The DOI matches its Crossref record; 84 of the 85 references it cites were found in a registry or an index.
Toward more predictive genetic mouse models of Alzheimer’s disease
Open accessAbstract
Genetic mouse models for Alzheimer's disease (AD) have been widely used to understand aspects of the biology of the disease, but have had limited success in translating these findings to the clinic. In this review, we discuss the benefits and limitations of existing genetic models and recent advances in technologies (including high throughput sequencing and genome editing) that promise more predictive models. We summarize widely used biomarkers and behavioral tests for mouse models of AD and highlight best practices that will maximize translatability of preclinical findings.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“traditional models created by incorporating a highly penetrant mutation in APP, PSEN1, or PSEN2 onto a single inbred background strain have largely failed to yield successful results in human clinical trials [286, 287]”
From Genetic architecture of Alzheimer's disease (2020) · cites this paper as [286]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Improving bioscience research reporting: The ARRIVE guidelines for reporting animal research
Kilkenny, C., Browne, W. J., Cuthill, I. C., Emerson, M., & Altman, D. G. (2010) · Journal of Pharmacology and Pharmacotherapeutics · doi:10.4103/0976-500x.72351 · Cited by 6,277
Iliff, J. J., Wang, M., Liao, Y., Plogg, B. A., Peng, W., Gundersen, G. A., Benveniste, H., Vates, G. E., Deane, R., Goldman, S. A., et al. (2012) · Science Translational Medicine · doi:10.1126/scitranslmed.3003748 · Cited by 5,824
Sleep Drives Metabolite Clearance from the Adult Brain
Xie, L., Kang, H., Xu, Q., Chen, M. J., Liao, Y., Thiyagarajan, M., O’Donnell, J., Christensen, D. J., Nicholson, C., Iliff, J. J., et al. (2013) · Science · doi:10.1126/science.1241224 · Cited by 5,411
CRISPR-Cas systems for editing, regulating and targeting genomes
Sander, J. D., & Joung, J. K. (2014) · Nature Biotechnology · doi:10.1038/nbt.2842 · Cited by 3,153
TREM2 Variants in Alzheimer's Disease
Guerreiro, R., Wojtas, A., Bras, J., Carrasquillo, M., Rogaeva, E., Majounie, E., Cruchaga, C., Sassi, C., Kauwe, J. S. K., Younkin, S., et al. (2013) · New England Journal of Medicine · doi:10.1056/nejmoa1211851 · Cited by 3,020
Development, maintenance and disruption of the blood-brain barrier
Obermeier, B., Daneman, R., & Ransohoff, R. M. (2013) · Nature Medicine · doi:10.1038/nm.3407 · Cited by 2,452
The glymphatic system: a beginner's guide
Jessen, N. A., Munk, A. S. F., Lundgaard, I., & Nedergaard, M. (2015) · Neurochemical Research · doi:10.1007/s11064-015-1581-6 · Cited by 2,075
Systematic meta-analyses of Alzheimer disease genetic association studies: the AlzGene database
Bertram, L., McQueen, M. B., Mullin, K., Blacker, D., & Tanzi, R. E. (2007) · Nature Genetics · doi:10.1038/ng1934 · Cited by 1,857
TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model
Wang, Y., Cella, M., Mallinson, K., Ulrich, J. D., Young, K. L., Robinette, M. L., Gilfillan, S., Krishnan, G. M., Sudhakar, S., Zinselmeyer, B. H., et al. (2015) · Cell · doi:10.1016/j.cell.2015.01.049 · Cited by 1,736
Single App knock-in mouse models of Alzheimer’s disease
Saito, T., Matsuba, Y., Mihira, N., Takano, J., Nilsson, P., Itohara, S., Iwata, N., & Saido, T. C. (2014) · Nature Neuroscience · doi:10.1038/nn.3697 · Cited by 1,366
Apolipoprotein E controls cerebrovascular integrity via cyclophilin A
Bell, R. D., Winkler, E. A., Singh, I., Sagare, A. P., Deane, R., Wu, Z., Holtzman, D. M., Betsholtz, C., Armulik, A., Sallstrom, J., et al. (2012) · Nature · doi:10.1038/nature11087 · Cited by 1,293
A call for transparent reporting to optimize the predictive value of preclinical research
Landis, S. C., Amara, S. G., Asadullah, K., Austin, C. P., Blumenstein, R., Bradley, E. W., Crystal, R. G., Darnell, R. B., Ferrante, R. J., Fillit, H., et al. (2012) · Nature · doi:10.1038/nature11556 · Cited by 1,196
Kilkenny, C., Parsons, N., Kadyszewski, E., Festing, M. F. W., Cuthill, I. C., Fry, D., Hutton, J., & Altman, D. G. (2009) · PLoS ONE · doi:10.1371/journal.pone.0007824 · Cited by 860
Webster, S. J., Bachstetter, A. D., Nelson, P. T., Schmitt, F. A., & Van Eldik, L. J. (2014) · Frontiers in Genetics · doi:10.3389/fgene.2014.00088 · Cited by 755
Jay, T. R., Miller, C. M., Cheng, P. J., Graham, L. C., Bemiller, S., Broihier, M. L., Xu, G., Margevicius, D., Karlo, J. C., Sousa, G. L., et al. (2015) · Journal of Experimental Medicine · doi:10.1084/jem.20142322 · Cited by 682
Sleep and Sleep Disorders in Older Adults
Crowley, K. E. (2011) · Neuropsychology Review · doi:10.1007/s11065-010-9154-6 · Cited by 655
Microglial dysfunction in brain aging and Alzheimer's disease
Mosher, K. I., & Wyss-Coray, T. (2014) · Biochemical Pharmacology · doi:10.1016/j.bcp.2014.01.008 · Cited by 618
β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Mander, B. A., Marks, S. M., Vogel, J. W., Rao, V., Lu, B., Saletin, J. M., Ancoli-Israel, S., Jagust, W. J., & Walker, M. P. (2015) · Nature Neuroscience · doi:10.1038/nn.4035 · Cited by 569
Permanent Alteration of PCSK9 With In Vivo CRISPR-Cas9 Genome Editing
Ding, Q., Strong, A., Patel, K. M., Ng, S.-L., Gosis, B. S., Regan, S. N., Cowan, C. A., Rader, D. J., & Musunuru, K. (2014) · Circulation Research · doi:10.1161/circresaha.115.304351 · Cited by 522
High-Resolution Genetic Mapping Using the Mouse Diversity Outbred Population
Svenson, K. L., Gatti, D. M., Valdar, W. S. J., Welsh, C. E., Cheng, R., Chesler, E. J., Palmer, A. A., McMillan, L., & Churchill, G. A. (2012) · Genetics · doi:10.1534/genetics.111.132597 · Cited by 474
Amyloid biomarkers in Alzheimer's disease
Blennow, K., Mattsson, N., Schöll, M., Hansson, O., & Zetterberg, H. (2015) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2015.03.002 · Cited by 470
Subspecific origin and haplotype diversity in the laboratory mouse
Yang, H., Wang, J., Didion, J. P., Buus, R. J., Bell, T. A., Welsh, C. E., Bonhomme, F., Yu, A. H.-T., Nachman, M. W., Piálek, J., et al. (2011) · Nature Genetics · doi:10.1038/ng.847 · Cited by 459
The Diversity Outbred Mouse Population
Churchill, G., Gatti, D. M., Munger, S. C., & Svenson, K. (2012) · Mammalian Genome · doi:10.1007/s00335-012-9414-2 · Cited by 451
Neurodegenerative disease and adult neurogenesis
Winner, B., Kohl, Z., & Gage, F. H. (2011) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2011.07613.x · Cited by 405
Rayaprolu, S., Mullen, B., Baker, M., Lynch, T., Finger, E., Seeley, W. W., Hatanpaa, K. J., Lomen-Hoerth, C., Kertesz, A., Bigio, E. H., et al. (2013) · Molecular Neurodegeneration · doi:10.1186/1750-1326-8-19 · Cited by 404
η-Secretase processing of APP inhibits neuronal activity in the hippocampus
Willem, M., Tahirovic, S., Busche, M. A., Ovsepian, S. V., Chafai, M., Kootar, S., Hornburg, D., Evans, L. D. B., Moore, S., Daria, A., et al. (2015) · Nature · doi:10.1038/nature14864 · Cited by 398
Endocannabinoid signalling and the deteriorating brain
Marzo, V. D., Stella, N., & Zimmer, A. (2014) · Nature reviews. Neuroscience · doi:10.1038/nrn3876 · Cited by 395
Preparation and Characterization of Neurotoxic Tau Oligomers
Lasagna-Reeves, C. A., Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Jackson, G. R., & Kayed, R. (2010) · Biochemistry · doi:10.1021/bi1016233 · Cited by 359
Mouse models of Alzheimer's disease
Hall, A. M., & Roberson, E. D. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2011.11.017 · Cited by 317
Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2
Ulrich, J. D., Finn, M. B., Wang, Y., Shen, A., Mahan, T. E., Jiang, H., Stewart, F. R., Piccio, L., Colonna, M., & Holtzman, D. M. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-20 · Cited by 302
Bussey, T. J., Holmes, A., Lyon, L., Mar, A. C., McAllister, K. A. L., Nithianantharajah, J., Oomen, C. A., & Saksida, L. M. (2012) · Neuropharmacology · doi:10.1016/j.neuropharm.2011.04.011 · Cited by 299
Effects of Age and Amyloid Deposition on Aβ Dynamics in the Human Central Nervous System
Huang, Y. (2011) · Archives of Neurology · doi:10.1001/archneurol.2011.235 · Cited by 291
Role of the MEOX2 homeobox gene in neurovascular dysfunction in Alzheimer disease
Wu, Z., Guo, H., Chow, N., Sallstrom, J., Bell, R. D., Deane, R., Brooks, A. I., Kanagala, S., Rubio, A., Sagare, A., et al. (2005) · Nature Medicine · doi:10.1038/nm1287 · Cited by 280
Synaptic Contacts Enhance Cell-to-Cell Tau Pathology Propagation
Calafate, S., Buist, A., Miśkiewicz, K., Vijayan, V. A., Daneels, G., Strooper, B. D., de Wit, J., Verstreken, P., & Moechars, D. (2015) · Cell Reports · doi:10.1016/j.celrep.2015.04.043 · Cited by 277
TREM2 Variant p.R47H as a Risk Factor for Sporadic Amyotrophic Lateral Sclerosis
Cady, J., Koval, E. D., Benitez, B. A., Zaidman, C., Jockel-Balsarotti, J., Allred, P., Baloh, R. H., Ravits, J., Simpson, E., Appel, S. H., et al. (2014) · JAMA Neurology · doi:10.1001/jamaneurol.2013.6237 · Cited by 262
TREM2and Neurodegenerative Disease
Reitz, C., & Mayeux, R. P. (2013) · New England Journal of Medicine · doi:10.1056/nejmc1306509 · Cited by 258
Age-related changes in the cognitive function of sleep
Pace-Schott, E. F., & Spencer, R. M. C. (2011) · Progress in brain research · doi:10.1016/b978-0-444-53752-2.00012-6 · Cited by 235
CB2 receptor and amyloid pathology in frontal cortex of Alzheimer's disease patients
Solas, M., Francis, P. T., Franco, R., & Ramírez, M. J. (2012) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2012.06.005 · Cited by 209
Altered neurogenesis in Alzheimer's disease
Ziabreva, I., Perry, E. K., Perry, R., Minger, S. L., Ekonomou, A., Przyborski, S. A., & Ballard, C. G. (2006) · Journal of Psychosomatic Research · doi:10.1016/j.jpsychores.2006.07.017 · Cited by 186
Landel, V., Baranger, K., Virard, I., Loriod, B., Khrestchatisky, M., Rivera, S., Benech, P., & Féron, F. (2014) · Molecular Neurodegeneration · doi:10.1186/1750-1326-9-33 · Cited by 176
Heterozygous TREM2 mutations in frontotemporal dementia
Borroni, B., Ferrari, F., Galimberti, D., Nacmias, B., Barone, C., Bagnoli, S., Fenoglio, C., Piaceri, I., Archetti, S., Bonvicini, C., et al. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.017 · Cited by 173
Broersen, K., Rousseau, F., & Schymkowitz, J. (2010) · Alzheimer's Research & Therapy · doi:10.1186/alzrt36 · Cited by 168
Tau reduction prevents Aβ-induced axonal transport deficits by blocking activation of GSK3β
Vossel, K. A., Xu, J. C., Fomenko, V., Miyamoto, T., Suberbielle, E., Knox, J. A., Ho, K., Kim, D. H., Yu, G.-Q., & Mucke, L. (2015) · Journal of Cell Biology · doi:10.1083/jcb.201407065 · Cited by 167
CD33 modulates TREM2: convergence of Alzheimer loci
Chan, G., White, C. C., Winn, P. A., Cimpean, M., Replogle, J. M., Glick, L. R., Cuerdon, N. E., Ryan, K. J., Johnson, K. A., Schneider, J. A., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4126 · Cited by 162
Impaired Attention in the 3xTgAD Mouse Model of Alzheimer's Disease: Rescue by Donepezil (Aricept)
Romberg, C., Mattson, M. P., Mughal, M. R., Bussey, T. J., & Saksida, L. M. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.5242-10.2011 · Cited by 160
ApoE Deficiency Compromises the Blood Brain Barrier Especially After Injury
Methia, N., André, P., Hafezi-Moghadam, A., Economopoulos, M., Thomas, K. L., & Wagner, D. D. (2001) · Molecular Medicine · doi:10.1007/bf03401973 · Cited by 150
Role of Neuroinflammation in Adult Neurogenesis and Alzheimer Disease: Therapeutic Approaches
Fuster-Matanzo, A., Llorens-Martı́n, M., Hernández, F., & Ávila, J. (2013) · Mediators of Inflammation · doi:10.1155/2013/260925 · Cited by 150
Castillo-Carranza, D. L., Guerrero-Muñoz, M. J., Sengupta, U., Hernandez, C., Barrett, A. D. T., Dineley, K., & Kayed, R. (2015) · The Journal of Neuroscience · doi:10.1523/jneurosci.4989-14.2015 · Cited by 149
Vardarajan, B. N., Ghani, M., Kahn, A., Sheikh, S., Sato, C., Barral, S., Lee, J. H., Cheng, R., Reitz, C., Lantigua, R., et al. (2015) · Annals of Neurology · doi:10.1002/ana.24466 · Cited by 148
Evidence for Neuroinflammatory and Microglial Changes in the Cerebral Response to Sleep Loss
Wisor, J. P., Schmidt, M. A., & Clegern, W. C. (2011) · Sleep · doi:10.1093/sleep/34.3.261 · Cited by 141
APOE Stabilization by Exercise Prevents Aging Neurovascular Dysfunction and Complement Induction
Soto, I., Graham, L. C., Richter, H. J., Simeone, S. N., Radell, J. E., Grabowska, W., Funkhouser, W. K., Howell, M. C., & Howell, G. R. (2015) · PLOS Biology · doi:10.1371/journal.pbio.1002279 · Cited by 140
Cognitive defects are reversible in inducible mice expressing pro-aggregant full-length human Tau
Van der Jeugd, A., Hochgräfe, K., Ahmed, T., Decker, J. M., Sydow, A., Hofmann, A., Wu, D., Messing, L., Balschun, D., D’Hooge, R., et al. (2012) · Acta Neuropathologica · doi:10.1007/s00401-012-0987-3 · Cited by 135
Crews, L. A., Rockenstein, E. M., & Masliah, E. (2009) · Brain Structure and Function · doi:10.1007/s00429-009-0232-6 · Cited by 110
The fallacy of behavioral phenotyping without standardisation
van der Staay, F. J., & Steckler, T. (2002) · Genes Brain & Behavior · doi:10.1046/j.1601-1848.2001.00007.x · Cited by 100
Tucker, B. A. (2014) · Journal of Stem Cell Research & Therapy · doi:10.4172/2157-7633.1000161 · Cited by 98
Savonenko, A. V., Melnikova, T., Wang, Y., Ravert, H. T., Gao, Y., Koppel, J. L., Lee, D., Pletniková, O., Cho, E., Sayyida, N., et al. (2015) · PLoS ONE · doi:10.1371/journal.pone.0129618 · Cited by 97
Moriyama, M., Fukuhara, T., Britschgi, M., He, Y., Narasimhan, R., Villeda, S., Molina, H. D., Huber, B. T., Holers, M., & Wyss‐Coray, T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.3617-10.2011 · Cited by 94
Singer, B. H., Gamelli, A., Fuller, C. L., Temme, S. J., Parent, J. M., & Murphy, G. G. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1015425108 · Cited by 92
Koppel, J. L., Vingtdeux, V., Marambaud, P., d’Abramo, C., Jimenez, H. T., Stauber, M., Friedman, R., & Davies, P. (2013) · Molecular Medicine · doi:10.2119/molmed.2013.00140.revised · Cited by 90
Núñez, E., Benito, C., Tolón, R. M., Hillard, C. J., Griffin, W. S. T., & Romero, J. (2008) · Neuroscience · doi:10.1016/j.neuroscience.2007.10.029 · Cited by 86
Fowler, S., Chiang, A. C. A., Savjani, R. R., Larson, M., Sherman, M. A., Schuler, D. R., Cirrito, J. R., Lesné, S., & Jankowsky, J. L. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0572-14.2014 · Cited by 80
Burns, T. C., Li, M. D., Mehta, S., Awad, A. J., & Morgan, A. A. (2015) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2015.03.021 · Cited by 79
Rodgers, S. P., Born, H. A., Das, P., & Jankowsky, J. L. (2012) · Molecular Neurodegeneration · doi:10.1186/1750-1326-7-28 · Cited by 69
Ber, I. L., van Bortel, I., Nicolas, G., Bouya-Ahmed, K., Camuzat, A., Wallon, D., de Septenville, A. L., Latouche, M., Lattante, S., Kabashi, E., et al. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.016 · Cited by 67
Jackson, H. M., Soto, I., Graham, L. C., Carter, G. W., & Howell, G. R. (2013) · BMC Genomics · doi:10.1186/1471-2164-14-831 · Cited by 66
Benítez, B. A., & Cruchaga, C. (2013) · PubMed Central · doi:10.1056/nejmc1306509#sa4 · Cited by 64
Knock-In of Human BACE1 Cleaves Murine APP and Reiterates Alzheimer-like Phenotypes
ska, K. P., Crouch, B., Koss, D. J., Robinson, L., Siebrecht, M., Riedel, G., & Platt, B. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0433-14.2014 · Cited by 62
Handoko, M., Grant, M. K. O., Kuskowski, M. A., Zahs, K. R., Wallin, A., Blennow, K., & Ashe, K. H. (2013) · JAMA Neurology · doi:10.1001/jamaneurol.2013.48 · Cited by 62
Rigor or Mortis: Best Practices for Preclinical Research in Neuroscience
Steward, O., & Balice‐Gordon, R. J. (2014) · Neuron · doi:10.1016/j.neuron.2014.10.042 · Cited by 60
Gene Expression as Peripheral Biomarkers for Sporadic Alzheimer's Disease
Grünblatt, E., Bartl, J., Zehetmayer, S., Ringel, T. M., Bauer, P., Riederer, P. F., & Jacob, C. (2009) · Journal of Alzheimer s Disease · doi:10.3233/jad-2009-0996 · Cited by 58
β-Amyloid oligomers in aging and Alzheimer’s disease
Zahs, K. R., & Ashe, K. H. (2013) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2013.00028 · Cited by 55
Reversible Pathologic and Cognitive Phenotypes in an Inducible Model of Alzheimer-Amyloidosis
Melnikova, T., Fromholt, S., Kim, H.-S., Lee, D., Xu, G. M., Price, A. R., Moore, B. D., Golde, T. E., Felsenstein, K. M., Savonenko, A. V., et al. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4251-12.2013 · Cited by 51
Romberg, C., Bussey, T. J., & Saksida, L. M. (2012) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2012.02.007 · Cited by 49
Morihara, T., Hayashi, N., Yokokoji, M., Akatsu, H., Silverman, M. A., Kimura, N., Sato, M., Saito, Y., Suzuki, T., Yanagida, K., et al. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1307345111 · Cited by 41
Shi, L., Du, X., Zhou, H., Tao, C.-L., Liu, Y.-T., Meng, F., Wu, G., Xiong, Y., Xia, C., Wang, Y., et al. (2014) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145714000601 · Cited by 40
Teng, E., Chow, N., Hwang, K., Thompson, P. M., Gylys, K. H., Cole, G. M., Jack, C. R., Shaw, L. M. J., Trojanowski, J. Q., Soares, H. D., et al. (2014) · Dementia and Geriatric Cognitive Disorders · doi:10.1159/000368982 · Cited by 33
All Is Not Well in the World of Translational Research
Unger, E. F. (2007) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2007.04.067 · Cited by 30
Preclinical data reproducibility for R&D—the challenge for neuroscience
Steckler, T. (2015) · Psychopharmacology · doi:10.1007/s00213-014-3836-3 · Cited by 25
Cerebrospinal fluid biomarkers for pathological processes in Alzheimer's disease
Rosén, C., & Zetterberg, H. (2013) · Current Opinion in Psychiatry · doi:10.1097/yco.0b013e32835f6747 · Cited by 23
Enhanced dentate gyrus synaptic plasticity but reduced neurogenesis in a mouse model of amyloidosis
Poirier, R., Veltman, I., Pflimlin, M., Knoflach, F., & Metzger, F. (2010) · Neurobiology of Disease · doi:10.1016/j.nbd.2010.06.014 · Cited by 20
Mouse Models for Drug Discovery
Proetzel, G., & Wiles, M. (2016) · Methods in Molecular Biology · doi:10.1007/978-1-4939-3661-8 · Cited by 20
Malthankar‐Phatak, G. H., Lin, Y., Giovannone, N., & Siman, R. G. (2012) · Europe PMC (PubMed Central) · Cited by 18
Future Viable Models of Psychiatry Drug Discovery in Pharma
Rizzo, S. J. S., Edgerton, J. R., Hughes, Z. A., & Brandon, N. J. (2013) · SLAS DISCOVERY · doi:10.1177/1087057113475871 · Cited by 14
Keeping score, strengthening policy and fighting bad actors over access to research tools
Bubela, T. M., & Cook-Deegan, R. M. (2015) · Nature Biotechnology · doi:10.1038/nbt.3131 · Cited by 5
Research works printed but not linked: 1
- Benitez, 2013, TREM2 and neurodegenerative disease, N. Engl. J. Med., 369, 1567
Cited by
Sorted by citations
Induced pluripotent stem cell technology: a decade of progress.
Shi, Y., Inoue, H., Wu, J. C., & Yamanaka, S. (2017) · Nature Reviews Drug Discovery · doi:10.1038/nrd.2016.245 · Cited by 1,525
APP mouse models for Alzheimer’s disease preclinical studies.
Sasaguri, H., Nilsson, P., Hashimoto, S., Nagata, K., Saito, T., De Strooper, B., Hardy, J., Vassar, R., Winblad, B., & Saido, T. C. (2017) · The EMBO Journal · doi:10.15252/embj.201797397 · Cited by 793
Animal models of neurodegenerative diseases
Dawson, T. M., Golde, T. E., & Lagier-Tourenne, C. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0236-8 · Cited by 576
The Amyloid Cascade Hypothesis in Alzheimer’s Disease: It’s Time to Change Our Mind
Ricciarelli, R., & Fedele, E. (2017) · Current Neuropharmacology · doi:10.2174/1570159x15666170116143743 · Cited by 380
Comparative transcriptomics in human and mouse
Breschi, A., Gingeras, T., & Guigó, R. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.19 · Cited by 389
Metadata
- Authors
- Onos, K. D., Sukoff Rizzo, S. J., Howell, G. R., & Sasner, M.
- Affiliations
- Jackson Laboratory (US)
- Tufts University (US)
- Corresponding author
- Howell, Gareth R.
- Sasner, Michael
- Venue
- Brain Research Bulletin
- Publisher
- Elsevier BV
- Published
- 2016-04
- Volume
- 122
- Pages
- 1-11
- ISSN
- 0361-9230 (ISSN-L)
- PMC
- PMC4843786
- OpenAlex
- W2207047877
- Cited by
- 156
- References
- 85
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 14 · 2023: 10 · 2022: 11 · 2021: 11 · 2020: 23 · 2019: 21 · 2018: 20 · 2017: 20 · 2016: 10
- FWCI
- 2.04
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- Locations
- Brain Research Bulletin (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- The Mouseion at the JAXlibrary (Jackson Laboratory) (submittedVersion)
- Funders
- National Institutes of Health
- National Institute on Aging (RF1AG051496)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (T32HD007065)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- Alzheimer's disease, genetic mouse models, translational research, next-generation sequencing, genome editing, biomarkers, behavioral tests, preclinical models
- MeSH terms
- Alzheimer Disease, Animals, Disease Models, Animal, Genetic Testing, Biomarkers, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
