature searches include PubMed, EMBASE and Web of Science; in addition, clinicaltrials.gov was used to search for clinical studies. Overall, animal research has shown very promising results in potentiating cognition, both physiologically and behaviourally. However, human studies are limited and results are less consistent, complicating their interpretation. These inconsistencies may be related to differences in methodology and the included population. Taking into account measurements of important inflammatory and antioxidant biomarkers, optimal dosages of curcumin, food interactions, and duration of treatment would increase our understanding on curcumin's promising effects on cognition. In addition, increasing curcumin's bioavailability could benefit future research.

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Authors: Voulgaropoulou, S. D., van Amelsvoort, T. A. M. J., Prickaerts, J., & Vingerhoets, C.
Affiliations: Maastricht University (NL)
Amsterdam UMC Location University of Amsterdam (NL)
Corresponding author: Voulgaropoulou, S.D.
ORCID: Voulgaropoulou, S.D.
Prickaerts, J.
Vingerhoets, C.
Venue: Brain Research
Publisher: Elsevier BV
Published: 2019-12
Volume: 1725
Pages: 146476
ISSN: 0006-8993 (ISSN-L)
DOI: 10.1016/j.brainres.2019.146476
OpenAlex: W2976713729
Cited by: 243
References: 89
Citations by year: 2026: 20 · 2025: 42 · 2024: 53 · 2023: 36 · 2022: 35 · 2021: 39 · 2020: 16 · 2019: 1
FWCI: 1.50
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by/4.0/ (vor, 59 d)
Locations: Brain Research (publishedVersion, cc-by)
PubMed (publishedVersion)
Pure Amsterdam UMC (publishedVersion, other-oa)
Data Archiving and Networked Services (DANS) (submittedVersion)
Research Publications (Maastricht University) (submittedVersion, cc-by)
Research Publications (Maastricht University) (submittedVersion, other-oa)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Curcumin's Biomedical Applications
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
Keywords: curcumin, Alzheimer's disease, healthy aging, cognitive impairment, neuroinflammation, oxidative stress, amyloid fibril formation, cognitive enhancement, curcumin bioavailability, dietary interactions, clinical trials
MeSH terms: Healthy Aging, Aging, Alzheimer Disease, Animals, Anti-Inflammatory Agents, Non-Steroidal, Antioxidants, Cognition, Curcumin, Humans, Treatment Outcome, Oxidative Stress

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The effect of curcumin on cognition in Alzheimer’s disease and healthy aging: A systematic review of pre-clinical and clinical studies

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